ES2087737T3 - Un derivado 5-o-desosaminil-eritronoluro a. - Google Patents

Un derivado 5-o-desosaminil-eritronoluro a.

Info

Publication number
ES2087737T3
ES2087737T3 ES93909403T ES93909403T ES2087737T3 ES 2087737 T3 ES2087737 T3 ES 2087737T3 ES 93909403 T ES93909403 T ES 93909403T ES 93909403 T ES93909403 T ES 93909403T ES 2087737 T3 ES2087737 T3 ES 2087737T3
Authority
ES
Spain
Prior art keywords
eritronolide
desosaminyl
derivative
methyleritronolide
acidally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93909403T
Other languages
English (en)
Inventor
Toshifumi Asaka
Masato Kashimura
Yoko Misawa
Shigeo Morimoto
Katsuo Hatayama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taisho Pharmaceutical Co Ltd
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2087737T3 publication Critical patent/ES2087737T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Abstract

UN NUEVO ANTIBIOTICO MACROLIDO QUE TIENE UNA POTENTE ACTIVIDAD ANTIBACTERIANA, DE CARBAMATO CICLICO METILERITRONOLIDA DEOXI UNA SAL DE ADICION ACIDA DEL MISMO FARMACEUTICAMENTE ACEPTABLE.
ES93909403T 1992-04-22 1993-04-21 Un derivado 5-o-desosaminil-eritronoluro a. Expired - Lifetime ES2087737T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10149292 1992-04-22

Publications (1)

Publication Number Publication Date
ES2087737T3 true ES2087737T3 (es) 1996-07-16

Family

ID=14302174

Family Applications (2)

Application Number Title Priority Date Filing Date
ES93909403T Expired - Lifetime ES2087737T3 (es) 1992-04-22 1993-04-21 Un derivado 5-o-desosaminil-eritronoluro a.
ES93909404T Expired - Lifetime ES2096915T3 (es) 1992-04-22 1993-04-21 Derivado de 5-o-desosaminileritronolida a.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES93909404T Expired - Lifetime ES2096915T3 (es) 1992-04-22 1993-04-21 Derivado de 5-o-desosaminileritronolida a.

Country Status (12)

Country Link
US (2) US5591837A (es)
EP (2) EP0638584B1 (es)
KR (2) KR100244729B1 (es)
AT (2) ATE135707T1 (es)
AU (2) AU661585B2 (es)
BR (1) BR1100235A (es)
CA (2) CA2118488C (es)
DE (2) DE69301916T2 (es)
DK (2) DK0638585T3 (es)
ES (2) ES2087737T3 (es)
GR (2) GR3019787T3 (es)
WO (2) WO1993021199A1 (es)

Families Citing this family (58)

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USRE38426E1 (en) 1995-10-09 2004-02-10 Aventis Pharma S.A. 5-O-deosaminyl 6-O-methyl erythronolide A derivatives, preparation method therefor and use thereof for preparing biologically active materials
FR2739620B1 (fr) * 1995-10-09 1997-12-19 Roussel Uclaf Nouveaux derives de la 5-0-desosaminyl 6-o-methyl erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
PT876388E (pt) * 1995-11-08 2004-07-30 Abbott Lab Derivados de eritromicina triciclica
US5747466A (en) * 1995-11-08 1998-05-05 Abbott Laboratories 3-deoxy-3-descladinose derivatives of erythromycins A and B
US6274715B1 (en) * 1995-11-08 2001-08-14 Abbott Laboratories Tricyclic erythromycin derivatives
US5750510A (en) * 1997-04-04 1998-05-12 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
KR100523679B1 (ko) * 1996-09-04 2005-10-26 아보트 러보러터리즈 항균 활성을 지닌 6-ｏ-치환된 케톨라이드
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
CN1238777A (zh) * 1996-11-27 1999-12-15 大正制药株式会社 红霉素a衍生物
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
AU4472897A (en) * 1997-03-10 1998-09-29 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
AU6421398A (en) * 1997-03-24 1998-10-20 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
AU6932098A (en) * 1997-05-09 1998-12-08 Pfizer Products Inc. Erythromycin derivatives
US5922683A (en) * 1997-05-29 1999-07-13 Abbott Laboratories Multicyclic erythromycin derivatives
MXPA99011001A (es) * 1997-05-29 2003-09-10 Abbott Lab Derivados de eritromicina multiciclicos.
US5780605A (en) * 1997-09-08 1998-07-14 Abbott Laboratories 6,9-bridged erythromycin derivatives
US5780604A (en) * 1997-09-26 1998-07-14 Abbott Laboratories 11,12-cyclic phosphite or phosphate derivatives of erythromycin and related macrolides
PA8461401A1 (es) * 1997-10-29 2000-05-24 Pfizer Prod Inc Derivados de eritromicina triciclicos
HN1998000159A (es) * 1997-10-29 1999-02-09 Monsanto Co Derivados de 9- amino - 3 ceto eritromicina
CO4990960A1 (es) * 1997-10-29 2000-12-26 Abbott Lab Derivados de cetolidos 2-halo-6-o sustituidos
US6124269A (en) * 1997-10-29 2000-09-26 Abbott Laboratories 2-Halo-6-O-substituted ketolide derivatives
FR2777282B1 (fr) * 1998-04-08 2001-04-20 Hoechst Marion Roussel Inc Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments
DK0952157T3 (da) 1998-04-24 2003-10-13 Pfizer Prod Inc 9a, 11b-dehydroderivater af 9-oxim-3-keto-6-0-methylerythromycin
US6248719B1 (en) 1998-06-03 2001-06-19 Pfizer Inc Tricyclic 3-keto derivatives of 6-O-methylerthromycin
FR2784682B1 (fr) 1998-10-15 2002-12-06 Hoechst Marion Roussel Inc Nouveaux derives 2-halogene de 5-0-desosaminylerythronolide a, leur procede de preparation et leur application comme medicaments
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
US6355620B1 (en) 1999-05-14 2002-03-12 Abbott Laboratories C-2 modified erythromycin derivatives
US6569836B2 (en) 1999-12-02 2003-05-27 Abbott Laboratories 6-O-alkyl-2-nor-2-substituted ketolide derivatives
US6946446B2 (en) 2000-02-24 2005-09-20 Abbott Laboratories Anti-infective agents useful against multidrug-resistant strains of bacteria
EP1146051A3 (en) * 2000-04-10 2001-10-31 Pfizer Products Inc. Erythromycin A derivatives
US6764998B1 (en) 2003-06-18 2004-07-20 Enanta Pharmaceuticals, Inc. 6,11-4C-bicyclic 9a-azalide derivatives
US6878691B2 (en) * 2002-05-13 2005-04-12 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
US6753318B1 (en) 2002-07-25 2004-06-22 Enanta Pharmaceuticals, Inc. 6,11-4-carbon bridged erythromycin derivatives
US7064110B2 (en) * 2002-05-13 2006-06-20 Enanta Pharmaceuticals, Inc. 6-11 bicycle ketolide derivatives
WO2005070918A1 (en) * 2002-05-13 2005-08-04 Enanta Pharmaceuticals, Inc. Process for the preparation of t-11 bicyclic erythromycin derivatives
CN1659178A (zh) * 2002-05-13 2005-08-24 英安塔制药有限公司 6、11二环红霉素衍生物
US7910558B2 (en) * 2002-05-13 2011-03-22 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
US7273853B2 (en) * 2002-05-13 2007-09-25 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
US6841664B2 (en) * 2002-07-25 2005-01-11 Enanra Pharmaceuticals, Inc. 6,11-4-carbon bridged ketolides
US7135573B2 (en) * 2002-05-13 2006-11-14 Enanta Pharmaceuticals, Inc. Processes for the preparation of O-(6-Pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine
US6645941B1 (en) 2003-03-26 2003-11-11 Enanta Pharmaceuticals, Inc. 6,11-3C-bicyclic 9a-azalide derivatives
US7276487B2 (en) * 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
US7414030B2 (en) * 2004-01-07 2008-08-19 Enanta Pharmaceuticals, Inc. 6-11 Bicyclic erythromycin derivatives
WO2005070113A2 (en) * 2004-01-09 2005-08-04 Enanta Pharmaceuticals, Inc. 9n-substituted 6-11 bicyclic erythromycin derivatives
US7163906B2 (en) * 2004-11-04 2007-01-16 Chevron Phillips Chemical Company, Llp Organochromium/metallocene combination catalysts for producing bimodal resins
US7419962B2 (en) 2004-12-07 2008-09-02 Enanta Pharmaceuticals, Inc. 3,6-bicyclolides
US7229972B2 (en) 2004-12-07 2007-06-12 Enanta Pharmaceuticals, Inc. 3,6-Bicyclolides
TW200635600A (en) 2004-12-13 2006-10-16 Enanta Pharm Inc Tetracyclic bicyclolides
WO2006065721A2 (en) 2004-12-13 2006-06-22 Enanta Pharmaceuticals, Inc. 11, 12-lactone bicyclolides
US7384922B2 (en) * 2005-05-04 2008-06-10 Enanta Pharmaceuticals, Inc. 6-11 bridged oxime erythromycin derivatives
WO2007129646A1 (ja) 2006-05-01 2007-11-15 Taisho Pharmaceutical Co., Ltd. マクロライド誘導体
US20070298811A1 (en) * 2006-06-21 2007-12-27 Lockheed Martin Corporation System for predicting bandwidth capacity
WO2009006403A2 (en) * 2007-06-29 2009-01-08 Georgia Tech Research Corporation Non-peptide macrocyclic histone deacetylase (hdac) inhibitors and methods of making and using thereof
US8871728B2 (en) 2007-06-29 2014-10-28 Georgia Tech Research Corporation Non-peptide macrocyclic histone deacetylese (HDAC) inhibitors and methods of making and using thereof
US8354383B2 (en) * 2007-09-17 2013-01-15 Enanta Pharmaceuticals, Inc. 6,11-bridged biaryl macrolides
CN101855219B (zh) * 2007-09-17 2014-06-25 英安塔制药有限公司 6，11-桥联的联芳大环内酯类
US8273720B2 (en) * 2007-09-17 2012-09-25 Enanta Pharmaceuticals, Inc. 6,11-bicyclolides: bridged biaryl macrolide derivatives
TW200946109A (en) * 2008-05-09 2009-11-16 Enanta Pharm Inc Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175150A (en) * 1985-08-31 1992-12-29 Kitasato, Kenkyusho Erythromycin derivative
US4742049A (en) * 1986-06-04 1988-05-03 Abbott Laboratories Semisynthetic erythromycin antibiotics
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of the history of erythromycin
KR0166096B1 (ko) * 1990-11-28 1999-01-15 우에하라 아키라 6-0-메틸에리쓰로마이신 a 유도체
US5523399A (en) * 1991-12-27 1996-06-04 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide derivatives

Also Published As

Publication number Publication date
DK0638585T3 (da) 1996-12-02
KR950700921A (ko) 1995-02-20
EP0638584A1 (en) 1995-02-15
WO1993021199A1 (en) 1993-10-28
GR3019787T3 (en) 1996-07-31
ATE135707T1 (de) 1996-04-15
KR0166996B1 (ko) 1999-01-15
EP0638585B1 (en) 1996-11-13
BR1100235A (pt) 2002-04-30
ES2096915T3 (es) 1997-03-16
CA2118488A1 (en) 1993-10-23
AU662420B2 (en) 1995-08-31
EP0638585A1 (en) 1995-02-15
KR950700920A (ko) 1995-02-20
US5631355A (en) 1997-05-20
GR3021992T3 (en) 1997-03-31
CA2118488C (en) 2002-11-05
DE69305987D1 (de) 1996-12-19
KR100244729B1 (ko) 2000-02-15
DE69301916D1 (de) 1996-04-25
DE69305987T2 (de) 1997-03-06
WO1993021200A1 (fr) 1993-10-28
DK0638584T3 (da) 1996-04-15
ATE145212T1 (de) 1996-11-15
DE69301916T2 (de) 1996-08-08
CA2118489A1 (en) 1993-10-23
US5591837A (en) 1997-01-07
EP0638584A4 (en) 1994-12-23
CA2118489C (en) 1999-07-13
EP0638585A4 (en) 1995-04-19
EP0638584B1 (en) 1996-03-20
AU661585B2 (en) 1995-07-27
AU4022393A (en) 1993-11-18
AU4022293A (en) 1993-11-18

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