IE36205B1 - Substituted biphenyls - Google Patents
Substituted biphenylsInfo
- Publication number
- IE36205B1 IE36205B1 IE284/72A IE28472A IE36205B1 IE 36205 B1 IE36205 B1 IE 36205B1 IE 284/72 A IE284/72 A IE 284/72A IE 28472 A IE28472 A IE 28472A IE 36205 B1 IE36205 B1 IE 36205B1
- Authority
- IE
- Ireland
- Prior art keywords
- cooh
- corresponding compound
- group
- conhoh
- reaction
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
- C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
- C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
- C07C45/58—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in three-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
- C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1382996 Biphenyl derivatives BOOTS CO Ltd 7 March 1972 [26 March 1971] 7936/71 Heading C2C Novel biphenyl derivatives of the general formula wherein each of R 1 , R 2 and R 3 is a chlorine, bromine or fluorine atom and Y is COOH, CONH 2 , CH 2 OH or CONHOH, and pharmaceutically acceptable esters, inorganic base addition salts and organic base addition salts of those derivatives wherein Y is COOH and inorganic base addition salts of those derivatives wherein Y is CONHOH, are prepared, e.g. (a) when Y is COOH, by hydrolysis of the corresponding compound in which Z is CONH 2 , an ester-forming group or a 4,4 - dialkyl - 2- oxazolinyl-(2) group; (b) when Y is COOH, by decarboxylation of the corresponding compound in which the -CH(CH 3 )Y group is replaced by a -C(CH 3 )(COOH) 2 group; (c) when Y is COOH, by oxidation of the corresponding compound in which Y is CHO; (d) when Y is esterified COOH, by esterification of the corresponding compound in which Y is COOH; (e) when Y is COHN 2 , by reaction of the corresponding compound in which Y is CO-halogen with ammonia; (f) when Y is CH 2 OH, by reduction of the corresponding compound in which Y is esterified COOH; (g) when Y is CONHOH, by reaction of the corresponding compound in which Y is esterified COOH with hydroxylamine; and (h) when Y is salified COOH, by reaction of the corresponding compound in which Y is COOH with a base. Pharmaceutical compositions having antiinflammatory activity comprise, as active ingredient, a biphenyl drivative of the above general formula or pharmaceutically acceptable ester or salt thereof as defined above, in association with a pharmaceutical excipient, and may be administered orally, rectally, topically or parenterally.
[GB1382996A]
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB793671A GB1382996A (en) | 1971-03-26 | 1971-03-26 | Substituted biphenyls |
Publications (2)
Publication Number | Publication Date |
---|---|
IE36205L IE36205L (en) | 1972-09-26 |
IE36205B1 true IE36205B1 (en) | 1976-09-15 |
Family
ID=9842634
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE284/72A IE36205B1 (en) | 1971-03-26 | 1972-03-07 | Substituted biphenyls |
Country Status (19)
Country | Link |
---|---|
AR (2) | AR195788A1 (en) |
AT (2) | AT321288B (en) |
BE (1) | BE781054A (en) |
BR (1) | BR7201721D0 (en) |
CA (1) | CA992090A (en) |
CH (3) | CH563331A5 (en) |
CS (2) | CS163800B2 (en) |
DE (1) | DE2214561A1 (en) |
ES (1) | ES401176A1 (en) |
FR (1) | FR2130492B1 (en) |
GB (1) | GB1382996A (en) |
HU (1) | HU164381B (en) |
IE (1) | IE36205B1 (en) |
IL (1) | IL38957A (en) |
NL (1) | NL7203920A (en) |
NO (1) | NO137546C (en) |
RO (2) | RO66640A (en) |
SE (1) | SE398112B (en) |
ZA (1) | ZA721706B (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1437783A (en) * | 1972-09-22 | 1976-06-03 | Boots Co Ltd | 2-substituted biphenylyl acetic acids and derivatives thereof |
ATA785173A (en) * | 1972-08-17 | 1975-01-15 | Thomae Gmbh Dr K | PROCESS FOR PREPARING NEW 4- (4-BIPHENYLYL) -4-HYDROXY-BUTTERIC ACID AMIDES |
JPS582934B2 (en) * | 1974-07-29 | 1983-01-19 | ニツシンセイフン カブシキガイシヤ | Process for producing 2-(substituted aryl)-propionic acid |
EP0275354B1 (en) * | 1987-01-21 | 1991-10-16 | Sumitomo Chemical Company, Limited | Process for preparing optically active arylacetic acid derivatives |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR7047A (en) * | 1904-07-11 |
-
1971
- 1971-03-26 GB GB793671A patent/GB1382996A/en not_active Expired
-
1972
- 1972-03-07 IE IE284/72A patent/IE36205B1/en unknown
- 1972-03-10 IL IL38957A patent/IL38957A/en unknown
- 1972-03-13 ZA ZA721706A patent/ZA721706B/en unknown
- 1972-03-14 CA CA137,098A patent/CA992090A/en not_active Expired
- 1972-03-21 FR FR7209812A patent/FR2130492B1/fr not_active Expired
- 1972-03-21 AR AR241057A patent/AR195788A1/en active
- 1972-03-22 BE BE781054A patent/BE781054A/en unknown
- 1972-03-23 SE SE7203796A patent/SE398112B/en unknown
- 1972-03-23 NL NL7203920A patent/NL7203920A/xx unknown
- 1972-03-23 AT AT1065572A patent/AT321288B/en not_active IP Right Cessation
- 1972-03-23 AT AT252672A patent/AT319920B/en not_active IP Right Cessation
- 1972-03-24 CS CS3030*A patent/CS163800B2/cs unknown
- 1972-03-24 DE DE19722214561 patent/DE2214561A1/en active Pending
- 1972-03-24 NO NO1015/72A patent/NO137546C/en unknown
- 1972-03-24 HU HUBO1359A patent/HU164381B/hu unknown
- 1972-03-24 CH CH311373A patent/CH563331A5/xx not_active IP Right Cessation
- 1972-03-24 CH CH444772A patent/CH552552A/en not_active IP Right Cessation
- 1972-03-24 BR BR721721A patent/BR7201721D0/en unknown
- 1972-03-24 CH CH311473A patent/CH562190A5/xx not_active IP Right Cessation
- 1972-03-24 CS CS1984A patent/CS163799B2/cs unknown
- 1972-03-25 ES ES401176A patent/ES401176A1/en not_active Expired
- 1972-03-27 RO RO7270285A patent/RO66640A/en unknown
- 1972-03-27 RO RO7200072923A patent/RO62846A/en unknown
- 1972-12-28 AR AR245896A patent/AR195813A1/en active
Also Published As
Publication number | Publication date |
---|---|
CA992090A (en) | 1976-06-29 |
CS163799B2 (en) | 1975-11-07 |
GB1382996A (en) | 1975-02-05 |
IL38957A (en) | 1975-08-31 |
RO66640A (en) | 1981-06-30 |
SE398112B (en) | 1977-12-05 |
CH552552A (en) | 1974-08-15 |
CS163800B2 (en) | 1975-11-07 |
AT319920B (en) | 1975-01-10 |
AR195788A1 (en) | 1973-11-09 |
CH562190A5 (en) | 1975-05-30 |
IL38957A0 (en) | 1972-05-30 |
FR2130492A1 (en) | 1972-11-03 |
IE36205L (en) | 1972-09-26 |
NO137546B (en) | 1977-12-05 |
NL7203920A (en) | 1972-09-28 |
CH563331A5 (en) | 1975-06-30 |
ZA721706B (en) | 1972-12-27 |
HU164381B (en) | 1974-02-28 |
BE781054A (en) | 1972-09-22 |
DE2214561A1 (en) | 1972-10-05 |
ES401176A1 (en) | 1975-02-01 |
RO62846A (en) | 1977-11-15 |
AT321288B (en) | 1975-03-25 |
BR7201721D0 (en) | 1973-11-01 |
FR2130492B1 (en) | 1975-10-31 |
NO137546C (en) | 1978-03-15 |
AR195813A1 (en) | 1973-11-09 |
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