ES2191449T3 - Derivados de ciclopentabenzofurano y su uso. - Google Patents

Derivados de ciclopentabenzofurano y su uso.

Info

Publication number
ES2191449T3
ES2191449T3 ES99939412T ES99939412T ES2191449T3 ES 2191449 T3 ES2191449 T3 ES 2191449T3 ES 99939412 T ES99939412 T ES 99939412T ES 99939412 T ES99939412 T ES 99939412T ES 2191449 T3 ES2191449 T3 ES 2191449T3
Authority
ES
Spain
Prior art keywords
derivatives
ciclopentabenzofurano
cyclopentabenzofuran derivatives
cyclopentabenzofuran
kappab
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99939412T
Other languages
English (en)
Inventor
Walter Guarnieri
Thomas Jaetsch
Andreas Schoop
Jorg Baumgarten
Axel Kretschmer
Horst-Peter Antonicek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2191449T3 publication Critical patent/ES2191449T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Uso de derivados de ciclopentabenzofurano de la fórmula (I) **(Fórmula)** en la que R1 y R3 representan hidrógeno, flúor, cloro, bromo, metilo o etilo, respectivamente, R2 y R4 representan metoxi, etoxi, trifluorometoxi, difluorometoxi, clorodifluorometoxi, 2-cloro-1, 1, 2-trifluoroetoxi, 1, 1, 2-trifluoroetoxi, 1, 1, 2, 2-tetrafluoroetoxi, 2, 2, 2-tricloro-1, 1-difluorometoxi o 1, 1-difluoroetoxi, respectivamente, R5 representa hidroxi, metilamino, etilamino, n-propilamino, isopropilamino, n-butilamino, isobutilamino, sec.-butilamino, terc.-butilamino o el resto -NR12-CHR13-COOR14, R6 representa hidrógeno, o R5 y R6 representan juntos oxígeno (oxo), R9 representa fenilo, metilendioxifenilo, furilo, tienilo, pirrolilo, oxazolilo, isoxazolilo, tiazolilo o piridilo que, dado el caso, pueden estar respectivamente sustituidos una o dos veces por sustituyentes del grupo de flúor, cloro, bromo, yodo, metilo, etilo, n-propilo, isopropilo, n-butilo, isobutilo, sec.-butilo, terc.-butilo, trifluorometilo, difluorometilo, clorodifluorometilo, 2-cloro-1, 1, 2-trifluoroetilo, 1, 35 1, 2-trifluoroetilo, 1, 1, 2, 2-tetrafluoroetilo, 1, 1-difluoro-2, 2, 2-tricloroetilo, 2, 2, 2-trifluoroetilo, 1, 1, 2, 3, 3, 3-hexafluoropropilo, 2, 2, 3, 3-tetrafluoropropilo, 2, 2, 3, 3, 3-pentafluoropropilo, hidroxi, metoxi, etoxi, n-propoxi, isopropoxi, n-butoxi, isobutoxi, sec.-butoxi, terc.-butoxi, trifluorometoxi, difluorometoxi, clorodifluorometoxi, 2-cloro-1, 1, 2-trifluoroetoxi, 1, 1, 2-trifluoroetoxi, 1, 1, 2, 2-tetrafluoroetoxi, 2, 2, 2tricloro-1, 1-difluorometoxi, 1, 1-difluoroetoxi, metiltio, etiltio, trifluorometiltio, 1, 1-difluoroetiltio, 40 2, 2, 2-trifluoroetiltio, fenilo, fenoxi, furilo, tienilo, pirrolilo, tiazolilo, piridilo, furiloxi, tieniloxi, pirroliloxi, tiazoliloxi, piridiloxi, acetilo, propionilo, propilcarbonilo, butilcarbonilo o 2-metilpropilcarbonilo, R10 representa hidrógeno, flúor, metilo, etilo, n-propilo, isopropilo, n-butilo, isobutilo, sec.-butilo, terc.45 butilo, metoxi,etoxi, n-propoxi, isopropoxi, n-butoxi, isobutoxi, sec.-butoxi o terc.-butoxi, R11 representa hidrógeno, flor, cloro, bromo, metilo, etilo, n-propilo, isopropilo, n-butilo, isobutilo, sec.-butilo o terc.-butilo, R12 representa hidrógeno, R13 representa hidrógeno, metilo, iso-propilo, iso-butilo, sec.-butilo, hidroximetilo, 1-hidroxietilo, mercaptometilo, 2-metiltioetilo, 3-aminopropilo, 4-aminobutilo, carboximetilo, 2-carboxietilo, carbamoilmetilo, 2-carbamoiletilo, 3-guanidinopropilo, fenilo, bencilo, 4-hidroxibencilo, 3-indolilmetilo o 4-imidazolilmetilo, y R14 representa metilo, etilo, n-propilo, isopropilo, n-butilo, isobutilo, sec.-butilo, terc.-butilo o bencilo, y las sales de los mismos para la preparación de un medicamento para el tratamiento de enfermedades inflamatorias, enfermedades inmunológicas, choque séptico, rechazo de trasplantes, daños por radiación, lesiones por reperfusión tras isquemia, ataque de apoplejía y traumatismo cerebral, enfermedades neurodegenerativas, cirrosis hepática, asma o de enfermedades complejas, inflamatorias crónicas, como arteriosclerosis y esclerosis múltiple.
ES99939412T 1998-08-05 1999-07-29 Derivados de ciclopentabenzofurano y su uso. Expired - Lifetime ES2191449T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19835324A DE19835324A1 (de) 1998-08-05 1998-08-05 Cyclopentabenzofuran-Derivate und ihre Verwendung

Publications (1)

Publication Number Publication Date
ES2191449T3 true ES2191449T3 (es) 2003-09-01

Family

ID=7876511

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99939412T Expired - Lifetime ES2191449T3 (es) 1998-08-05 1999-07-29 Derivados de ciclopentabenzofurano y su uso.

Country Status (8)

Country Link
US (2) US6420393B1 (es)
EP (1) EP1102761B1 (es)
JP (1) JP2002522428A (es)
AT (1) ATE231849T1 (es)
AU (1) AU5372199A (es)
DE (2) DE19835324A1 (es)
ES (1) ES2191449T3 (es)
WO (1) WO2000008007A2 (es)

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CN104844545B (zh) * 2015-04-07 2017-09-15 王青虎 一种黄酮类化合物及其提取工艺
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CN113149942B (zh) * 2021-02-10 2023-06-02 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 一种洛克米兰醇酚羟基衍生物、其制备方法和应用
CN115073407A (zh) * 2021-03-10 2022-09-20 上海中医药大学 一种具有合成致死性的药用组合物及其应用
CN113912577B (zh) * 2021-10-15 2023-12-29 深圳湾实验室 洛克米兰醇中间体、洛克米兰醇及其衍生物和制备与应用

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Also Published As

Publication number Publication date
DE19835324A1 (de) 2000-02-10
JP2002522428A (ja) 2002-07-23
WO2000008007A3 (de) 2000-05-11
DE59904180D1 (de) 2003-03-06
AU5372199A (en) 2000-02-28
EP1102761B1 (de) 2003-01-29
US6943182B2 (en) 2005-09-13
US6420393B1 (en) 2002-07-16
ATE231849T1 (de) 2003-02-15
EP1102761A2 (de) 2001-05-30
WO2000008007A2 (de) 2000-02-17
US20030144334A1 (en) 2003-07-31

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