ES2137137B1 - Nuevo polimorfo de gabapentina no hidratada, su procedimiento de obtencion y su utilizacion para la obtencion de gabapentina de calidad farmaceutica. - Google Patents
Nuevo polimorfo de gabapentina no hidratada, su procedimiento de obtencion y su utilizacion para la obtencion de gabapentina de calidad farmaceutica.Info
- Publication number
- ES2137137B1 ES2137137B1 ES009801078A ES9801078A ES2137137B1 ES 2137137 B1 ES2137137 B1 ES 2137137B1 ES 009801078 A ES009801078 A ES 009801078A ES 9801078 A ES9801078 A ES 9801078A ES 2137137 B1 ES2137137 B1 ES 2137137B1
- Authority
- ES
- Spain
- Prior art keywords
- obtaining
- gabapentine
- procedure
- gabapentin
- unhydrated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 title abstract 12
- 229960002870 gabapentin Drugs 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 4
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000001694 spray drying Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
- C07C227/42—Crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Nuevo polimorfo de gabapentina no hidratada, su procedimiento de obtención y su utilización para la obtención de gabapentina de calidad farmacéutica; se describe un nuevo polimorfo de gabapentina no hidratada, obtenido mediante la desecación por atomización o turbo-secado de una disolución acuosa de gabapentina, y su utilización para obtener gabapentina apta para su uso farmacéutico mediante un procedimiento consistente en someter dicho nuevo polimorfo a un proceso de cristalización en disolventes.
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009801078A ES2137137B1 (es) | 1998-05-25 | 1998-05-25 | Nuevo polimorfo de gabapentina no hidratada, su procedimiento de obtencion y su utilizacion para la obtencion de gabapentina de calidad farmaceutica. |
HU0102104A HUP0102104A3 (en) | 1998-05-25 | 1999-05-10 | Non-hydrated gabapentine polymorph, production process and utilization for producing pharmaceutical grade gabapentine |
AU37106/99A AU3710699A (en) | 1998-05-25 | 1999-05-10 | Non-hydrated gabapentine polymorph, production process and utilization for producing pharmaceutical grade gabapentine |
DE69912773T DE69912773T2 (de) | 1998-05-25 | 1999-05-10 | Nicht hydratisiertes gabapentin polymorph, herstellungsprozess und verwendung zur herstellung von gabapentin pharmazeutischer reinheit. |
EP99919275A EP1083164B1 (en) | 1998-05-25 | 1999-05-10 | Non-hydrated gabapentin polymorph, production process and utilization for producing pharmaceutical grade gabapentin |
IL13981799A IL139817A (en) | 1998-05-25 | 1999-05-10 | Non-hydrated gabapentin polymorpha process for thepreparation thereof and the use thereof for the p reparation of pharmaceutical grade gabapentin |
PCT/ES1999/000127 WO1999061408A1 (es) | 1998-05-25 | 1999-05-10 | Polimorfo de gabapentina no hidratada, procedimiento para su obtención y su utilización para la obtención de gabapentina de calidad farmacéutica |
US09/700,939 US6521787B1 (en) | 1998-05-25 | 1999-05-10 | Non-hydrated gabapentine polymorph, production process and utilization for producing pharmaceutical grade gabapentine |
CA002333408A CA2333408A1 (en) | 1998-05-25 | 1999-05-10 | Non-hydrated gabapentin polymorph, a process for the preparation thereof and the use therefor for the preparation of pharmaceutical grade gabapentin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009801078A ES2137137B1 (es) | 1998-05-25 | 1998-05-25 | Nuevo polimorfo de gabapentina no hidratada, su procedimiento de obtencion y su utilizacion para la obtencion de gabapentina de calidad farmaceutica. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2137137A1 ES2137137A1 (es) | 1999-12-01 |
ES2137137B1 true ES2137137B1 (es) | 2000-08-16 |
Family
ID=8303893
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES009801078A Expired - Fee Related ES2137137B1 (es) | 1998-05-25 | 1998-05-25 | Nuevo polimorfo de gabapentina no hidratada, su procedimiento de obtencion y su utilizacion para la obtencion de gabapentina de calidad farmaceutica. |
Country Status (9)
Country | Link |
---|---|
US (1) | US6521787B1 (es) |
EP (1) | EP1083164B1 (es) |
AU (1) | AU3710699A (es) |
CA (1) | CA2333408A1 (es) |
DE (1) | DE69912773T2 (es) |
ES (1) | ES2137137B1 (es) |
HU (1) | HUP0102104A3 (es) |
IL (1) | IL139817A (es) |
WO (1) | WO1999061408A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000061188A1 (en) | 1999-04-09 | 2000-10-19 | Euro-Celtique S.A. | Sodium channel blocker compositions and the use thereof |
ES2164527B1 (es) * | 1999-04-26 | 2003-04-01 | Medichen S A | Procedimiento de obtencion de gabapentina de calidad farmaceutica. |
SI1423168T1 (sl) | 2001-09-03 | 2006-06-30 | Newron Pharm Spa | Farmacevtski sestavek, ki vsebuje gabapentin ali njegov analog in alfa-aminoamid, in njegova analgetska uporaba |
US6800782B2 (en) | 2001-10-09 | 2004-10-05 | Warner-Lambert Co. | Anhydrous crystalline forms of gabapentin |
ITMI20022071A1 (it) * | 2002-10-01 | 2004-04-02 | Erregierre Spa | Processo di sintesi dell'acido 1-(aminometil)cicloesanacetico cloridato. |
US7417036B2 (en) | 2002-11-12 | 2008-08-26 | Tianjin Kinsly Pharmaceutical Co. Ltd. | Crystal form of adefovir dipivoxil and its preparation |
WO2004106281A1 (en) * | 2003-05-30 | 2004-12-09 | Ranbaxy Laboratories Limited | Crystalline gabapentin |
US7169812B2 (en) * | 2003-07-01 | 2007-01-30 | Medtronic, Inc. | Process for producing injectable gabapentin compositions |
US20050187295A1 (en) * | 2004-02-19 | 2005-08-25 | Surendra Kalyan | Processes for the preparation of gabapentin |
US20110224435A1 (en) * | 2007-08-07 | 2011-09-15 | Ranbaxy Laboratories Limited | Process for preparation of amorphous lopinavir |
US20100222584A1 (en) * | 2009-02-06 | 2010-09-02 | Bach Pharma, Inc. | Pharmaceutical grade phthalazinediones, process for their preparation and pharmaceutical compositions containing them |
PT2858989T (pt) | 2012-05-17 | 2020-06-25 | Genentech Inc | Forma amorfa de um composto de pirimidinil-ciclopentano inibidor de akt, composições e métodos das mesmas |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2460891C2 (de) * | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
US4087544A (en) * | 1974-12-21 | 1978-05-02 | Warner-Lambert Company | Treatment of cranial dysfunctions using novel cyclic amino acids |
US4960931A (en) * | 1988-05-02 | 1990-10-02 | Warner-Lambert Company | Gabapentin mohohydrate and a process for producing the same |
US4894476A (en) | 1988-05-02 | 1990-01-16 | Warner-Lambert Company | Gabapentin monohydrate and a process for producing the same |
DE3928184A1 (de) * | 1989-08-25 | 1991-02-28 | Goedecke Ag | Verfahren zur herstellung von cyclischen aminosaeurederivaten sowie zwischenprodukte |
IL119890A (en) * | 1996-12-24 | 2002-03-10 | Teva Pharma | Gabapentin form iii and preparation of gabapentin form ii |
-
1998
- 1998-05-25 ES ES009801078A patent/ES2137137B1/es not_active Expired - Fee Related
-
1999
- 1999-05-10 IL IL13981799A patent/IL139817A/xx not_active IP Right Cessation
- 1999-05-10 CA CA002333408A patent/CA2333408A1/en not_active Abandoned
- 1999-05-10 WO PCT/ES1999/000127 patent/WO1999061408A1/es active IP Right Grant
- 1999-05-10 EP EP99919275A patent/EP1083164B1/en not_active Expired - Lifetime
- 1999-05-10 AU AU37106/99A patent/AU3710699A/en not_active Abandoned
- 1999-05-10 HU HU0102104A patent/HUP0102104A3/hu unknown
- 1999-05-10 DE DE69912773T patent/DE69912773T2/de not_active Expired - Fee Related
- 1999-05-10 US US09/700,939 patent/US6521787B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6521787B1 (en) | 2003-02-18 |
DE69912773T2 (de) | 2004-09-30 |
HUP0102104A2 (hu) | 2001-11-28 |
CA2333408A1 (en) | 1999-12-02 |
EP1083164A1 (en) | 2001-03-14 |
EP1083164B1 (en) | 2003-11-12 |
IL139817A (en) | 2005-11-20 |
WO1999061408A1 (es) | 1999-12-02 |
IL139817A0 (en) | 2002-02-10 |
HUP0102104A3 (en) | 2002-11-28 |
DE69912773D1 (de) | 2003-12-18 |
ES2137137A1 (es) | 1999-12-01 |
AU3710699A (en) | 1999-12-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19991201 Kind code of ref document: A1 Effective date: 19991201 |
|
FD1A | Patent lapsed |
Effective date: 20101018 |