ES2915058R1 - Proceso para preparar (15alfa,16alfa,17beta)-estra-1,3,5(10)-trieno-3,15,16,17-tetrol (Estetrol) e intermedios de dicho proceso - Google Patents
Proceso para preparar (15alfa,16alfa,17beta)-estra-1,3,5(10)-trieno-3,15,16,17-tetrol (Estetrol) e intermedios de dicho procesoInfo
- Publication number
- ES2915058R1 ES2915058R1 ES202290021A ES202290021A ES2915058R1 ES 2915058 R1 ES2915058 R1 ES 2915058R1 ES 202290021 A ES202290021 A ES 202290021A ES 202290021 A ES202290021 A ES 202290021A ES 2915058 R1 ES2915058 R1 ES 2915058R1
- Authority
- ES
- Spain
- Prior art keywords
- 15alpha
- estetrol
- 16alpha
- 17beta
- estra
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- AJIPIJNNOJSSQC-UHFFFAOYSA-N (15alpha,16alpha,17beta)-Estra-1,3,5(10)-triene-3,15,16,17-tetrol Natural products OC1=CC=C2C3CCC(C)(C(C(O)C4O)O)C4C3CCC2=C1 AJIPIJNNOJSSQC-UHFFFAOYSA-N 0.000 title 1
- AJIPIJNNOJSSQC-NYLIRDPKSA-N estetrol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)[C@@H]4O)O)[C@@H]4[C@@H]3CCC2=C1 AJIPIJNNOJSSQC-NYLIRDPKSA-N 0.000 title 1
- 229950009589 estetrol Drugs 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0007—Androstane derivatives not substituted in position 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C07J1/0074—Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT102019000017414A IT201900017414A1 (it) | 2019-09-27 | 2019-09-27 | Processo per la preparazione di (15α,16α,17β)-estra-1,3,5(10)-triene-3,15,16,17-tetrolo (Estetrolo) ed intermedi di detto processo |
IT102019000021879A IT201900021879A1 (it) | 2019-11-22 | 2019-11-22 | PROCESSO PER LA PREPARAZIONE DI (15α,16α,17β)-ESTRA-1,3,5(10)-TRIENE-3,15,16,17-TETROLO (ESTETROLO) ED INTERMEDI DI DETTO PROCESSO |
PCT/EP2020/076843 WO2021058716A1 (en) | 2019-09-27 | 2020-09-25 | Process for preparing (15αlpha,16αlpha,17βeta)-estra-1,3,5(10)-triene-3,15,16,17-tetrol (estetrol) and intermediates of said process |
Publications (3)
Publication Number | Publication Date |
---|---|
ES2915058A2 ES2915058A2 (es) | 2022-06-20 |
ES2915058R1 true ES2915058R1 (es) | 2023-12-11 |
ES2915058B2 ES2915058B2 (es) | 2024-06-21 |
Family
ID=72895895
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES202290021A Active ES2915058B2 (es) | 2019-09-27 | 2020-09-25 | Proceso para preparar (15alfa,16alfa,17beta)-estra-1,3,5(10)-trieno-3,15,16,17-tetrol (Estetrol) e intermedios de dicho proceso |
Country Status (15)
Country | Link |
---|---|
US (1) | US20220348607A1 (es) |
JP (1) | JP2022549585A (es) |
CN (1) | CN116355031A (es) |
AU (2) | AU2020355615B2 (es) |
BR (1) | BR112022005359A2 (es) |
CA (1) | CA3151465C (es) |
CH (1) | CH718008B1 (es) |
DE (1) | DE112020004564T5 (es) |
ES (1) | ES2915058B2 (es) |
FR (2) | FR3101348B1 (es) |
GB (2) | GB2617040B (es) |
MX (2) | MX2022003688A (es) |
UY (1) | UY38895A (es) |
WO (1) | WO2021058716A1 (es) |
ZA (1) | ZA202204137B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU231240B1 (hu) * | 2019-09-03 | 2022-04-28 | Richter Gedeon Nyrt. | Ipari eljárás nagytisztaságú ösztetrol hatóanyag előállítására |
GB2626482A (en) * | 2021-10-01 | 2024-07-24 | Ind Chimica Srl | Process for preparing (15alpha,16alpha,17eta)-estra-1,3,5-(10)-triene-3,15,16,17-tetrol(estetrol) monohydrate |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004041839A2 (en) * | 2002-11-08 | 2004-05-21 | Pantarhei Bioscience B.V. | Synthesis of estetrol via estrone derived steroids |
WO2015040051A1 (en) * | 2013-09-18 | 2015-03-26 | Crystal Pharma, S.A.U. | Process for the preparation of estetrol |
ES2855923T3 (es) * | 2019-09-03 | 2023-04-28 | Richter Gedeon Nyrt | Procedimiento industrial para la preparación de estetrol de alta pureza |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE029252T2 (en) | 2011-06-01 | 2017-02-28 | Estetra Sprl | Process for the preparation of intermediates of estetrol |
EP2383279A1 (en) * | 2011-07-19 | 2011-11-02 | Pantarhei Bioscience B.V. | Process for the preparation of estetrol |
MX348917B (es) | 2011-10-07 | 2017-07-04 | Estetra Sprl | Proceso para la producción de estetrol. |
-
2020
- 2020-09-25 MX MX2022003688A patent/MX2022003688A/es unknown
- 2020-09-25 JP JP2022515787A patent/JP2022549585A/ja active Pending
- 2020-09-25 GB GB2310271.8A patent/GB2617040B/en active Active
- 2020-09-25 GB GB2205967.9A patent/GB2603868B/en active Active
- 2020-09-25 CN CN202310346726.XA patent/CN116355031A/zh active Pending
- 2020-09-25 AU AU2020355615A patent/AU2020355615B2/en active Active
- 2020-09-25 BR BR112022005359A patent/BR112022005359A2/pt unknown
- 2020-09-25 US US17/763,267 patent/US20220348607A1/en active Pending
- 2020-09-25 DE DE112020004564.1T patent/DE112020004564T5/de active Pending
- 2020-09-25 WO PCT/EP2020/076843 patent/WO2021058716A1/en active Application Filing
- 2020-09-25 UY UY0001038895A patent/UY38895A/es unknown
- 2020-09-25 CA CA3151465A patent/CA3151465C/en active Active
- 2020-09-25 FR FR2009758A patent/FR3101348B1/fr active Active
- 2020-09-25 CH CH000332/2022A patent/CH718008B1/it unknown
- 2020-09-25 ES ES202290021A patent/ES2915058B2/es active Active
-
2022
- 2022-03-25 MX MX2023004110A patent/MX2023004110A/es unknown
- 2022-04-12 ZA ZA2022/04137A patent/ZA202204137B/en unknown
-
2023
- 2023-02-24 FR FR2301733A patent/FR3132908A1/fr active Pending
- 2023-04-12 AU AU2023202251A patent/AU2023202251A1/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004041839A2 (en) * | 2002-11-08 | 2004-05-21 | Pantarhei Bioscience B.V. | Synthesis of estetrol via estrone derived steroids |
WO2015040051A1 (en) * | 2013-09-18 | 2015-03-26 | Crystal Pharma, S.A.U. | Process for the preparation of estetrol |
ES2855923T3 (es) * | 2019-09-03 | 2023-04-28 | Richter Gedeon Nyrt | Procedimiento industrial para la preparación de estetrol de alta pureza |
Non-Patent Citations (1)
Title |
---|
FISHMAN, J. & GUZIK, H. . ¿Synthesis of Epimeric 15-Hydroxyestriols, New and Potential Metabolites of Estradiol¿. Journal of Organic Chemistry, 1968, Vol. 33, Páginas 3133-3135 0022-3263; 1520-6904 (en línea) , (DOI: 10.1021/jo01272a023) Ver página 3133, figura; página 3135, columna 1, párrafo 3-columna 2, párrafo 1. * |
Also Published As
Publication number | Publication date |
---|---|
JP2022549585A (ja) | 2022-11-28 |
GB2603868A (en) | 2022-08-17 |
US20220348607A1 (en) | 2022-11-03 |
GB2617040A (en) | 2023-09-27 |
DE112020004564T5 (de) | 2022-06-15 |
GB202310271D0 (en) | 2023-08-16 |
CA3151465C (en) | 2024-05-07 |
BR112022005359A2 (pt) | 2022-07-19 |
FR3101348B1 (fr) | 2024-01-19 |
WO2021058716A1 (en) | 2021-04-01 |
ZA202204137B (en) | 2023-06-28 |
CA3151465A1 (en) | 2021-04-01 |
AU2020355615B2 (en) | 2023-12-14 |
FR3132908A1 (fr) | 2023-08-25 |
ES2915058B2 (es) | 2024-06-21 |
GB202205967D0 (en) | 2022-06-08 |
UY38895A (es) | 2021-04-30 |
AU2023202251A1 (en) | 2023-05-04 |
CH718008B1 (it) | 2024-01-31 |
FR3101348A1 (fr) | 2021-04-02 |
AU2020355615A1 (en) | 2022-05-19 |
ES2915058A2 (es) | 2022-06-20 |
GB2603868B (en) | 2023-10-11 |
CN114514237A (zh) | 2022-05-17 |
CN116355031A (zh) | 2023-06-30 |
GB2617040B (en) | 2024-03-27 |
MX2023004110A (es) | 2023-04-27 |
MX2022003688A (es) | 2022-04-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2020002043A1 (es) | Métodos y composiciones para la entrega de proteínas terapeuticas. | |
ES2933249R1 (es) | Composiciones para la liberación controlada de ingredientes activos y métodos de preparación de las mismas | |
CL2018002814A1 (es) | Composiciones y metodos para el tratamiento de heridas, trastornos, y enfermedades de la piel. | |
ES2915058R1 (es) | Proceso para preparar (15alfa,16alfa,17beta)-estra-1,3,5(10)-trieno-3,15,16,17-tetrol (Estetrol) e intermedios de dicho proceso | |
BR112015019440A8 (pt) | curativo regulável, kit, uso e método para fortalecimento da pele | |
BR112016022318A2 (pt) | método, composição farmacêutica para uso no tratamento de doenças de retina e uso de um anticorpo | |
ECSP18050575A (es) | Composiciones y métodos para disminuir la expresión de tau | |
EP3606552A4 (en) | COMPOSITIONS AND PROCEDURES RELATED TO HUMAN NEUTRALIZING ANTIBODIES AGAINST ZIKA AND DENGUE-1 VIRUS | |
CL2021000855A1 (es) | Replicones basados en alfavirus para la administración de bioterapias. | |
EP3678701A4 (en) | THERAPEUTIC PROTEIN COMPOSITIONS AND METHOD FOR MANUFACTURING AND USING THEREOF | |
PH12017501722A1 (en) | Composition for promoting hair growth or hair restoration and for anti-inflammation | |
MX2021010989A (es) | Formulacion que incluye una combinacion de la hormona beta-endorfina y adrenocorticotropica. | |
EP3826594A4 (en) | PENIS AND OTHER IMPLANTS TO FACILITATE TISSUE STRETCHING | |
EP3902605A4 (en) | METHODS AND COMPOSITIONS FOR THE TREATMENT OF SKIN AND HAIR DISEASES | |
UY36262A (es) | Anticuerpos anti proteína similar a angiopoyetina 4 y métodos de uso | |
EP3849591A4 (en) | METHODS AND COMPOSITIONS FOR THE TREATMENT OF SKIN DISEASES | |
EP3768095A4 (en) | Compositions and methods for treating diarrheal diseases | |
BR112017023316A2 (pt) | método cosmético e uso terapêutico para redução de gordura | |
ES2850278R1 (es) | COMPLEJO DE ETINIL ESTRADIOL-ß-CICLODEXTRINA Y PROCEDIMIENTO PARA SU PREPARACION | |
EP3876755A4 (en) | METHODS AND COMPOSITIONS FOR TREATING INFECTIOUS, AUTOIMMUNE AND ALLERGIC DISEASES | |
EP3617222A4 (en) | PEPTIDE ALLOWING TO INDUCE THE REGENERATION OF A TISSUE AND ASSOCIATED USE | |
EP3766356A4 (en) | MULTI-PH BUFFER FORMULATION AND COMPOSITION TO FACILITATE PROTEIN DIGESTION, AND USE OF THEM | |
EP3668526A4 (en) | COMPOSITIONS FOR TREATMENT OF SKIN AND MUCCOAL INFECTIONS | |
WO2016135732A8 (en) | Method of promoting hair growth | |
EP3856210A4 (en) | EXTRACELLULAR MATRIX PROTEIN COMPOSITIONS AND WOUND TREATMENT METHODS |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
BA2A | Patent application published |
Ref document number: 2915058 Country of ref document: ES Kind code of ref document: A2 Effective date: 20220620 |
|
EC2A | Search report published |
Ref document number: 2915058 Country of ref document: ES Kind code of ref document: R1 Effective date: 20231130 |
|
FG2A | Definitive protection |
Ref document number: 2915058 Country of ref document: ES Kind code of ref document: B2 Effective date: 20240621 |