ES2422162T3 - Membrana de fibra hueca para hemodiálisis con permeabilidad y selectividad mejoradas - Google Patents
Membrana de fibra hueca para hemodiálisis con permeabilidad y selectividad mejoradasInfo
- Publication number
- ES2422162T3 ES2422162T3 ES08008229T ES08008229T ES2422162T3 ES 2422162 T3 ES2422162 T3 ES 2422162T3 ES 08008229 T ES08008229 T ES 08008229T ES 08008229 T ES08008229 T ES 08008229T ES 2422162 T3 ES2422162 T3 ES 2422162T3
- Authority
- ES
- Spain
- Prior art keywords
- membrane
- weight
- molecular weight
- layer
- polyvinylpyrrolidone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000035699 permeability Effects 0.000 title abstract 3
- 239000012510 hollow fiber Substances 0.000 title abstract 2
- 238000001631 haemodialysis Methods 0.000 title 1
- 230000000322 hemodialysis Effects 0.000 title 1
- 239000012528 membrane Substances 0.000 abstract 6
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 5
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 5
- 239000011148 porous material Substances 0.000 abstract 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 102000036675 Myoglobin Human genes 0.000 abstract 1
- 108010062374 Myoglobin Proteins 0.000 abstract 1
- 239000004695 Polyether sulfone Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229920006393 polyether sulfone Polymers 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/08—Hollow fibre membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3403—Regulation parameters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3403—Regulation parameters
- A61M1/3406—Physical characteristics of the filtrate, e.g. urea
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
- B01D67/0002—Organic membrane manufacture
- B01D67/0009—Organic membrane manufacture by phase separation, sol-gel transition, evaporation or solvent quenching
- B01D67/0011—Casting solutions therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/08—Hollow fibre membranes
- B01D69/087—Details relating to the spinning process
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
- B01D71/06—Organic material
- B01D71/66—Polymers having sulfur in the main chain, with or without nitrogen, oxygen or carbon only
- B01D71/68—Polysulfones; Polyethersulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2323/00—Details relating to membrane preparation
- B01D2323/06—Specific viscosities of materials involved
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2323/00—Details relating to membrane preparation
- B01D2323/12—Specific ratios of components used
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2325/00—Details relating to properties of membranes
- B01D2325/02—Details relating to pores or porosity of the membranes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2325/00—Details relating to properties of membranes
- B01D2325/02—Details relating to pores or porosity of the membranes
- B01D2325/0283—Pore size
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2325/00—Details relating to properties of membranes
- B01D2325/20—Specific permeability or cut-off range
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2325/00—Details relating to properties of membranes
- B01D2325/34—Molecular weight or degree of polymerisation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Manufacturing & Machinery (AREA)
- Dispersion Chemistry (AREA)
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
Membrana asimétrica semipermeable de fibra hueca, estando compuesto el material de la membrana por entre un80 y un 99% en peso de una polietersulfona y por entre un 1 y un 20% en peso de una polivinilpirrolidona, endonde la polivinilpirrolidona está compuesta por un componente de bajo peso molecular que tiene un pesomolecular por debajo de 100 kD y un componente de alto peso molecular que tiene un peso molecular de 100 kD omayor, caracterizada porque la polivinilpirrolidona está compuesta por entre un 10 y un 45% en peso sobre la basedel peso total de PVP en la membrana, del componente de alto peso molecular, y por entre un 55 y un 90% enpeso, sobre la base del peso total de PVP en la membrana, del componente de bajo peso molecular, en donde lamembrana tiene una estructura de cuatro capas que comprende una primera capa de separación interna en formade una capa densa bastante fina que tiene un grosor menor que 1 μm y un tamaño de poro de orden nanométrico,una segunda capa en forma de una estructura de esponja, una tercera capa en forma de una estructura dactilar, yuna cuarta capa externa que tiene una superficie externa que tiene poros en el intervalo de entre 0,5 y 3 μm y quetiene un número de dichos poros en el intervalo de entre 10.000 y 150.000 poros por mm2, y en donde lamembrana tiene un coeficiente de cribado para la mioglobina en solución acuosa, de entre el 86% y el 90%, unapermeabilidad convectiva Lp de agua a 37ºC de entre 56x10-4 y 84x10-4 cm/bar x s, una permeabilidad difusiva PClde cloruro a 37ºC de entre 18x10-4 y 21x10-4 cm/s; y está caracterizada por una selectividad SCMio/SCAlbu de 9,4 ómayor.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08008229.0A EP2113298B1 (en) | 2008-04-30 | 2008-04-30 | Hollow fibre membrane for hemodialysis with improved permeability and selectivity |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2422162T3 true ES2422162T3 (es) | 2013-09-09 |
Family
ID=39744511
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES08008229T Active ES2422162T3 (es) | 2008-04-30 | 2008-04-30 | Membrana de fibra hueca para hemodiálisis con permeabilidad y selectividad mejoradas |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP2113298B1 (es) |
ES (1) | ES2422162T3 (es) |
PL (1) | PL2113298T3 (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2168668A1 (en) | 2008-09-25 | 2010-03-31 | Gambro Lundia AB | Membrane for cell expansion |
EP2177603A1 (en) | 2008-09-25 | 2010-04-21 | Gambro Lundia AB | Device for renal cell expansion |
EP2168666A1 (en) | 2008-09-25 | 2010-03-31 | Gambro Lundia AB | Irradiated membrane for cell expansion |
EP2314672B1 (en) | 2008-09-25 | 2015-04-15 | Gambro Lundia AB | Hybrid bioartificial kidney |
ES2602757T3 (es) | 2009-05-15 | 2017-02-22 | Interface Biologics Inc. | Membranas de fibra hueca, material de encapsulación y tubo para la sangre antitrombogénicos |
ITBO20090705A1 (it) * | 2009-10-29 | 2011-04-29 | Medica S R L | Procedimento per la preparazione di una membrana cava per lo scambio di materia tra una fase liquida e una fase gassosa |
EP2412798A1 (en) | 2010-07-27 | 2012-02-01 | Gambro Lundia AB | Biomimetic membrane for cell expansion |
US9844625B2 (en) * | 2011-04-13 | 2017-12-19 | 3M Innovative Properties Company | Macroporous filtration membrane |
EP2535069B1 (en) * | 2011-06-15 | 2013-12-18 | Gambro Lundia AB | Apparatus |
EP2556848A1 (en) | 2011-08-08 | 2013-02-13 | Gambro Lundia AB | Separation material comprising saccharide ligands |
EP2556849A1 (en) | 2011-08-08 | 2013-02-13 | Gambro Lundia AB | Separation material |
EP2567750B1 (en) | 2011-09-08 | 2014-12-24 | Gambro Lundia AB | Hollow fiber membrane |
EP2735359B1 (en) | 2012-11-26 | 2017-02-08 | Gambro Lundia AB | Integrated device for liver support systems |
PL2735360T3 (pl) | 2012-11-26 | 2017-09-29 | Gambro Lundia Ab | Urządzenie adsorbujące łączące granulki i membrany z włókien kanalikowych |
ES2625510T3 (es) | 2012-11-26 | 2017-07-19 | Gambro Lundia Ab | Sistema de soporte hepático |
GB201300465D0 (en) | 2013-01-11 | 2013-02-27 | Aquaporin As | A hollow fiber module having tfc-aquaporin modified membranes |
DK177696B1 (en) | 2013-02-25 | 2014-03-17 | Aquaporin As | Systems for water extraction |
EP2845641B1 (en) | 2013-09-05 | 2018-05-09 | Gambro Lundia AB | Permselective asymmetric membranes with high molecular weight polyvinylpyrrolidone, the preparation and use thereof |
CN103585902B (zh) * | 2013-10-25 | 2015-09-02 | 中科院广州化学有限公司 | 一种亲水性手性拆分聚砜膜及其制备方法和应用 |
CN103585901B (zh) * | 2013-10-25 | 2015-11-18 | 中国科学院广州化学研究所 | 一种自组装亲水性聚砜膜及其制备方法和应用 |
JP2015116212A (ja) * | 2013-12-16 | 2015-06-25 | 旭化成メディカル株式会社 | 血液処理用中空糸膜及びその膜を組み込んだ血液処理器 |
KR102431427B1 (ko) | 2014-02-06 | 2022-08-10 | 감브로 룬디아 아베 | 혈액 정화를 위한 멤브레인 |
CN105722582A (zh) | 2014-02-06 | 2016-06-29 | 甘布罗伦迪亚股份公司 | 用于血液净化的血液透析器 |
CA2959291C (en) * | 2014-08-25 | 2020-10-27 | Asahi Kasei Medical Co., Ltd. | Porous membrane with gradient asymmetric structure |
EP3178539A1 (en) | 2015-12-11 | 2017-06-14 | Gambro Lundia AB | Filter device, system and method for filtration of fluids |
EP3290067B1 (en) | 2016-09-06 | 2021-03-03 | Gambro Lundia AB | Liver support system |
CN110167995B (zh) | 2016-10-18 | 2022-07-01 | 界面生物公司 | 具有表面改性大分子的塑化pvc混合物和由其制成的制品 |
EP3388139A1 (en) | 2017-04-13 | 2018-10-17 | Gambro Lundia AB | Optimized hemodialyzer for blood purification |
EP3415225B1 (en) | 2017-06-14 | 2021-03-03 | Gambro Lundia AB | System and method for filtration and/or dilation of fluids |
CN110891997B (zh) | 2017-07-14 | 2022-05-24 | 费森尤斯医疗保健控股公司 | 利用改进的副产物去除来提供表面改性组合物的方法 |
EP3669888A1 (en) | 2018-12-20 | 2020-06-24 | Gambro Lundia AB | Extracorporeal devices for methods for treating diseases associated with anti-neutrophil cytoplasmic antibodies |
CA3130651A1 (en) | 2019-03-06 | 2020-09-10 | Gambro Lundia Ab | Blood treatment device comprising alkaline phosphatase |
CN112245691A (zh) | 2019-07-22 | 2021-01-22 | 巴克斯特医疗保健股份有限公司 | 从原水制备透析液的方法和*** |
CN114173915B (zh) | 2019-08-06 | 2024-05-31 | 索尔维特殊聚合物美国有限责任公司 | 膜以及制造其的聚合物 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3149976A1 (de) | 1981-12-17 | 1983-06-30 | Hoechst Ag, 6230 Frankfurt | Makroporoese asymmetrische hydrophile membran aus synthetischem polymerisat |
ATE68991T1 (de) | 1984-06-13 | 1991-11-15 | Inst Nat Rech Chimique | Verfahren zur herstellung von hohlfasern und ihre verwendung in membrantrennverfahren. |
DE3426331A1 (de) | 1984-07-17 | 1986-01-30 | 6380 Bad Homburg Fresenius AG | Asymmetrische mikroporoese hohlfaser fuer die haemodialyse sowie verfahren zu ihrer herstellung |
SE460521B (sv) | 1987-08-31 | 1989-10-23 | Gambro Dialysatoren | Permselektiv asymmetriskt membran samt foerfarande foer dess framstaellning |
US5340480A (en) | 1992-04-29 | 1994-08-23 | Kuraray Co., Ltd. | Polysulfone-based hollow fiber membrane and process for manufacturing the same |
ES2181852T5 (es) | 1995-06-30 | 2020-04-29 | Toray Industries | Membranas de permeabilidad selectiva y procedimientos para su obtención |
US6355730B1 (en) | 1995-06-30 | 2002-03-12 | Toray Industries, Inc. | Permselective membranes and methods for their production |
KR100289413B1 (ko) * | 1997-12-30 | 2001-05-02 | 구광시 | 폴리설폰계 중공사 막 및 그의 제조 방법 |
SE0203857L (sv) | 2002-12-20 | 2004-06-21 | Gambro Lundia Ab | Permselektivt membran och förfarande för tillverkning därav |
EP1710011A1 (en) | 2005-04-07 | 2006-10-11 | Gambro Lundia AB | Filtration membrane |
ES2342966T3 (es) | 2006-07-07 | 2010-07-20 | Gambro Lundia Ab | Membrana de separacion de plasma. |
-
2008
- 2008-04-30 ES ES08008229T patent/ES2422162T3/es active Active
- 2008-04-30 EP EP08008229.0A patent/EP2113298B1/en active Active
- 2008-04-30 PL PL08008229T patent/PL2113298T3/pl unknown
Also Published As
Publication number | Publication date |
---|---|
PL2113298T3 (pl) | 2013-11-29 |
EP2113298A9 (en) | 2010-06-02 |
EP2113298A1 (en) | 2009-11-04 |
EP2113298B1 (en) | 2013-04-24 |
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