ES2145044T3 - Inmovilizacion de especies quimicas en matrices reticuladas. - Google Patents

Inmovilizacion de especies quimicas en matrices reticuladas.

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Publication number
ES2145044T3
ES2145044T3 ES93905897T ES93905897T ES2145044T3 ES 2145044 T3 ES2145044 T3 ES 2145044T3 ES 93905897 T ES93905897 T ES 93905897T ES 93905897 T ES93905897 T ES 93905897T ES 2145044 T3 ES2145044 T3 ES 2145044T3
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ES
Spain
Prior art keywords
chemical species
coupling
reactive groups
molecula
latent reactive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93905897T
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English (en)
Inventor
Dale Gustaf Swan
Mark William Josephson
Melvin John Swanson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Surmodics Inc
Original Assignee
Surmodics Inc
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Publication date
Application filed by Surmodics Inc filed Critical Surmodics Inc
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Publication of ES2145044T3 publication Critical patent/ES2145044T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0002—Organic membrane manufacture
    • B01D67/0006—Organic membrane manufacture by chemical reactions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
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    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01D71/5211—Polyethylene glycol or polyethyleneoxide
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    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
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    • C12N11/087—Acrylic polymers
    • C—CHEMISTRY; METALLURGY
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    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract

UN METODO DE INMOVILIZACION DE UNA ESPECIE EN UNA MATRIZ RETICULADA TRIDIMENSIONAL. EL METODO SE REFIERE A LLEVAR JUNTOS EN ENLACE COVALENTE DE PROXIMIDAD UNA ESPECIE QUIMICA DESEADA Y UN COMPUESTO DE ACOPLAMIENTO POLIMERICO QUE TIENE AL MENOS DOS GRUPOS REACTIVOS LATENTES POR MOLECULA, SIENDO CADA GRUPO REACTIVO LATENTE CAPAZ CUANDO SE ACTIVA PARA ENLAZAR COVALENTEMENTE A OTRA MOLECULA DE COMPUESTO DE ACOPLAMIENTO O A LA ESPECIE QUIMICA. LA ESPECIE QUIMICA DESEABLEMENTE ESTA LIBRE DE GRUPOS REACTIVOS LATENTES QUE SON ACTIVADOS BAJO ACTIVACION DE LOS GRUPOS REACTIVOS LATENTES SE ACTIVAN SIMULTANEAMENTE PARA CAUSAR LA FORMACION POR ENLACE COVALENTE DE UNA RED MOLECULAR TRIDIMENSIONAL EN LA QUE LAS MOLECULAS DE LA ESPECIE QUIMICA SE ENLAZAN COVALENTEMENTE A MOLECULAS DEL COMPUESTOS DE ACOPLAMIENTO, Y MOLECULAS DEL COMPUESTO DE ACOPLAMIENTO SE ENLAZAN COVALENTEMENTE UNA A OTRA. PREFERENTEMENTE, LA MATRIZ TRIDIMENSIONAL SE FORMA COMO UN REVESTIMIENTO SOBRE UNA SUPERFICIE A LA QUE LOS ENLACES COVALENTE SE FORMAN SOBRE ACTIVACION DE LOS GRUPOS REACTIVOS LATENTES DEL COMPUESTO DE ACOPLAMIENTO.
ES93905897T 1992-02-13 1993-02-11 Inmovilizacion de especies quimicas en matrices reticuladas. Expired - Lifetime ES2145044T3 (es)

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CA2107683C (en) 2004-07-20
EP0585436A4 (es) 1994-03-30
DE69328523T2 (de) 2000-09-21
ATE192487T1 (de) 2000-05-15
AU716543B2 (en) 2000-02-24
WO1993016176A1 (en) 1993-08-19
US5563056A (en) 1996-10-08
EP0585436A1 (en) 1994-03-09
EP0585436B1 (en) 2000-05-03
AU3664693A (en) 1993-09-03
AU1482797A (en) 1997-06-26
CA2107683A1 (en) 1993-08-14
JPH06506959A (ja) 1994-08-04
DE69328523D1 (de) 2000-06-08
JP3455217B2 (ja) 2003-10-14

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