CA2247900A1 - Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents - Google Patents
Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolventsInfo
- Publication number
- CA2247900A1 CA2247900A1 CA002247900A CA2247900A CA2247900A1 CA 2247900 A1 CA2247900 A1 CA 2247900A1 CA 002247900 A CA002247900 A CA 002247900A CA 2247900 A CA2247900 A CA 2247900A CA 2247900 A1 CA2247900 A1 CA 2247900A1
- Authority
- CA
- Canada
- Prior art keywords
- antisolvent
- coating
- dispersant
- supercritical
- particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012296 anti-solvent Substances 0.000 title abstract 6
- 239000002245 particle Substances 0.000 title abstract 4
- 238000000576 coating method Methods 0.000 title abstract 3
- 238000001556 precipitation Methods 0.000 title abstract 3
- 239000011248 coating agent Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000012530 fluid Substances 0.000 abstract 4
- 239000002270 dispersing agent Substances 0.000 abstract 3
- 239000006185 dispersion Substances 0.000 abstract 3
- 239000000126 substance Substances 0.000 abstract 3
- 239000007771 core particle Substances 0.000 abstract 2
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D1/00—Processes for applying liquids or other fluent materials
- B05D1/02—Processes for applying liquids or other fluent materials performed by spraying
- B05D1/025—Processes for applying liquids or other fluent materials performed by spraying using gas close to its critical state
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D2401/00—Form of the coating product, e.g. solution, water dispersion, powders or the like
- B05D2401/90—Form of the coating product, e.g. solution, water dispersion, powders or the like at least one component of the composition being in supercritical state or close to supercritical state
Landscapes
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
Abstract
Improved method and apparatus (110) for particle precipitation and coating using near- or supercritical fluid conditions. A fluid dispersion (128) having a continuous phase dispersant and at least one precipitable substance therein is contacted with a supercritical fluid (SCF) antisolvent (126) so as to generate focused high frequency antisolvent sonic waves, breaking up the dispersion into extremely small droplets. The enhanced mass transfer rates between the droplets and the antisolvent causes precipitation of very small particles on the order of 0.1-10 microns. In coating processes, a turbulent fluidized flow of core particles is created using SCF antisolvent in an enclosed zone.
The core particles are contacted therein at or near supercritical conditions by fluid dispersion containing a dispersant and together with a precipitable substance. The antisolvent depletes the dispersant and the substance is precipitated onto fluidized particles.
The core particles are contacted therein at or near supercritical conditions by fluid dispersion containing a dispersant and together with a precipitable substance. The antisolvent depletes the dispersant and the substance is precipitated onto fluidized particles.
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1259296P | 1996-03-01 | 1996-03-01 | |
US1259396P | 1996-03-01 | 1996-03-01 | |
US08/723,463 US5874029A (en) | 1996-10-09 | 1996-10-09 | Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent |
US60/012,592 | 1997-02-27 | ||
US60/012,593 | 1997-02-27 | ||
US08/723,463 | 1997-02-27 | ||
US08/805,215 | 1997-02-27 | ||
US08/805,215 US5833891A (en) | 1996-10-09 | 1997-02-27 | Methods for a particle precipitation and coating using near-critical and supercritical antisolvents |
PCT/US1997/003207 WO1997031691A1 (en) | 1996-03-01 | 1997-02-28 | Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2247900A1 true CA2247900A1 (en) | 1997-09-04 |
CA2247900C CA2247900C (en) | 2006-08-01 |
Family
ID=36764348
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002247900A Expired - Lifetime CA2247900C (en) | 1996-03-01 | 1997-02-28 | Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2247900C (en) |
-
1997
- 1997-02-28 CA CA002247900A patent/CA2247900C/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2247900C (en) | 2006-08-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2192811A1 (en) | Method and apparatus for the formation of particles | |
US20030047824A1 (en) | Method and apparatus for the formation of particles | |
Riera et al. | Airborne ultrasound for the precipitation of smokes and powders and the destruction of foams | |
CA2329902A1 (en) | Methods and apparatus for particle formation | |
Furusawa et al. | Syntheses of composite polystyrene latices with silica particles in the core | |
CA2166301A1 (en) | Method and apparatus for the formation of particles | |
WO2002093132A3 (en) | Method for manufacture of fine particles | |
CA2256743A1 (en) | Methods and apparatus for continuous ambient particulate mass monitoring | |
CA2175269A1 (en) | Fluidized Particle Production System and Process | |
TW375621B (en) | Process for obtaining polymers which are super-absorbent for water and aqueous fluids in the form of particle aggregates | |
ES2165913T3 (en) | CONTINUOUS METHOD OF CRUSHING OF PHARMACEUTICAL SUBSTANCES. | |
AU1876100A (en) | Process and apparatus for producing particles using a supercritical fluid | |
CA2078277A1 (en) | Ultrasonic Characterization of Polymer Melts Under Processing Conditions | |
HU9600821D0 (en) | Process i | |
EP0424049A3 (en) | Method and equipment for the preparation of a carrier of a polymerization catalyst | |
AR010729A1 (en) | PROCESS TO PREPARE A DETERGENT COMPOSITION THROUGH A PROCESS NOT DONE IN TORRE | |
MXPA04000201A (en) | Method and apparatus for preparing particles. | |
EP1028820A4 (en) | Supercritical fluid aided coating of particulate material | |
KR970014840A (en) | Method and Device for Crushing Solid Particles | |
US4804355A (en) | Apparatus and method for ultrasound enhancement of sedimentation during centrifugation | |
Gupta et al. | Filtration of particulate suspensions in acoustically driven porous media | |
JPS63117040A (en) | Disklike particle and its production | |
CA2247900A1 (en) | Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents | |
Bekker et al. | Separation of solid-liquid suspensions with ultrasonic acoustic energy | |
KR880004845A (en) | Method and apparatus for preparing liquid droplets |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20170228 |