ES2180456B1 - Isoxazoles sustituidos y su utilizacion como antibioticos. - Google Patents
Isoxazoles sustituidos y su utilizacion como antibioticos.Info
- Publication number
- ES2180456B1 ES2180456B1 ES200101793A ES200101793A ES2180456B1 ES 2180456 B1 ES2180456 B1 ES 2180456B1 ES 200101793 A ES200101793 A ES 200101793A ES 200101793 A ES200101793 A ES 200101793A ES 2180456 B1 ES2180456 B1 ES 2180456B1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- substituted
- alkoxy
- het
- triazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn - After Issue
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
Isoxazoles sustituidos y su utilización como antibióticos. Los compuestos de fórmula (I), donde X es O, NH, OCO, NH-CO, NH-COO, NH-CO-NH, NH-CS o NH-CS-NH; R4 es H, (C1-C3)-alquilo opcionalmente sustituido por halógeno, o un radical heterocíclico de carbono seleccionado entre varias posibilidades; R1 y R3 son H o F; y R2 es un radical heterocíclico de nitrógeno o carbono, son útiles para el tratamiento de infecciones microbianas en el cuerpo humano o animal.
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200101793A ES2180456B1 (es) | 2001-07-20 | 2001-07-20 | Isoxazoles sustituidos y su utilizacion como antibioticos. |
EP02748888A EP1437349B9 (en) | 2001-07-20 | 2002-07-17 | Substituted isoxazoles and the use thereof as antibiotics |
US10/484,027 US20050014806A1 (en) | 2001-07-20 | 2002-07-17 | Substituted isoxazoles and their use as antibiotics |
AU2002319320A AU2002319320B2 (en) | 2001-07-20 | 2002-07-17 | Substituted isoxazoles and the use thereof as antibiotics |
CNA02818517XA CN1556797A (zh) | 2001-07-20 | 2002-07-17 | 取代的异噁唑化合物及其作为抗生素的应用 |
ES02748888T ES2291481T3 (es) | 2001-07-20 | 2002-07-17 | Isoxazoles sustituidos y su utilizacion como antibioticos. |
PCT/ES2002/000358 WO2003008395A1 (es) | 2001-07-20 | 2002-07-17 | Isoxazoles sustituidos y su utilizacion como antibioticos |
DE60221870T DE60221870T2 (de) | 2001-07-20 | 2002-07-17 | Substituierte isoxazole und deren verwendung als antibiotika |
CA002453846A CA2453846A1 (en) | 2001-07-20 | 2002-07-17 | Substituted isoxazoles and the use thereof as antibiotics |
JP2003513955A JP2005502634A (ja) | 2001-07-20 | 2002-07-17 | 置換イソオキサゾールおよびその抗生物質としての使用 |
BR0211588-3A BR0211588A (pt) | 2001-07-20 | 2002-07-17 | Isoxazóis substituìdos e o uso deles como antibióticos |
AT02748888T ATE370129T1 (de) | 2001-07-20 | 2002-07-17 | Substituierte isoxazole und deren verwendung als antibiotika |
PT02748888T PT1437349E (pt) | 2001-07-20 | 2002-07-17 | Isoxazóis substituídos e sua utilização como antibióticos |
KR1020047001066A KR100882377B1 (ko) | 2001-07-20 | 2002-07-17 | 치환된 이속사졸 및 항생제로서의 이들의 용도 |
DK02748888T DK1437349T3 (da) | 2001-07-20 | 2002-07-17 | Substituerede isoxazoler og anvendelse deraf som antibiotika |
SI200230622T SI1437349T1 (sl) | 2001-07-20 | 2002-07-17 | Substituirani izoksazoli in njihova uporaba kot antibiotiki |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200101793A ES2180456B1 (es) | 2001-07-20 | 2001-07-20 | Isoxazoles sustituidos y su utilizacion como antibioticos. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2180456A1 ES2180456A1 (es) | 2003-02-01 |
ES2180456B1 true ES2180456B1 (es) | 2004-05-01 |
Family
ID=8498579
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200101793A Withdrawn - After Issue ES2180456B1 (es) | 2001-07-20 | 2001-07-20 | Isoxazoles sustituidos y su utilizacion como antibioticos. |
ES02748888T Expired - Lifetime ES2291481T3 (es) | 2001-07-20 | 2002-07-17 | Isoxazoles sustituidos y su utilizacion como antibioticos. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES02748888T Expired - Lifetime ES2291481T3 (es) | 2001-07-20 | 2002-07-17 | Isoxazoles sustituidos y su utilizacion como antibioticos. |
Country Status (14)
Country | Link |
---|---|
US (1) | US20050014806A1 (es) |
EP (1) | EP1437349B9 (es) |
JP (1) | JP2005502634A (es) |
KR (1) | KR100882377B1 (es) |
CN (1) | CN1556797A (es) |
AT (1) | ATE370129T1 (es) |
AU (1) | AU2002319320B2 (es) |
BR (1) | BR0211588A (es) |
CA (1) | CA2453846A1 (es) |
DE (1) | DE60221870T2 (es) |
DK (1) | DK1437349T3 (es) |
ES (2) | ES2180456B1 (es) |
PT (1) | PT1437349E (es) |
WO (1) | WO2003008395A1 (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003035073A1 (en) | 2001-10-25 | 2003-05-01 | Astrazeneca Ab | Isoxazoline derivatives useful as antimicrobials |
US7589199B2 (en) | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
CA2488202C (en) | 2002-06-12 | 2011-03-08 | Chemocentryx, Inc. | 1-aryl-4-substituted piperazine derivatives for use as ccr1 antagonists for the treatment of inflammation and immune disorders |
US20050256130A1 (en) * | 2002-06-12 | 2005-11-17 | Chemocentryx, Inc. | Substituted piperazines |
US7842693B2 (en) | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
EP1517898A1 (de) * | 2002-06-29 | 2005-03-30 | Zentaris GmbH | Aryl- und heteroarylcarbonylpiperazine und deren verwendung zur behandlung gutartiger und b sartiger tumorerkrankungen |
WO2005082892A2 (en) * | 2004-02-17 | 2005-09-09 | Dr. Reddy's Laboratories Ltd. | Triazole compounds as antibacterial agents and pharmaceutical compositions containing them |
US7435831B2 (en) | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
EP1720545B1 (en) | 2004-03-03 | 2014-10-29 | ChemoCentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
US7696352B2 (en) | 2004-06-18 | 2010-04-13 | Millennium Pharmaceuticals, Inc. | Factor Xa inhibitors |
WO2006002099A2 (en) | 2004-06-18 | 2006-01-05 | Millennium Pharmaceuticals, Inc. | Factor xa inhibitors |
AU2007206889A1 (en) * | 2006-01-19 | 2007-07-26 | Laboratorios Salvat, S.A. | Dicarbonylic compounds with antibacterial activity |
WO2007131179A1 (en) | 2006-05-05 | 2007-11-15 | Millennium Pharmaceuticals, Inc. | Factor xa inhibitors |
WO2007134457A1 (en) * | 2006-05-22 | 2007-11-29 | Merck Frosst Canada Ltd. | Cyclic amine derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
CN101220000B (zh) * | 2007-12-28 | 2010-12-22 | 天津药物研究院 | 酰氯和磺酰氯类衍生物及其用途 |
US8722686B2 (en) | 2008-09-19 | 2014-05-13 | Pfizer Inc. | Hydroxamic acid derivatives useful as antibacterial agents |
WO2011073845A1 (en) | 2009-12-16 | 2011-06-23 | Pfizer Inc. | N-linked hydroxamic acid derivatives useful as antibacterial agents |
US8742120B2 (en) | 2009-12-17 | 2014-06-03 | Millennium Pharmaceuticals, Inc. | Methods of preparing factor xa inhibitors and salts thereof |
US8530501B2 (en) | 2009-12-17 | 2013-09-10 | Millennium Pharmaceuticals, Inc. | Salts and crystalline forms of a factor Xa inhibitor |
CN101798303B (zh) * | 2010-03-10 | 2011-09-07 | 天津药物研究院 | 一类氮唑的衍生物、其制备方法和用途 |
CN101781294B (zh) * | 2010-03-10 | 2012-02-01 | 天津药物研究院 | 一类咪唑的衍生物、其制备方法和用途 |
UA107423C2 (en) | 2011-03-07 | 2014-12-25 | Pfizer | Fluoro-pyridinone derivatives useful as antibacterial agents |
DK2694488T3 (en) | 2011-04-08 | 2014-12-15 | Pfizer | Isoxazole derivatives useful as antibacterial SUBSTANCES |
KR20130140164A (ko) | 2011-04-08 | 2013-12-23 | 화이자 인코포레이티드 | 항박테리아제로서 유용한 이미다졸, 피라졸 및 트라이아졸 유도체 |
KR101369584B1 (ko) * | 2011-04-19 | 2014-03-06 | 일양약품주식회사 | 페닐-이속사졸 유도체 및 그의 제조방법 |
WO2013055793A1 (en) | 2011-10-12 | 2013-04-18 | University Of Pittsburg-Of The Commonwealth System Of Higher Education | Small molecules targeting androgen receptor nuclear localization and/or level in prostate cancer |
PL2970244T3 (pl) | 2013-03-15 | 2020-01-31 | Università Degli Studi Di Milano - Bicocca | Nowe związki 1,2,4-oksadiazolu aktywne względem patogenów Gram-dodatnich |
CN103172584A (zh) * | 2013-03-15 | 2013-06-26 | 吉林大学 | 双异噁唑甲醚衍生物及制备方法 |
JP6564380B2 (ja) | 2013-09-20 | 2019-08-21 | ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | 前立腺癌を治療するための化合物 |
US20160257657A1 (en) | 2013-09-20 | 2016-09-08 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer |
US10518196B2 (en) * | 2014-01-29 | 2019-12-31 | General Electric Company | Devices for separation of particulates, associated methods and systems |
US10980806B2 (en) | 2016-03-24 | 2021-04-20 | University of Pittsburgh—of the Commonwealth System of Higher Education | Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer |
CN109369553B (zh) * | 2018-10-22 | 2023-04-11 | 上海凌凯医药科技有限公司 | 一种合成n-3-异恶唑氨基甲酸叔丁酯的方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002503655A (ja) * | 1998-02-13 | 2002-02-05 | ファルマシア・アンド・アップジョン・カンパニー | 抗菌剤として有用な置換アミノフェニルイソオキサゾリン誘導体 |
TW572757B (en) * | 1998-08-24 | 2004-01-21 | Bristol Myers Squibb Co | Novel isoxazolinone antibacterial agents |
GB9928568D0 (en) * | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
-
2001
- 2001-07-20 ES ES200101793A patent/ES2180456B1/es not_active Withdrawn - After Issue
-
2002
- 2002-07-17 WO PCT/ES2002/000358 patent/WO2003008395A1/es active IP Right Grant
- 2002-07-17 EP EP02748888A patent/EP1437349B9/en not_active Expired - Lifetime
- 2002-07-17 JP JP2003513955A patent/JP2005502634A/ja active Pending
- 2002-07-17 CA CA002453846A patent/CA2453846A1/en not_active Abandoned
- 2002-07-17 KR KR1020047001066A patent/KR100882377B1/ko not_active IP Right Cessation
- 2002-07-17 US US10/484,027 patent/US20050014806A1/en not_active Abandoned
- 2002-07-17 AT AT02748888T patent/ATE370129T1/de not_active IP Right Cessation
- 2002-07-17 DK DK02748888T patent/DK1437349T3/da active
- 2002-07-17 AU AU2002319320A patent/AU2002319320B2/en not_active Ceased
- 2002-07-17 ES ES02748888T patent/ES2291481T3/es not_active Expired - Lifetime
- 2002-07-17 CN CNA02818517XA patent/CN1556797A/zh active Pending
- 2002-07-17 PT PT02748888T patent/PT1437349E/pt unknown
- 2002-07-17 DE DE60221870T patent/DE60221870T2/de not_active Expired - Fee Related
- 2002-07-17 BR BR0211588-3A patent/BR0211588A/pt not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE60221870D1 (de) | 2007-09-27 |
DE60221870T2 (de) | 2008-05-08 |
KR20040043164A (ko) | 2004-05-22 |
DK1437349T3 (da) | 2007-12-03 |
BR0211588A (pt) | 2004-07-13 |
EP1437349A1 (en) | 2004-07-14 |
US20050014806A1 (en) | 2005-01-20 |
KR100882377B1 (ko) | 2009-02-05 |
CA2453846A1 (en) | 2003-01-30 |
EP1437349B9 (en) | 2008-09-10 |
ES2291481T3 (es) | 2008-03-01 |
WO2003008395A1 (es) | 2003-01-30 |
CN1556797A (zh) | 2004-12-22 |
PT1437349E (pt) | 2007-11-19 |
ATE370129T1 (de) | 2007-09-15 |
AU2002319320B2 (en) | 2008-03-06 |
JP2005502634A (ja) | 2005-01-27 |
ES2180456A1 (es) | 2003-02-01 |
EP1437349B1 (en) | 2007-08-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 20030201 Kind code of ref document: A1 |
|
FG2A | Definitive protection |
Ref document number: 2180456B1 Country of ref document: ES |
|
FA2A | Application withdrawn |
Effective date: 20050401 |