ES2177961T3 - Procedimiento y dispositivo para la determinacion de un analito en una matriz dispersante. - Google Patents

Procedimiento y dispositivo para la determinacion de un analito en una matriz dispersante.

Info

Publication number
ES2177961T3
ES2177961T3 ES97914097T ES97914097T ES2177961T3 ES 2177961 T3 ES2177961 T3 ES 2177961T3 ES 97914097 T ES97914097 T ES 97914097T ES 97914097 T ES97914097 T ES 97914097T ES 2177961 T3 ES2177961 T3 ES 2177961T3
Authority
ES
Spain
Prior art keywords
light
matrix
depth
pct
analyte
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97914097T
Other languages
English (en)
Inventor
Alexander Knuttel
Dirk Boecker
Matthias Essenpreis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Roche Diagnostics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics GmbH filed Critical Roche Diagnostics GmbH
Application granted granted Critical
Publication of ES2177961T3 publication Critical patent/ES2177961T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062Arrangements for scanning
    • A61B5/0066Optical coherence imaging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47Scattering, i.e. diffuse reflection
    • G01N21/49Scattering, i.e. diffuse reflection within a body or fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Emergency Medicine (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCEDIMIENTO PARA DETERMINAR UN ANALITO CONTENIDO EN UNA MATRIZ DISPERSORA, EN ESPECIAL BIOLOGICA. EN UN PASO DE LA DETERMINACION SE REALIZAN MEDICIONES DE DETECCION, EN LAS CUALES UNA RADIACION LUMINOSA SE DIRIGE A LA MATRIZ (6) COMO LUZ PRIMARIA Y LA RADIACION EMERGENTE DE LA MATRIZ (6) SE DETECTA COMO LUZ SECUNDARIA, CON EL FIN DE DETERMINAR COMO MAGNITUD DE MEDIDA LA PROPIEDAD FISICA MEDIBLE DE LA LUZ QUE VARIA POR LA INTERACCION DE LA LUZ CON LA MATRIZ (6). EN UN PASO DE EVALUACION SE OBTIENE INFORMACION SOBRE LA PRESENCIA DEL ANALITO EN LA MATRIZ (6). LA DETERMINACION DE ANALITOS ABSORBENTES DEBILES DE LA LUZ FRENTE A UN FONDO ABSORBENTE FUERTE PUEDE MEJORARSE SI SE EMPLEAN, COMBINADOS ENTRE SI, DOS PROCEDIMIENTOS DE SELECCION PARA LA RECOGIDA SELECTIVA DE LA LUZ SECUNDARIA. EN EL PRIMERO, LA LUZ PRIMARIA (14) SE ENFOCA MEDIANTE UN ELEMENTO DE ENFOQUE OPTICO (16) SOBRE UN AREA DE FOCO (17) QUE SE ENCUENTRA A UNA PROFUNDIDAD ESPECIFICADA (D) DENTRO DE LA MATRIZ (6) Y EL AREA DE FOCO (17) SE REPRODUCE, MEDIANTE UN ELEMENTO DE ENFOQUE OPTICO (16, 21), EN UNA ABERTURA DE ENTRADA DE LUZ (24) DISPUESTA EN EL CAMINO OPTICO DE LA LUZ SECUNDARIA (19) HACIA EL DETECTOR. EN EL SEGUNDO, UN MEDIO ADICIONAL DE SELECCION DE PROFUNDIDAD, CON PREFERENCIA UN PROCEDIMIENTO DE MEDIDA DE BAJA COHERENCIA, DETECTA COMO LUZ SECUNDARIA LA LUZ REFLEJADA A UNA PROFUNDIDAD DE MEDIDA DEFINIDA, EN QUE LA PROFUNDIDAD DE MEDIDA COINCIDE CON LA PROFUNDIDAD DEL FOCO.
ES97914097T 1996-01-26 1997-01-23 Procedimiento y dispositivo para la determinacion de un analito en una matriz dispersante. Expired - Lifetime ES2177961T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19602656 1996-01-26

Publications (1)

Publication Number Publication Date
ES2177961T3 true ES2177961T3 (es) 2002-12-16

Family

ID=7783677

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97914097T Expired - Lifetime ES2177961T3 (es) 1996-01-26 1997-01-23 Procedimiento y dispositivo para la determinacion de un analito en una matriz dispersante.

Country Status (12)

Country Link
US (1) US5962852A (es)
EP (1) EP0876596B1 (es)
KR (1) KR19990076724A (es)
AT (1) ATE220202T1 (es)
AU (1) AU711422B2 (es)
CA (1) CA2243571A1 (es)
DE (1) DE59707650D1 (es)
ES (1) ES2177961T3 (es)
IL (1) IL125475A0 (es)
NZ (1) NZ330905A (es)
WO (1) WO1997027469A1 (es)
ZA (1) ZA97599B (es)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19919092A1 (de) * 1999-04-27 2000-11-02 Zeiss Carl Jena Gmbh Anordnung zur optischen Auswertung eines Gegenstandsarrays
US6495833B1 (en) * 2000-01-20 2002-12-17 Research Foundation Of Cuny Sub-surface imaging under paints and coatings using early light spectroscopy
US6909509B2 (en) * 2001-02-20 2005-06-21 Zygo Corporation Optical surface profiling systems
US20030045798A1 (en) * 2001-09-04 2003-03-06 Richard Hular Multisensor probe for tissue identification
DE20213607U1 (de) 2002-02-21 2003-07-03 Paul Hartmann AG, 89522 Heidenheim Blutanalysegerät zur Bestimmung eines Analyten
US7038208B2 (en) * 2002-08-31 2006-05-02 The Research Foundation of the City of New York Systems and methods for non-destructively detecting material abnormalities beneath a coated surface
US6992762B2 (en) * 2002-11-11 2006-01-31 Art Advanced Research Technologies Inc. Method and apparatus for time resolved optical imaging of biological tissues as part of animals
JP2004222870A (ja) * 2003-01-21 2004-08-12 Pentax Corp 内視鏡用プローブ
US7307734B2 (en) * 2003-08-14 2007-12-11 University Of Central Florida Interferometric sensor for characterizing materials
US8221332B2 (en) 2003-11-12 2012-07-17 Facet Technologies, Llc Multi-lancet cartridge and lancing device
WO2005046477A2 (en) * 2003-11-12 2005-05-26 Facet Technologies, Llc Lancing device and multi-lancet cartridge
US20080082117A1 (en) * 2003-11-12 2008-04-03 Facet Technologies, Llc Lancing device
US20050151976A1 (en) * 2003-12-16 2005-07-14 Toma Cristian E. Method for monitoring of analytes in biological samples using low coherence interferometry
JP4944770B2 (ja) 2004-04-16 2012-06-06 ファセット・テクノロジーズ・エルエルシー 穿刺装置用のキャップ変位機構及びマルチランセットカートリッジ
US7242480B2 (en) * 2004-05-14 2007-07-10 Medeikon Corporation Low coherence interferometry for detecting and characterizing plaques
US7327463B2 (en) 2004-05-14 2008-02-05 Medrikon Corporation Low coherence interferometry utilizing magnitude
US20050254059A1 (en) * 2004-05-14 2005-11-17 Alphonse Gerard A Low coherence interferometric system for optical metrology
US7184148B2 (en) 2004-05-14 2007-02-27 Medeikon Corporation Low coherence interferometry utilizing phase
US7474408B2 (en) * 2004-05-14 2009-01-06 Medeikon Corporation Low coherence interferometry utilizing phase
US7190464B2 (en) * 2004-05-14 2007-03-13 Medeikon Corporation Low coherence interferometry for detecting and characterizing plaques
EP1804663A4 (en) 2004-06-30 2015-05-20 Facet Technologies Llc AUTOPIQUEUR AND CARTRIDGE WITH MULTIPLE LANCETTES
WO2006041447A1 (en) * 2004-09-25 2006-04-20 Josh Hogan A compact non-invasive analysis system
DE502005006493D1 (de) * 2004-10-29 2009-03-05 Degudent Gmbh Verfahren und vorrichtung zur erfassung von konturdaten und/oder optischen eigenschaften eines dreidimensionalen semitransparenten objekts
DE202005014449U1 (de) * 2005-04-07 2005-12-22 Universität Duisburg-Essen Vorrichtung zur optischen Untersuchung des menschlichen oder tierischen Körpers
US7488930B2 (en) * 2006-06-02 2009-02-10 Medeikon Corporation Multi-channel low coherence interferometer
WO2008152604A1 (en) * 2007-06-15 2008-12-18 Koninklijke Philips Electronics N.V. Spectroscopy measurements
DE102007054309A1 (de) 2007-11-08 2009-05-14 Laser- und Medizin-Technologie GmbH, Berlin (LMTB) Optische Anordnung zur Erhöhung der Wechselwirkungslänge in stark steuernder Matrix
DE102008022372A1 (de) * 2008-05-06 2009-11-12 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Vorrichtung zur Trübungsmessung
US8914098B2 (en) * 2009-03-08 2014-12-16 Oprobe, Llc Medical and veterinary imaging and diagnostic procedures utilizing optical probe systems
FR2948801A1 (fr) * 2009-11-24 2011-02-04 Thomson Licensing Procede d'estimation de diffusion de la lumiere
US8711364B2 (en) 2010-05-13 2014-04-29 Oprobe, Llc Optical coherence tomography with multiple sample arms
CN103260501B (zh) 2010-10-06 2015-09-02 普罗弗萨股份有限公司 组织整合性传感器
CN113274007A (zh) 2013-03-14 2021-08-20 普罗菲尤萨股份有限公司 用于校正光学信号的方法和装置
AU2014274784B2 (en) 2013-06-06 2018-12-06 Profusa, Inc. Apparatus and methods for detecting optical signals from implanted sensors
JP6539876B2 (ja) * 2014-03-31 2019-07-10 ソニー株式会社 測定装置、測定方法、プログラム及び記録媒体
CN106163399B (zh) 2014-03-31 2019-07-12 索尼公司 测量装置、测量方法、程序和记录介质
DE102014014872A1 (de) * 2014-10-06 2016-04-07 Dräger Safety AG & Co. KGaA System zur transkutanen Bestimmung der Blutalkoholkonzentration
US9752981B2 (en) * 2015-04-30 2017-09-05 Lam Research Corporation Apparatus with a spectral reflectometer for processing substrates
CN110411947B (zh) * 2018-04-28 2022-07-22 天津大学 时间门定光程参考测量浓度的方法及装置
JP6849889B2 (ja) * 2020-03-04 2021-03-31 キヤノン株式会社 光学センサ及び画像形成装置

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0581871B2 (en) * 1991-04-29 2009-08-12 Massachusetts Institute Of Technology Apparatus for optical imaging and measurement
US5203328A (en) * 1991-07-17 1993-04-20 Georgia Tech Research Corporation Apparatus and methods for quantitatively measuring molecular changes in the ocular lens
IL107396A (en) * 1992-11-09 1997-02-18 Boehringer Mannheim Gmbh Method and apparatus for analytical determination of glucose in a biological matrix
JP3234353B2 (ja) * 1993-06-15 2001-12-04 富士写真フイルム株式会社 断層情報読取装置
DE4337570A1 (de) * 1993-11-04 1995-05-11 Boehringer Mannheim Gmbh Verfahren zur Analyse von Glucose in einer biologischen Matrix
JP2826265B2 (ja) * 1994-03-28 1998-11-18 株式会社生体光情報研究所 断層像撮影装置
DE4411017C2 (de) * 1994-03-30 1995-06-08 Alexander Dr Knuettel Optische stationäre spektroskopische Bildgebung in stark streuenden Objekten durch spezielle Lichtfokussierung und Signal-Detektion von Licht unterschiedlicher Wellenlängen
DE4415728A1 (de) * 1994-05-05 1995-11-09 Boehringer Mannheim Gmbh Verfahren und Vorrichtung zur Analyse von Glucose in einer biologischen Probe
US5501226A (en) * 1994-10-19 1996-03-26 Carl Zeiss, Inc. Short coherence length, doppler velocimetry system

Also Published As

Publication number Publication date
ATE220202T1 (de) 2002-07-15
CA2243571A1 (en) 1997-07-31
AU2150397A (en) 1997-08-20
NZ330905A (en) 2000-03-27
EP0876596B1 (de) 2002-07-03
DE59707650D1 (de) 2002-08-08
KR19990076724A (ko) 1999-10-15
EP0876596A1 (de) 1998-11-11
AU711422B2 (en) 1999-10-14
US5962852A (en) 1999-10-05
WO1997027469A1 (de) 1997-07-31
ZA97599B (en) 1998-07-24
IL125475A0 (en) 1999-03-12

Similar Documents

Publication Publication Date Title
ES2177961T3 (es) Procedimiento y dispositivo para la determinacion de un analito en una matriz dispersante.
KR930000692B1 (ko) 생체검지장치 및 이것을 사용하는 지문조합 시스템.
CN102549445B (zh) 用于单个颗粒检测的生物传感器***
CN101622566B (zh) 用于组织的光学分析的方法和设备
TW275570B (es)
DK0988525T3 (da) Metode til karakterisering af prøver på basis af intermediære statistiske data
JP2006300950A (ja) ラテラルフローアッセイシステム及び方法
JP2019512701A (ja) 粒子特性評価
US7274445B1 (en) Confocal scatterometer and method for single-sided detection of particles and defects on a transparent wafer or disk
CN101563596A (zh) 具有参照的测试元件
CN100580436C (zh) 双光点相敏的检测
JPS61280548A (ja) 粒子解析装置
JPH11230901A (ja) 光反射計測装置
JP4009442B2 (ja) 低コヒーレンス干渉法を用いた動的光散乱測定装置
NZ331979A (en) Coin testing, coins passed between laser source and detector
JPH02133892A (ja) 指紋像入力装置
RU2398218C2 (ru) Способ измерения анализируемого вещества в биологической пробе и коаксиальная считывающая головка, используемая для указанного способа измерения
JPH08101914A (ja) パターン検査装置
Kim et al. Simplified laser fluorescence scanner for proteomics studies and early cancer diagnosis
JPWO2019230624A1 (ja) 粒子径分布測定装置及び粒子径分布測定装置用プログラム
CA2073344C (en) Fluorescence assay apparatus
KR100551581B1 (ko) 씨씨디 카메라를 이용한 오씨티 시스템
JPH09292326A (ja) キャピラリー式光検出センサ及びこれを用いた光計測装置及び懸濁液中の微粒子測定方法
CN101809431A (zh) 用于观察样本表面的设备
JP7342223B2 (ja) 光学検査装置及び方法