ES2196116T3 - Dosificado de homocisteina. - Google Patents

Dosificado de homocisteina.

Info

Publication number
ES2196116T3
ES2196116T3 ES96200534T ES96200534T ES2196116T3 ES 2196116 T3 ES2196116 T3 ES 2196116T3 ES 96200534 T ES96200534 T ES 96200534T ES 96200534 T ES96200534 T ES 96200534T ES 2196116 T3 ES2196116 T3 ES 2196116T3
Authority
ES
Spain
Prior art keywords
homocysteine
enzyme
sample
substrate
homocisteine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96200534T
Other languages
English (en)
Other versions
ES2196116T5 (es
Inventor
Erling Sundrehagen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Axis Shield ASA
Original Assignee
Axis Shield ASA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27266081&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2196116(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from NO920282A external-priority patent/NO920282D0/no
Priority claimed from GB929204922A external-priority patent/GB9204922D0/en
Application filed by Axis Shield ASA filed Critical Axis Shield ASA
Publication of ES2196116T3 publication Critical patent/ES2196116T3/es
Application granted granted Critical
Publication of ES2196116T5 publication Critical patent/ES2196116T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G01N33/5735—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes co-enzymes or co-factors, e.g. NAD, ATP
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G01N33/6812—Assays for specific amino acids
    • G01N33/6815—Assays for specific amino acids containing sulfur, e.g. cysteine, cystine, methionine, homocysteine

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

SE SUMINISTRA UN METODO PARA COMPROBAR LA HOMOCISTEINA EN UNA MUESTRA POR EJEMPLO SANGRE, PLASMA U ORINA, QUE COMPRENDE LOS PASOS DE PONER EN CONTACTO CON LA MUESTRA CON UNA ENZIMA DE CONVERSION DE LA HOMOCISTEINA DIFERENTE DE LA SAH-HIDROLASA Y AL MENOS UN SUBSTRATO PARA LA ENZIMA DIFERENTE DE LA HOMOCISTEINA Y SIN SEPARACION CROMATOGRAFICA COMPROBAR LA PRESENCIA DE UNA SUBSTANCIA NO ETIQUETADA SELECCIONADA ENTRE UN CO-SUBSTRATO DE HOMOCISTEINA Y LOS PRODUCTOS DE CONVERSION DE LA HOMOCISTEINA DE LA CONVERSION ENZIMATICA DE LA HOMOCISTEINA MEDIANTE LA ENZIMA.
ES96200534T 1992-01-22 1993-01-22 Ensayo de homocisteína Expired - Lifetime ES2196116T5 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
NO920282 1992-01-22
NO920282A NO920282D0 (no) 1992-01-22 1992-01-22 Fremgangsmaate ved proeving av cystein
US83311892A 1992-02-10 1992-02-10
GB929204922A GB9204922D0 (en) 1992-03-06 1992-03-06 Assay
GB9204922 1992-03-06
US833118 2010-07-09

Publications (2)

Publication Number Publication Date
ES2196116T3 true ES2196116T3 (es) 2003-12-16
ES2196116T5 ES2196116T5 (es) 2012-04-11

Family

ID=27266081

Family Applications (2)

Application Number Title Priority Date Filing Date
ES93902437T Expired - Lifetime ES2094524T3 (es) 1992-01-22 1993-01-22 Ensayo para homocisteina.
ES96200534T Expired - Lifetime ES2196116T5 (es) 1992-01-22 1993-01-22 Ensayo de homocisteína

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES93902437T Expired - Lifetime ES2094524T3 (es) 1992-01-22 1993-01-22 Ensayo para homocisteina.

Country Status (18)

Country Link
EP (2) EP0623174B1 (es)
JP (1) JP2870704B2 (es)
AT (2) ATE142271T1 (es)
AU (1) AU676480B2 (es)
BR (1) BR9305780A (es)
CA (1) CA2128512C (es)
CZ (1) CZ287334B6 (es)
DE (2) DE69332891T3 (es)
DK (2) DK0623174T3 (es)
ES (2) ES2094524T3 (es)
FI (1) FI106728B (es)
GR (1) GR3021365T3 (es)
HU (1) HU219607B (es)
NO (1) NO314946B1 (es)
PT (1) PT726322E (es)
RU (1) RU2121001C1 (es)
SK (1) SK281517B6 (es)
WO (1) WO1993015220A1 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5478729A (en) * 1994-04-28 1995-12-26 Syntex (U.S.A.) Inc. Immunoassay for homocysteine
GB9617683D0 (en) * 1996-08-23 1996-10-02 Univ Glasgow Homocysteine desulphurase
DE19713088C1 (de) * 1997-03-27 1998-11-26 Reiner Dr Probst Verfahren und Blutabnahmegefäß zur Aufbereitung von Blutproben für die Homocystein- und/oder Folatbestimmung
US6020206A (en) * 1997-06-23 2000-02-01 Nexstar Pharmaceuticals, Inc. Homocysteine assay
US6066467A (en) * 1997-07-24 2000-05-23 Anticancer, Inc. High specificity homocysteine assays for biological samples
US6140102A (en) * 1997-07-24 2000-10-31 Anticancer, Inc. High specificity homocysteinases and genes therefor
US5985540A (en) * 1997-07-24 1999-11-16 Anticancer, Inc. High specificity homocysteine assays for biological samples
US6468762B1 (en) 1997-07-24 2002-10-22 Anticancer, Inc. High specificity homocysteinases
AU4835599A (en) 1998-06-29 2000-01-17 Edwin F. Ullman Assay for homocysteine
GB9900159D0 (en) * 1999-01-05 1999-02-24 Axis Biochemicals Asa Assay
WO2000040746A1 (en) * 1999-01-08 2000-07-13 Medical Analysis Systems, Inc. Compositions and methods for stabilizing thiol-containing biomolecules
DE60037311T2 (de) 1999-02-01 2008-10-23 Anticancer Inc., San Diego Homogene enzymatische bestimmungsmethode für vitamin b6
WO2001002600A2 (en) * 1999-07-06 2001-01-11 General Atomics Detection of analytes using attenuated enzymes
US7192729B2 (en) 1999-07-06 2007-03-20 General Atomics Methods for assaying homocysteine
US6376210B1 (en) 1999-07-06 2002-04-23 General Atomics Methods and compositions for assaying analytes
GB0008784D0 (en) * 2000-04-10 2000-05-31 Axis Shield Plc Assay
US6610504B1 (en) 2000-04-10 2003-08-26 General Atomics Methods of determining SAM-dependent methyltransferase activity using a mutant SAH hydrolase
ES2295174T3 (es) * 2000-06-30 2008-04-16 Alfresa Pharma Corporation Metodo para determinar homocisteina total.
WO2004068115A2 (en) * 2003-01-30 2004-08-12 Bellbrook Labs, Llc Assay method for group transfer reactions
JP2006149203A (ja) * 2003-02-19 2006-06-15 Alfresa Pharma Corp ホモシステインの測定方法
US7097968B2 (en) * 2003-07-10 2006-08-29 General Atomics Methods and compositions for assaying homocysteine
US8476034B2 (en) 2003-07-10 2013-07-02 General Atomics Methods and compositions for assaying homocysteine
US7384760B2 (en) 2004-04-30 2008-06-10 General Atomics Methods for assaying inhibitors of S-adenosylhomocysteine (SAH) hydrolase and S-adenosylmethionine (SAM)-dependent methyltransferase
GB0503836D0 (en) * 2005-02-24 2005-04-06 Axis Shield Asa Method
JP2007170992A (ja) * 2005-12-22 2007-07-05 Abbott Japan Co Ltd ホモシステインの免疫学的測定方法
JP6056138B2 (ja) * 2010-12-28 2017-01-11 東ソー株式会社 免疫学的測定方法
JP5803104B2 (ja) * 2010-12-28 2015-11-04 東ソー株式会社 安定化されたｓ−アデノシルホモシステイン加水分解酵素調製物
JP5919914B2 (ja) * 2012-03-15 2016-05-18 東ソー株式会社 ホモシステイン測定用前処理試薬

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5811857A (ja) * 1981-07-15 1983-01-22 Yamasa Shoyu Co Ltd アデノシンの定量法
JPS6030679A (ja) * 1983-07-29 1985-02-16 Nippon Zeon Co Ltd Ｓ−アデノシル−ｌ−ホモシステインハイドロラ−ゼの製造法

Also Published As

Publication number Publication date
FI106728B (fi) 2001-03-30
EP0726322B2 (en) 2011-12-07
DE69332891T3 (de) 2012-06-14
JPH08506478A (ja) 1996-07-16
RU2121001C1 (ru) 1998-10-27
SK281517B6 (sk) 2001-04-09
FI943462A (fi) 1994-09-14
NO942729L (no) 1994-09-15
AU4340893A (en) 1993-09-01
EP0623174B1 (en) 1996-09-04
DE69332891T2 (de) 2004-02-19
CA2128512C (en) 1999-12-07
DE69304511T2 (de) 1997-01-23
WO1993015220A1 (en) 1993-08-05
ES2094524T3 (es) 1997-01-16
JP2870704B2 (ja) 1999-03-17
RU94038061A (ru) 1996-05-27
HU219607B (hu) 2001-05-28
NO942729D0 (no) 1994-07-21
PT726322E (pt) 2003-09-30
ES2196116T5 (es) 2012-04-11
ATE142271T1 (de) 1996-09-15
EP0623174A1 (en) 1994-11-09
EP0726322B1 (en) 2003-04-16
DE69304511D1 (de) 1996-10-10
BR9305780A (pt) 1997-02-18
AU676480B2 (en) 1997-03-13
DE69332891D1 (de) 2003-05-22
HU9402170D0 (en) 1994-09-28
ATE237696T1 (de) 2003-05-15
FI943462A0 (fi) 1994-07-21
CA2128512A1 (en) 1993-08-05
EP0726322A1 (en) 1996-08-14
CZ176394A3 (en) 1994-12-15
GR3021365T3 (en) 1997-01-31
HUT67550A (en) 1995-04-28
NO314946B1 (no) 2003-06-16
DK0726322T4 (da) 2012-03-19
DK0623174T3 (da) 1997-01-13
CZ287334B6 (en) 2000-10-11
SK87894A3 (en) 1995-04-12
DK0726322T3 (da) 2003-07-28

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