ES2317116T3 - Derivados de carbonilos sustituidos heterociclicos y su uso como ligandos del receptor de dopamina d3. - Google Patents
Derivados de carbonilos sustituidos heterociclicos y su uso como ligandos del receptor de dopamina d3. Download PDFInfo
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- ES2317116T3 ES2317116T3 ES05018120T ES05018120T ES2317116T3 ES 2317116 T3 ES2317116 T3 ES 2317116T3 ES 05018120 T ES05018120 T ES 05018120T ES 05018120 T ES05018120 T ES 05018120T ES 2317116 T3 ES2317116 T3 ES 2317116T3
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- disorders
- dopamine
- compounds
- receptors
- disease
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- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title 2
- 229960003638 dopamine Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 102000004073 Dopamine D3 Receptors Human genes 0.000 abstract 3
- 108090000525 Dopamine D3 Receptors Proteins 0.000 abstract 3
- 208000015114 central nervous system disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 208000011117 substance-related disease Diseases 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000017164 Chronobiology disease Diseases 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 208000019022 Mood disease Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000027089 Parkinsonian disease Diseases 0.000 abstract 1
- 206010034010 Parkinsonism Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 206010043118 Tardive Dyskinesia Diseases 0.000 abstract 1
- 208000000323 Tourette Syndrome Diseases 0.000 abstract 1
- 208000016620 Tourette disease Diseases 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 230000000142 dyskinetic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000012216 imaging agent Substances 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
- 201000009032 substance abuse Diseases 0.000 abstract 1
- 231100000736 substance abuse Toxicity 0.000 abstract 1
- 201000006152 substance dependence Diseases 0.000 abstract 1
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- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicinal Preparation (AREA)
- Pyridine Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un compuesto de fórmula (I): ** ver fórmula** dibde A es CH O N; n es 1 y es 0; g es 1 ó 2 cada R 3 es independientemente hidrógeno, alquilo C 1-C 6,
Applications Claiming Priority (4)
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US26967201P | 2001-02-16 | 2001-02-16 | |
US269672P | 2001-02-16 | ||
GB0117577 | 2001-07-19 | ||
GBGB0117577.7A GB0117577D0 (en) | 2001-02-16 | 2001-07-19 | Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D receptor ligands |
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ES2317116T3 true ES2317116T3 (es) | 2009-04-16 |
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ES02718999T Expired - Lifetime ES2253526T3 (es) | 2001-02-16 | 2002-02-15 | Derivados de carbonilo sustituidos heterociclicos y su uso como ligandos de receptores d3 de dopamina. |
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EP (3) | EP1935887B1 (es) |
JP (2) | JP2009185055A (es) |
AT (3) | ATE313534T1 (es) |
AU (1) | AU2002250107B8 (es) |
CA (1) | CA2438264A1 (es) |
DE (2) | DE60208157T2 (es) |
DK (2) | DK1362039T3 (es) |
ES (2) | ES2317116T3 (es) |
IL (1) | IL157413A0 (es) |
MX (1) | MXPA03006943A (es) |
PT (1) | PT1632483E (es) |
WO (1) | WO2002066446A1 (es) |
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US7355042B2 (en) | 2001-10-16 | 2008-04-08 | Hypnion, Inc. | Treatment of CNS disorders using CNS target modulators |
US7247725B2 (en) * | 2002-10-30 | 2007-07-24 | Merck & Co., Inc. | Gamma-aminoamide modulators of chemokine receptor activity |
DE10358004A1 (de) * | 2003-12-11 | 2005-07-14 | Abbott Gmbh & Co. Kg | Ketolactam-Verbindungen und ihre Verwendung |
US20080275028A1 (en) * | 2004-07-20 | 2008-11-06 | Giovanni Gaviraghi | Modulators or Alpha7 Nicotinic Acetylcholine Receptors and Therapeutic Uses Thereof |
CN101083982A (zh) * | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 用于治疗硬脂酰CoA去饱和酶介导的疾病的杂环衍生物 |
AU2005329423A1 (en) | 2004-09-20 | 2006-09-28 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
AR051091A1 (es) | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
TW200626138A (en) | 2004-09-20 | 2006-08-01 | Xenon Pharmaceuticals Inc | Heterocyclic derivatives and their use as therapeutic agents |
JP4958786B2 (ja) | 2004-09-20 | 2012-06-20 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 複素環誘導体および治療薬としてのそれらの使用 |
CN101083992A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 抑制人硬脂酰CoA去饱和酶的哒嗪衍生物 |
WO2006034441A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
DE602006012650D1 (de) | 2005-04-26 | 2010-04-15 | Hypnion Inc | Benzisoxazolpiperidinverbindungen und verfahren zu deren anwendung |
WO2006116615A1 (en) * | 2005-04-26 | 2006-11-02 | Hypnion, Inc. | Benzisoxazole piperazine compounds and methods of use thereof |
US7767827B2 (en) | 2005-05-23 | 2010-08-03 | Kaken Pharmaceutical Co., Ltd. | Pyrazole-1-carboxylate derivatives, process for the production thereof and process for the production of pyrazole derivatives |
MX2007015216A (es) | 2005-06-03 | 2008-02-22 | Xenon Pharmaceuticals Inc | Derivados de aminotiazol y sus usos como agentes terapeuticos. |
KR101288781B1 (ko) | 2006-06-28 | 2013-07-22 | 암젠 인크 | 글리신 수송자-1 억제제 |
CA2666275A1 (en) * | 2006-10-13 | 2008-04-17 | Neuromed Pharmaceuticals Ltd. | Cyclopropyl-piperazine compounds as calcium channel blockers |
TW200901974A (en) | 2007-01-16 | 2009-01-16 | Wyeth Corp | Compounds, compositions, and methods of making and using them |
JP5502733B2 (ja) | 2007-07-26 | 2014-05-28 | エフ.ホフマン−ラ ロシュ アーゲー | 5−ht2a及びd3受容体の二重のモジュレーター |
EP2334657B1 (en) | 2008-09-22 | 2013-03-06 | F. Hoffmann-La Roche AG | Piperazine d3 and 5-ht2a receptor modulators |
MX2011002752A (es) * | 2008-09-23 | 2011-04-07 | Hoffmann La Roche | Derivados de benzo[d]isoxazol-3-il-piperazina utiles como moduladores de receptores de dopamina d3. |
WO2010040808A1 (en) * | 2008-10-10 | 2010-04-15 | Neurosearch A/S | Novel quinolinylamide derivatives useful as modulators of dopamine and serotonin receptors |
TW201113280A (en) | 2009-07-03 | 2011-04-16 | Nensius Res As | Aminoalkamides for use in the treatment of inflammatory, degenerative or demyelinating diseases of the CNS |
EP2592071B1 (en) | 2009-10-29 | 2019-09-18 | Bristol-Myers Squibb Company | Tricyclic heterocyclic compounds |
US8877778B2 (en) | 2010-12-15 | 2014-11-04 | Hoffmann-La Roche Inc. | Benzofurane compounds |
US8921397B2 (en) | 2011-05-04 | 2014-12-30 | Hoffmann-La Roche Inc. | Benzofurane-piperidine compounds |
SI2922845T1 (sl) * | 2012-11-20 | 2018-10-30 | Merial, Inc. | Antihelmintske spojine in sestavki ter postopek za njihovo uporabo |
CA2949511A1 (en) | 2014-05-19 | 2015-11-26 | Merial, Inc. | Anthelmintic compounds |
WO2018021447A1 (ja) | 2016-07-28 | 2018-02-01 | 塩野義製薬株式会社 | ドーパミンd3受容体拮抗作用を有する含窒素縮環化合物 |
US11447484B2 (en) | 2018-01-26 | 2022-09-20 | Shionogi & Co., Ltd. | Cyclic compound having dopamine D3 receptor antagonistic effect |
US11578084B2 (en) | 2018-01-26 | 2023-02-14 | Shionogi & Co., Ltd. | Condensed ring compounds having dopamine D3 receptor antagonistic effect |
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US5776963A (en) * | 1989-05-19 | 1998-07-07 | Hoechst Marion Roussel, Inc. | 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility |
US5364866A (en) * | 1989-05-19 | 1994-11-15 | Hoechst-Roussel Pharmaceuticals, Inc. | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics |
US5134139A (en) | 1989-08-31 | 1992-07-28 | Tanabe Seiyaku Co., Ltd. | 1,5-benzothiazepine derivatives and preparation thereof |
US5143923B1 (en) | 1991-04-29 | 1993-11-02 | Hoechst-Roussel Pharmaceuticals Incorporated | Benzoisothiazole-and benzisoxazole-3-carboxamides |
DE19600934A1 (de) | 1996-01-12 | 1997-07-17 | Basf Ag | Substituierte Aza- und Diazacycloheptan- und Cyclooctanverbindungen und deren Verwendung |
GB9821978D0 (en) * | 1998-10-08 | 1998-12-02 | Smithkline Beecham Plc | Compounds |
HUP0203054A3 (en) | 1998-12-18 | 2004-01-28 | Schering Corp | Farnesyl protein transferase inhibitors, pharmaceutical compositions containing them and their use |
DE19922443A1 (de) | 1999-05-07 | 2000-11-09 | Basf Ag | Verwendung von Dopamin-D3-Rezeptorliganden zur Herstellung von Arzneimittel für die Behandlung von Nierenfunktionsstörungen |
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2002
- 2002-02-15 EP EP08004461A patent/EP1935887B1/en not_active Expired - Lifetime
- 2002-02-15 ES ES05018120T patent/ES2317116T3/es not_active Expired - Lifetime
- 2002-02-15 MX MXPA03006943A patent/MXPA03006943A/es active IP Right Grant
- 2002-02-15 DE DE60208157T patent/DE60208157T2/de not_active Expired - Lifetime
- 2002-02-15 DK DK02718999T patent/DK1362039T3/da active
- 2002-02-15 EP EP05018120A patent/EP1632483B1/en not_active Expired - Lifetime
- 2002-02-15 DK DK05018120T patent/DK1632483T3/da active
- 2002-02-15 IL IL15741302A patent/IL157413A0/xx unknown
- 2002-02-15 EP EP02718999A patent/EP1362039B1/en not_active Expired - Lifetime
- 2002-02-15 AT AT02718999T patent/ATE313534T1/de not_active IP Right Cessation
- 2002-02-15 CA CA002438264A patent/CA2438264A1/en not_active Abandoned
- 2002-02-15 AT AT08004461T patent/ATE455108T1/de not_active IP Right Cessation
- 2002-02-15 ES ES02718999T patent/ES2253526T3/es not_active Expired - Lifetime
- 2002-02-15 DE DE60235130T patent/DE60235130D1/de not_active Expired - Lifetime
- 2002-02-15 PT PT05018120T patent/PT1632483E/pt unknown
- 2002-02-15 WO PCT/US2002/004713 patent/WO2002066446A1/en active IP Right Grant
- 2002-02-15 AU AU2002250107A patent/AU2002250107B8/en not_active Ceased
- 2002-02-15 AT AT05018120T patent/ATE412638T1/de active
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2009
- 2009-04-14 JP JP2009097550A patent/JP2009185055A/ja not_active Abandoned
- 2009-04-14 JP JP2009097547A patent/JP2009185054A/ja not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2002066446A1 (en) | 2002-08-29 |
JP2009185054A (ja) | 2009-08-20 |
ES2253526T3 (es) | 2006-06-01 |
JP2009185055A (ja) | 2009-08-20 |
EP1632483B1 (en) | 2008-10-29 |
DE60208157D1 (de) | 2006-01-26 |
EP1935887B1 (en) | 2010-01-13 |
MXPA03006943A (es) | 2005-04-29 |
DK1632483T3 (da) | 2009-03-02 |
AU2002250107B2 (en) | 2008-05-29 |
ATE313534T1 (de) | 2006-01-15 |
DE60235130D1 (de) | 2010-03-04 |
DE60208157T2 (de) | 2006-08-10 |
ATE455108T1 (de) | 2010-01-15 |
PT1632483E (pt) | 2009-01-12 |
DK1362039T3 (da) | 2006-05-08 |
CA2438264A1 (en) | 2002-08-29 |
AU2002250107B8 (en) | 2008-06-12 |
EP1632483A1 (en) | 2006-03-08 |
IL157413A0 (en) | 2004-03-28 |
ATE412638T1 (de) | 2008-11-15 |
EP1362039A1 (en) | 2003-11-19 |
EP1935887A1 (en) | 2008-06-25 |
EP1362039B1 (en) | 2005-12-21 |
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