ES306577A1 - Procedure for the obtaining of new benzofuran compounds. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Process for obtaining new benzofuran compounds of the general formula where R is selected from the group consisting of lower alkyl, phenyl and phenyl substituted with lower alkyl, lower alkoxy, fluorine, chlorine, bromine or trifluoromethyl, R1 and R2 are the same or different and are selected from the group consisting of hydrogen, lower alkyl , lower alkoxy, fluorine, chlorine, bromine and, if R1 is hydrogen, R2 represents nitro, amino, hydroxy, lower acyloxy, lower dialkylamino or lower acylamino, A is an alkylene group with not more than four carbon atoms, R3 is hydrogen or lower alkyl, R 4 is lower alkyl or -NR 3 R 4 is pyrrolidino, piperidino, hexamethylene imino, morpholino, lower dialkylmorpholino, piperazino, lower alkylpiperazine or tetrahydropyridino as well as pharmaceutically useful salts thereof, characterized by reacting a benzofuran derivative of the formula general ** (See formula) ** where R and R1 have the same meaning as indicated above and R represents hydrogen, lower alkyl, lower alkoxy, fluorine, chlorine, bromine, nitro, a protected amino group, a protected hydroxy group or dialkylamino lower, with a compound of the general formula where A, R3, R4 and -NR3r4 have the meanings indicated above, with the exception that the hydrogen atoms eventually present in oxygen and nitrogen atoms are replaced by ordinary protecting groups, and x and y represent atoms or groups of atoms capable of reacting between yes with the formation of an ether bridge between the furan fragment and A and, if necessary, by removing the protecting groups by hydrolysis or hydrogenation and, if desired, by converting the reaction product thus obtained into a pharmaceutically useful salt. (Machine-translation by Google Translate, not legally binding)