ES2103809T3 - Polimeros como medios de contraste para la formacion de imagenes por resonancia magnetica. - Google Patents
Polimeros como medios de contraste para la formacion de imagenes por resonancia magnetica.Info
- Publication number
- ES2103809T3 ES2103809T3 ES91908011T ES91908011T ES2103809T3 ES 2103809 T3 ES2103809 T3 ES 2103809T3 ES 91908011 T ES91908011 T ES 91908011T ES 91908011 T ES91908011 T ES 91908011T ES 2103809 T3 ES2103809 T3 ES 2103809T3
- Authority
- ES
- Spain
- Prior art keywords
- magnetic resonance
- polymers
- images
- formation
- contrast means
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
- A61K49/105—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA the metal complex being Gd-DTPA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1803—Semi-solid preparations, e.g. ointments, gels, hydrogels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
- A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
- A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
- A61K49/1851—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule
- A61K49/1863—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule the organic macromolecular compound being a polysaccharide or derivative thereof, e.g. chitosan, chitin, cellulose, pectin, starch
Landscapes
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nanotechnology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Molecular Biology (AREA)
- High Energy & Nuclear Physics (AREA)
- Signal Processing (AREA)
- Medicinal Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Graft Or Block Polymers (AREA)
Abstract
SE DESCRIBEN MEDIOS CONTRASTANTES NUEVOS PARA SU USO EN LA FORMACION DE IMAGENES POR RESONANCIA MAGNETICA. TALES AGENTES CONTRASTANTES ESTAN FORMADOS POR POLIMEROS BIOCOMPATIBLES BIEN SOLOS BIEN EN MEZCLA CON UNO O MAS AGENTES CONTRASTANTES TALES COMO LOS AGENTES PARAMAGNETICOS, SUPERPARAMAGNETICOS O DE DENSIDAD PROTONICA. ADICIONALMENTE, SE PUEDEN MEZCLAR LOS POLIMEROS O POLIMERO Y EL AGENTE CONTRASTANTE CON UNO O MAS GASES BIOCOMPATIBLES PARA INCREMENTAR LA RELAJABILIDAD DE LA PREPARACION RESULTANTE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50712590A | 1990-04-10 | 1990-04-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2103809T3 true ES2103809T3 (es) | 1997-10-01 |
Family
ID=24017359
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91908011T Expired - Lifetime ES2103809T3 (es) | 1990-04-10 | 1991-04-09 | Polimeros como medios de contraste para la formacion de imagenes por resonancia magnetica. |
ES95111117T Expired - Lifetime ES2138122T3 (es) | 1990-04-10 | 1991-04-09 | Polimeros como medios de contraste para resonancia magnetica. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95111117T Expired - Lifetime ES2138122T3 (es) | 1990-04-10 | 1991-04-09 | Polimeros como medios de contraste para resonancia magnetica. |
Country Status (8)
Country | Link |
---|---|
EP (2) | EP0526503B1 (es) |
JP (1) | JPH05506227A (es) |
AT (2) | ATE153860T1 (es) |
DE (2) | DE69126429T2 (es) |
DK (1) | DK0526503T3 (es) |
ES (2) | ES2103809T3 (es) |
GR (1) | GR3023806T3 (es) |
WO (1) | WO1991015753A1 (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5368840A (en) * | 1990-04-10 | 1994-11-29 | Imarx Pharmaceutical Corp. | Natural polymers as contrast media for magnetic resonance imaging |
US5420176A (en) * | 1990-06-01 | 1995-05-30 | Imarx Pharmaceutical Corp. | Contrast media for ultrasonic imaging |
EP0531421B1 (en) * | 1990-06-01 | 1997-12-10 | Imarx Pharmaceutical Corp. | Contrast media for ultrasonic imaging |
US5948387A (en) * | 1990-06-01 | 1999-09-07 | Imarx Pharmaceutical Corp. | Contrast media for ultrasonic imaging |
DE4117782C2 (de) * | 1991-05-28 | 1997-07-17 | Diagnostikforschung Inst | Nanokristalline magnetische Eisenoxid-Partikel, Verfahren zu ihrer Herstellung sowie diagnostische und/oder therapeutische Mittel |
CA2121681A1 (en) * | 1991-11-19 | 1993-05-27 | Evan C. Unger | Gel particle contrast media for improved diagnostic imaging |
US5514379A (en) * | 1992-08-07 | 1996-05-07 | The General Hospital Corporation | Hydrogel compositions and methods of use |
US5323780A (en) * | 1992-08-07 | 1994-06-28 | University Of Florida Research Foundation, Inc. | Artifact-free imaging contrast agent |
DE69332952T2 (de) * | 1992-09-04 | 2004-02-19 | The General Hospital Corp., Boston | Diagnostische und therapeutische Einheiten enthaltende biokompatible Polymere |
US5871710A (en) * | 1992-09-04 | 1999-02-16 | The General Hospital Corporation | Graft co-polymer adducts of platinum (II) compounds |
US5756688A (en) * | 1992-10-14 | 1998-05-26 | Sterling Winthrop Inc. | MR imaging compositions and methods |
JPH08502300A (ja) * | 1992-10-14 | 1996-03-12 | スターリング ウィンスロップ アイエヌシー. | 治療および診断像形成組成物および方法 |
US5817292A (en) * | 1992-10-14 | 1998-10-06 | Nycomed Imaging As | MR imaging compositions and methods |
EP0664819B1 (en) * | 1992-10-14 | 1997-08-06 | Nycomed Imaging As | Chelating polymers |
US5650156A (en) * | 1993-02-22 | 1997-07-22 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of nutriceuticals and compositions useful therefor |
US5665382A (en) * | 1993-02-22 | 1997-09-09 | Vivorx Pharmaceuticals, Inc. | Methods for the preparation of pharmaceutically active agents for in vivo delivery |
US5362478A (en) * | 1993-03-26 | 1994-11-08 | Vivorx Pharmaceuticals, Inc. | Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell |
US6753006B1 (en) | 1993-02-22 | 2004-06-22 | American Bioscience, Inc. | Paclitaxel-containing formulations |
US5605672A (en) * | 1993-06-09 | 1997-02-25 | The General Hospital Corporation | Blood pool imaging composition and method of its use |
ATE187079T1 (de) | 1994-09-27 | 1999-12-15 | Nycomed Imaging As | Kontrastmittel |
US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
WO1999052564A1 (en) * | 1998-04-09 | 1999-10-21 | Nycomed Imaging A.S | Method |
DE19942278C2 (de) * | 1999-09-04 | 2001-09-13 | Messer Griesheim Gmbh | Quantitative Bestimmung des Xenongehaltes in Flüssigkeiten mit Hilfe der NMR-Spektroskopie |
DK2206736T3 (da) | 2005-12-05 | 2012-04-23 | Nitto Denko Corp | Polyglutamat-aminosyre-konjugater og fremgangsmåder |
BRPI0712066A2 (pt) * | 2006-05-17 | 2011-12-20 | Otsuka Pharma Co Ltd | meio de contraste para ressonáncia magnética usando polietilenoglicol e método para captação de imagens de ressonáncia magnética |
PT2155255E (pt) | 2007-05-09 | 2013-10-15 | Nitto Denko Corp | Composições que incluem um composto hidrofóbico e um conjugado de poliaminoácido |
KR101303567B1 (ko) * | 2011-03-08 | 2013-09-23 | 주식회사 인트론바이오테크놀로지 | 카르복실기가 도입된 만난으로 코팅된 자기공명영상 조영제 및 그것의 제조 방법 |
CN107206111B (zh) | 2014-12-31 | 2021-04-27 | 蓝瑟斯医学影像公司 | 脂质封装的气体微球组合物及相关方法 |
KR20220165808A (ko) | 2016-05-04 | 2022-12-15 | 랜티우스 메디컬 이메징, 인크. | 초음파 조영제의 제조 방법 및 장치 |
US9789210B1 (en) | 2016-07-06 | 2017-10-17 | Lantheus Medical Imaging, Inc. | Methods for making ultrasound contrast agents |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4069306A (en) * | 1974-03-14 | 1978-01-17 | Pharmacia Aktiebolag | X-ray contrast preparation containing a hydrophilic polymer containing amino groups |
US4775522A (en) * | 1983-03-04 | 1988-10-04 | Children's Hospital Research Foundation, A Division Of Children's Hospital Medical Center | NMR compositions for indirectly detecting a dissolved gas in an animal |
US4586511A (en) * | 1983-03-04 | 1986-05-06 | Children's Hospital Medical Center | Methods and compositions for detecting and imaging a gas in an animal by nuclear magnetic resonance |
DE3316703A1 (de) * | 1983-05-04 | 1984-11-08 | Schering AG, 1000 Berlin und 4709 Bergkamen | Orales kontrastmittel fuer die kernspintomographie und dessen herstellung |
GB8408127D0 (en) * | 1984-03-29 | 1984-05-10 | Nyegaard & Co As | Contrast agents |
DE3577185D1 (de) * | 1984-11-01 | 1990-05-23 | Nycomed As | Paramagnetische kontrastmittel fuer die anwendung in "in vivo" nmr-diagnostischen methoden und die herstellung davon. |
US4849210A (en) * | 1985-05-08 | 1989-07-18 | Molecular Biosystems, Inc. | Magnetic resonance imaging of liver and spleen with superparamagnetic contrast agents |
JPS62153229A (ja) * | 1985-12-27 | 1987-07-08 | Nippon Oil Co Ltd | 皮膚マ−カ− |
US4871716A (en) * | 1986-02-04 | 1989-10-03 | University Of Florida | Magnetically responsive, hydrophilic microspheres for incorporation of therapeutic substances and methods of preparation thereof |
US4729892A (en) * | 1986-03-21 | 1988-03-08 | Ciba-Geigy Corporation | Use of cross-linked hydrogel materials as image contrast agents in proton nuclear magnetic resonance tomography and tissue phantom kits containing such materials |
US4822594A (en) * | 1987-01-27 | 1989-04-18 | Gibby Wendell A | Contrast enhancing agents for magnetic resonance images |
US4933441A (en) * | 1987-01-27 | 1990-06-12 | Gibby Wendell A | Contrast enhancing agents for magnetic resonance images |
DE3709851A1 (de) * | 1987-03-24 | 1988-10-06 | Silica Gel Gmbh Adsorptions Te | Nmr-diagnostische fluessigkeitszusammensetzungen |
US4838274A (en) * | 1987-09-18 | 1989-06-13 | Air Products And Chemicals, Inc. | Perfluoro-crown ethers in fluorine magnetic resonance imaging |
GB8813425D0 (en) * | 1988-06-07 | 1988-07-13 | Hall L D | Magnetic resonance imaging |
US4925648A (en) * | 1988-07-29 | 1990-05-15 | Immunomedics, Inc. | Detection and treatment of infectious and inflammatory lesions |
US4996041A (en) * | 1988-08-19 | 1991-02-26 | Toshiyuki Arai | Method for introducing oxygen-17 into tissue for imaging in a magnetic resonance imaging system |
GB8916780D0 (en) * | 1989-07-21 | 1989-09-06 | Nycomed As | Compositions |
-
1991
- 1991-04-09 AT AT91908011T patent/ATE153860T1/de not_active IP Right Cessation
- 1991-04-09 AT AT95111117T patent/ATE185489T1/de not_active IP Right Cessation
- 1991-04-09 EP EP91908011A patent/EP0526503B1/en not_active Expired - Lifetime
- 1991-04-09 ES ES91908011T patent/ES2103809T3/es not_active Expired - Lifetime
- 1991-04-09 WO PCT/US1991/002429 patent/WO1991015753A1/en active IP Right Grant
- 1991-04-09 DE DE69126429T patent/DE69126429T2/de not_active Expired - Fee Related
- 1991-04-09 DK DK91908011.9T patent/DK0526503T3/da active
- 1991-04-09 EP EP95111117A patent/EP0693288B1/en not_active Expired - Lifetime
- 1991-04-09 ES ES95111117T patent/ES2138122T3/es not_active Expired - Lifetime
- 1991-04-09 DE DE69131721T patent/DE69131721T2/de not_active Expired - Fee Related
- 1991-04-09 JP JP91507878A patent/JPH05506227A/ja active Pending
-
1997
- 1997-06-19 GR GR970401444T patent/GR3023806T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0693288B1 (en) | 1999-10-13 |
JPH05506227A (ja) | 1993-09-16 |
EP0526503A4 (en) | 1993-02-24 |
GR3023806T3 (en) | 1997-09-30 |
EP0526503A1 (en) | 1993-02-10 |
EP0693288A1 (en) | 1996-01-24 |
DE69126429T2 (de) | 1997-10-23 |
ATE185489T1 (de) | 1999-10-15 |
EP0526503B1 (en) | 1997-06-04 |
DK0526503T3 (da) | 1997-10-27 |
DE69131721D1 (de) | 1999-11-18 |
WO1991015753A1 (en) | 1991-10-17 |
DE69131721T2 (de) | 2000-03-02 |
ATE153860T1 (de) | 1997-06-15 |
DE69126429D1 (de) | 1997-07-10 |
ES2138122T3 (es) | 2000-01-01 |
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