ES368518A1 - Improvements in or relating to new steroid 21-esters, method for their preparation and therapeutic composition containing same - Google Patents
Improvements in or relating to new steroid 21-esters, method for their preparation and therapeutic composition containing sameInfo
- Publication number
- ES368518A1 ES368518A1 ES368518A ES368518A ES368518A1 ES 368518 A1 ES368518 A1 ES 368518A1 ES 368518 A ES368518 A ES 368518A ES 368518 A ES368518 A ES 368518A ES 368518 A1 ES368518 A1 ES 368518A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- methylacetamido
- esters
- relating
- composition containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises the 21-[4-(N-methylacetamido)-benzoates] of 21-hydroxy steroids of the pregnane, 4-pregnene and 1,4-pregnadiene series, and their preparation by reacting the appropriate acyl chloride with the appropriate 21-hydroxy steroids, e.g. prednisolone, triamcinolone, betamethasone, prednisone and dexamethasone. 4 - (N - methylacetamido) - benzoyl chloride is prepared by reacting 4-(N-methylacetamido)- benzoic acid with thionyl chloride. The inventive steroids are stated to possess antiphlogistic, antianaphylactic and corticoid activity, and may be made up with carriers into pharmaceutical compositions for oral, parenteral, rectal and topical administration.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR154433A FR7455M (en) | 1968-06-10 | 1968-06-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES368518A1 true ES368518A1 (en) | 1971-05-01 |
Family
ID=8650990
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES368518A Expired ES368518A1 (en) | 1968-06-10 | 1969-06-07 | Improvements in or relating to new steroid 21-esters, method for their preparation and therapeutic composition containing same |
Country Status (6)
Country | Link |
---|---|
BE (1) | BE733889A (en) |
CH (1) | CH510656A (en) |
DE (1) | DE1929264A1 (en) |
ES (1) | ES368518A1 (en) |
FR (1) | FR7455M (en) |
GB (1) | GB1223087A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4011317A (en) * | 1975-08-22 | 1977-03-08 | Rorer Italiana S.P.A. | Steroid derivatives |
-
1968
- 1968-06-10 FR FR154433A patent/FR7455M/fr not_active Expired
-
1969
- 1969-05-30 BE BE733889D patent/BE733889A/xx unknown
- 1969-06-06 CH CH867969A patent/CH510656A/en not_active IP Right Cessation
- 1969-06-06 GB GB28708/69A patent/GB1223087A/en not_active Expired
- 1969-06-07 ES ES368518A patent/ES368518A1/en not_active Expired
- 1969-06-10 DE DE19691929264 patent/DE1929264A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CH510656A (en) | 1971-07-31 |
FR7455M (en) | 1969-11-24 |
DE1929264A1 (en) | 1970-12-03 |
GB1223087A (en) | 1971-02-24 |
BE733889A (en) | 1969-11-03 |
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