BR112022005359A2 - Processo de preparação de (15a,16a,17ss)-estra-1,3,5(10)-trieno-3,15,16,17-tetrol(estetrol) e intermediários do referido processo - Google Patents

Processo de preparação de (15a,16a,17ss)-estra-1,3,5(10)-trieno-3,15,16,17-tetrol(estetrol) e intermediários do referido processo

Info

Publication number
BR112022005359A2
BR112022005359A2 BR112022005359A BR112022005359A BR112022005359A2 BR 112022005359 A2 BR112022005359 A2 BR 112022005359A2 BR 112022005359 A BR112022005359 A BR 112022005359A BR 112022005359 A BR112022005359 A BR 112022005359A BR 112022005359 A2 BR112022005359 A2 BR 112022005359A2
Authority
BR
Brazil
Prior art keywords
estetrol
estra
tetrol
trieno
intermediates
Prior art date
Application number
BR112022005359A
Other languages
English (en)
Inventor
Lenna Roberto
Fasana Andrea
Lucentini Riccardo
Original Assignee
Ind Chimica Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT102019000017414A external-priority patent/IT201900017414A1/it
Priority claimed from IT102019000021879A external-priority patent/IT201900021879A1/it
Application filed by Ind Chimica Srl filed Critical Ind Chimica Srl
Publication of BR112022005359A2 publication Critical patent/BR112022005359A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0007—Androstane derivatives not substituted in position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0074—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCESSO DE PREPARAÇÃO DE (15a,16a,17ß)-ESTRA-1,3,5(10)- TRIENO-3,15,16,17-TETROL(ESTETROL) E INTERMEDIÁRIOS DO REFERIDO PROCESSO. A presente invenção se refere a um processo para preparação de (15a,16a,17ß)-estra-l,3,5(10)-trieno-3,15,16,17-tetrol, também conhecido como Estetrol.
BR112022005359A 2019-09-27 2020-09-25 Processo de preparação de (15a,16a,17ss)-estra-1,3,5(10)-trieno-3,15,16,17-tetrol(estetrol) e intermediários do referido processo BR112022005359A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT102019000017414A IT201900017414A1 (it) 2019-09-27 2019-09-27 Processo per la preparazione di (15α,16α,17β)-estra-1,3,5(10)-triene-3,15,16,17-tetrolo (Estetrolo) ed intermedi di detto processo
IT102019000021879A IT201900021879A1 (it) 2019-11-22 2019-11-22 PROCESSO PER LA PREPARAZIONE DI (15α,16α,17β)-ESTRA-1,3,5(10)-TRIENE-3,15,16,17-TETROLO (ESTETROLO) ED INTERMEDI DI DETTO PROCESSO
PCT/EP2020/076843 WO2021058716A1 (en) 2019-09-27 2020-09-25 Process for preparing (15αlpha,16αlpha,17βeta)-estra-1,3,5(10)-triene-3,15,16,17-tetrol (estetrol) and intermediates of said process

Publications (1)

Publication Number Publication Date
BR112022005359A2 true BR112022005359A2 (pt) 2022-07-19

Family

ID=72895895

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022005359A BR112022005359A2 (pt) 2019-09-27 2020-09-25 Processo de preparação de (15a,16a,17ss)-estra-1,3,5(10)-trieno-3,15,16,17-tetrol(estetrol) e intermediários do referido processo

Country Status (15)

Country Link
US (1) US20220348607A1 (pt)
JP (1) JP2022549585A (pt)
CN (2) CN114514237A (pt)
AU (2) AU2020355615B2 (pt)
BR (1) BR112022005359A2 (pt)
CA (1) CA3151465C (pt)
CH (1) CH718008B1 (pt)
DE (1) DE112020004564T5 (pt)
ES (1) ES2915058B2 (pt)
FR (2) FR3101348B1 (pt)
GB (2) GB2617040B (pt)
MX (2) MX2022003688A (pt)
UY (1) UY38895A (pt)
WO (1) WO2021058716A1 (pt)
ZA (1) ZA202204137B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU231240B1 (hu) 2019-09-03 2022-04-28 Richter Gedeon Nyrt. Ipari eljárás nagytisztaságú ösztetrol hatóanyag előállítására
WO2023051937A1 (en) * 2021-10-01 2023-04-06 Industriale Chimica S.R.L. Process for preparing (15alpha,16alpha,17 eta)-estra-1,3,5(10)-triene-3,15,16,17-tetrol (estetrol) monohydrate

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1562976T1 (sl) * 2002-11-08 2010-08-31 Pantarhei Bioscience Bv Sinteza estetrola preko steroidov, izvedenih iz estrona
US11053274B2 (en) 2011-06-01 2021-07-06 Estetra S.P.R.L. Process for the production of estetrol intermediates
EP2383279A1 (en) * 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
US8987484B2 (en) 2011-10-07 2015-03-24 Estetra S.P.R.L. Process for the production of estetrol
CA2924255C (en) * 2013-09-18 2022-11-22 Crystal Pharma, S.A.U. Process for the preparation of estetrol
HU231240B1 (hu) * 2019-09-03 2022-04-28 Richter Gedeon Nyrt. Ipari eljárás nagytisztaságú ösztetrol hatóanyag előállítására

Also Published As

Publication number Publication date
MX2023004110A (es) 2023-04-27
CA3151465A1 (en) 2021-04-01
ES2915058R1 (es) 2023-12-11
GB2603868B (en) 2023-10-11
CH718008B1 (it) 2024-01-31
WO2021058716A1 (en) 2021-04-01
UY38895A (es) 2021-04-30
ES2915058A2 (es) 2022-06-20
GB2617040B (en) 2024-03-27
US20220348607A1 (en) 2022-11-03
CN114514237A (zh) 2022-05-17
CN116355031A (zh) 2023-06-30
DE112020004564T5 (de) 2022-06-15
FR3132908A1 (fr) 2023-08-25
GB2617040A (en) 2023-09-27
FR3101348A1 (fr) 2021-04-02
MX2022003688A (es) 2022-04-26
ES2915058B2 (es) 2024-06-21
FR3101348B1 (fr) 2024-01-19
AU2020355615B2 (en) 2023-12-14
GB202310271D0 (en) 2023-08-16
AU2023202251A1 (en) 2023-05-04
GB202205967D0 (en) 2022-06-08
GB2603868A (en) 2022-08-17
JP2022549585A (ja) 2022-11-28
ZA202204137B (en) 2023-06-28
AU2020355615A1 (en) 2022-05-19
CA3151465C (en) 2024-05-07

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Legal Events

Date Code Title Description
B154 Notification of filing of divisional application [chapter 15.50 patent gazette]

Free format text: O PEDIDO FOI DIVIDIDO NO BR122023006888-2 PROTOCOLO 870230030856 EM 13/04/2023 10:26.