ES2532502T3 - Proceso para la preparación de tenofovir - Google Patents

Proceso para la preparación de tenofovir Download PDF

Info

Publication number
ES2532502T3
ES2532502T3 ES07827516.1T ES07827516T ES2532502T3 ES 2532502 T3 ES2532502 T3 ES 2532502T3 ES 07827516 T ES07827516 T ES 07827516T ES 2532502 T3 ES2532502 T3 ES 2532502T3
Authority
ES
Spain
Prior art keywords
tenofovir
preparation process
tenofovir disoproxil
disoproxil hemifumarate
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES07827516.1T
Other languages
English (en)
Inventor
Uma Maheswer Rao Vasireddy
Siva Rama Prasad Vellanki
Raja Babu Balusu
Naga Durga Rao Bandi
Pravan Kumar Jujjavarapu
Sambasiva Rao Ginjupalli
Rama Krishna Pilli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mylan Laboratories Ltd
Original Assignee
Mylan Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mylan Laboratories Ltd filed Critical Mylan Laboratories Ltd
Application granted granted Critical
Publication of ES2532502T3 publication Critical patent/ES2532502T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Tenofovir disoproxil hemifumarato.

Description

DESCRIPCIÓN
imagen1
imagen2

Claims (1)

  1. REIVINDICACIONES
ES07827516.1T 2006-07-12 2007-07-11 Proceso para la preparación de tenofovir Active ES2532502T3 (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
INCH12182006 2006-07-12
IN1218CH2006 2006-07-12
IN1352CH2006 2006-07-31
INCH13522006 2006-07-31
INCH04842007 2007-03-09
IN484CH2007 2007-03-09
PCT/IN2007/000286 WO2008007392A2 (en) 2006-07-12 2007-07-11 Process for the preparation of tenofovir

Publications (1)

Publication Number Publication Date
ES2532502T3 true ES2532502T3 (es) 2015-03-27

Family

ID=38923686

Family Applications (1)

Application Number Title Priority Date Filing Date
ES07827516.1T Active ES2532502T3 (es) 2006-07-12 2007-07-11 Proceso para la preparación de tenofovir

Country Status (4)

Country Link
US (1) US8049009B2 (es)
EP (1) EP2046792B1 (es)
ES (1) ES2532502T3 (es)
WO (1) WO2008007392A2 (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008007392A2 (en) * 2006-07-12 2008-01-17 Matrix Laboratories Limited Process for the preparation of tenofovir
US20090270352A1 (en) * 2007-05-22 2009-10-29 Ultimorphix Technologies B.V. Tenofovir Disoproxil Hemi-Fumaric Acid Co-Crystal
WO2009064174A1 (en) * 2007-11-14 2009-05-22 Ultimorphix Technologies B.V. Polymorphic form of tenofovir disoproxil fumarate, method for its preparation and use
CA2713105C (en) 2008-01-25 2016-06-07 Chimerix, Inc. Methods of treating viral infections
NZ588796A (en) * 2008-04-25 2012-07-27 Cipla Ltd Crystalline form of tenofovir disoproxil and a process for its preparation
WO2010026603A2 (en) * 2008-09-05 2010-03-11 Matrix Laboratories Limited Novel amine salts of tenofovir, process for producing the same and use thereof in production of tenofovir dioproxil
CA2744211A1 (en) * 2008-11-21 2010-05-27 Ultimorphix Technologies B.V. Wet granulation of tenofovir, emtricitabine and efavirenz
CN101906119B (zh) * 2009-06-03 2012-12-26 中国人民解放军军事医学科学院毒物药物研究所 制备替诺福韦的新方法
WO2011014704A2 (en) 2009-07-30 2011-02-03 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
ES2629165T3 (es) 2010-02-12 2017-08-07 Chimerix, Inc. Métodos de tratamiento de una infección vírica
WO2011111074A2 (en) 2010-03-11 2011-09-15 Matrix Laboratories Ltd An improved process for the preparation of tenofovir disoproxil fumarate
EP2563367A4 (en) 2010-04-26 2013-12-04 Chimerix Inc METHODS OF TREATING RETROVIRAL INFECTIONS AND ASSOCIATED DOSAGE REGIMES
CN101870713A (zh) * 2010-05-28 2010-10-27 杭州和素化学技术有限公司 一种替诺福韦酯的产业化生产工艺
AU2011288091B2 (en) * 2010-08-01 2016-06-09 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Crystals of Tenofovir disoproxil fumarate
ZA201103820B (en) * 2010-12-13 2012-01-25 Laurus Labs Private Ltd Process for the preparation of tenofovir
CN102219805A (zh) * 2011-03-10 2011-10-19 苏州腾龙生物医药技术有限公司 一种新型的泰诺福韦生产工艺
CN103732594A (zh) 2011-08-16 2014-04-16 吉联亚科学公司 替诺福韦艾拉酚胺(tenofovir alafenamide)半反丁烯二酸盐
WO2013072745A1 (en) 2011-11-16 2013-05-23 Laurus Labs Private Limited Process for the preparation of tenofovir
CN103374038B (zh) * 2012-04-11 2016-04-13 广州白云山医药集团股份有限公司白云山制药总厂 一种抗病毒药物的制备方法
CN107312039B (zh) 2012-08-30 2019-06-25 江苏豪森药业集团有限公司 一种替诺福韦前药的制备方法
GB201215696D0 (en) * 2012-09-03 2012-10-17 Ithemba Pharmaceuticals Pty Ltd A process for the preparation of (R)-9-[2-(Phosphonometh-Oxy)propyl]adenine (PMPA)
CN103848869B (zh) * 2012-12-04 2016-12-21 上海医药工业研究院 制备替诺福韦的方法
CN103848868B (zh) * 2012-12-04 2017-04-12 蚌埠丰原涂山制药有限公司 制备替诺福韦的方法
CN104045667A (zh) * 2013-03-14 2014-09-17 上海卫思化学科技有限公司 一种替诺福韦酯半富马酸盐的制备方法
WO2015040640A2 (en) * 2013-09-20 2015-03-26 Laurus Labs Private Limited An improved process for the preparation of tenofovir alafenamide or pharmaceutically acceptable salts thereof
EP2860185A1 (en) 2013-10-09 2015-04-15 Zentiva, k.s. An improved process for the preparation of Tenofovir disoproxil and pharmaceutically acceptable salts thereof
PT2860184T (pt) 2013-10-09 2018-11-20 Zentiva Ks Sal de di-hidrogenofosfato de tenofovir disoproxil
MX362752B (es) 2013-11-15 2019-02-07 Chimerix Inc Formas mórficas de ésteres de hexadeciloxipropil-fosfonato.
TWI660965B (zh) * 2014-01-15 2019-06-01 美商基利科學股份有限公司 泰諾福韋之固體形式
CN104530129A (zh) * 2014-03-26 2015-04-22 广东东阳光药业有限公司 制备(r)-9-(2-磷酸甲氧基丙基)腺嘌呤的方法
CN104974188B (zh) * 2014-04-11 2019-01-08 浙江九洲药业股份有限公司 一种替诺福韦酯晶型及其制备方法
CN104230992A (zh) * 2014-08-27 2014-12-24 太仓运通生物化工有限公司 一种高纯度富马酸泰诺福韦酯的制备方法
CN106687467A (zh) * 2014-09-30 2017-05-17 韩美精密化学株式会社 高纯度（r）‑9‑[2‑（磷酰甲氧基）丙基]腺嘌呤的制备方法
CN105985381B (zh) * 2014-12-30 2018-10-30 安徽贝克联合制药有限公司 一种替诺福韦的制备方法
RU2665037C2 (ru) * 2016-12-12 2018-08-27 Общество с ограниченной ответственностью "Вириом" Изопропил N-[{ [(1R)-2-(6-амино-9H-пурин-9-ил)-1-метилэтокси]метил} (1,3-бензотиазол-6-ил-окси)фосфорил]-L-аланинат фумарат в качестве противовирусного препарата - пролекарства Тенофовира
CN110372748B (zh) * 2018-04-12 2023-04-07 湖南千金湘江药业股份有限公司 一种无定形半富马酸替诺福韦二吡呋酯及其制备方法
CN110615814B (zh) * 2019-09-10 2021-07-06 株洲千金药业股份有限公司 一种半富马酸替诺福韦二吡呋酯的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5733788A (en) 1996-07-26 1998-03-31 Gilead Sciences, Inc. PMPA preparation
US5922695A (en) 1996-07-26 1999-07-13 Gilead Sciences, Inc. Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability
SG106657A1 (en) 1997-07-25 2004-10-29 Gilead Sciences Inc Nycleotide analog composition and sythesis method
US5935946A (en) * 1997-07-25 1999-08-10 Gilead Sciences, Inc. Nucleotide analog composition and synthesis method
US6465649B1 (en) 1999-08-18 2002-10-15 Gilead Sciences, Inc. Methods for the dealkylation of phosphonate esters
PT1301519E (pt) 2000-07-21 2015-06-11 Gilead Sciences Inc Profármacos de análogos de nucleótidos de fosfonato e métodos para selecionar e preparar os mesmos
WO2008007392A2 (en) * 2006-07-12 2008-01-17 Matrix Laboratories Limited Process for the preparation of tenofovir
US20090270352A1 (en) * 2007-05-22 2009-10-29 Ultimorphix Technologies B.V. Tenofovir Disoproxil Hemi-Fumaric Acid Co-Crystal
US20110009368A1 (en) * 2007-12-12 2011-01-13 Ultimorphix Technologies B.V. Solid forms of tenofovir disoproxil

Also Published As

Publication number Publication date
WO2008007392A3 (en) 2008-07-17
EP2046792B1 (en) 2015-02-25
EP2046792A2 (en) 2009-04-15
US8049009B2 (en) 2011-11-01
US20090286981A1 (en) 2009-11-19
WO2008007392A2 (en) 2008-01-17

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