ES2547827T8 - Procedimiento para la purificación de la micafungina - Google Patents

Procedimiento para la purificación de la micafungina Download PDF

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Publication number
ES2547827T8
ES2547827T8 ES12713998.8T ES12713998T ES2547827T8 ES 2547827 T8 ES2547827 T8 ES 2547827T8 ES 12713998 T ES12713998 T ES 12713998T ES 2547827 T8 ES2547827 T8 ES 2547827T8
Authority
ES
Spain
Prior art keywords
micafungin
purification
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES12713998.8T
Other languages
English (en)
Other versions
ES2547827T3 (es
Inventor
Lene Aassveen
Eli Karin Dale
Espen Fridtjof Hansen
Kjersti Meldahl Eide
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xellia Pharmaceuticals ApS
Original Assignee
Xellia Pharmaceuticals ApS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xellia Pharmaceuticals ApS filed Critical Xellia Pharmaceuticals ApS
Application granted granted Critical
Publication of ES2547827T3 publication Critical patent/ES2547827T3/es
Publication of ES2547827T8 publication Critical patent/ES2547827T8/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32Bonded phase chromatography
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32Bonded phase chromatography
    • B01D15/325Reversed phase
    • B01D15/327Reversed phase with hydrophobic interaction
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Photolithography (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES12713998.8T 2011-04-20 2012-04-13 Procedimiento para la purificación de la micafungina Active ES2547827T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161477190P 2011-04-20 2011-04-20
US201161477190P 2011-04-20
PCT/EP2012/056768 WO2012143293A1 (en) 2011-04-20 2012-04-13 Method for purification of micafungin

Publications (2)

Publication Number Publication Date
ES2547827T3 ES2547827T3 (es) 2015-10-08
ES2547827T8 true ES2547827T8 (es) 2015-10-21

Family

ID=45953151

Family Applications (1)

Application Number Title Priority Date Filing Date
ES12713998.8T Active ES2547827T3 (es) 2011-04-20 2012-04-13 Procedimiento para la purificación de la micafungina

Country Status (18)

Country Link
US (1) US9132163B2 (es)
EP (2) EP2918324A1 (es)
JP (1) JP5992507B2 (es)
KR (1) KR101944512B1 (es)
CN (1) CN103533995B (es)
AU (1) AU2012244435B2 (es)
BR (1) BR112013026420A2 (es)
CA (1) CA2832145C (es)
DK (1) DK2699327T3 (es)
ES (1) ES2547827T3 (es)
HR (1) HRP20151033T1 (es)
HU (1) HUE027806T2 (es)
IL (1) IL228913A (es)
PL (1) PL2699327T3 (es)
RS (1) RS54240B1 (es)
RU (1) RU2583262C2 (es)
SI (1) SI2699327T1 (es)
WO (1) WO2012143293A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2699327T1 (sl) * 2011-04-20 2015-11-30 Xelia Pharmaceuticals Aps Postopek čiščenja mikafungina
CN102775476B (zh) * 2011-05-12 2015-01-07 上海天伟生物制药有限公司 一种米卡芬净钠盐的制备方法
CN105254721B (zh) * 2014-05-13 2021-05-18 江苏豪森药业集团有限公司 米卡芬净的纯化转盐方法
WO2015180678A1 (zh) * 2014-05-29 2015-12-03 上海天伟生物制药有限公司 环肽类化合物的晶体及其制备方法和用途
JP6491325B2 (ja) * 2014-05-29 2019-03-27 シャンハイ テックウェル バイオファーマシューティカル カンパニー リミテッドShanghai Techwell Biopharmaceutical Co.,Ltd シクロペプチド系化合物の溶媒和物およびその製造方法と使用
CN105693824A (zh) * 2015-08-27 2016-06-22 博瑞生物医药(苏州)股份有限公司 一种降低米卡芬净钠原料药溶剂残留量的方法
KR101880179B1 (ko) * 2016-11-03 2018-07-20 한국생명공학연구원 미카펀진(micafungin) 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 함유하는 항바이러스용 약학적 조성물
CN108250274A (zh) * 2016-12-28 2018-07-06 浙江华谱新创科技有限公司 米卡芬净高效分离纯化方法
EP3485873A1 (en) * 2017-11-17 2019-05-22 Cadila Healthcare Limited Stable pharmaceutical injectable compositions of micafungin
CN108752430B (zh) * 2018-05-31 2022-02-18 杭州中美华东制药有限公司 米卡芬净钠新晶型及其制备方法
CN111909244A (zh) * 2020-08-14 2020-11-10 卓和药业集团有限公司 一种高纯度米卡芬净前体fr901379的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR901379A (fr) 1943-09-10 1945-07-25 Télégraphie par variations de fréquence
US5202309A (en) * 1989-06-30 1993-04-13 Merck & Co., Inc. Antibiotic cyclopeptide fermentation product
IE990233A1 (en) 1990-06-18 2000-11-15 Fujisawa Pharmaceutical Co New Polypeptide Compound and a Process for Preparation thereof
US6107458A (en) 1994-10-07 2000-08-22 Fujisawa Pharmaceutical Co., Ltd. Cyclic hexapeptides having antibiotic activity
US6227164B1 (en) 1998-04-24 2001-05-08 Cooper Automotive Products, Inc. Insulator shield for spark plug
JP2003511345A (ja) * 1998-12-09 2003-03-25 イーライ リリー アンド カンパニー Echinocandinシクロペプチド化合物の精製
JP2005053782A (ja) * 2001-08-31 2005-03-03 Fujisawa Pharmaceut Co Ltd 環状リポペプチド化合物の新規結晶
WO2004014879A1 (en) 2002-08-08 2004-02-19 Fujisawa Pharmaceutical Co., Ltd. New process
TW200826957A (en) * 2006-10-16 2008-07-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Purification processes for echinocandin-type compounds
US9394340B2 (en) 2009-03-24 2016-07-19 Cadila Healthcare Limited Purification process for lipopeptides
CN103180336B (zh) 2010-09-28 2016-06-15 中化帝斯曼制药有限公司荷兰公司 用于分离环六肽的方法
CA2813330A1 (en) 2010-09-29 2012-04-05 Shanghai Techwell Biopharmaceutical Co., Ltd. Process for purifying cyclolipopeptide compounds or the salts thereof
SI2699327T1 (sl) * 2011-04-20 2015-11-30 Xelia Pharmaceuticals Aps Postopek čiščenja mikafungina

Also Published As

Publication number Publication date
WO2012143293A1 (en) 2012-10-26
IL228913A (en) 2017-03-30
SI2699327T1 (sl) 2015-11-30
JP5992507B2 (ja) 2016-09-14
IL228913A0 (en) 2013-12-31
AU2012244435A1 (en) 2013-10-24
EP2699327A1 (en) 2014-02-26
RS54240B1 (en) 2015-12-31
HRP20151033T1 (hr) 2015-11-06
CA2832145A1 (en) 2012-10-26
HUE027806T2 (en) 2016-11-28
RU2583262C2 (ru) 2016-05-10
CA2832145C (en) 2020-10-20
AU2012244435B2 (en) 2017-06-15
EP2918324A1 (en) 2015-09-16
ES2547827T3 (es) 2015-10-08
US9132163B2 (en) 2015-09-15
EP2699327B1 (en) 2015-07-01
CN103533995A (zh) 2014-01-22
BR112013026420A2 (pt) 2020-11-03
KR20140029453A (ko) 2014-03-10
CN103533995B (zh) 2016-03-02
US20140371423A1 (en) 2014-12-18
RU2013150600A (ru) 2015-05-27
PL2699327T3 (pl) 2015-12-31
DK2699327T3 (en) 2015-10-05
JP2014511886A (ja) 2014-05-19
KR101944512B1 (ko) 2019-01-31

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