ES2172734T3 - Intermediarios para la preparacion de compuestos benzoheterociclicos. - Google Patents
Intermediarios para la preparacion de compuestos benzoheterociclicos.Info
- Publication number
- ES2172734T3 ES2172734T3 ES97120444T ES97120444T ES2172734T3 ES 2172734 T3 ES2172734 T3 ES 2172734T3 ES 97120444 T ES97120444 T ES 97120444T ES 97120444 T ES97120444 T ES 97120444T ES 2172734 T3 ES2172734 T3 ES 2172734T3
- Authority
- ES
- Spain
- Prior art keywords
- sup
- group
- halogen atom
- rent
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A UN COMPUESTO SELECCIONADO DEL GRUPO FORMADO POR LOS COMPUESTOS CON LAS FORMULAS SIGUIENTES: DONDE R SUP,1} ES UN GRUPO CICLOPROPILO QUE PUEDE ESTAR SUSTITUIDO POR 1 A 3 SUSTITUYENTES SELECCIONADOS DEL GRUPO FORMADO POR UN GRUPO ALQUILO INFERIOR Y UN ATOMO DE HALOGENO, UN GRUPO FENILO QUE PUEDE ESTAR SUSTITUIDO POR 1 A 3 SUSTITUYENTES SELECCIONADOS DEL GRUPO FORMADO POR UN GRUPO ALCOXI INFERIOR, UN ATOMO DE HALOGENO Y UN GRUPO HIDROXI SOBRE ANILLO FENILO, UN GRUPO ALQUILO INFERIOR QUE PUEDE ESTAR SUSTITUIDO POR UN ATOMO DE HALOGENO, UN GRUPO ALCANOILOXI INFERIOR O UN GRUPO HIDROXI, UN GRUPO ALQUENILO INFERIOR O UN GRUPO TIENILO; R SUP,2 } ES UN ATOMO DE HALOGENO O UN GRUPO HETEROCICLICO SATURADO O INSATURADO DE 5 A 9 MIEMBROS QUE PUEDE ESTAR SUSTITUIDO; R SUP,3} ES UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO INFERIOR O UN ATOMO DE HALOGENO; R SUP,3 } ES UN GRUPO DE FORMULA: CH(R SUP,20})SR SUP,21}(R SUP,20} Y R SUP,21} TIENEN EL SIGNIFICADO DEFINIDO DESPUES) OR SUP,3}; R SUP,4} ES UN GRUPO ALQUILO INFERIOR O UN ATOMO DE HALOGENO; R SUP,5} ES UN GRUPO DE FORMULA: 10} (R SUP,10} ES UN GRUPO ALQUILO INFERIOR) O UN GRUPO DE FORMULA: R SUP,6} ES UN GRUPO ALQUILO INFERIOR; R SUP,7} ES UN GRUPO DE FORMULA: -NR SUP,12} SUP,13} (R SUP,12} Y R SUP,13} SON RESPECTIVAMENTE UN GRUPO ALQUILO INFERIOR) O UN GRUPO ALCOXI INFERIOR; R SUP,20} ES UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO INFERIOR; R SUP,21} ES UN GRUPO ALQUILO INFERIOR; R SUP,25}, R SUP,27} Y R SUP,28} SON RESPECTIVAMENTE UN GRUPO ALQUILO INFERIOR; R SUP,32} ES UN ALQUILO INFERIOR; Y X, X SUP,2}, X SUP,3}, X SUP,4} Y X SUP,7} SON RESPECTIVAMENTE UN ATOMO DE HALOGENO.
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9419887 | 1987-04-16 | ||
JP10235187 | 1987-04-24 | ||
JP10836187 | 1987-04-30 | ||
JP12659887 | 1987-05-22 | ||
JP14954487 | 1987-06-16 | ||
JP17612687 | 1987-07-14 | ||
JP28377687 | 1987-11-09 | ||
JP28710887 | 1987-11-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2172734T3 true ES2172734T3 (es) | 2002-10-01 |
Family
ID=27572879
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88105959T Expired - Lifetime ES2091180T3 (es) | 1987-04-16 | 1988-04-14 | Derivados del acido 7-piperazinil- o 7-morfolino-4-oxo-quinolino-3-carboxilico, su preparacion y su utilizacion como agentes antimicrobianos. |
ES93107626T Expired - Lifetime ES2152936T3 (es) | 1987-04-16 | 1988-04-14 | Compuestos benzoheterociclicos. |
ES97120444T Expired - Lifetime ES2172734T3 (es) | 1987-04-16 | 1988-04-14 | Intermediarios para la preparacion de compuestos benzoheterociclicos. |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88105959T Expired - Lifetime ES2091180T3 (es) | 1987-04-16 | 1988-04-14 | Derivados del acido 7-piperazinil- o 7-morfolino-4-oxo-quinolino-3-carboxilico, su preparacion y su utilizacion como agentes antimicrobianos. |
ES93107626T Expired - Lifetime ES2152936T3 (es) | 1987-04-16 | 1988-04-14 | Compuestos benzoheterociclicos. |
Country Status (13)
Country | Link |
---|---|
US (5) | US5591744A (es) |
EP (3) | EP0565132B1 (es) |
JP (2) | JPH0696557B2 (es) |
KR (2) | KR940002113B1 (es) |
CN (1) | CN1053666C (es) |
CY (1) | CY2050B1 (es) |
DE (4) | DE3856515T2 (es) |
DK (2) | DK170640B1 (es) |
ES (3) | ES2091180T3 (es) |
HK (1) | HK128797A (es) |
NL (1) | NL980011I2 (es) |
SA (1) | SA97180461A (es) |
SG (3) | SG101541A1 (es) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5164392A (en) * | 1987-10-16 | 1992-11-17 | Dainippon Pharmaceutical Co., Ltd. | Quinoline derivatives and antibacterial agent containing them |
IL88003A (en) * | 1987-10-16 | 1992-11-15 | Dainippon Pharmaceutical Co | Quinoline derivatives,their preparation and pharmaceutical compositions containing them |
NO885426L (no) * | 1987-12-11 | 1989-06-12 | Dainippon Pharmaceutical Co | Kinolinderivater, samt fremgangsmaate ved fremstilling derav. |
US4920120A (en) * | 1988-01-25 | 1990-04-24 | Warner-Lambert Company | Antibacterial agents |
US5585491A (en) * | 1988-01-25 | 1996-12-17 | Otsuka Pharmaceutical Co., Ltd. | Antibacterial agents |
FI901201A0 (fi) * | 1989-03-13 | 1990-03-09 | Bristol Myers Squibb Co | Antibakteriella 5-substituerade 1,4-dihydro-4-oxonaftyridin-3-karboxylatderivat och deras framstaellning. |
DE3910663A1 (de) * | 1989-04-03 | 1990-10-04 | Bayer Ag | 5-alkylchinoloncarbonsaeuren |
CA2078444A1 (en) | 1990-04-18 | 1991-10-19 | Thomas P. Demuth, Jr. | Antimicrobial quinolonyl lactams |
US5342846A (en) * | 1990-12-05 | 1994-08-30 | Synphar Laboratories, Inc. | 7-substituted-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid compounds and 7-(substituted triazolyl pyrrolidin-1-yl) 4-oxoquinoline-3-carboxylic acid derivatives useful as antibacterial agents |
US5696132A (en) * | 1991-05-28 | 1997-12-09 | Daiichi Pharmaceutical Co., Ltd. | Pyridonecarboxylic acid derivatives |
FR2692577B1 (fr) * | 1992-05-26 | 1996-02-02 | Bouchara Sa | Nouvelles quinolones fluorees, leur procede de preparation et les compositions pharmaceutiques en renfermant. |
CN1088586C (zh) * | 1993-03-10 | 2002-08-07 | 大塚制药株式会社 | 白介素-1抑制剂 |
DE4329600A1 (de) * | 1993-09-02 | 1995-03-09 | Bayer Ag | Pyrido [1,2,3-d,e] [1,3,4] benzoxadiazinderivate |
ATE205209T1 (de) * | 1993-10-28 | 2001-09-15 | Kaken Pharma Co Ltd | Chinolincarbonsäurederivate und ihre salze |
DE4408212A1 (de) * | 1994-03-11 | 1995-09-14 | Bayer Ag | 5-Vinyl- und 5-Ethinyl-chinolon- und -naphthyridon-carbonsäuren |
DE4431821A1 (de) * | 1994-09-07 | 1996-03-14 | Bayer Ag | Verfahren zur Herstellung von N-Arylaminoacrylsäurederivaten und die Verwendung so hergestellter N-Arylaminoacrylsäurederivate zur Herstellung von 4-Chinolon-3-carbonsäurederivaten |
CA2210007A1 (en) * | 1995-01-24 | 1996-08-01 | Yasuo Ito | Quinoline carboxylic acid |
KR100516379B1 (ko) * | 1996-11-28 | 2005-09-26 | 와쿠나가 세이야쿠 가부시키 가이샤 | 신규 피리돈카르복실산 유도체 또는 그의 염 및 이를 유효 성분으로 하는 의약 |
DE19652239A1 (de) * | 1996-12-16 | 1998-06-18 | Bayer Ag | Verwendung von 7-(2-Oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-chinolon- und -naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen |
ATE365152T1 (de) * | 1998-09-14 | 2007-07-15 | Otsuka Pharma Co Ltd | Verfahren zur herstellung fluorierter benzoesäuren |
EP1117406A1 (en) * | 1998-09-30 | 2001-07-25 | Alcon Laboratories, Inc. | Antibiotic compositions for treatment of the eye, ear and nose |
US6716830B2 (en) * | 1998-09-30 | 2004-04-06 | Alcon, Inc. | Ophthalmic antibiotic compositions containing moxifloxacin |
US6395746B1 (en) | 1998-09-30 | 2002-05-28 | Alcon Manufacturing, Ltd. | Methods of treating ophthalmic, otic and nasal infections and attendant inflammation |
US6509327B1 (en) | 1998-09-30 | 2003-01-21 | Alcon Manufacturing, Ltd. | Compositions and methods for treating otic, ophthalmic and nasal infections |
DE19850788A1 (de) * | 1998-11-04 | 2000-05-11 | Clariant Gmbh | Verfahren zur Herstellung von Trifluorbenzoesäuren |
AU3192700A (en) | 1999-03-17 | 2000-10-04 | Daiichi Pharmaceutical Co., Ltd. | Medicinal compositions |
DE19962470A1 (de) * | 1999-12-22 | 2001-07-12 | Schulz Hans Herrmann | Verwendung von Chemotherapeutika |
US6608078B2 (en) | 2000-05-08 | 2003-08-19 | Wockhardt Limited | Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment |
US7098219B2 (en) | 2000-08-01 | 2006-08-29 | Wockhart Limited | Inhibitors of cellular efflux pumps of microbes |
AU2002239395A1 (en) * | 2000-11-01 | 2002-06-03 | The Procter And Gamble Company | Hiv treatment with benzimidazoles |
US6964966B2 (en) | 2001-04-25 | 2005-11-15 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
US6878713B2 (en) | 2001-04-25 | 2005-04-12 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
JP2005521712A (ja) * | 2002-03-26 | 2005-07-21 | アリゾナ ボード オブ リージェンツ オン ビハーフ オブ ザ ユニバーシティー オブ アリゾナ | 弱塩基の可溶化 |
WO2003099815A1 (en) | 2002-05-28 | 2003-12-04 | Wockhardt Limited | Crystalline fluoroquinolone arginine salt form |
SK2662004A3 (sk) | 2002-11-20 | 2005-06-02 | Japan Tobacco, Inc. | Zlúčenina s obsahom 4-oxochinolínu a jej použitie ako inhibítora integráz |
CA2537066C (en) | 2003-09-04 | 2011-05-24 | Wockhardt Limited | Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate |
PT1666477E (pt) * | 2003-09-10 | 2013-08-28 | Kyorin Seiyaku Kk | Derivado de 7-(4-substituído-3-ciclopropilaminometil-1- pirrolidinil) quinolonecarboxílico |
WO2005026145A2 (en) * | 2003-09-12 | 2005-03-24 | Warner-Lambert Company Llc | Quinolone antibacterial agents |
WO2007102499A1 (ja) | 2006-03-06 | 2007-09-13 | Japan Tobacco Inc. | 4-オキソキノリン化合物の製造方法 |
AP2914A (en) | 2006-03-06 | 2014-05-31 | Japan Tobacco Inc | Method for producing 4-oxoquinoline compound |
AU2007301686B2 (en) | 2006-09-29 | 2013-02-14 | Cipla Limited | An improved process for the preparation of temozolomide and analogs |
WO2008143343A1 (ja) * | 2007-05-24 | 2008-11-27 | Kyorin Pharmaceutical Co., Ltd. | 14位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体 |
WO2009064836A2 (en) * | 2007-11-15 | 2009-05-22 | University Of Maryland, Baltimore | Kynurenine-aminotransferase inhibitors |
US20090270379A1 (en) * | 2008-04-23 | 2009-10-29 | Macielag Mark J | Quinolone derivatives useful as antibacterial agents |
CN106913569B (zh) * | 2016-01-04 | 2022-04-22 | 广东工业大学 | 苯酞类化合物在制备抗耐药菌药物中的应用 |
CN112266326A (zh) * | 2020-11-10 | 2021-01-26 | 杭州臻挚生物科技有限公司 | 二氯甲苯硝化物中间体的制备方法 |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS604820B2 (ja) * | 1979-02-26 | 1985-02-06 | 大塚製薬株式会社 | キノリンカルボン酸誘導体 |
JPS5630964A (en) * | 1979-08-22 | 1981-03-28 | Kyorin Pharmaceut Co Ltd | Novel substituted quinolinecarboxylic acid and its preparation |
DE3142854A1 (de) * | 1981-10-29 | 1983-05-11 | Bayer Ag, 5090 Leverkusen | 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
DE3142856A1 (de) * | 1981-10-29 | 1983-05-11 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von 2,4-dichlor-5-fluor-benzoylchlorid |
JPS58174367A (ja) * | 1982-04-07 | 1983-10-13 | Tanabe Seiyaku Co Ltd | キノリン誘導体及びその製法 |
DE3318145A1 (de) * | 1983-05-18 | 1984-11-22 | Bayer Ag, 5090 Leverkusen | 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
US4577473A (en) * | 1983-10-17 | 1986-03-25 | Hoshizaki Electric Co., Ltd. | Ice product making machine |
JPS60123837A (ja) * | 1983-12-09 | 1985-07-02 | Mitsubishi Paper Mills Ltd | ハロゲン化銀写真乳剤 |
US4571396A (en) * | 1984-04-16 | 1986-02-18 | Warner-Lambert Company | Antibacterial agents |
DE3420770A1 (de) * | 1984-06-04 | 1985-12-05 | Bayer Ag, 5090 Leverkusen | 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-(3-oxo-1-piperazinyl)-3-chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
DE3502935A1 (de) * | 1984-09-29 | 1986-04-10 | Bayer Ag, 5090 Leverkusen | 3-amino-2-benzoyl-acrylsaeurederivate und ein verfahren zu ihrer herstellung |
JPS6191183A (ja) * | 1984-10-11 | 1986-05-09 | Kyorin Pharmaceut Co Ltd | キノロンカルボン酸誘導体 |
DE3441788A1 (de) * | 1984-11-15 | 1986-05-15 | Bayer Ag, 5090 Leverkusen | Alkyl-1-cyclopropyl-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
JPS61205258A (ja) * | 1985-03-08 | 1986-09-11 | Kyorin Pharmaceut Co Ltd | キノロンカルボン酸誘導体及びその製造方法 |
US4578473A (en) * | 1985-04-15 | 1986-03-25 | Warner-Lambert Company | Process for quinoline-3-carboxylic acid antibacterial agents |
US4657913A (en) * | 1985-04-18 | 1987-04-14 | Warner-Lambert Company | Trifluoro- quinoline -3- carboxylic acids and their use as anti-bacterial agents |
DE3522406A1 (de) * | 1985-06-22 | 1987-01-02 | Bayer Ag | Verfahren zur herstellung von 1,8-verbrueckten 4-chinolon-3-carbonsaeuren |
JPS62469A (ja) * | 1985-06-27 | 1987-01-06 | Dainippon Pharmaceut Co Ltd | 新規キノロン誘導体、そのエステルおよびその塩 |
AU594983B2 (en) * | 1985-10-29 | 1990-03-22 | Dainippon Pharmaceutical Co. Ltd. | Novel quinoline derivatives and processes for preparation thereof |
US4668680A (en) * | 1985-12-12 | 1987-05-26 | Warner-Lambert Company | 5-amino-6,8-difluoroquinolones as antibacterial agents |
EP0230053A3 (en) * | 1986-01-17 | 1988-03-30 | American Cyanamid Company | 7-(substituted)piperazinyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids |
JPH089597B2 (ja) * | 1986-01-21 | 1996-01-31 | 杏林製薬株式会社 | 選択毒性に優れた8‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法 |
JPS62215572A (ja) * | 1986-03-17 | 1987-09-22 | Kyorin Pharmaceut Co Ltd | キノロンカルボン酸誘導体 |
EP0242789A3 (en) * | 1986-04-25 | 1990-09-05 | Dainippon Pharmaceutical Co., Ltd. | Novel quinoline derivates and processes for preparation thereof |
GB8612137D0 (en) * | 1986-05-19 | 1986-06-25 | Fujisawa Pharmaceutical Co | Quinolone compounds |
US4771055A (en) * | 1986-07-28 | 1988-09-13 | Warner-Lambert Company | 7-[[3-(aminomethyl)-3-alkyl]-1-pyrrolidinyl]-quinoline-carboxylic acids |
JPS63152318A (ja) * | 1986-08-07 | 1988-06-24 | Dainippon Pharmaceut Co Ltd | 抗マイコプラズマ剤 |
GB8702508D0 (en) * | 1987-02-04 | 1987-03-11 | Fujisawa Pharmaceutical Co | Quinoline compound |
DE3711193A1 (de) * | 1987-04-02 | 1988-10-13 | Bayer Ag | 5-substituierte chinolon- und naphthyridoncarbonsaeure-derivate |
YU46451B (sh) * | 1987-04-08 | 1993-10-20 | Chinoin Gyogyszer Es Vegyeszeti Ter Mekek Gyara Rt. | Postupak za dobivanje mešovitih anhidrida hinolin-karboksilne i borne kiseline |
US4766844A (en) * | 1987-05-28 | 1988-08-30 | Westinghouse Electric Corp. | Robotic tinning station for axial lead electronic components |
US4929613A (en) * | 1987-08-26 | 1990-05-29 | Warner-Lambert Company | Antibacterial agents |
DE3811341A1 (de) * | 1987-10-09 | 1989-04-27 | Bayer Ag | In 7-stellung c-verknuepfte chinolon- und 1,8-naphthyridin-4-on-carbonsaeure und ein verfahren zu ihrer herstellung |
US4920120A (en) * | 1988-01-25 | 1990-04-24 | Warner-Lambert Company | Antibacterial agents |
US4945160A (en) * | 1988-11-22 | 1990-07-31 | Warner-Lambert Company | Preparation of certain 7-substituted quinolones |
-
1988
- 1988-04-08 US US07/179,300 patent/US5591744A/en not_active Expired - Fee Related
- 1988-04-08 US US07/179,239 patent/US5563138A/en not_active Expired - Lifetime
- 1988-04-13 JP JP63091121A patent/JPH0696557B2/ja not_active Expired - Lifetime
- 1988-04-14 ES ES88105959T patent/ES2091180T3/es not_active Expired - Lifetime
- 1988-04-14 EP EP93107626A patent/EP0565132B1/en not_active Expired - Lifetime
- 1988-04-14 EP EP88105959A patent/EP0287951B1/en not_active Expired - Lifetime
- 1988-04-14 EP EP97120444A patent/EP0823413B1/en not_active Expired - Lifetime
- 1988-04-14 ES ES93107626T patent/ES2152936T3/es not_active Expired - Lifetime
- 1988-04-14 DE DE3856515T patent/DE3856515T2/de not_active Expired - Lifetime
- 1988-04-14 ES ES97120444T patent/ES2172734T3/es not_active Expired - Lifetime
- 1988-04-14 SG SG200203819A patent/SG101541A1/en unknown
- 1988-04-14 DE DE3855388T patent/DE3855388T2/de not_active Expired - Lifetime
- 1988-04-14 DE DE3856434T patent/DE3856434T2/de not_active Expired - Lifetime
- 1988-04-14 SG SG9900120A patent/SG97777A1/en unknown
- 1988-04-14 DE DE1997175083 patent/DE19775083I2/de active Active
- 1988-04-14 SG SG1996007292A patent/SG49836A1/en unknown
- 1988-04-15 DK DK207688A patent/DK170640B1/da not_active IP Right Cessation
- 1988-04-16 KR KR1019880004336A patent/KR940002113B1/ko not_active IP Right Cessation
- 1988-04-16 CN CN88102360A patent/CN1053666C/zh not_active Expired - Lifetime
-
1990
- 1990-08-02 US US07/562,034 patent/US5495020A/en not_active Expired - Lifetime
-
1992
- 1992-08-13 DK DK101492A patent/DK171820B1/da not_active IP Right Cessation
-
1993
- 1993-07-26 KR KR1019930014139A patent/KR960006145B1/ko not_active IP Right Cessation
-
1994
- 1994-04-25 JP JP6086368A patent/JP2654537B2/ja not_active Expired - Lifetime
-
1996
- 1996-07-05 US US08/676,034 patent/US5723648A/en not_active Expired - Fee Related
-
1997
- 1997-06-26 HK HK128797A patent/HK128797A/xx not_active IP Right Cessation
- 1997-09-03 US US08/922,108 patent/US5811576A/en not_active Expired - Fee Related
- 1997-09-30 SA SA97180461A patent/SA97180461A/ar unknown
-
1998
- 1998-03-11 NL NL980011C patent/NL980011I2/nl unknown
- 1998-04-30 CY CY9802050A patent/CY2050B1/xx unknown
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