ES368518A1 - Improvements in or relating to new steroid 21-esters, method for their preparation and therapeutic composition containing same - Google Patents

Improvements in or relating to new steroid 21-esters, method for their preparation and therapeutic composition containing same

Info

Publication number
ES368518A1
ES368518A1 ES368518A ES368518A ES368518A1 ES 368518 A1 ES368518 A1 ES 368518A1 ES 368518 A ES368518 A ES 368518A ES 368518 A ES368518 A ES 368518A ES 368518 A1 ES368518 A1 ES 368518A1
Authority
ES
Spain
Prior art keywords
preparation
methylacetamido
esters
relating
composition containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES368518A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PHARMA CHEMIE
Original Assignee
PHARMA CHEMIE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PHARMA CHEMIE filed Critical PHARMA CHEMIE
Publication of ES368518A1 publication Critical patent/ES368518A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises the 21-[4-(N-methylacetamido)-benzoates] of 21-hydroxy steroids of the pregnane, 4-pregnene and 1,4-pregnadiene series, and their preparation by reacting the appropriate acyl chloride with the appropriate 21-hydroxy steroids, e.g. prednisolone, triamcinolone, betamethasone, prednisone and dexamethasone. 4 - (N - methylacetamido) - benzoyl chloride is prepared by reacting 4-(N-methylacetamido)- benzoic acid with thionyl chloride. The inventive steroids are stated to possess antiphlogistic, antianaphylactic and corticoid activity, and may be made up with carriers into pharmaceutical compositions for oral, parenteral, rectal and topical administration.
ES368518A 1968-06-10 1969-06-07 Improvements in or relating to new steroid 21-esters, method for their preparation and therapeutic composition containing same Expired ES368518A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR154433A FR7455M (en) 1968-06-10 1968-06-10

Publications (1)

Publication Number Publication Date
ES368518A1 true ES368518A1 (en) 1971-05-01

Family

ID=8650990

Family Applications (1)

Application Number Title Priority Date Filing Date
ES368518A Expired ES368518A1 (en) 1968-06-10 1969-06-07 Improvements in or relating to new steroid 21-esters, method for their preparation and therapeutic composition containing same

Country Status (6)

Country Link
BE (1) BE733889A (en)
CH (1) CH510656A (en)
DE (1) DE1929264A1 (en)
ES (1) ES368518A1 (en)
FR (1) FR7455M (en)
GB (1) GB1223087A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4011317A (en) * 1975-08-22 1977-03-08 Rorer Italiana S.P.A. Steroid derivatives

Also Published As

Publication number Publication date
CH510656A (en) 1971-07-31
FR7455M (en) 1969-11-24
DE1929264A1 (en) 1970-12-03
GB1223087A (en) 1971-02-24
BE733889A (en) 1969-11-03

Similar Documents

Publication Publication Date Title
PH12415A (en) 16a,17-cyclopentylidenedioxy-9a-fluoro-11,21-dihydroxy-1,4-pregnadiene-3,20-dione 21-acetate,anti-inflammatory composition and method of use thereof
GB1296458A (en)
ES445488A1 (en) Retinoic acid esters of steroids of the pregnane series, their use in the treatment of acne and pharmaceutical formulations useful therefor
ES368518A1 (en) Improvements in or relating to new steroid 21-esters, method for their preparation and therapeutic composition containing same
CH644614A5 (en) 17-ALPHA-ACYLOXY-5-BETA AND 17-ALPHA-ACYLOXY-5-ALPHA-CORTICOIDS.
GB1508745A (en) Steroidal(16alpha,17-d)cyclohexenes
IE38074B1 (en) Delta 8(9)-steroids of the pregnane series
ES342750A1 (en) Terpenic esters of glucocorticoids
US3766223A (en) Disteroidyl ethers
GB959378A (en) 21-substituted 17ª‡, 21-dioxy steroids and processes for their preparation
GB1028745A (en) Pharmaceutical preparations containing corticosteroids
SE7513200L (en) STEROID (16ALFA, 17-B) NAFTALENER
US3652604A (en) Halohydrins and process for the preparation thereof
US3016392A (en) 16-fluoro steroids of the pregnane series
GB924931A (en)
GB903049A (en) Steroid compounds, preparation thereof and compositions thereof
GB1037891A (en) Process for the manufacture of 19-nor-steroids
GB1097656A (en) A process for the manufacture of steroids of the pregnane series
GB1323383A (en) Pregna-4,9-diene processes for its preparation and compositions thereof
GB1505461A (en) Steriod 21-o-esters with a substituted acetic acid their preparation and use
GB1430932A (en) 21-fluoro-pregnanes
GB1395820A (en) Preparation of 21-inorganic esters of corticosteroids and salts thereof
JPS51149258A (en) A process for preparing steroid derivatives
GB1377993A (en) 6alpha, 16alpha-dimethyl-steroids
US3158628A (en) 21-carbethoxylates of prednisone and prednisolone