ES464412A1 - Un procedimiento para la preparacion de cefazolina sodica, esencialmente cristalina y rapidamente soluble. - Google Patents
Un procedimiento para la preparacion de cefazolina sodica, esencialmente cristalina y rapidamente soluble.Info
- Publication number
- ES464412A1 ES464412A1 ES464412A ES464412A ES464412A1 ES 464412 A1 ES464412 A1 ES 464412A1 ES 464412 A ES464412 A ES 464412A ES 464412 A ES464412 A ES 464412A ES 464412 A1 ES464412 A1 ES 464412A1
- Authority
- ES
- Spain
- Prior art keywords
- cefazolin sodium
- parenteral administration
- preparing
- rapidly dissolving
- dissolving powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Cephalosporin Compounds (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un procedimiento para la preparación de cefazolina sódica esencialmente cristalina y rápidamente solublecaracterizado por las siguientes operaciones:a) enfriar lentamente una solución que contiene cefazolina sódica en un disolvente constituido por 2 a 25% de un alcanol C1-C3 y 75 a 98% (v/v) de aguadurante un periodo de 3 a 12 horashasta -10ºC;b) continuar enfriando el preparado de a) hasta que la mezcla ha solidificado por completo;c) reducir la presión del ambiente en el que se mantiene el preparado de b) hasta 1 mm absoluto de mercurio como máximo;d) elevar la temperatura del ambiente en el que se mantiene el preparado de c) hasta 50ºC como máximoevitando la fusión de dicho preparado ye) sublimar el disolvente del preparado de d) hasta que los cristales de cefazolina sódica resultantes presentan un contenido en humedad no superior al 60% y un contenido en alcanol no superior al 10% (p/p).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74455276A | 1976-11-24 | 1976-11-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES464412A1 true ES464412A1 (es) | 1978-09-01 |
Family
ID=24993135
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES464412A Expired ES464412A1 (es) | 1976-11-24 | 1977-11-23 | Un procedimiento para la preparacion de cefazolina sodica, esencialmente cristalina y rapidamente soluble. |
Country Status (12)
Country | Link |
---|---|
US (1) | US4146971A (es) |
JP (1) | JPS6019758B2 (es) |
BE (1) | BE861134A (es) |
CA (1) | CA1097341A (es) |
DD (1) | DD136967A5 (es) |
DE (1) | DE2752443C2 (es) |
ES (1) | ES464412A1 (es) |
FR (1) | FR2372168A1 (es) |
GB (1) | GB1589316A (es) |
IE (1) | IE45994B1 (es) |
IL (1) | IL53427A0 (es) |
NL (1) | NL189357C (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5726692A (en) * | 1980-07-22 | 1982-02-12 | Fujisawa Pharmaceut Co Ltd | Preparation of stable crystal of salt of ceftizoxime |
US4458070A (en) * | 1982-07-19 | 1984-07-03 | Pfizer Inc. | Process for the manufacture of crystalline sodium cefoperazone |
US4456753A (en) * | 1983-02-07 | 1984-06-26 | Pfizer Inc. | Process for the manufacture of highly crystalline sodium cefoperazone |
FR2561916B1 (fr) * | 1984-03-30 | 1987-12-11 | Lafon Labor | Forme galenique pour administration orale et son procede de preparation par lyophilisation d'une emission huile dans eau |
JPS60255723A (ja) * | 1984-05-31 | 1985-12-17 | Ono Pharmaceut Co Ltd | メシル酸ガベキサートの結晶性凍結乾燥製剤及びその製造方法 |
DE3911321A1 (de) * | 1989-04-07 | 1990-10-11 | Hoechst Ag | Verfahren zur herstellung von cefazolin-natriumsalz |
TW264475B (es) * | 1991-09-20 | 1995-12-01 | Takeda Pharm Industry Co Ltd | |
JPH06122630A (ja) * | 1992-10-12 | 1994-05-06 | Taiyo Yakuhin Kogyo Kk | 安定な塩酸セフォチアム製剤 |
DE69528166T2 (de) * | 1994-05-02 | 2003-04-30 | Shionogi & Co., Ltd. | Kristalline pyrrolidylthiocarbapenem derivate, lyophilisierste präparationen dieser kristalle und verfahren zu deren herstellung |
CN101287446A (zh) | 2005-09-29 | 2008-10-15 | 尼克塔治疗公司 | 抗生素制剂、单位剂量、试剂盒以及方法 |
CN100391961C (zh) | 2005-11-16 | 2008-06-04 | 天津大学 | 五水头孢唑林钠晶体结构及晶体分子组装制备方法 |
EP1870649A1 (en) * | 2006-06-20 | 2007-12-26 | Octapharma AG | Lyophilisation targetting defined residual moisture by limited desorption energy levels |
CN103751123A (zh) * | 2014-01-22 | 2014-04-30 | 邓学峰 | 一种头孢唑林的组合药物 |
CN103965215B (zh) * | 2014-04-30 | 2016-04-27 | 悦康药业集团有限公司 | 一种头孢唑林钠化合物及其无菌粉针 |
CN104530087B (zh) * | 2014-12-25 | 2017-07-21 | 天津大学 | 一种头孢唑林钠新晶型及其制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3449885A (en) * | 1966-03-31 | 1969-06-17 | Ben Venue Lab Inc | Method of packaging viral antisera and other research diagnostic reagents |
DE2362785A1 (de) * | 1973-12-18 | 1975-06-26 | Atmos Fritzsching & Co Gmbh | Verfahren zum haltbarmachen von kristallsuspensionen |
US4029655A (en) * | 1975-04-11 | 1977-06-14 | Eli Lilly And Company | Method of preparing stable sterile crystalline cephalosporins for parenteral administration |
-
1977
- 1977-11-20 IL IL53427A patent/IL53427A0/xx not_active IP Right Cessation
- 1977-11-21 NL NLAANVRAGE7712823,A patent/NL189357C/xx not_active IP Right Cessation
- 1977-11-23 ES ES464412A patent/ES464412A1/es not_active Expired
- 1977-11-24 GB GB48915/77A patent/GB1589316A/en not_active Expired
- 1977-11-24 CA CA291,616A patent/CA1097341A/en not_active Expired
- 1977-11-24 FR FR7735429A patent/FR2372168A1/fr active Granted
- 1977-11-24 JP JP52141435A patent/JPS6019758B2/ja not_active Expired
- 1977-11-24 IE IE2379/77A patent/IE45994B1/en not_active IP Right Cessation
- 1977-11-24 BE BE1008537A patent/BE861134A/xx not_active IP Right Cessation
- 1977-11-24 DE DE2752443A patent/DE2752443C2/de not_active Expired
- 1977-11-24 DD DD77202233A patent/DD136967A5/xx not_active IP Right Cessation
- 1977-12-14 US US05/860,365 patent/US4146971A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPS6019758B2 (ja) | 1985-05-17 |
IL53427A0 (en) | 1978-01-31 |
NL189357B (nl) | 1992-10-16 |
IE45994B1 (en) | 1983-01-26 |
JPS5369821A (en) | 1978-06-21 |
IE45994L (en) | 1978-05-24 |
DE2752443A1 (de) | 1978-06-01 |
GB1589316A (en) | 1981-05-13 |
DD136967A5 (de) | 1979-08-08 |
BE861134A (fr) | 1978-05-24 |
DE2752443C2 (de) | 1983-07-14 |
US4146971A (en) | 1979-04-03 |
FR2372168A1 (fr) | 1978-06-23 |
FR2372168B1 (es) | 1980-11-14 |
NL7712823A (nl) | 1978-05-26 |
NL189357C (nl) | 1993-03-16 |
CA1097341A (en) | 1981-03-10 |
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