ES372615A1 - A procedure for the preparation of new 5-aroil-pirrol-2-carboxylic acids and derivatives of carboxylic acid. (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for the preparation of new 5-aroil-pirrol-2-carboxylic acids and derivatives of carboxylic acid. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES372615A1 ES372615A1 ES372615A ES372615A ES372615A1 ES 372615 A1 ES372615 A1 ES 372615A1 ES 372615 A ES372615 A ES 372615A ES 372615 A ES372615 A ES 372615A ES 372615 A1 ES372615 A1 ES 372615A1
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- acid
- carboxylic acid
- general formula
- carboxylic acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
A procedure for the preparation of new 5-aroyl-pyrrole-2-carboxylic acids and carboxylic acid derivatives of general formula: **(See formula)** and the therapeutically useful salts of the corresponding carboxylic acids, where Ar is a phenyl group or a phenyl group substituted with one or more of the halogen, lower alkyl, lower alkoxy, nitro, amino, methylthio and cyano radicals and R3 represents a member selected from the group consisting of COOH, COO-lower alkyl, CONH2, CONH-lower alkyl and CON- (lower alkyl) 2, whose process is characterized by reacting a carboxylic acid halide of general formula: **(See formula)** where Ar'has the meaning given above to Ar except for the aminophenyl group, with a pyrrole derivative of general formula: **(See formula)** in the presence of a Lewis acid and a solvent and, if desired, subjecting the ester thus obtained of the general formula **(See formula)** to one or both of the following operations, in arbitrary order: a) hydrolysis to free carboxylic acid and, if desired, subsequent conversion of said acid to the corresponding amide with ammonia or with an appropriate lower alkylamine or di (lower alkyl) amine or treating said acid with a base, in order to convert said acid in a therapeutically useful salt; b) in the case that Ar'is a nitrophenyl group, catalytically hydrogenate said product to give the corresponding compound in which Ar is aminophenyl. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74134868A | 1968-07-01 | 1968-07-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES372615A1 true ES372615A1 (en) | 1972-02-16 |
Family
ID=24980356
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES372615A Expired ES372615A1 (en) | 1968-07-01 | 1969-10-16 | A procedure for the preparation of new 5-aroil-pirrol-2-carboxylic acids and derivatives of carboxylic acid. (Machine-translation by Google Translate, not legally binding) |
| ES372616A Expired ES372616A1 (en) | 1968-07-01 | 1969-10-16 | A procedure for the preparation of new 5-aroil-pirrol-2-o-3-carboxylic acids and derivatives of carboxylic acid. (Machine-translation by Google Translate, not legally binding) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES372616A Expired ES372616A1 (en) | 1968-07-01 | 1969-10-16 | A procedure for the preparation of new 5-aroil-pirrol-2-o-3-carboxylic acids and derivatives of carboxylic acid. (Machine-translation by Google Translate, not legally binding) |
Country Status (2)
| Country | Link |
|---|---|
| AT (2) | AT292686B (en) |
| ES (2) | ES372615A1 (en) |
-
1968
- 1968-07-26 AT AT446470A patent/AT292686B/en active
- 1968-07-26 AT AT446370A patent/AT292685B/en not_active IP Right Cessation
-
1969
- 1969-10-16 ES ES372615A patent/ES372615A1/en not_active Expired
- 1969-10-16 ES ES372616A patent/ES372616A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AT292686B (en) | 1971-09-10 |
| AT292685B (en) | 1971-09-10 |
| ES372616A1 (en) | 1972-02-16 |
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