ES2182397T3 - Comprimido para la liberacion instantanea y prolongada de una o mas substancias activas. - Google Patents

Comprimido para la liberacion instantanea y prolongada de una o mas substancias activas.

Info

Publication number
ES2182397T3
ES2182397T3 ES98965814T ES98965814T ES2182397T3 ES 2182397 T3 ES2182397 T3 ES 2182397T3 ES 98965814 T ES98965814 T ES 98965814T ES 98965814 T ES98965814 T ES 98965814T ES 2182397 T3 ES2182397 T3 ES 2182397T3
Authority
ES
Spain
Prior art keywords
layer
active substances
prolonged release
instant
compressed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98965814T
Other languages
English (en)
Inventor
Olivier Saslawski
Laurence Orlando
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Application granted granted Critical
Publication of ES2182397T3 publication Critical patent/ES2182397T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

Un comprimido de capas múltiples para la liberación instantánea y luego prolongada de substancias activas del tipo que comprende al menos dos capas superpuestas, caracterizado porque: - una primera capa exterior está compuesta de una mezcla de excipientes y de una primera substancia activa, permitiendo dicha primera capa la liberación inmediata de dicha primera substancia activa; - una segunda capa, dispuesta en contacto con dicha primera capa, consiste en una matriz polimérica porosa, inerte, no biodegradable, en donde está dispersada una segunda substancia activa.
ES98965814T 1997-12-23 1998-12-11 Comprimido para la liberacion instantanea y prolongada de una o mas substancias activas. Expired - Lifetime ES2182397T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9716402A FR2772615B1 (fr) 1997-12-23 1997-12-23 Comprime multicouche pour la liberation instantanee puis prolongee de substances actives

Publications (1)

Publication Number Publication Date
ES2182397T3 true ES2182397T3 (es) 2003-03-01

Family

ID=9515042

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98965814T Expired - Lifetime ES2182397T3 (es) 1997-12-23 1998-12-11 Comprimido para la liberacion instantanea y prolongada de una o mas substancias activas.

Country Status (24)

Country Link
US (1) US6372255B1 (es)
EP (1) EP1041972B1 (es)
JP (1) JP4451563B2 (es)
KR (1) KR100574207B1 (es)
CN (1) CN1163220C (es)
AR (1) AR017897A1 (es)
AT (1) ATE223207T1 (es)
AU (1) AU743195B2 (es)
BR (1) BR9814345A (es)
CA (1) CA2316277C (es)
CZ (1) CZ291884B6 (es)
DE (1) DE69807747T2 (es)
DK (1) DK1041972T3 (es)
ES (1) ES2182397T3 (es)
FR (1) FR2772615B1 (es)
HU (1) HU226069B1 (es)
ID (1) ID26313A (es)
NO (1) NO20003289L (es)
PT (1) PT1041972E (es)
RU (1) RU2212885C2 (es)
SK (1) SK283236B6 (es)
UA (1) UA55503C2 (es)
WO (1) WO1999033448A1 (es)
ZA (1) ZA9811799B (es)

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DE69807747T2 (de) 2003-06-12
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JP4451563B2 (ja) 2010-04-14
US6372255B1 (en) 2002-04-16
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DE69807747D1 (de) 2002-10-10
PT1041972E (pt) 2003-01-31
EP1041972B1 (en) 2002-09-04
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UA55503C2 (uk) 2003-04-15
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AR017897A1 (es) 2001-10-24
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