ES2139728T3 - Soporte bioespecifico en fase solida. - Google Patents

Soporte bioespecifico en fase solida.

Info

Publication number
ES2139728T3
ES2139728T3 ES94850024T ES94850024T ES2139728T3 ES 2139728 T3 ES2139728 T3 ES 2139728T3 ES 94850024 T ES94850024 T ES 94850024T ES 94850024 T ES94850024 T ES 94850024T ES 2139728 T3 ES2139728 T3 ES 2139728T3
Authority
ES
Spain
Prior art keywords
different
bio
microparticles
solid phase
specific support
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94850024T
Other languages
English (en)
Inventor
Antti Juhana Iitia
Timo Nils-Erik Lovgren
Kim Sverker Immanue Pettersson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wallac Oy
Original Assignee
Wallac Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wallac Oy filed Critical Wallac Oy
Application granted granted Critical
Publication of ES2139728T3 publication Critical patent/ES2139728T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

LA INVENCION SE REFIERE A UN METODO DE ENSAYO BIOESPECIFICO, MULTIPARAMETRICO QUE UTILIZA MICROPARTICULAS DISTRIBUIDAS EN CATEGORIAS DIFERENTES Y QUE REPRESENTAN SUJETOS DE ANALISIS DIFERENTES, EN DICHO METODO LAS MICROPARTICULAS QUE PERTENECEN A CATEGORIAS DIFERENTES SE ETIQUETAN CON UNA MOLECULA FLUORESCENTE (1) Y EN DICHO METODO LAS MICROPARTICULAS QUE PERTENECEN A CATEGORIAS DIFERENTES SE RECUBREN CON REACTANTES DE AFINIDAD A QUE SE UNEN A OBJETOS DE ANALISIS DIFERENTES. ESTA INVENCION SE CARACTERIZA POR ETIQUETAR LAS MICROPARTICULAS Y LOS RESTANTES DE BIOAFINIDAD B, ETIQUETADOS CON UNA MOLECULA FLUORESCENTE (2), CON MOLECULAS DIFERENTES QUE EMITEN UNA LARGA FLUORESCENCIA (1, 2).
ES94850024T 1993-03-18 1994-02-16 Soporte bioespecifico en fase solida. Expired - Lifetime ES2139728T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI931198A FI93781C (fi) 1993-03-18 1993-03-18 Biospesifinen multiparametrinen määritysmenetelmä

Publications (1)

Publication Number Publication Date
ES2139728T3 true ES2139728T3 (es) 2000-02-16

Family

ID=8537581

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94850024T Expired - Lifetime ES2139728T3 (es) 1993-03-18 1994-02-16 Soporte bioespecifico en fase solida.

Country Status (5)

Country Link
EP (1) EP0617286B1 (es)
JP (1) JPH06317593A (es)
DE (1) DE69422210T2 (es)
ES (1) ES2139728T3 (es)
FI (1) FI93781C (es)

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Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE454781B (sv) * 1986-10-17 1988-05-30 Wallac Oy Hybridiseringsforfarande for detektion av polynukleotidsekvens
SE458968B (sv) * 1987-06-16 1989-05-22 Wallac Oy Biospecifikt analysfoerfarande foer flera analyter i vilket ingaar partikelraekning och maerkning med fluorescerande maerksubstanser
EP0566629A4 (en) * 1990-12-28 1995-01-25 Abbott Lab SIMULTANEOUS DETERMINATION OF MULTIPLE ANALYTES USING A HETEROGENEOUS TIME RESOLUTION CHEMOLUMINESCENCE TECHNIQUE.

Also Published As

Publication number Publication date
FI93781C (fi) 1995-05-26
EP0617286B1 (en) 1999-12-22
EP0617286A3 (en) 1995-07-26
EP0617286A2 (en) 1994-09-28
DE69422210T2 (de) 2000-04-20
FI931198A0 (fi) 1993-03-18
JPH06317593A (ja) 1994-11-15
FI93781B (fi) 1995-02-15
FI931198A (fi) 1994-09-19
DE69422210D1 (de) 2000-01-27

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