ES2160591T3 - Celulas transformadas por convertasas prohormonales. - Google Patents
Celulas transformadas por convertasas prohormonales.Info
- Publication number
- ES2160591T3 ES2160591T3 ES93900978T ES93900978T ES2160591T3 ES 2160591 T3 ES2160591 T3 ES 2160591T3 ES 93900978 T ES93900978 T ES 93900978T ES 93900978 T ES93900978 T ES 93900978T ES 2160591 T3 ES2160591 T3 ES 2160591T3
- Authority
- ES
- Spain
- Prior art keywords
- prohormonal
- converts
- cells transformed
- polypeptide
- prorelaxin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/48—Nerve growth factor [NGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/64—Relaxins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6454—Dibasic site splicing serine proteases, e.g. kexin (3.4.21.61); furin (3.4.21.75) and other proprotein convertases
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Diabetes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
SE DESCRIBE LA PRODUCCION DE CELULAS DE MAMIFERO QUE EXPRESAN CONVERTASA DE PROHORMONA QUE FACILITA EL PROCESAMIENTO DE LOS PRECURSORES DE LA PROHORMONA EN HORMONAS ACTIVAS. TAMBIEN SE DESCRIBEN CONVERTASAS DE PROHORMONAS VARIANTES, Y PROHORMONAS. LAS CELULAS TRANSFORMADAS DE LA INVENCION PUEDEN UTILIZARSE EN LA SINTESIS DE HORMONAS DE POLIPEPTIDO APROPIADAMENTE PROCESADAS, Y EN EL CULTIVO DE CELULAS PARA REDUCIR LA DEPENDENCIA SOBRE HORMONAS AÑADIDAS Y DE LOS FACTORES DE POLIPEPTIDOS DEL SUERO REQUERIDOS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80363191A | 1991-12-06 | 1991-12-06 | |
US88726592A | 1992-05-22 | 1992-05-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2160591T3 true ES2160591T3 (es) | 2001-11-16 |
Family
ID=27122612
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93900978T Expired - Lifetime ES2160591T3 (es) | 1991-12-06 | 1992-12-04 | Celulas transformadas por convertasas prohormonales. |
Country Status (9)
Country | Link |
---|---|
EP (2) | EP0616645B1 (es) |
JP (1) | JPH07501703A (es) |
AT (1) | ATE204606T1 (es) |
CA (1) | CA2123430C (es) |
DE (1) | DE69232017T2 (es) |
DK (1) | DK0616645T3 (es) |
ES (1) | ES2160591T3 (es) |
PT (1) | PT616645E (es) |
WO (1) | WO1993011247A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6348327B1 (en) | 1991-12-06 | 2002-02-19 | Genentech, Inc. | Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells |
SG47030A1 (en) * | 1994-01-03 | 1998-03-20 | Genentech Inc | Thrombopoietin |
US8147844B1 (en) | 1994-01-03 | 2012-04-03 | Genentech, Inc. | Mpl ligand (thrombopoietin), nucleic acids encoding such, and methods of treatment using mpl ligand |
IL139335A (en) * | 1994-01-03 | 2005-08-31 | Genentech Inc | Mpl ligand polypeptides, nucleic acids encoding them, vectors and host cells comprising such nucleic acids, processes for producing such polypeptides pharmaceutical compositions containing them and use thereof in the preparation of medicaments for treating thrombocytopenia |
US8241900B1 (en) | 1994-01-03 | 2012-08-14 | Genentech, Inc. | mpl ligand |
US8357513B1 (en) | 1994-01-03 | 2013-01-22 | Genentech, Inc. | Nucleic acids encoding mpl ligand (thrombopoietin) and fragments thereof |
US6660256B1 (en) | 1994-01-03 | 2003-12-09 | Genetech, Inc. | Porcine mpl ligand |
US8192955B1 (en) | 1994-01-03 | 2012-06-05 | Genentech, Inc. | Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof |
US8278099B1 (en) | 1994-02-15 | 2012-10-02 | Genentech, Inc. | Monoclonal antibody to human thrombopoietin |
CA2188675A1 (en) * | 1994-04-11 | 1995-10-19 | Savio L. C. Woo | Compositions and methods for gene therapy to treat disease |
AUPN442295A0 (en) | 1995-07-26 | 1995-08-17 | Commonwealth Scientific And Industrial Research Organisation | Regulated autocrine growth of mammalian cells |
JPH09295945A (ja) * | 1996-04-30 | 1997-11-18 | Hoechst Yakuhin Kogyo Kk | 成熟型骨誘導因子の製造方法 |
US6709659B1 (en) | 1996-08-02 | 2004-03-23 | Zymogenetics, Inc. | Antibodies that bind testis-specific insulin homolog polypeptides |
US5959075A (en) * | 1996-08-02 | 1999-09-28 | Zymogenetics, Inc. | Testis-specific insulin homolog polypeptides |
US6114307A (en) * | 1996-12-16 | 2000-09-05 | Zymogenetics, Inc. | Methods for stimulating pancreatic islet cell regeneration |
EP1725585A2 (en) * | 2004-03-10 | 2006-11-29 | Lonza Ltd | Method for producing antibodies |
US8188335B2 (en) | 2009-07-17 | 2012-05-29 | Abbott Laboratories | Δ9-elongase for production of polyunsaturated fatty acid-enriched oils |
KR101787956B1 (ko) * | 2011-06-07 | 2017-10-18 | 아사히 가세이 파마 가부시키가이샤 | 고순도 pth 함유 동결 건조 제제 및 그의 제조 방법 |
US11230583B2 (en) | 2015-11-26 | 2022-01-25 | Hudson Institute of Medical Research | Inhibin analogs |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL87737A (en) * | 1987-09-11 | 1993-08-18 | Genentech Inc | Method for culturing polypeptide factor dependent vertebrate recombinant cells |
JP2643968B2 (ja) * | 1988-02-03 | 1997-08-25 | サントリー株式会社 | Kex2エンドプロテアーゼ及びその製造方法 |
JP2857684B2 (ja) * | 1989-05-04 | 1999-02-17 | ジェネンテク,インコーポレイテッド | ヒトリラキシンの単離のための方法および組成物 |
-
1992
- 1992-12-04 CA CA002123430A patent/CA2123430C/en not_active Expired - Fee Related
- 1992-12-04 EP EP93900978A patent/EP0616645B1/en not_active Expired - Lifetime
- 1992-12-04 DE DE69232017T patent/DE69232017T2/de not_active Expired - Fee Related
- 1992-12-04 ES ES93900978T patent/ES2160591T3/es not_active Expired - Lifetime
- 1992-12-04 JP JP5510388A patent/JPH07501703A/ja not_active Withdrawn
- 1992-12-04 AT AT93900978T patent/ATE204606T1/de not_active IP Right Cessation
- 1992-12-04 WO PCT/US1992/010621 patent/WO1993011247A1/en active IP Right Grant
- 1992-12-04 DK DK93900978T patent/DK0616645T3/da active
- 1992-12-04 PT PT93900978T patent/PT616645E/pt unknown
- 1992-12-04 EP EP01103965A patent/EP1099758A3/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP1099758A3 (en) | 2001-05-23 |
DE69232017D1 (de) | 2001-09-27 |
DE69232017T2 (de) | 2002-03-21 |
CA2123430C (en) | 2004-02-10 |
ATE204606T1 (de) | 2001-09-15 |
EP1099758A2 (en) | 2001-05-16 |
EP0616645A1 (en) | 1994-09-28 |
PT616645E (pt) | 2002-02-28 |
EP0616645B1 (en) | 2001-08-22 |
JPH07501703A (ja) | 1995-02-23 |
CA2123430A1 (en) | 1993-06-10 |
WO1993011247A1 (en) | 1993-06-10 |
DK0616645T3 (da) | 2001-10-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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