ES2683846T3 - ROS quinasa mutante y de translocación en el carcinoma pulmonar no microcítico humano - Google Patents
ROS quinasa mutante y de translocación en el carcinoma pulmonar no microcítico humano Download PDFInfo
- Publication number
- ES2683846T3 ES2683846T3 ES13176525.7T ES13176525T ES2683846T3 ES 2683846 T3 ES2683846 T3 ES 2683846T3 ES 13176525 T ES13176525 T ES 13176525T ES 2683846 T3 ES2683846 T3 ES 2683846T3
- Authority
- ES
- Spain
- Prior art keywords
- ros
- translocation
- mutant
- kinase
- small cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- 230000005945 translocation Effects 0.000 title 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract 2
- 201000005202 lung cancer Diseases 0.000 abstract 2
- 208000020816 lung neoplasm Diseases 0.000 abstract 2
- 239000012472 biological sample Substances 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
Abstract
Un método para caracterizar un cáncer de pulmón que comprende detectar la presencia de una mutación de ROS en una muestra biológica procedente de un cáncer de pulmón humano.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76063406P | 2006-01-20 | 2006-01-20 | |
US760634P | 2006-01-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2683846T3 true ES2683846T3 (es) | 2018-09-28 |
Family
ID=38288244
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES07718104.8T Active ES2539830T3 (es) | 2006-01-20 | 2007-01-19 | ROS quinasa mutante y de translocación en el carcinoma pulmonar no microcítico humano |
ES13176525.7T Active ES2683846T3 (es) | 2006-01-20 | 2007-01-19 | ROS quinasa mutante y de translocación en el carcinoma pulmonar no microcítico humano |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES07718104.8T Active ES2539830T3 (es) | 2006-01-20 | 2007-01-19 | ROS quinasa mutante y de translocación en el carcinoma pulmonar no microcítico humano |
Country Status (10)
Country | Link |
---|---|
EP (4) | EP3360965A1 (es) |
JP (7) | JP5554925B2 (es) |
CN (2) | CN101528921B (es) |
DK (2) | DK1973946T3 (es) |
ES (2) | ES2539830T3 (es) |
HK (2) | HK1120272A1 (es) |
HU (1) | HUE039085T2 (es) |
PT (1) | PT2671954T (es) |
SI (1) | SI2671954T1 (es) |
WO (1) | WO2007084631A2 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009051846A2 (en) | 2007-10-18 | 2009-04-23 | Cell Signaling Technology, Inc. | Translocation and mutant ros kinase in human non-small cell lung carcinoma |
ES2539830T3 (es) * | 2006-01-20 | 2015-07-06 | Cell Signaling Technology, Inc. | ROS quinasa mutante y de translocación en el carcinoma pulmonar no microcítico humano |
US20120208824A1 (en) | 2006-01-20 | 2012-08-16 | Cell Signaling Technology, Inc. | ROS Kinase in Lung Cancer |
US8383799B2 (en) | 2006-01-20 | 2013-02-26 | Cell Signaling Technology, Inc. | Translocation and mutant ROS kinase in human non-small cell lung carcinoma |
ES2637174T3 (es) | 2009-02-12 | 2017-10-11 | Cell Signaling Technology, Inc. | Expresión de ROS mutante en el cáncer de hígado humano |
JP5861244B2 (ja) | 2010-06-22 | 2016-02-16 | 公益財団法人がん研究会 | 新規ros1融合体の検出法 |
US20160206608A1 (en) | 2011-08-02 | 2016-07-21 | Pfizer Inc. | Crizotinib for use in the treatment of cancer |
EP2812451A4 (en) * | 2012-02-08 | 2016-01-06 | Insight Genetics Inc | METHODS AND COMPOSITIONS RELATING TO ROS1 FUSIONS FOR DIAGNOSING AND TREATING CANCER |
US10385401B2 (en) | 2013-11-21 | 2019-08-20 | Assistance Publique Hopitaux De Paris | Method for detecting chromosomal rearrangements |
CN107236818A (zh) * | 2017-07-19 | 2017-10-10 | 臻悦生物科技江苏有限公司 | 肺癌临床用药突变基因检测试剂盒 |
EP3665301B1 (en) * | 2017-08-09 | 2023-10-04 | PamGene B.V. | Method for predicting the response of non-small-cell lung carcinoma patients to a medicament |
CN108148912B (zh) * | 2018-03-08 | 2021-10-08 | 四川大学 | 肿瘤的生物标志物、应用和肿瘤检测试剂盒 |
US20220227889A1 (en) * | 2019-04-30 | 2022-07-21 | Encodia, Inc. | Methods and reagents for cleavage of the n-terminal amino acid from a polypeptide |
CN110655080B (zh) * | 2019-10-25 | 2022-08-05 | 山东大学 | 一种具有选择性杀灭癌细胞功能的无氧化Ti3C2量子点及其制备方法与应用 |
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DE3023787A1 (de) | 1980-06-25 | 1982-01-21 | Studiengesellschaft Kohle mbH, 4330 Mülheim | Verfahren zur erhoehung der inkorporation und der expression von genetischem material in die kerne von intakten zellen mit hilfe von liposomen |
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US4659678A (en) | 1982-09-29 | 1987-04-21 | Serono Diagnostics Limited | Immunoassay of antigens |
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ES2539830T3 (es) * | 2006-01-20 | 2015-07-06 | Cell Signaling Technology, Inc. | ROS quinasa mutante y de translocación en el carcinoma pulmonar no microcítico humano |
-
2007
- 2007-01-19 ES ES07718104.8T patent/ES2539830T3/es active Active
- 2007-01-19 EP EP17205134.4A patent/EP3360965A1/en not_active Withdrawn
- 2007-01-19 CN CN2007800089653A patent/CN101528921B/zh active Active
- 2007-01-19 JP JP2008551396A patent/JP5554925B2/ja active Active
- 2007-01-19 EP EP13176525.7A patent/EP2671954B1/en not_active Revoked
- 2007-01-19 SI SI200732051T patent/SI2671954T1/sl unknown
- 2007-01-19 EP EP07718104.8A patent/EP1973946B1/en active Active
- 2007-01-19 CN CN201310484766.7A patent/CN103981198B/zh active Active
- 2007-01-19 WO PCT/US2007/001360 patent/WO2007084631A2/en active Application Filing
- 2007-01-19 ES ES13176525.7T patent/ES2683846T3/es active Active
- 2007-01-19 EP EP21177974.9A patent/EP3936621A1/en active Pending
- 2007-01-19 PT PT13176525T patent/PT2671954T/pt unknown
- 2007-01-19 DK DK07718104.8T patent/DK1973946T3/da active
- 2007-01-19 HU HUE13176525A patent/HUE039085T2/hu unknown
- 2007-01-19 DK DK13176525.7T patent/DK2671954T3/en active
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2009
- 2009-01-08 HK HK09100200.7A patent/HK1120272A1/xx unknown
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2014
- 2014-03-04 JP JP2014041462A patent/JP6259320B2/ja active Active
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2016
- 2016-11-04 JP JP2016215900A patent/JP6521928B2/ja active Active
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2018
- 2018-11-30 HK HK18115370.8A patent/HK1256305A1/zh unknown
- 2018-12-06 JP JP2018228744A patent/JP7262214B2/ja active Active
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2019
- 2019-03-29 JP JP2019065633A patent/JP6957546B2/ja active Active
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2020
- 2020-09-09 JP JP2020151188A patent/JP2021006039A/ja active Pending
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2022
- 2022-12-13 JP JP2022198413A patent/JP2023039988A/ja active Pending
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