ES456755A1 - Quaternary derivatives of sandwicin and a method of producing them - Google Patents
Quaternary derivatives of sandwicin and a method of producing themInfo
- Publication number
- ES456755A1 ES456755A1 ES456755A ES456755A ES456755A1 ES 456755 A1 ES456755 A1 ES 456755A1 ES 456755 A ES456755 A ES 456755A ES 456755 A ES456755 A ES 456755A ES 456755 A1 ES456755 A1 ES 456755A1
- Authority
- ES
- Spain
- Prior art keywords
- halide
- sandwicin
- producing
- formula
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Novel sandwicinium salts of the formula I < IMAGE > in which R represents an alkyl group having up to 5 carbon atoms, are obtained by reacting sandwicin with an appropriate alkyl halide. In order to convert the halide into another salt of the formula I', in which X denotes the anion of an organic or inorganic acid, the halide is converted with alkali into the corresponding, open-ring, aldehyde base, which, together with an appropriate acid, yields the desired salt. The novel salts exhibit adrenolytic and cardiac-rhythm-promoting activity.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19762611162 DE2611162A1 (en) | 1976-03-17 | 1976-03-17 | NEW QUARTERLY DERIVATIVES OF SANDWICIN AND THE METHOD FOR THEIR PRODUCTION |
Publications (1)
Publication Number | Publication Date |
---|---|
ES456755A1 true ES456755A1 (en) | 1978-02-01 |
Family
ID=5972662
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES456755A Expired ES456755A1 (en) | 1976-03-17 | 1977-03-11 | Quaternary derivatives of sandwicin and a method of producing them |
Country Status (25)
Country | Link |
---|---|
JP (1) | JPS52113988A (en) |
AR (1) | AR211567A1 (en) |
AT (1) | AT353986B (en) |
BE (1) | BE852493A (en) |
CA (1) | CA1072959A (en) |
CH (1) | CH631714A5 (en) |
CS (1) | CS197287B2 (en) |
DD (1) | DD128774A5 (en) |
DE (1) | DE2611162A1 (en) |
DK (1) | DK143602C (en) |
ES (1) | ES456755A1 (en) |
FI (1) | FI61898C (en) |
FR (2) | FR2344557A1 (en) |
GB (2) | GB1583554A (en) |
GR (1) | GR62637B (en) |
IL (1) | IL51630A (en) |
IN (1) | IN146149B (en) |
IT (1) | IT1084656B (en) |
MX (1) | MX4788E (en) |
NL (1) | NL7702609A (en) |
NO (1) | NO146282C (en) |
PT (1) | PT66298B (en) |
SE (1) | SE7702907L (en) |
YU (1) | YU70177A (en) |
ZA (1) | ZA771569B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2941531A1 (en) * | 1979-10-13 | 1981-04-23 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 10-BROMSANDWICIN AND 10-BROMISOSANDWICIN, METHOD FOR THE PRODUCTION AND USE THEREOF |
DE2941530A1 (en) * | 1979-10-13 | 1981-04-23 | Kali-Chemie Pharma Gmbh, 3000 Hannover | N (DOWN ARROW) B (UP ARROW) QUARTERS DERIVATIVES OF SANDWICIN AND ISOSANDWICIN, METHODS AND INTERMEDIATE PRODUCTS FOR THE PRODUCTION OF THE DERIVATIVES, THE MEDICINAL PRODUCT CONTAINING THE DERIVATIVES AND THE USE OF THE DERIVATIVES |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1154120B (en) * | 1962-01-10 | 1963-09-12 | Thomae Gmbh Dr K | Process for the production of new ajmaline derivatives |
GB1582627A (en) * | 1976-01-16 | 1981-01-14 | Inverni Della Beffa Spa | Derivatives of sandwicine and isosandwicine and pharmaceutical compositions comprising sandwicine isosandwicine and derivatives thereof |
-
1976
- 1976-03-17 DE DE19762611162 patent/DE2611162A1/en active Granted
-
1977
- 1977-02-23 MX MX775461U patent/MX4788E/en unknown
- 1977-03-02 AR AR266736A patent/AR211567A1/en active
- 1977-03-04 CH CH275377A patent/CH631714A5/en not_active IP Right Cessation
- 1977-03-04 CS CS771481A patent/CS197287B2/en unknown
- 1977-03-08 IT IT21028/77A patent/IT1084656B/en active
- 1977-03-08 IL IL51630A patent/IL51630A/en unknown
- 1977-03-10 NL NL7702609A patent/NL7702609A/en not_active Application Discontinuation
- 1977-03-11 GB GB10521/77A patent/GB1583554A/en not_active Expired
- 1977-03-11 ES ES456755A patent/ES456755A1/en not_active Expired
- 1977-03-11 GB GB41140/79A patent/GB1583555A/en not_active Expired
- 1977-03-14 PT PT66298A patent/PT66298B/en unknown
- 1977-03-15 BE BE6045928A patent/BE852493A/en not_active IP Right Cessation
- 1977-03-15 SE SE7702907A patent/SE7702907L/en not_active Application Discontinuation
- 1977-03-15 DD DD7700197869A patent/DD128774A5/en unknown
- 1977-03-15 FR FR7707630A patent/FR2344557A1/en active Granted
- 1977-03-15 GR GR53002A patent/GR62637B/en unknown
- 1977-03-16 AT AT179277A patent/AT353986B/en not_active IP Right Cessation
- 1977-03-16 ZA ZA00771569A patent/ZA771569B/en unknown
- 1977-03-16 YU YU00701/77A patent/YU70177A/en unknown
- 1977-03-16 DK DK114677A patent/DK143602C/en active
- 1977-03-16 NO NO770934A patent/NO146282C/en unknown
- 1977-03-17 CA CA274,191A patent/CA1072959A/en not_active Expired
- 1977-03-17 JP JP2976377A patent/JPS52113988A/en active Pending
- 1977-03-17 FI FI770855A patent/FI61898C/en not_active IP Right Cessation
- 1977-05-11 IN IN707/CAL/77A patent/IN146149B/en unknown
-
1978
- 1978-09-05 FR FR7825511A patent/FR2392995A1/en active Granted
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19981103 |