ES260595A1 - Plastic tablet coating - Google Patents
Plastic tablet coatingInfo
- Publication number
- ES260595A1 ES260595A1 ES0260595A ES260595A ES260595A1 ES 260595 A1 ES260595 A1 ES 260595A1 ES 0260595 A ES0260595 A ES 0260595A ES 260595 A ES260595 A ES 260595A ES 260595 A1 ES260595 A1 ES 260595A1
- Authority
- ES
- Spain
- Prior art keywords
- agents
- plastic
- colouring agent
- weight
- contain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
- A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2873—Proteins, e.g. gelatin
Abstract
A liquid for coating composition for applying a thin, colour-stable plastic film to solid medicaments, comprises a volatile organic solvent containing a water-dispersible, non-toxic, filmforming plastic, a physiologically acceptable colouring agent, and a complexing agent which comprises tannin when the colouring agent either forms an aqueous solution having a pH greater than 7 or contains basic nitrogen, and which comprises albumin when the colouring agent either forms an aqueous solution of pH less than 7 or contains sulphonic acid groups. Film-forming plastics suitable include those of Specification 762,229, which are combinations of a water-soluble wax-like material, e.g. polyethylene glycol and glyceryl monostearate, and cellulose esterified partially with a lower aliphatic mono-carboxylic acid and partially with a polycarboxylic acid, e.g. cellulose acetatephthalate combinations of a copolymer of maleic anhydride and ethylene with partial hydrolysis products thereof according to U.S.A. Specification 2,857,365, the combination of water-soluble waxes and a cellulose ester of aliphatic carboxylic acids having 1-4 carbon atoms, e.g. cellulose acetate, acrylic polymers and copolymers, e.g. methyl methacrylate, methyl methacrylate/methacrylic acid, methyl acrylate/methyl methacrylate, and vinyl polymers, e.g. polyvinyl pyrollidene/vinyl acetate with a water-soluble wax. Cellulose acetate phthalate with propylene glycol is used as a plastic material in the examples. The composition may contain both tannin and albumin. Suitable solvents include 1-4 carbon atom alkanols, e.g. methanol, ethanol, n- and isopropanol, acetone, methylene chloride, methyl ethyl acetone, and ethyl acetate. A mixture of acetone with an alkanol is preferred. A preferred liquid coating composition comprises 180-250 parts by weight of the film-forming plastic, 0,04-4,0 parts by weight of the colouring agent, and 5-30 parts by weight of the complexing agent or agents in 1,000 parts by volume of the solution. The dried coating prepared therefrom may contain 88-97% plastic, 0,051,5% colouring agent and 2,5-10,5% by weight of complexing agent. A liquid coating composition containing other additives may be used, e.g. silicone resins, long-chain fatty acids, long-chain metallic soaps and long-chain alcohols as gloss-producing agents, titanium dioxide, calcium carbonate, dehydrated calcium sulphate, and dicalcium phosphate as opaquing agents, "Bentone" (Registered Trade Mark), and alkyl ammonium montmorillonite and Veegum, a colloidal magnesium aluminium silicate, as suspending agents, plasticizers, e.g. mineral oil, castor oil, polyethylene and polypropylene glycols, and glycerine and sweetening agents, e.g. vanillin, saccharin, sodium cyclohexyl sulphamate, coumarin and heliotropin. Such a liquid coating composition may contain, in addition to the plastic, colouring agents and complexing agents present, 15-25 g. plasticizer, 5-15 g. opaquing agents, 2-5 g. flavouring agents and 5-10 g. wetting agents per litre of solution. The dried coating prepared therefrom may contain 75-85% plastic, 0,02-1,0% colouring agent, 2-8% complexing agent, and 13-16% by weight tableting excipients and adjuvants. Tablets so coated show a reduced tendency to fading of the colouring agent on exposure to ultra-violet light. U.S.A. Specifications 2,093,462 2,093,464 and 2,126,460 also are referred to.ALSO:Solid medicaments having a reduced tendency to fading of the colouring agent on exposure to ultra-violet light are made by the use of a liquid coating composition comprising a volatile organic solvent containing a water-dispersible, non-toxic, film-forming plastic, a physiologically acceptable colouring agent, and a complexing agent which comprises tannin when the colouring agent either forms an aqueous solution having a pH greater than 7 or contains basic nitrogen, and which comprises albumin when the colouring agent either forms an aqueous solution of pH less than 7 or contains sulphonic acid groups. Film-forming plastics suitable include those of Specification 762,229, which are combinations of a water-soluble wax-like material, e.g. polyethylene glycol and glyceryl monostearate, and cellulose esterified partially with a lower aliphatic mono-carboxylic acid and partially with a polycarboxylic acid, e.g. cellulose acetate-phthalate combinations of a copolymer of maleic anhydride and ethylene with partial hydrolysis products thereof according to U.S.A. Specification 2,857,365, the combination of water-soluble waxes and a cellulose ester of aliphatic carboxylic acids having 1-4 carbon atoms, e.g. cellulose acetate, acrylic polymers and copolymers, e.g. methyl methacrylate, methyl methacrylate/methacrylic acid, methyl acrylate/methyl methacrylate, and vinyl polymers, e.g. polyvinyl pyrollidene/vinyl acetate with a water-soluble wax. Cellulose acetate phthalate with propylene glycol is used as a plastic material in the examples. The composition may contain both tannin and albumin. Suitable solvents include 1-4 carbon atom alkanols, e.g. methanol, ethanol, n- and iso-propanol, acetone, methylene chloride, methyl ethyl acetone, and ethyl acetate. A mixture of acetone with an alkanol is preferred. A preferred liquid coating composition comprises 180-250 parts by weight of the film-forming plastic, 0.04-4.0 parts by weight of the colouring agent, and 5-30 parts by weight of the complexing agent or agents in 1000 parts volume of the solution. The dried coating prepared therefrom may contain 88-97% plastic, 0.05-1.5% colouring agent and 2.5-10.5% by weight of complexing agent. A liquid coating composition containing other additives may be used, e.g. silicone resins, long-chain fatty acids, long-chain metallic soaps and long-chain alcohols as gloss-producing agents, titanium dioxide, calcium carbonate, dehydrated calcium sulphate, and dicalcium phosphate as opaquing agents, "Bentone" (Registered Trade Mark), and alkyl ammonium montmorillonite and Veegum, a colloidal magnesium aluminium silicate, as suspending agents, plasticizers, e.g. mineral oil, castor oil, polyethylene and polypropylene glycols, and glycerine and sweetening agents, e.g. vanillin, saccharin, sodium cyclohexyl sulphamate, coumarin and heliotropin. Such a liquid coating composition may contain, in addition to the plastic, colouring agents and complexing agents present, 15-25 g. plasticizer, 5-15 g. opaquing agents, 2-5 g. flavouring agents and 5-10 g. wetting agents per litre of solution. The dried coating prepared therefrom may contain 78-85% plastic, 0.02-1.0% colouring agent, 2-8% complexing agent, and 13-16% by weight tableting excipients and adjuvants. U.S.A. Specifications 2,093,462, 2,093,464 and 2,126,460 also are referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US837586A US3030273A (en) | 1959-09-02 | 1959-09-02 | Plastic tablet coating |
Publications (1)
Publication Number | Publication Date |
---|---|
ES260595A1 true ES260595A1 (en) | 1961-03-16 |
Family
ID=25274890
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES0260595A Expired ES260595A1 (en) | 1959-09-02 | 1960-08-25 | Plastic tablet coating |
Country Status (7)
Country | Link |
---|---|
US (1) | US3030273A (en) |
BE (1) | BE594492A (en) |
DE (1) | DE1118932B (en) |
ES (1) | ES260595A1 (en) |
FR (1) | FR1266265A (en) |
GB (1) | GB935386A (en) |
NL (1) | NL255509A (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3097144A (en) * | 1960-10-14 | 1963-07-09 | Upjohn Co | Heat-cured, polymeric, medicinal dosage film coatings containing a polyvinylpyrrolidone copolymer, polyethenoid acid, and polyethylene glycol |
NL287846A (en) * | 1962-01-20 | |||
US3149041A (en) * | 1962-04-09 | 1964-09-15 | Dow Chemical Co | Thin film coating for tablets and the like and method of coating |
US3149040A (en) * | 1962-04-09 | 1964-09-15 | Dow Chemical Co | Thin film coating for tablets and the like and method of coating |
DE1228757B (en) * | 1962-06-28 | 1966-11-17 | Haessle Ab | Process for the production of a coating on solid dosage forms which disintegrates rapidly in water and gastric juice |
US3409570A (en) * | 1964-11-02 | 1968-11-05 | Merck & Co Inc | Stabilization of dyes in a film coating material |
US3538214A (en) * | 1969-04-22 | 1970-11-03 | Merck & Co Inc | Controlled release medicinal tablets |
US3751277A (en) * | 1971-03-24 | 1973-08-07 | Dow Chemical Co | Tablet coating process and composition |
JPS517116A (en) * | 1974-06-11 | 1976-01-21 | Shinetsu Chemical Co | Choyoseihifukuyakuzaino seizohoho |
US4800087A (en) * | 1986-11-24 | 1989-01-24 | Mehta Atul M | Taste-masked pharmaceutical compositions |
US5084278A (en) * | 1989-06-02 | 1992-01-28 | Nortec Development Associates, Inc. | Taste-masked pharmaceutical compositions |
US6482516B1 (en) * | 1993-07-20 | 2002-11-19 | Banner Pharmacaps, Inc. | Enrobed tablet |
DE10127897B4 (en) * | 2001-06-08 | 2006-04-20 | Bionorica Ag | Coated tablet with dry plant extracts |
EP1413624B1 (en) * | 2002-10-22 | 2006-03-08 | Rohm and Haas Company | Tablet coating |
JP3759949B2 (en) * | 2002-12-17 | 2006-03-29 | 湧永製薬株式会社 | Shielding agent and coating composition |
WO2006079091A1 (en) * | 2005-01-24 | 2006-07-27 | Mallinckrodt Inc. | Methods of providing long-term stability to biocompatible optical dyes and bodily fluids |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2881085A (en) * | 1953-11-09 | 1959-04-07 | Abbott Lab | Thin film coating for tablets and the like |
-
0
- NL NL255509D patent/NL255509A/xx unknown
-
1959
- 1959-09-02 US US837586A patent/US3030273A/en not_active Expired - Lifetime
-
1960
- 1960-08-23 GB GB29148/60A patent/GB935386A/en not_active Expired
- 1960-08-25 ES ES0260595A patent/ES260595A1/en not_active Expired
- 1960-08-29 BE BE594492A patent/BE594492A/en unknown
- 1960-08-29 FR FR837055A patent/FR1266265A/en not_active Expired
- 1960-09-02 DE DEA35481A patent/DE1118932B/en active Pending
Also Published As
Publication number | Publication date |
---|---|
GB935386A (en) | 1963-08-28 |
US3030273A (en) | 1962-04-17 |
NL255509A (en) | |
FR1266265A (en) | 1961-07-07 |
BE594492A (en) | 1961-02-28 |
DE1118932B (en) | 1961-12-07 |
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