ES306577A1 - Procedure for the obtaining of new benzofuran compounds. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the obtaining of new benzofuran compounds. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES306577A1 ES306577A1 ES0306577A ES306577A ES306577A1 ES 306577 A1 ES306577 A1 ES 306577A1 ES 0306577 A ES0306577 A ES 0306577A ES 306577 A ES306577 A ES 306577A ES 306577 A1 ES306577 A1 ES 306577A1
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- hydrogen
- group
- atoms
- bromine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Safety Valves (AREA)
Abstract
Process for obtaining new benzofuran compounds of the general formula where R is selected from the group consisting of lower alkyl, phenyl and phenyl substituted with lower alkyl, lower alkoxy, fluorine, chlorine, bromine or trifluoromethyl, R1 and R2 are the same or different and are selected from the group consisting of hydrogen, lower alkyl , lower alkoxy, fluorine, chlorine, bromine and, if R1 is hydrogen, R2 represents nitro, amino, hydroxy, lower acyloxy, lower dialkylamino or lower acylamino, A is an alkylene group with not more than four carbon atoms, R3 is hydrogen or lower alkyl, R 4 is lower alkyl or -NR 3 R 4 is pyrrolidino, piperidino, hexamethylene imino, morpholino, lower dialkylmorpholino, piperazino, lower alkylpiperazine or tetrahydropyridino as well as pharmaceutically useful salts thereof, characterized by reacting a benzofuran derivative of the formula general ** (See formula) ** where R and R1 have the same meaning as indicated above and R represents hydrogen, lower alkyl, lower alkoxy, fluorine, chlorine, bromine, nitro, a protected amino group, a protected hydroxy group or dialkylamino lower, with a compound of the general formula where A, R3, R4 and -NR3r4 have the meanings indicated above, with the exception that the hydrogen atoms eventually present in oxygen and nitrogen atoms are replaced by ordinary protecting groups, and x and y represent atoms or groups of atoms capable of reacting between yes with the formation of an ether bridge between the furan fragment and A and, if necessary, by removing the protecting groups by hydrolysis or hydrogenation and, if desired, by converting the reaction product thus obtained into a pharmaceutically useful salt. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE13318/63A SE311167B (en) | 1963-12-02 | 1963-12-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES306577A1 true ES306577A1 (en) | 1965-05-01 |
Family
ID=20297200
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES0306577A Expired ES306577A1 (en) | 1963-12-02 | 1964-11-30 | Procedure for the obtaining of new benzofuran compounds. (Machine-translation by Google Translate, not legally binding) |
Country Status (13)
Country | Link |
---|---|
AT (1) | AT252227B (en) |
BE (1) | BE656100A (en) |
BR (1) | BR6464404D0 (en) |
CH (1) | CH451962A (en) |
DE (1) | DE1445465A1 (en) |
DK (1) | DK109989C (en) |
ES (1) | ES306577A1 (en) |
FR (1) | FR3884M (en) |
GB (1) | GB1084290A (en) |
IL (1) | IL22428A (en) |
NL (1) | NL6413996A (en) |
NO (1) | NO117923B (en) |
SE (1) | SE311167B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1209558A (en) * | 1968-07-06 | 1970-10-21 | Delalande Sa | Derivatives of 5-cinnamoyl benzofuran and process for their preparation |
WO2000046194A1 (en) * | 1999-02-08 | 2000-08-10 | Shionogi & Co., Ltd. | Cyclic amine derivatives and uses thereof |
FR2862646B1 (en) * | 2003-11-20 | 2006-02-24 | Merck Sante Sas | NOVEL ANTIDIABETIC COMPOUNDS CONTAINING BENZOFURAN, BENZOTHIOPHENIC DERIVATIVES |
-
0
- GB GB1084290D patent/GB1084290A/en not_active Expired
-
1963
- 1963-12-02 SE SE13318/63A patent/SE311167B/xx unknown
-
1964
- 1964-11-11 IL IL22428A patent/IL22428A/en unknown
- 1964-11-17 BR BR164404/64A patent/BR6464404D0/en unknown
- 1964-11-21 DE DE19641445465 patent/DE1445465A1/en active Pending
- 1964-11-23 CH CH1507264A patent/CH451962A/en unknown
- 1964-11-23 BE BE656100A patent/BE656100A/xx unknown
- 1964-11-25 AT AT997764A patent/AT252227B/en active
- 1964-11-30 ES ES0306577A patent/ES306577A1/en not_active Expired
- 1964-12-01 NO NO155816A patent/NO117923B/no unknown
- 1964-12-01 DK DK591164AA patent/DK109989C/en active
- 1964-12-02 NL NL6413996A patent/NL6413996A/xx unknown
- 1964-12-02 FR FR997050A patent/FR3884M/fr not_active Expired
Also Published As
Publication number | Publication date |
---|---|
DK109989C (en) | 1968-08-19 |
SE311167B (en) | 1969-06-02 |
CH451962A (en) | 1968-05-15 |
NO117923B (en) | 1969-10-13 |
DE1445465A1 (en) | 1972-04-20 |
GB1084290A (en) | 1900-01-01 |
BE656100A (en) | 1965-03-16 |
AT252227B (en) | 1967-02-10 |
IL22428A (en) | 1969-01-29 |
FR3884M (en) | 1966-01-31 |
NL6413996A (en) | 1965-06-03 |
BR6464404D0 (en) | 1973-08-02 |
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