ES479166A1 - Un procedimiento para la preparacion de acido 7&-metoxi-7b-(4-metilen sustituido 1,3-ditietan-2il) carboxamido-3-hetero-ciclotiometil-3-cefem-4-carboxilico. - Google Patents

Un procedimiento para la preparacion de acido 7&-metoxi-7b-(4-metilen sustituido 1,3-ditietan-2il) carboxamido-3-hetero-ciclotiometil-3-cefem-4-carboxilico.

Info

Publication number
ES479166A1
ES479166A1 ES479166A ES479166A ES479166A1 ES 479166 A1 ES479166 A1 ES 479166A1 ES 479166 A ES479166 A ES 479166A ES 479166 A ES479166 A ES 479166A ES 479166 A1 ES479166 A1 ES 479166A1
Authority
ES
Spain
Prior art keywords
alpha
beta
diethietane
carboxyamido
methoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES479166A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP52068699A external-priority patent/JPS5854157B2/ja
Priority claimed from JP9077277A external-priority patent/JPS5811956B2/ja
Priority claimed from JP53010772A external-priority patent/JPS6052714B2/ja
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Publication of ES479166A1 publication Critical patent/ES479166A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/57—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un procedimiento para la preparación de ácido 7alpha-metoxi-7beta-(4-metilen sustituido-1,3-ditietan-2-il)carboxamido-3-heterociclo-tiometil-delta3-cefem-4-carboxílico representado por la fórmula general: ***1 (Ver fórmula 1) donde R1 es un grupo carboxilo o un resto derivado funcional del mismo; R2 es un átomo de hidrógeno, un grupo alquilo inferior, un grupo alcoxi inferior, un grupo alcanoílo inferior, un grupo R4S(O)n (donde R4 es un grupo alquilo inferior y n representa 0, 1 o 2), un grupo arilo, un grupo aroílo, un grupo carboxilo, un grupo derivado funcional de un grupo carboxilo, un grupo alquenilo inferior, un grupo sulfamoílo o un resto heterocíclico y R3 es un grupo (alquil inferior)tetrazolilo o un grupo (alquil inferior)tiadiazolilo.
ES479166A 1977-06-10 1979-03-31 Un procedimiento para la preparacion de acido 7&-metoxi-7b-(4-metilen sustituido 1,3-ditietan-2il) carboxamido-3-hetero-ciclotiometil-3-cefem-4-carboxilico. Expired ES479166A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP52068699A JPS5854157B2 (ja) 1977-06-10 1977-06-10 セフアロスポリン化合物の新規誘導体ならびにその製造方法
JP9077277A JPS5811956B2 (ja) 1977-07-28 1977-07-28 新抗菌化合物
JP53010772A JPS6052714B2 (ja) 1978-02-02 1978-02-02 新規抗菌化合物

Publications (1)

Publication Number Publication Date
ES479166A1 true ES479166A1 (es) 1979-07-01

Family

ID=27279078

Family Applications (4)

Application Number Title Priority Date Filing Date
ES470689A Expired ES470689A1 (es) 1977-06-10 1978-06-09 Un procedimiento para la preparacion de acido 7-metoxi-7- (4-metilen sustituido-1,3-ditietan-2-il-carboxamido)-3-hete-rociclotiometil-3-cefem-4-carboxilico
ES479168A Expired ES479168A1 (es) 1977-06-10 1979-03-31 Un procedimiento para la preparacion de derivados de acido 7&-metoxicefalosporanico.
ES479167A Expired ES479167A1 (es) 1977-06-10 1979-03-31 Un procedimiento para la preparacion de acido 7&-metoxi-7b( 4-metilen sustituido-1,3-ditietan-2-il)carboxamido-3-hete- ro-ciclotiometil-3-cefem-4-carboxilico.
ES479166A Expired ES479166A1 (es) 1977-06-10 1979-03-31 Un procedimiento para la preparacion de acido 7&-metoxi-7b-(4-metilen sustituido 1,3-ditietan-2il) carboxamido-3-hetero-ciclotiometil-3-cefem-4-carboxilico.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES470689A Expired ES470689A1 (es) 1977-06-10 1978-06-09 Un procedimiento para la preparacion de acido 7-metoxi-7- (4-metilen sustituido-1,3-ditietan-2-il-carboxamido)-3-hete-rociclotiometil-3-cefem-4-carboxilico
ES479168A Expired ES479168A1 (es) 1977-06-10 1979-03-31 Un procedimiento para la preparacion de derivados de acido 7&-metoxicefalosporanico.
ES479167A Expired ES479167A1 (es) 1977-06-10 1979-03-31 Un procedimiento para la preparacion de acido 7&-metoxi-7b( 4-metilen sustituido-1,3-ditietan-2-il)carboxamido-3-hete- ro-ciclotiometil-3-cefem-4-carboxilico.

Country Status (11)

Country Link
US (3) US4263432A (es)
CA (1) CA1103659A (es)
CH (1) CH648317A5 (es)
DE (1) DE2824559C2 (es)
DK (1) DK164224C (es)
ES (4) ES470689A1 (es)
FR (1) FR2405952A1 (es)
IT (1) IT1159721B (es)
MX (1) MX5137E (es)
NL (2) NL185622C (es)
SE (1) SE438338B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH648317A5 (de) * 1977-06-10 1985-03-15 Yamanouchi Pharma Co Ltd 7alpha-methoxy-7betha-(1,3-dithietan-2- carboxamido)cephalosporansaeurederivate und verfahren zu ihrer herstellung.
GB1604738A (en) * 1977-07-28 1981-12-16 Yamanouchi Pharma Co Ltd 1,3-dithietane-2-carboxylic acid derivatives and the preparation thereof
EP0062119B1 (en) * 1981-04-03 1986-01-02 Nihon Nohyaku Co., Ltd. Process of producing 1,3-dithiol-2-ylidene malonic acid dialkyl esters
ATE20664T1 (de) * 1981-04-03 1986-07-15 Nihon Nohyaku Co Ltd Verfahren zur herstellung von 1,3-dithiol-2yliden-malonaten.
JPS6011917B2 (ja) * 1981-04-09 1985-03-28 山之内製薬株式会社 新規なセファロスポリン化合物
US5147871A (en) * 1986-07-03 1992-09-15 Hoffmann La-Roche, Inc. Anti-bacterial cephalosporin compounds
CS273349B2 (en) * 1988-03-31 1991-03-12 Hoffmann La Roche Method of cephalosporin's new derivatives production
US5336768A (en) * 1988-05-24 1994-08-09 Hoffmann-La Roche Inc. Antibacterial cephalosporin compounds
US5159077A (en) * 1989-07-21 1992-10-27 Hoffmann-La Roche Inc. Penam antibacterial compounds
US5162523A (en) * 1989-07-21 1992-11-10 Hoffmann-La Roche Inc. Cephalosporin antibacterial compounds
JP2566680B2 (ja) 1990-12-21 1996-12-25 塩野義製薬株式会社 ビニルチオ酢酸誘導体
JPH0713032B2 (ja) * 1993-03-19 1995-02-15 工業技術院長 ターシャリーブチルメチルエーテルの光脱水素二量化方法
US5811419A (en) * 1996-01-16 1998-09-22 Hoffmann-La Roche Inc. Isooxacephem-derivatives
US5883247A (en) * 1996-06-10 1999-03-16 Hoffmann-La Roche Inc. Preparation of cephem and isooxacephem derivatives
ITMI20010964A1 (it) * 2001-05-10 2002-11-10 Acs Dobfar Spa Procedimento per l'ottenimento di composti utili per la produzione del cefotetan e nuovi composti cosi' ottenuti
ITMI20051085A1 (it) * 2005-06-10 2006-12-11 Acs Dobfar Spa Metodo di purificazione del cefotetan
ITMI20051115A1 (it) * 2005-06-14 2006-12-15 Acs Dobfar Spa Procedimento per l'ottenimento di cefotetan con resa elevata
WO2007122628A1 (en) * 2006-04-21 2007-11-01 Lupin Limited Improved process for preparation of highly pure cefotetan disodium
CN102161669A (zh) * 2011-02-21 2011-08-24 江苏济川制药有限公司 一种除去头孢替坦二钠中杂质△2-isomer的方法
CN102250125B (zh) * 2011-05-20 2013-10-16 海南合瑞制药股份有限公司 一种头孢替坦的制备方法
CN106478670B (zh) * 2016-08-30 2018-11-20 济川药业集团有限公司 一种头孢替坦酸的新结晶及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL29235A (en) 1967-01-05 1971-10-20 Bristol Myers Co 7-(pyridylthioacetamido)cephalosporanic acid derivatives and their preparation
CH557381A (de) * 1967-04-15 1974-12-31 Fujisawa Pharmaceutical Co Verfahren zur herstellung von (delta)3-cephemverbindungen.
AR205728A1 (es) * 1973-11-14 1976-05-31 Rhone Poulenc Sa Procedimiento para preparar ((dihidro-5,6-oxa)-(di) tiino-1,4-il-2) acetamido)-7 cefalosporina y sus sales
OA05033A (fr) * 1974-07-01 1980-12-31 Rhone Poulenc Ind Nouveaux dérivés de la céphalosporine et leur préparation.
JPS5119765A (en) * 1974-08-09 1976-02-17 Takeda Chemical Industries Ltd Aminochiazoorujudotaino seizoho
JPS5530714B2 (es) * 1974-08-22 1980-08-13
US4182868A (en) * 1974-10-29 1980-01-08 Takeda Chemical Industries, Ltd. 7-Methoxycephalosporin derivatives
US4203899A (en) * 1974-12-19 1980-05-20 Takeda Chemical Industries, Ltd. Thiazolylacetamido compounds
DE2539214C2 (de) * 1975-09-03 1984-03-29 E.R. Squibb & Sons, Inc., 08540 Princeton, N.J. 7-Methoxythienyl-ureido-cephalosporin und dieses enthaltendes Arzneimittel
US4299829A (en) * 1976-03-12 1981-11-10 Fujisawa Pharmaceutical Co., Ltd. 2-Lower alkyl-7-substituted-2 or 3-cephem 4-carboxylic acid compounds
US4058609A (en) * 1976-06-28 1977-11-15 Smithkline Corporation 7-Dithioacetamido cephalosporins
CH648317A5 (de) * 1977-06-10 1985-03-15 Yamanouchi Pharma Co Ltd 7alpha-methoxy-7betha-(1,3-dithietan-2- carboxamido)cephalosporansaeurederivate und verfahren zu ihrer herstellung.
GB1604738A (en) * 1977-07-28 1981-12-16 Yamanouchi Pharma Co Ltd 1,3-dithietane-2-carboxylic acid derivatives and the preparation thereof

Also Published As

Publication number Publication date
IT1159721B (it) 1987-03-04
MX5137E (es) 1983-03-28
US4263432A (en) 1981-04-21
DK164224B (da) 1992-05-25
FR2405952A1 (fr) 1979-05-11
NL185622C (nl) 1990-06-01
NL8901120A (nl) 1989-08-01
ES479167A1 (es) 1979-07-01
US4404373A (en) 1983-09-13
CA1103659A (en) 1981-06-23
NL7806208A (nl) 1978-12-12
ES470689A1 (es) 1979-09-01
DE2824559A1 (de) 1979-01-04
SE438338B (sv) 1985-04-15
USRE32491E (en) 1987-09-01
CH648317A5 (de) 1985-03-15
IT7868369A0 (it) 1978-06-12
DE2824559C2 (de) 1985-01-10
FR2405952B1 (es) 1983-02-25
ES479168A1 (es) 1979-07-01
NL185622B (nl) 1990-01-02
DK164224C (da) 1992-10-19
DK258078A (da) 1979-01-23
SE7806711L (sv) 1978-12-11

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