ES2128629T3 - Derivados de bencilpiperidina con afinidad elevada a puntos de enlace de receptores de aminoacidos. - Google Patents

Derivados de bencilpiperidina con afinidad elevada a puntos de enlace de receptores de aminoacidos.

Info

Publication number
ES2128629T3
ES2128629T3 ES95116458T ES95116458T ES2128629T3 ES 2128629 T3 ES2128629 T3 ES 2128629T3 ES 95116458 T ES95116458 T ES 95116458T ES 95116458 T ES95116458 T ES 95116458T ES 2128629 T3 ES2128629 T3 ES 2128629T3
Authority
ES
Spain
Prior art keywords
bencilpiperidine
derivatives
amino acid
high affinity
acid receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95116458T
Other languages
English (en)
Inventor
Helmut Pruecher
Joachim Leibrock
Rudolf Gottschlich
Harry Schwartz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4438810A external-priority patent/DE4438810A1/de
Priority claimed from DE1995126269 external-priority patent/DE19526269A1/de
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Application granted granted Critical
Publication of ES2128629T3 publication Critical patent/ES2128629T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

DERIVADOS BENCILPIPERIDINA DE LA FORMULA I DONDE R 1 ES H, HAL O NITRO, R{SUP, 2} ES UN GRUPO BENCILO INSUSTITUIDO O SUSTITUIDO POR HAL EN AROMATICOS EN LA POSICION 2,3 O 4 DEL ANILLO PIPERIDINA, CON LA CONDICION DE QUE R{SUP, 2} NO ES IGUAL A 4 - BENCILO, CUANDO X SIGNIFICA - CO -, Y Y Z SIGNIFICA CH{SUB, 2} - Y R{SUP, 1} SIGNIFICA H, R{SUP, 3} ES H O A, X ES - CO - O - SO{SUB, 2} -, Y ES - CH{SUB, 2} -, - NH -, - O -, S -, O TAMBIEN - CO -, CUANDO X ES - CO - Y Z ES - NH -, - NA -, Z ES - CH{SUB, 2} -, - C(A){SUB, 2} -, - CH{SUB, 2}CH{SUB, 2} -, - CH = CH{SUB, 2} -, - CO -, - NH -, - NA -, - O -, O UN ENLACE, DONDE UNO DE LOS RESTOS X, Y Y Z PUEDEN SER - O -, - S -, O - NH -, SIN EMBARGO X - Y O Y - Z NO SON - O - O -, - S S -, - NH O -, - O - NH -, - NH - NH -, - O -, - S -, - SO -, A ES ALQUILO CON 1 - 6 ATOMOS DE C Y B ES O, H + OH, HAL ES F, CL, BR O I N ES 0,1,2 ASI COMO SUS SALES QUE MUESTRAN UNA ALTA AFINIDAD A LUGARES DE ENLACE DE RECEPTORES DE AMINOACIDOS Y SON APROPIADOS PARA TRATAMIENTO DE ENFERMEDADES NEURODEGENERATIVAS.
ES95116458T 1994-10-31 1995-10-19 Derivados de bencilpiperidina con afinidad elevada a puntos de enlace de receptores de aminoacidos. Expired - Lifetime ES2128629T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4438810A DE4438810A1 (de) 1994-10-31 1994-10-31 Benzylpiperidinderivate
DE1995126269 DE19526269A1 (de) 1995-07-19 1995-07-19 Benzylpiperidinderivate

Publications (1)

Publication Number Publication Date
ES2128629T3 true ES2128629T3 (es) 1999-05-16

Family

ID=25941544

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95116458T Expired - Lifetime ES2128629T3 (es) 1994-10-31 1995-10-19 Derivados de bencilpiperidina con afinidad elevada a puntos de enlace de receptores de aminoacidos.

Country Status (23)

Country Link
US (1) US5698553A (es)
EP (1) EP0709384B1 (es)
JP (1) JPH08225569A (es)
KR (1) KR100388593B1 (es)
CN (1) CN1064358C (es)
AT (1) ATE174915T1 (es)
AU (1) AU703487B2 (es)
BR (1) BR9505008A (es)
CA (1) CA2161618A1 (es)
CZ (1) CZ288039B6 (es)
DE (1) DE59504622D1 (es)
DK (1) DK0709384T3 (es)
ES (1) ES2128629T3 (es)
FI (1) FI955184A (es)
GR (1) GR3029771T3 (es)
HU (1) HUT76068A (es)
NO (1) NO310023B1 (es)
PL (1) PL182210B1 (es)
RU (1) RU2160259C2 (es)
SK (1) SK282476B6 (es)
TR (1) TR199501331A2 (es)
TW (1) TW394770B (es)
UA (1) UA41927C2 (es)

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* Cited by examiner, † Cited by third party
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ATE174915T1 (de) * 1994-10-31 1999-01-15 Merck Patent Gmbh Benzylpiperidinderivate mit hoher affinität zu bindungsstellen von aminosäure-rezeptoren
ZA9610736B (en) * 1995-12-22 1997-06-27 Warner Lambert Co 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
DE19643790A1 (de) * 1996-10-30 1998-05-07 Merck Patent Gmbh Benzoxazol-Derivat
US6110935A (en) * 1997-02-13 2000-08-29 The Regents Of The University Of California Benzofurazan compounds for enhancing glutamatergic synaptic responses
US6534496B1 (en) * 1997-04-17 2003-03-18 Takeda Chemical Industries, Inc. Thermogenic composition and benzazepine thermogenics
GB9725541D0 (en) * 1997-12-02 1998-02-04 Pharmacia & Upjohn Spa Amino-benzothiazole derivatives
DE19812331A1 (de) 1998-03-20 1999-09-23 Merck Patent Gmbh Piperidinderivate
US6867209B1 (en) 1998-05-22 2005-03-15 Scios, Inc. Indole-type derivatives as inhibitors of p38 kinase
US6589954B1 (en) 1998-05-22 2003-07-08 Scios, Inc. Compounds and methods to treat cardiac failure and other disorders
US6130235A (en) * 1998-05-22 2000-10-10 Scios Inc. Compounds and methods to treat cardiac failure and other disorders
CN1229351C (zh) * 1998-05-22 2005-11-30 西奥斯股份有限公司 杂环化合物和治疗心力衰竭及其它疾病的方法
US6340685B1 (en) 1998-05-22 2002-01-22 Scios, Inc. Compounds and methods to treat cardiac failure and other disorders
US6448257B1 (en) 1998-05-22 2002-09-10 Scios, Inc. Compounds and methods to treat cardiac failure and other disorders
PE20000728A1 (es) 1998-06-26 2000-08-21 Cocensys Inc Heterociclos 4-bencil piperidina alquilsulfoxido y su uso como antagonistas receptores subtipo-selectivo nmda
IL146309A (en) * 1999-05-21 2008-03-20 Scios Inc Derivatives of the indole type and pharmaceutical preparations containing them as inhibitors of kinase p38
US6376514B1 (en) 2000-10-17 2002-04-23 The Procter & Gamble Co. Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
US6693099B2 (en) * 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
DE10120159A1 (de) * 2001-04-25 2002-10-31 Merck Patent Gmbh NMDA-Antagonisten und NMDA-Agonisten zur Behandlung von Suchterkrankungen
JPWO2003035641A1 (ja) * 2001-10-22 2005-02-10 塩野義製薬株式会社 新規カルバモイルピロリドン誘導体
DE10210779A1 (de) * 2002-03-12 2003-10-09 Merck Patent Gmbh Cyclische Amide
DE10217006A1 (de) 2002-04-16 2003-11-06 Merck Patent Gmbh Substituierte Indole
US7116108B2 (en) * 2002-06-11 2006-10-03 The Regents Of The University Of California Method and system for seafloor geological survey using vertical electric field measurement
WO2005097782A1 (ja) * 2004-04-07 2005-10-20 Kyowa Hakko Kogyo Co., Ltd. ピペリジン誘導体
SG163545A1 (en) * 2007-01-03 2010-08-30 Servier Lab 3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamatergic synaptic responses
DE102007047737A1 (de) 2007-10-05 2009-04-30 Merck Patent Gmbh Piperidin- und Piperazinderivate
TWI410420B (zh) * 2008-02-05 2013-10-01 Dainippon Sumitomo Pharma Co 苄基哌啶化合物
US8778970B2 (en) 2009-08-04 2014-07-15 Dainippon Sumitomo Pharma Co., Ltd Benzyl piperidine compound
DE102009049211A1 (de) 2009-10-13 2011-04-28 Merck Patent Gmbh Sulfoxide
KR101825251B1 (ko) * 2010-12-21 2018-02-02 스미또모 가가꾸 가부시키가이샤 고분자 화합물 및 그것을 이용한 발광 소자
KR101799137B1 (ko) * 2010-12-21 2017-11-17 스미또모 가가꾸 가부시키가이샤 고분자 화합물 및 그것을 이용한 발광 소자
KR102277538B1 (ko) * 2015-06-08 2021-07-14 주식회사 대웅제약 신규한 헤테로 고리 화합물, 이의 제조 방법 및 이를 포함하는 약학적 조성물
AR110963A1 (es) 2017-02-07 2019-05-22 Dae Woong Pharma Compuestos heterocíclicos, su método de preparación y composición farmacéutica que los comprende

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Publication number Priority date Publication date Assignee Title
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.
JPS57142972A (en) * 1981-02-27 1982-09-03 Otsuka Pharmaceut Co Ltd Carbostyril derivative
FR2640266B2 (fr) * 1988-07-12 1992-07-10 Synthelabo Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique
JPH0753913B2 (ja) * 1990-11-14 1995-06-07 新日本製鐵株式会社 有機複合めっき鋼板の製造方法
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FR2688504B1 (fr) * 1992-03-13 1995-05-05 Synthelabo Derives de 2-(piperidin-1-yl)ethanol, leur preparation et leur application en therapeutique.
ATE174915T1 (de) * 1994-10-31 1999-01-15 Merck Patent Gmbh Benzylpiperidinderivate mit hoher affinität zu bindungsstellen von aminosäure-rezeptoren

Also Published As

Publication number Publication date
NO954349D0 (no) 1995-10-30
SK135595A3 (en) 1996-06-05
DK0709384T3 (da) 1999-08-23
FI955184A0 (fi) 1995-10-30
GR3029771T3 (en) 1999-06-30
CZ281695A3 (en) 1996-05-15
HU9503101D0 (en) 1995-12-28
PL182210B1 (pl) 2001-11-30
JPH08225569A (ja) 1996-09-03
RU2160259C2 (ru) 2000-12-10
KR960014119A (ko) 1996-05-22
UA41927C2 (uk) 2001-10-15
NO310023B1 (no) 2001-05-07
TW394770B (en) 2000-06-21
EP0709384A1 (de) 1996-05-01
TR199501331A2 (tr) 1996-06-21
BR9505008A (pt) 1997-10-14
ATE174915T1 (de) 1999-01-15
AU703487B2 (en) 1999-03-25
NO954349L (no) 1996-05-02
EP0709384B1 (de) 1998-12-23
CA2161618A1 (en) 1996-05-01
US5698553A (en) 1997-12-16
FI955184A (fi) 1996-05-01
CN1128762A (zh) 1996-08-14
HUT76068A (en) 1997-06-30
CN1064358C (zh) 2001-04-11
DE59504622D1 (de) 1999-02-04
KR100388593B1 (ko) 2003-09-19
PL311185A1 (en) 1996-05-13
AU3443595A (en) 1996-05-09
SK282476B6 (sk) 2002-02-05
CZ288039B6 (cs) 2001-04-11

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