ES401176A1 - Substituted biphenyls - Google Patents

Substituted biphenyls

Info

Publication number
ES401176A1
ES401176A1 ES401176A ES401176A ES401176A1 ES 401176 A1 ES401176 A1 ES 401176A1 ES 401176 A ES401176 A ES 401176A ES 401176 A ES401176 A ES 401176A ES 401176 A1 ES401176 A1 ES 401176A1
Authority
ES
Spain
Prior art keywords
compound
general formula
formula
see formula
see
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES401176A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boots Co PLC
Original Assignee
Boots Co PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boots Co PLC filed Critical Boots Co PLC
Publication of ES401176A1 publication Critical patent/ES401176A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/58—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in three-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A procedure for the preparation of a compound of general formula I: **(See formula)** in which R1, R2 and R3 are individually selected from fluorine, chlorine and bromine X is COOH, CONH2, CH2OH or CONHOH; together with esters, inorganic salts and pharmaceutically acceptable organic salts of those compounds, where Y is COOH and inorganic salts where Y is CONHOH; characterized by (1) hydrolyzing a compound of the general formula II **(See formula)** where Z is cyano, carbamoyl, thiocarbamoyl N, N-disubstituted, or COOR4 where R4 is an ester-forming group; or (2) decarboxylate a compound of general formula III **(See formula)** or (3) methylate a compound of general formula IV **(See formula)** or an ester or amide thereof; or (4) oxidize a compound of general formula V **(See formula)** or (5) subjecting to reductive cleavage a compound of general formula VI **(See formula)** or (6) hydrogenate a compound of general formula VII **(See formula)** or an ester or amide thereof; or (7) treating with carbon dioxide a compound of general formula VIII **(See formula)** in which Hal is chlorine, bromine or iodine; or (8) reacting a compound of general formula IX **(See formula)** with a compound of general formula X **(See formula)** or an ester or alcohol derived therefrom, where A and B are halogen atoms; or (9) subjecting to hydrolysis or alcohololysis a compound of the general formula XI **(See formula)** or (10) separating sulfur dioxide from a compound of the general formula XII **(See formula)** or an ester, amide, or alcohol derived therefrom, in which the at least one of the symbols R5, R6, and R7 is a halosulfonyl group, and the remaining symbols correspond to the desired values of R1, R2, or R3; or (11) reacting a compound of the general formula XIII **(See formula)** or an ester, amide, or alcohol derived therefrom; in which at least one of the symbols R8, R9 and R10 is an amino group and the other symbols correspond to the desired values of R1, R2, or R3 with an agent capable of converting said amino group into the desired halogen atom; or (12) esterify a compound of the general formula XIV **(See formula)** or (13) subjecting a compound of the general formula XV to alcohololysis **(See formula)** in which Z1 is cyano, carbamoyl or thiocarbamoyl N, N-disubstituted; or (14) amidate a compound of the general formula XVI **(See formula)** in which Hal is a halogen atom; or (15) hydrolyze a compound of the general formula XVII **(See formula)** to convert the cyano group into a carbamoyl group; or (16) reducing a compound of general formula XVIII **(See formula)** or an ester thereof to convert the COOH group to CH2OH; or (17) reacting a compound of the general formula XIX **(See formula)** where Z2 is COOR4, or COHal, with hydroxylamine; and, if desired, form a pharmaceutically acceptable salt of any acid thus obtained. (Machine-translation by Google Translate, not legally binding)
ES401176A 1971-03-26 1972-03-25 Substituted biphenyls Expired ES401176A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB793671A GB1382996A (en) 1971-03-26 1971-03-26 Substituted biphenyls

Publications (1)

Publication Number Publication Date
ES401176A1 true ES401176A1 (en) 1975-02-01

Family

ID=9842634

Family Applications (1)

Application Number Title Priority Date Filing Date
ES401176A Expired ES401176A1 (en) 1971-03-26 1972-03-25 Substituted biphenyls

Country Status (19)

Country Link
AR (2) AR195788A1 (en)
AT (2) AT321288B (en)
BE (1) BE781054A (en)
BR (1) BR7201721D0 (en)
CA (1) CA992090A (en)
CH (3) CH563331A5 (en)
CS (2) CS163800B2 (en)
DE (1) DE2214561A1 (en)
ES (1) ES401176A1 (en)
FR (1) FR2130492B1 (en)
GB (1) GB1382996A (en)
HU (1) HU164381B (en)
IE (1) IE36205B1 (en)
IL (1) IL38957A (en)
NL (1) NL7203920A (en)
NO (1) NO137546C (en)
RO (2) RO66640A (en)
SE (1) SE398112B (en)
ZA (1) ZA721706B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1437783A (en) * 1972-09-22 1976-06-03 Boots Co Ltd 2-substituted biphenylyl acetic acids and derivatives thereof
ATA785173A (en) * 1972-08-17 1975-01-15 Thomae Gmbh Dr K PROCESS FOR PREPARING NEW 4- (4-BIPHENYLYL) -4-HYDROXY-BUTTERIC ACID AMIDES
JPS582934B2 (en) * 1974-07-29 1983-01-19 ニツシンセイフン カブシキガイシヤ Process for producing 2-(substituted aryl)-propionic acid
DE3773882D1 (en) * 1987-01-21 1991-11-21 Sumitomo Chemical Co METHOD FOR PRODUCING OPTICALLY ACTIVE ARYL ACETIC DERIVATIVES.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR7047A (en) * 1904-07-11

Also Published As

Publication number Publication date
IE36205L (en) 1972-09-26
AT319920B (en) 1975-01-10
HU164381B (en) 1974-02-28
AR195813A1 (en) 1973-11-09
IE36205B1 (en) 1976-09-15
NL7203920A (en) 1972-09-28
BE781054A (en) 1972-09-22
SE398112B (en) 1977-12-05
CS163800B2 (en) 1975-11-07
CH552552A (en) 1974-08-15
NO137546B (en) 1977-12-05
AT321288B (en) 1975-03-25
ZA721706B (en) 1972-12-27
CS163799B2 (en) 1975-11-07
CH562190A5 (en) 1975-05-30
BR7201721D0 (en) 1973-11-01
CH563331A5 (en) 1975-06-30
NO137546C (en) 1978-03-15
IL38957A0 (en) 1972-05-30
DE2214561A1 (en) 1972-10-05
RO62846A (en) 1977-11-15
IL38957A (en) 1975-08-31
CA992090A (en) 1976-06-29
AR195788A1 (en) 1973-11-09
FR2130492B1 (en) 1975-10-31
FR2130492A1 (en) 1972-11-03
GB1382996A (en) 1975-02-05
RO66640A (en) 1981-06-30

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