ES2142827T3 - Mezcla de proteinas osteoinductivas y procedimiento de purificacion. - Google Patents
Mezcla de proteinas osteoinductivas y procedimiento de purificacion.Info
- Publication number
- ES2142827T3 ES2142827T3 ES92915177T ES92915177T ES2142827T3 ES 2142827 T3 ES2142827 T3 ES 2142827T3 ES 92915177 T ES92915177 T ES 92915177T ES 92915177 T ES92915177 T ES 92915177T ES 2142827 T3 ES2142827 T3 ES 2142827T3
- Authority
- ES
- Spain
- Prior art keywords
- exchange process
- mhos
- ultrafiltration
- cation exchange
- anion exchange
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/32—Joints for the hip
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/38—Joints for elbows or knees
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
- A61F2002/30011—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in porosity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
- A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0023—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in porosity
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/84—Bones; tendons; teeth; cartilage
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Inorganic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Detergent Compositions (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Radar Systems Or Details Thereof (AREA)
Abstract
UN PROCESO PARA PURIFICAR FACTORES OSTEOINDUCTIVOS DERIVADOS DE HUESO QUE COMPRENDEN UN PROCESO DE ULTRAFILTRACION, UN PROCESO DE INTERCAMBIO DE ANIONES, UN PROCESOS DE INTERCAMBIO DE CATIONES, Y UN PROCESO HPLC DA FASE INVERSA. EL PROCESO DE ULTRAFILTRACION COMPRENDE PREFERENTEMENTE UN PRIMER PASO DE ULTRAFILTRACION QUE UTILIZA UNA MEMBRANA QUE TIENE UN CORTE DE PESO MOLECULAR NOMINAL DE APROXIMADAMENTE 100KD (KILODALTON) Y UNA SEGUNDA ETAPA DE ULTRAFILTRACION QUE EMPLEA UNA MEMBRANA QUE TIENE UN CORTE DE PESO MOLECULAR NOMINAL DE APROXIMADAMENTE 10 KD. PARA EL PROCESO DE INTERCAMBIO DE ANIONES SE USA UNA RESINA FUERTEMENTE CATIONICA, PREFERENTEMENTE QUE TIENE GRUPOS FUNCIONALES DE AMINA CUATERNARIA. TIPICAMENTE, EL ELUYENTE PARA EL PROCESO DE INTERCAMBIO DE ANIONES TIENE UNA CONDUCTIVIDAD DE APROXIMADAMENTE 10,260 (MU)MHOS (MICROOMHIOS (1,026 X 10-2 SIEMENS (S) A APROXIMADAMENTE 11,200 230MHOS (1.120 X 10-2S). PARA EL PROCESO DE INTERCAMBIO DE CATIONES SE USA UNA RESINA ALTAMENTE ANIONICA, PREFERENTEMENTE QUE TENGA GRUPOS FUNCIONALES DE ACIDO SULONICO. EL ELUYENTE PARA EL PROCESO DE INTERCAMBIO DE CATIONES TIENE TIPICAMENTE UNA CONDUCTIVIDAD DE APROXIMADAMENTE 39,100 (MU)HMOS (3.9 X 10-2S) A APROXIMADAMENTE 82,700 (MU)MHOS (8.27 X 10-2S) O MAS. EL PROCESO DE HLPC UTILIZA TIPICAMENTE UNA COLUMNA QUE CONTIENE MATERIAL DE GUARNICION DE SILICE DE HIDROCARBONO MODIFICADO. LAS PROTEINAS OSTEOINDUCTIVAS PUEDE OBTENERSE A PARTIR DE LA COLUMNA DE HPLC CON UNA SOLUCION DE ACETONITRILO EN COMBINACION CON ACIDO TRIFLUORACETICO ACUOSO. LOS PROCESOS DE PURIFICACION PRODUCEN MEZCLAS DE PROTEINA OSTEOINDUCTIVAMENTE ACTIVAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/689,459 US5290763A (en) | 1991-04-22 | 1991-04-22 | Osteoinductive protein mixtures and purification processes |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2142827T3 true ES2142827T3 (es) | 2000-05-01 |
Family
ID=24768570
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92915177T Expired - Lifetime ES2142827T3 (es) | 1991-04-22 | 1992-04-21 | Mezcla de proteinas osteoinductivas y procedimiento de purificacion. |
Country Status (10)
Country | Link |
---|---|
US (2) | US5290763A (es) |
EP (1) | EP0584283B1 (es) |
JP (1) | JP3641726B2 (es) |
AT (1) | ATE187739T1 (es) |
CA (1) | CA2107481C (es) |
DE (1) | DE69230434T2 (es) |
DK (1) | DK0584283T3 (es) |
ES (1) | ES2142827T3 (es) |
GR (1) | GR3032957T3 (es) |
WO (1) | WO1992018142A1 (es) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5563124A (en) * | 1991-04-22 | 1996-10-08 | Intermedics Orthopedics/ Denver, Inc. | Osteogenic product and process |
US5531791A (en) * | 1993-07-23 | 1996-07-02 | Bioscience Consultants | Composition for repair of defects in osseous tissues, method of making, and prosthesis |
US5782919A (en) * | 1995-03-27 | 1998-07-21 | Sdgi Holdings, Inc. | Interbody fusion device and method for restoration of normal spinal anatomy |
US6187346B1 (en) | 1995-06-07 | 2001-02-13 | Ablation Products, Inc. | Intrauterine chemical cauterizing method and composition |
WO1996040171A1 (en) | 1995-06-07 | 1996-12-19 | Neuwirth Robert S | Intrauterine chemical necrosing method and composition |
JP2000505077A (ja) | 1996-01-16 | 2000-04-25 | レンセレール ポリテクニック インスティチュート | 骨芽細胞の接着を改良するためのペプチド |
US5891457A (en) * | 1997-05-12 | 1999-04-06 | Neuwirth; Robert S. | Intrauterine chemical necrosing method, composition, and apparatus |
JP3780638B2 (ja) * | 1997-06-27 | 2006-05-31 | 東ソー株式会社 | 分離法及びこれを用いた装置 |
US6511958B1 (en) | 1997-08-14 | 2003-01-28 | Sulzer Biologics, Inc. | Compositions for regeneration and repair of cartilage lesions |
ATE220564T1 (de) | 1997-08-14 | 2002-08-15 | Sulzer Innotec Ag | Zusammensetzung und vorrichtung zur reparatur von knorpelgewebe in vivo bestehend aus nanokapseln mit osteoinduktiven und/oder chondroinduktiven faktoren |
US20040081704A1 (en) * | 1998-02-13 | 2004-04-29 | Centerpulse Biologics Inc. | Implantable putty material |
US6211157B1 (en) * | 1998-05-01 | 2001-04-03 | Sulzer Biologics, Inc. | Protein mixtures to induce therapeutic angiogenesis |
US7087577B2 (en) * | 1998-10-16 | 2006-08-08 | Zimmer Orthobiologies, Inc. | Method of promoting natural bypass |
US6992066B2 (en) * | 1998-10-16 | 2006-01-31 | Zimmer Orthobiologics, Inc. | Povidone-containing carriers for polypeptide growth factors |
US6630333B1 (en) * | 1999-03-23 | 2003-10-07 | Invitrogen Corporation | Substantially pure reverse transriptases and methods of production thereof |
WO2000064460A2 (en) * | 1999-04-23 | 2000-11-02 | Sulzer Orthopedics Ltd. | Composition for enhancing functional recovery of a mammal from central and/or peripheral nervous system injury of traumatic or pathological origin |
US6723335B1 (en) * | 2000-04-07 | 2004-04-20 | Jeffrey William Moehlenbruck | Methods and compositions for treating intervertebral disc degeneration |
US7081240B1 (en) * | 2000-06-28 | 2006-07-25 | Zimmer Orthobiologics, Inc. | Protein mixtures for wound healing |
EP1335686B1 (en) * | 2000-10-24 | 2008-12-17 | Warsaw Orthopedic, Inc. | Spinal fusion devices |
US6492327B2 (en) | 2000-12-19 | 2002-12-10 | Sulzer Biologics Inc. | Isolation of purified TGF- β1 and TGF -β2 from bone tissue |
US20020114795A1 (en) * | 2000-12-22 | 2002-08-22 | Thorne Kevin J. | Composition and process for bone growth and repair |
US6627230B2 (en) | 2000-12-22 | 2003-09-30 | Centerpulse Biologics Inc. | Method of preparing a bone product by removing cancellous bone matrix |
US6669725B2 (en) | 2000-12-28 | 2003-12-30 | Centerpulse Biologics Inc. | Annuloplasty ring for regeneration of diseased or damaged heart valve annulus |
US7132110B2 (en) * | 2001-08-30 | 2006-11-07 | Isotis Orthobiologics, Inc. | Tissue repair compositions and methods for their manufacture and use |
US8546334B2 (en) | 2001-11-19 | 2013-10-01 | Scil Technology Gmbh | Device having osteoinductive and osteoconductive properties |
ATE434996T1 (de) * | 2001-12-10 | 2009-07-15 | Colbar Lifescience Ltd | Verwendung von vernetztem kollagen zur behandlung von bandscheiben |
US7232802B2 (en) | 2001-12-21 | 2007-06-19 | Zimmer Orthobiologics, Inc. | Compositions and methods for promoting myocardial and peripheral angiogenesis |
US7166133B2 (en) * | 2002-06-13 | 2007-01-23 | Kensey Nash Corporation | Devices and methods for treating defects in the tissue of a living being |
JP2005536489A (ja) * | 2002-06-20 | 2005-12-02 | デュネアス,ニコラス | 骨誘導性の生体材料 |
US7622562B2 (en) * | 2002-06-26 | 2009-11-24 | Zimmer Orthobiologics, Inc. | Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue |
US7241874B2 (en) * | 2002-06-26 | 2007-07-10 | Zimmer Ortho Biologics, Inc. | Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue |
CN100522241C (zh) * | 2002-09-10 | 2009-08-05 | Scil技术股份有限公司 | 在低氧气浓度下用骨诱导蛋白包被的金属植入物 |
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PL1737734T3 (pl) | 2004-03-10 | 2011-02-28 | Scil Tech Gmbh | Powlekane implanty, ich wytwarzanie i zastosowanie |
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WO2009034452A2 (en) * | 2007-09-10 | 2009-03-19 | Sbf Synthetic Bone Factory Gmbh | Compound and device for treating bone and/or cartilage defects |
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US9554920B2 (en) * | 2007-06-15 | 2017-01-31 | Warsaw Orthopedic, Inc. | Bone matrix compositions having nanoscale textured surfaces |
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US20110054408A1 (en) * | 2007-07-10 | 2011-03-03 | Guobao Wei | Delivery systems, devices, tools, and methods of use |
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CA2702499A1 (en) | 2007-10-19 | 2009-04-23 | Osteotech, Inc. | Demineralized bone matrix compositions and methods |
US20090136929A1 (en) * | 2007-11-28 | 2009-05-28 | Zimmer Orthobiologics, Inc. | Novel in vitro method of quantifying demineralized bone osteoinductivity |
WO2009086305A2 (en) * | 2007-12-21 | 2009-07-09 | Rti Biologics, Inc. | Osteoinductive putties and methods of making and using such putties |
WO2010093950A1 (en) | 2009-02-12 | 2010-08-19 | Osteotech, Inc. | Delivery system cartridge |
JP2013542837A (ja) | 2010-11-15 | 2013-11-28 | ジンマー オーソバイオロジクス,インコーポレイティド | 骨空隙充填剤 |
CA2860713C (en) | 2012-01-09 | 2020-06-30 | Matthew E. MONAGHAN | Composite device that combines porous metal and bone stimuli |
US9775862B2 (en) * | 2012-01-30 | 2017-10-03 | Warsaw Orthopedic, Inc. | Modification of reactivity of bone constructs |
US9220518B2 (en) | 2012-05-08 | 2015-12-29 | Zimmer, Inc. | Porous spacers, instruments, and methods for foot and ankle fusion |
AU2013346732B2 (en) * | 2012-11-15 | 2017-02-02 | Arla Foods Amba | Method of producing a composition containing caseinomacropeptide |
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-
1991
- 1991-04-22 US US07/689,459 patent/US5290763A/en not_active Expired - Lifetime
-
1992
- 1992-04-21 EP EP92915177A patent/EP0584283B1/en not_active Expired - Lifetime
- 1992-04-21 ES ES92915177T patent/ES2142827T3/es not_active Expired - Lifetime
- 1992-04-21 DK DK92915177T patent/DK0584283T3/da active
- 1992-04-21 DE DE69230434T patent/DE69230434T2/de not_active Expired - Fee Related
- 1992-04-21 JP JP51176392A patent/JP3641726B2/ja not_active Expired - Fee Related
- 1992-04-21 AT AT92915177T patent/ATE187739T1/de not_active IP Right Cessation
- 1992-04-21 CA CA002107481A patent/CA2107481C/en not_active Expired - Fee Related
- 1992-04-21 WO PCT/US1992/003295 patent/WO1992018142A1/en active IP Right Grant
-
1993
- 1993-10-26 US US08/142,686 patent/US5371191A/en not_active Expired - Lifetime
-
2000
- 2000-03-14 GR GR20000400657T patent/GR3032957T3/el unknown
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EP0584283A1 (en) | 1994-03-02 |
GR3032957T3 (en) | 2000-07-31 |
CA2107481A1 (en) | 1992-10-23 |
DE69230434D1 (de) | 2000-01-20 |
US5371191A (en) | 1994-12-06 |
EP0584283B1 (en) | 1999-12-15 |
WO1992018142A1 (en) | 1992-10-29 |
EP0584283A4 (en) | 1994-11-02 |
DK0584283T3 (da) | 2000-06-13 |
DE69230434T2 (de) | 2000-08-03 |
JPH06507173A (ja) | 1994-08-11 |
CA2107481C (en) | 2002-12-03 |
ATE187739T1 (de) | 2000-01-15 |
JP3641726B2 (ja) | 2005-04-27 |
US5290763A (en) | 1994-03-01 |
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