ES2128743T3 - Procedimiento y aparato para la formacion de particulas. - Google Patents

Procedimiento y aparato para la formacion de particulas.

Info

Publication number
ES2128743T3
ES2128743T3 ES95923444T ES95923444T ES2128743T3 ES 2128743 T3 ES2128743 T3 ES 2128743T3 ES 95923444 T ES95923444 T ES 95923444T ES 95923444 T ES95923444 T ES 95923444T ES 2128743 T3 ES2128743 T3 ES 2128743T3
Authority
ES
Spain
Prior art keywords
vehicle
supercritical fluid
suspension
solution
substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95923444T
Other languages
English (en)
Inventor
Mazen Hanna
Peter York
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nektar Therapeutics UK Ltd
Original Assignee
Bradford Particle Design Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10757607&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2128743(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bradford Particle Design Ltd filed Critical Bradford Particle Design Ltd
Application granted granted Critical
Publication of ES2128743T3 publication Critical patent/ES2128743T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
    • B01D11/0407—Solvent extraction of solutions which are liquid with a supercritical fluid the supercritical fluid acting as solvent for the solute
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
    • B01D11/0411—Solvent extraction of solutions which are liquid with a supercritical fluid the supercritical fluid acting as solvent for the solvent and as anti-solvent for the solute, e.g. formation of particles from solutions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0488—Flow sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J3/00—Processes of utilising sub-atmospheric or super-atmospheric pressure to effect chemical or physical change of matter; Apparatus therefor
    • B01J3/008—Processes carried out under supercritical conditions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J3/00—Processes of utilising sub-atmospheric or super-atmospheric pressure to effect chemical or physical change of matter; Apparatus therefor
    • B01J3/02—Feed or outlet devices therefor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Peptides Or Proteins (AREA)

Abstract

LA INVENCION PROPORCIONA UN METODO PARA LA FORMACION DE PARTICULAS DE UNA SUSTANCIA, MEDIANTE LA COINTRODUCCION DE UN FLUIDO SUPERCRITICO EN UN RECIPIENTE DE FORMACION DE PARTICULAS, EN LA QUE SE CONTROLAN LA PRESION Y LA TEMPERATURA; UNA SOLUCION O SUSPENSION DE UNA SUSTANCIA EN UN PRIMER VEHICULO; Y UN SEGUNDO VEHICULO QUE ES MISCIBLE CON EL PRIMER VEHICULO Y SOLUBLE SUSTANCIALMENTE CON EL FLUIDO SUPERCRITICO, DE UNA MANERA TAL QUE LA DISPERSION DE LA SOLUCION O SUSPENSION Y EL SEGUNDO VEHICULO, Y LA EXTRACCION DE LOS VEHICULOS, ESENCIALMENTE OCURREN SIMULTANEA E INMEDIATAMENTE EN EL MOMENTO DE LA INTRODUCCION DE LOS FLUIDOS DENTRO DEL RECIPIENTE, POR MEDIO DE LA ACCION DEL FLUIDO SUPERCRITICO. PREFERIBLEMENTE, SE INTRODUCE LA SOLUCION O SUSPENSION DE LA SUSTANCIA SEPARADAS DEL SEGUNDO VEHICULO DE TAL FORMA QUE EL CONTACTO ENTRE LA SOLUCION O SUSPENSION Y EL SEGUNDO VEHICULO OCURRE ESENCIALMENTE O BIEN SIMULTANEAMENTE, O BIEN INMEDIATAMENTE ANTES DE LA DISPERSION POR EL FLUIDO SUPERCRITICO Y LA EXTRACCION DE LOS VEHICULO POR EL FLUIDO SUPERCRITICO. EL METODO PERMITE UN GRADO ALTO DE CONTROL DEL TAMAÑO, FORMA, FORMA CRISTALINA Y OTRAS PROPIEDADES PSICOQUIMIMCAS DEL PRODUCTO PARTICULADO. ADEMAS, LA INVENCION PROPORCIONA UN APARATO PARA LLEVAR A CABO ESTE METODO, EL CUAL UTILIZA UNA BOQUILLA COAXIAL PARA INTRODUCIR LOS FLUIDOS DENTRO DEL RECIPIENTE DE FORMACION DE PARTICULAS, Y UN PRODUCTO PARTICULADO HECHO MEDIANTE LA UTILIZACION DEL METODO Y EL APARATO.
ES95923444T 1994-06-30 1995-06-30 Procedimiento y aparato para la formacion de particulas. Expired - Lifetime ES2128743T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9413202A GB9413202D0 (en) 1994-06-30 1994-06-30 Method and apparatus for the formation of particles

Publications (1)

Publication Number Publication Date
ES2128743T3 true ES2128743T3 (es) 1999-05-16

Family

ID=10757607

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95923444T Expired - Lifetime ES2128743T3 (es) 1994-06-30 1995-06-30 Procedimiento y aparato para la formacion de particulas.

Country Status (15)

Country Link
US (4) US6063138A (es)
EP (1) EP0767702B1 (es)
JP (1) JP3386470B2 (es)
AT (1) ATE174531T1 (es)
AU (1) AU688526B2 (es)
CA (1) CA2192811C (es)
DE (1) DE69506707T2 (es)
DK (1) DK0767702T3 (es)
ES (1) ES2128743T3 (es)
GB (1) GB9413202D0 (es)
GR (1) GR3029531T3 (es)
IN (1) IN191374B (es)
MX (1) MX9606730A (es)
WO (1) WO1996000610A1 (es)
ZA (1) ZA955437B (es)

Families Citing this family (175)

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