ES2109230T3 - Procedimiento para reticular materiales colaginosos y producto resultante. - Google Patents

Procedimiento para reticular materiales colaginosos y producto resultante.

Info

Publication number
ES2109230T3
ES2109230T3 ES90308469T ES90308469T ES2109230T3 ES 2109230 T3 ES2109230 T3 ES 2109230T3 ES 90308469 T ES90308469 T ES 90308469T ES 90308469 T ES90308469 T ES 90308469T ES 2109230 T3 ES2109230 T3 ES 2109230T3
Authority
ES
Spain
Prior art keywords
catalyst
collagous
reticulating
procedure
materials
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90308469T
Other languages
English (en)
Inventor
Gerald L Mechanic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Carolina at Chapel Hill
University of North Carolina System
Original Assignee
University of North Carolina at Chapel Hill
University of North Carolina System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/557,639 external-priority patent/US5147514A/en
Application filed by University of North Carolina at Chapel Hill, University of North Carolina System filed Critical University of North Carolina at Chapel Hill
Application granted granted Critical
Publication of ES2109230T3 publication Critical patent/ES2109230T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
    • C08H1/00—Macromolecular products derived from proteins
    • C08H1/06—Macromolecular products derived from proteins derived from horn, hoofs, hair, skin or leather

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Botany (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)

Abstract

EL PRESENTE INVENTO RELATA UN PROCESO PARA ENLAZAR CRUZADO UN MATERIAL PROTEINACEO. EL PROCESO COMPRENDE : I) REMOJAR EL MATERIAL QUE VA A SER ENLAZADO CRUZADO EN UNA SOLUCION ACUOSA DE ALTA OSMOLALIDAD; II) INCUBAR EL MATERIAL EN UN AMORTIGUADOR ACUOSO QUE INCLUYA UNA CANTIDAD DE UN CATALIZADOR FOTOOXIDATIVO, SUFICIENTE PARA CATALIZAR LA FOTOOXIDACION DEL MATERIAL; Y III) IRRADIAR EL MATERIAL Y EL CATALIZADOR DEL PASO I) CON LUZ QUE INCLUYE UN RANGO DE LONGUITUD DE ONDA SELECTIVAMENTE ABSORVIDAS POR EL CATALIZADOR. LA IRRADIACION ES EFECTUADA BAJO CONDICIONES TALES QUE, SUCEDA EL ENLACE CRUZADO DEL MATERIAL. EN OTRO CASO, EL PRESENTE INVENTO RELATA UN PRODUCTO ENLAZADO CRUZADO, PRODUCIDO POR EL METODO ANTES DESCRITO.
ES90308469T 1989-08-02 1990-08-01 Procedimiento para reticular materiales colaginosos y producto resultante. Expired - Lifetime ES2109230T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38800389A 1989-08-02 1989-08-02
US07/557,639 US5147514A (en) 1987-08-02 1990-07-30 Process for cross-linking collagenous material and resulting product

Publications (1)

Publication Number Publication Date
ES2109230T3 true ES2109230T3 (es) 1998-01-16

Family

ID=27012096

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90308469T Expired - Lifetime ES2109230T3 (es) 1989-08-02 1990-08-01 Procedimiento para reticular materiales colaginosos y producto resultante.

Country Status (6)

Country Link
US (2) US5332475A (es)
EP (1) EP0411925B1 (es)
JP (1) JP3014726B2 (es)
CA (1) CA2022480C (es)
DE (1) DE69031483T2 (es)
ES (1) ES2109230T3 (es)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6350732B1 (en) 1987-08-02 2002-02-26 Carbomedics, Inc. Method for extracting lipids from tissue samples using high osmolality storage medium and product
EP0411925B1 (en) * 1989-08-02 1997-09-24 University Of North Carolina At Chapel Hill Process for cross-linking collagenous materials and resulting product
WO1993014170A1 (en) * 1992-01-15 1993-07-22 Invente S A Method for the removal of metals from starting materials comprising proteinaceous substances as well as material obtainable according to such a method
US5800373A (en) * 1995-03-23 1998-09-01 Focal, Inc. Initiator priming for improved adherence of gels to substrates
US5714582A (en) * 1995-03-17 1998-02-03 Bioscience Consultants Invertebrate type V telopeptide collagen, methods of making, and use thereof
US6337389B1 (en) * 1995-03-17 2002-01-08 Bioscience Consultants, L.L.C. Method and process for the production of collagen preparations from invertebrate marine animals and compositions thereof
ATE369402T1 (de) 1995-03-23 2007-08-15 Genzyme Corp Redox und photoinitiatorsystem zur grundierung von verbesserter adhäsion von gelen zu substraten
US5900245A (en) * 1996-03-22 1999-05-04 Focal, Inc. Compliant tissue sealants
AU5789796A (en) * 1995-05-04 1996-11-21 Carbomedics Inc. Cross-linking of proteins, including collagen, using high os molality storage medium
DE59509135D1 (de) * 1995-10-11 2001-05-03 Sulzer Markets & Technology Ag Verfahren zu einer photooxidativen Behandlung von kollagenhaltigen Geweben
US5782931A (en) * 1996-07-30 1998-07-21 Baxter International Inc. Methods for mitigating calcification and improving durability in glutaraldehyde-fixed bioprostheses and articles manufactured by such methods
ZA978537B (en) 1996-09-23 1998-05-12 Focal Inc Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
US5958669A (en) * 1997-05-02 1999-09-28 St. Jude Medical, Inc. Apparatus and method for crosslinking to fix tissue or crosslink molecules to tissue
DE69714035T2 (de) 1997-08-14 2003-03-06 Sulzer Innotec Ag Zusammensetzung und Vorrichtung zur Reparatur von Knorpelgewebe in vivo bestehend aus Nanokapseln mit osteoinduktiven und/oder chondroinduktiven Faktoren
US6093530A (en) * 1998-02-06 2000-07-25 Sulzer Carbomedics Inc. Non-calcific biomaterial by glutaraldehyde followed by oxidative fixation
US6123731A (en) 1998-02-06 2000-09-26 Osteotech, Inc. Osteoimplant and method for its manufacture
US6187038B1 (en) 1998-04-08 2001-02-13 Sulzer Carbomedics Inc. Small bore biologic graft with therapeutic delivery system
US6156531A (en) * 1998-07-20 2000-12-05 Sulzer Carbomedics Inc. Cross-linking tissue with a compound having a C8 to C40 aliphatic chain
US6214054B1 (en) 1998-09-21 2001-04-10 Edwards Lifesciences Corporation Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby
AU760114B2 (en) 1998-09-30 2003-05-08 Medtronic, Inc. Process for reducing mineralization of tissue used in transplantation
US6361551B1 (en) * 1998-12-11 2002-03-26 C. R. Bard, Inc. Collagen hemostatic fibers
US6454787B1 (en) 1998-12-11 2002-09-24 C. R. Bard, Inc. Collagen hemostatic foam
US20020081732A1 (en) * 2000-10-18 2002-06-27 Bowlin Gary L. Electroprocessing in drug delivery and cell encapsulation
US7615373B2 (en) * 1999-02-25 2009-11-10 Virginia Commonwealth University Intellectual Property Foundation Electroprocessed collagen and tissue engineering
US6132986A (en) * 1999-04-23 2000-10-17 Sulzer Carbomedics Inc. Tissue crosslinking for bioprostheses using activated difunctional or polyfunctional acids
US6358275B1 (en) 1999-10-04 2002-03-19 Sulzer Carbomedics Inc. Tissue-derived vascular grafts and methods for making the same
US20030228288A1 (en) 1999-10-15 2003-12-11 Scarborough Nelson L. Volume maintaining osteoinductive/osteoconductive compositions
US6479079B1 (en) 1999-12-13 2002-11-12 Sulzer Carbomedics Inc. Anticalcification treatments for fixed biomaterials
US6723335B1 (en) * 2000-04-07 2004-04-20 Jeffrey William Moehlenbruck Methods and compositions for treating intervertebral disc degeneration
US9387094B2 (en) 2000-07-19 2016-07-12 Warsaw Orthopedic, Inc. Osteoimplant and method of making same
JP2004508305A (ja) * 2000-09-01 2004-03-18 ヴァージニア　コモンウェルス　ユニバーシティ　インテレクチュアル　プロパティー　ファンデーション 電気処理されたフィブリンをベースとするマトリックスおよび組織
US7323193B2 (en) 2001-12-14 2008-01-29 Osteotech, Inc. Method of making demineralized bone particles
US6933103B1 (en) * 2001-03-21 2005-08-23 Brennen Medical, Inc. Biocompatible tissue for therapeutic use and method of making same
US7078163B2 (en) * 2001-03-30 2006-07-18 Medtronic, Inc. Process for reducing mineralization of tissue used in transplantation
US20030022146A1 (en) * 2001-07-26 2003-01-30 Cunanan Crystal M. Oxidized bioprosthetic materials
WO2003030956A2 (en) 2001-10-12 2003-04-17 Osteotech, Inc. Improved bone graft
MXPA04005707A (es) * 2001-12-10 2005-06-20 Colbar Lifescience Ltd D Metodos, dispositivos, y preparaciones para tratamiento de discos intervertebrales.
US7232802B2 (en) 2001-12-21 2007-06-19 Zimmer Orthobiologics, Inc. Compositions and methods for promoting myocardial and peripheral angiogenesis
US6878168B2 (en) 2002-01-03 2005-04-12 Edwards Lifesciences Corporation Treatment of bioprosthetic tissues to mitigate post implantation calcification
US7622562B2 (en) 2002-06-26 2009-11-24 Zimmer Orthobiologics, Inc. Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
US7008763B2 (en) * 2002-09-23 2006-03-07 Cheung David T Method to treat collagenous connective tissue for implant remodeled by host cells into living tissue
CA2513055A1 (en) * 2003-01-31 2004-08-19 Zimmer Orthobiologics, Inc. Hydrogel compositions comprising nucleus pulposus tissue
US7585499B2 (en) 2003-04-10 2009-09-08 Surmodics, Inc. Method for encapsulation of cellular material using a charged initiator polymer
US7820158B2 (en) * 2003-04-10 2010-10-26 Surmodics, Inc. Ligand-coupled initiator polymers and methods of use
JP2007503292A (ja) 2003-06-11 2007-02-22 オステオテック インコーポレーテッド 骨インプラント及びその製造方法
US7955788B2 (en) * 2003-10-30 2011-06-07 Medtronic, Inc. Bioprosthetic tissue preparation with synthetic hydrogels
US8202833B2 (en) * 2003-11-26 2012-06-19 Surmodics, Inc. Composition containing biocompatible polymerization accelerator and polymerizable material
US20050266390A1 (en) * 2004-06-01 2005-12-01 Yuichiro Ueda Processes for removing cells and cell debris from tissue and tissue constructs used in transplantation and tissue reconstruction
US7393437B2 (en) * 2004-09-14 2008-07-01 The University Of Hong Kong Photochemically crosslinked collagen scaffolds and methods for their preparation
WO2007056671A1 (en) 2005-11-02 2007-05-18 Osteotech, Inc. Hemostatic bone graft
US7670762B2 (en) * 2006-01-17 2010-03-02 Brennen Medical, Llc Biocompatible tissue graft material for implant and method of making
US20080026032A1 (en) * 2006-07-27 2008-01-31 Zubery Yuval Composite implants for promoting bone regeneration and augmentation and methods for their preparation and use
CN101626682B (zh) 2006-10-27 2014-04-16 爱德华兹生命科学公司 用于外科植入的生物组织
US20080306610A1 (en) * 2007-06-07 2008-12-11 Zimmer Orthobiologics, Inc. Tissue processing for nonimmunogenic implants
US9101691B2 (en) * 2007-06-11 2015-08-11 Edwards Lifesciences Corporation Methods for pre-stressing and capping bioprosthetic tissue
US8357387B2 (en) 2007-12-21 2013-01-22 Edwards Lifesciences Corporation Capping bioprosthetic tissue to reduce calcification
WO2009099253A1 (ja) * 2008-02-07 2009-08-13 Riken 可視光硬化型接着剤
CA2742047A1 (en) 2008-10-24 2010-04-29 Warsaw Orthopedic, Inc. Compositions and methods for promoting bone formation
WO2011014563A1 (en) * 2009-07-29 2011-02-03 Vatrix Medical, Inc. Tissue stabilization for heart failure
US20110060412A1 (en) * 2009-09-08 2011-03-10 Musculoskeletal Transplant Foundation Inc. Tissue Engineered Meniscus Repair Composition
US20110059178A1 (en) * 2009-09-08 2011-03-10 Musculoskeletal Transplant Foundation Inc. Tissue Engineered Meniscus Repair Composition
DE102010001271B8 (de) * 2010-01-27 2012-12-06 Urotiss Gmbh Vernähbares Gewebetransplantatkonstrukt zur Rekonstruktion eines menschlichen oder tierischen Organs
NZ602066A (en) 2010-03-23 2013-09-27 Edwards Lifesciences Corp Methods of conditioning sheet bioprosthetic tissue
US8906601B2 (en) 2010-06-17 2014-12-09 Edwardss Lifesciences Corporation Methods for stabilizing a bioprosthetic tissue by chemical modification of antigenic carbohydrates
US8435305B2 (en) 2010-08-31 2013-05-07 Zimmer, Inc. Osteochondral graft delivery device and uses thereof
US9351829B2 (en) 2010-11-17 2016-05-31 Edwards Lifesciences Corporation Double cross-linkage process to enhance post-implantation bioprosthetic tissue durability
US10238771B2 (en) 2012-11-08 2019-03-26 Edwards Lifesciences Corporation Methods for treating bioprosthetic tissue using a nucleophile/electrophile in a catalytic system
FR3016293B1 (fr) * 2014-01-10 2019-12-20 Mbp (Mauritius) Ltd Procede de fabrication de dispositifs d'osteosynthese, dispositifs d'osteosynthese et implants en materiau hybride semi-synthetique obtenu par modification structurale des composants d'un biomateriau naturel marin
US10478309B2 (en) 2014-01-10 2019-11-19 Mbp (Mauritius) Ltd Method for producing osteosynthesis devices, osteosynthesis devices and implants made of semi-synthetic hybrid material obtained by structural modification of the components of a natural marine biomaterial

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3152976A (en) * 1961-09-21 1964-10-13 Ethicon Inc Preparation of collagenous materials
JPS5785051A (en) * 1980-11-18 1982-05-27 Toppan Printing Co Ltd Water-soluble photosensitive material
US4835258A (en) * 1986-12-24 1989-05-30 Northwestsern University Conjugation of aromatic amines or nitro-containing compounds with proteins or polypeptides by photoirradiation of the azide derivatives with ultraviolet light in order to produce antibodies against the haptens
US5147514A (en) * 1987-08-02 1992-09-15 University Of North Carolina Process for cross-linking collagenous material and resulting product
US5024742A (en) * 1988-02-24 1991-06-18 Cedars-Sinai Medical Center Method of crosslinking amino acid containing polymers using photoactivatable chemical crosslinkers
JPH0283395A (ja) * 1988-09-19 1990-03-23 Teijin Ltd 架橋した蛋白質・ペプチドの製造方法
EP0411925B1 (en) * 1989-08-02 1997-09-24 University Of North Carolina At Chapel Hill Process for cross-linking collagenous materials and resulting product

Also Published As

Publication number Publication date
US5854397A (en) 1998-12-29
JP3014726B2 (ja) 2000-02-28
US5332475A (en) 1994-07-26
EP0411925A2 (en) 1991-02-06
EP0411925A3 (en) 1991-08-14
JPH03148293A (ja) 1991-06-25
CA2022480C (en) 2001-02-27
DE69031483T2 (de) 1998-02-05
DE69031483D1 (de) 1997-10-30
EP0411925B1 (en) 1997-09-24
CA2022480A1 (en) 1991-02-03

Similar Documents

Publication Publication Date Title
ES2109230T3 (es) Procedimiento para reticular materiales colaginosos y producto resultante.
ES2179215T3 (es) Gel de acido hialuronico con enlaces cruzados fotorreticulado y procedimiento para su preparacion.
ES2106984T3 (es) Metodo para la produccion de una resina absorbente.
SE7608502L (sv) Absorberande engangsartikel
BR9005634A (pt) Processo para produzir fibras celulosicas reticuladas,individualizadas e produto obtido pelo mesmo
KR850000249A (ko) 외과용 구조재의 개질법
JPS5667581A (en) Harmful life disposal method
ES506668A0 (es) Metodo de producir embalajes de material plastico con polimero halogenado.
ES2135377T3 (es) Procedimiento para la preparacion de polimeros absorbentes.
SE8301986L (sv) Sett och anordning for att utforma perforeringar i artiklar med stangform
KR960702864A (ko) 생물학적 조성물의 살균 방법 및 이것에 의해 제조된 제품(process for the sterilization of biological compositions and the product produced thereby)
BR9001890A (pt) Processo para fabricacao de uma estopa de matriz de resina,estopa e artigo moldado por compressao
ATE146514T1 (de) Verfahren zur aufsaugen von hydrophoben und im wasser unlöslichen flüssigkeiten
MX166613B (es) Metodo para la separacion de gas por adsorcion
AR011035A1 (es) Composicion veterinaria inyectable de ivermectina de liberacion programable
ES2065974T3 (es) Agente para ensayos inmunoquimicos que contiene polimeros con contenido de grupos carboxilo.
BR9806861B1 (pt) processo para tratar e embalar, de modo asséptico, uma composição contendo proteìna.
ES2121385T3 (es) Procedimiento de produccion de una estructura absorbente y vendaje absorbente que incluye una estructura absorbente producida segun el indicado procedimiento.
EP0779320A3 (en) Process for cross-linking collagenous materials and resulting product
CN116099049A (zh) 一种改性胶原蛋白支架的制备方法及其产品和应用
ES2045838T3 (es) Procducto de ensimage de fibras de carbono para material compuesto y procedimiento para la fabricacion de este material.
AR240783A2 (es) Procedimiento de esterilizacion de materiales de embalaje para el envasado aseptico de jugos de fruta y vino
CU34427A (es) Procedimiento de peletización con caliza para minerales finos y de alta humedad de peletización
RU95119016A (ru) Способ получения сорбента из лигноцеллюлозного сырья
JPS56112907A (en) Production of polymer composition including bioactive substance

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 411925

Country of ref document: ES