ES2085352T3 - Metodo y composicion para el tratamiento de la trombosis en un mamifero. - Google Patents
Metodo y composicion para el tratamiento de la trombosis en un mamifero.Info
- Publication number
- ES2085352T3 ES2085352T3 ES90909024T ES90909024T ES2085352T3 ES 2085352 T3 ES2085352 T3 ES 2085352T3 ES 90909024 T ES90909024 T ES 90909024T ES 90909024 T ES90909024 T ES 90909024T ES 2085352 T3 ES2085352 T3 ES 2085352T3
- Authority
- ES
- Spain
- Prior art keywords
- mammal
- plasminogen activator
- composition
- core
- thrombosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- A61K38/166—Streptokinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Dispersion Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
UNA COMPOSICION QUE COMPRENDE UNA MULTITUD DE MICROCAPSULAS ADECUADAS PARA INYECCION PARENTERAL EN UN MAMIFERO QUE CONSTA DE UN NUCLEO CONTENIENDO ESTREPTOQUINASA, Y UNA CAPA BIOCOMPATIBLE SEMI-PERMEABLE QUE RODEA AL NUCLEO PERMITIENDO LA LIBERACION CONTROLADA DE AL MENOS UNA PORCION DE ESTREPTOQUINASA. ES UN METODO DE REDUCIR EL TIEMPO EXIGIDO PARA LA REPERFUSION DE UNA ARTERIA QUE CONTENGA UN TROMBO Y UN METODO DE REDUCIR EL REQUERIMIENTO DE DOSIS ESTANDAR DE UN ACTIVADOR PLASMINOGENO EN UN MAMIFERO COMPRENDIENDO LA INYECCION INTRAVENOSA DE UNA COMPOSICION QUE CONSTA DE UNA MULTITUD DE MICROCAPSULAS COMPUESTAS DE UN NUCLEO ACTIVADOR PLASMINOGENO MEDIANTE UNA CAPA SEMI-PERMEABLE DE LIBERACION CONTROLADA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35369389A | 1989-05-17 | 1989-05-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2085352T3 true ES2085352T3 (es) | 1996-06-01 |
Family
ID=23390149
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90909024T Expired - Lifetime ES2085352T3 (es) | 1989-05-17 | 1990-05-15 | Metodo y composicion para el tratamiento de la trombosis en un mamifero. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5503850A (es) |
EP (1) | EP0472657B1 (es) |
JP (1) | JPH05501855A (es) |
AT (1) | ATE135200T1 (es) |
AU (1) | AU635541B2 (es) |
CA (1) | CA2016949C (es) |
DE (1) | DE69025934T2 (es) |
DK (1) | DK0472657T3 (es) |
ES (1) | ES2085352T3 (es) |
WO (1) | WO1990014078A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6461640B1 (en) | 1995-12-08 | 2002-10-08 | Board Of Regents, The University Of Texas System | Local delivery of fibrinolysis enhancing agents |
KR19980067002A (ko) * | 1997-01-30 | 1998-10-15 | 김종국 | 스트렙토키나제를 리포좀에 봉입하여 얻는 혈중체류성 혈전용해제 및 그 제조방법 |
US6586011B2 (en) * | 1999-06-10 | 2003-07-01 | Southpac Trust International, Inc. | Microencapsulated plasminogen activators |
WO2003028756A2 (en) * | 2001-10-01 | 2003-04-10 | Strauss Bradley H | An in vivo animal model of chronic arterial occlusion and use of collagenase to facilitate guide wire crossing in chronic arterial occlusions |
CA2506746A1 (en) * | 2002-11-26 | 2004-06-10 | Gilead Sciences, Inc. | Method of drug loading in liposomes by gradient |
US9814672B2 (en) * | 2007-03-09 | 2017-11-14 | Susan T. Laing | Echogenic vehicle for clinical delivery of plasminogen activator and other fibrin-binding therapeutics to thrombi |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH588887A5 (es) * | 1974-07-19 | 1977-06-15 | Battelle Memorial Institute | |
US4235871A (en) * | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
JPS54147916A (en) * | 1978-05-12 | 1979-11-19 | Sumitomo Chem Co Ltd | Preparation of urokinase injection |
EP0028489B1 (en) * | 1979-11-05 | 1983-10-05 | Beecham Group Plc | Enzyme derivatives, and their preparation |
JPS574913A (en) * | 1980-06-11 | 1982-01-11 | Green Cross Corp:The | Urokinase preparation for oral administration |
US4640835A (en) * | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
JPS58222410A (ja) * | 1982-06-19 | 1983-12-24 | Mitsubishi Electric Corp | 2進デ−タの記録再生装置 |
JPS59196824A (ja) * | 1983-04-21 | 1984-11-08 | Kowa Co | 吸着防止剤 |
JPS59222410A (ja) * | 1983-06-01 | 1984-12-14 | Terumo Corp | 薬物保持リポソ−ム製剤 |
EP0143949B1 (en) * | 1983-11-01 | 1988-10-12 | TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION | Pharmaceutical composition containing urokinase |
JPS60215633A (ja) * | 1984-04-11 | 1985-10-29 | Terumo Corp | 腸管吸収性ウロキナ−ゼリポソ−ム組成物 |
JPS60155109A (ja) * | 1984-01-23 | 1985-08-15 | Terumo Corp | リポソ−ム製剤 |
EP0156169B1 (en) * | 1984-02-29 | 1991-12-18 | Asahi Kasei Kogyo Kabushiki Kaisha | An aqueous solution of a tissue plasminogen activator dissolved therein at an increased concentration and a method |
JPS60231609A (ja) * | 1984-04-28 | 1985-11-18 | Terumo Corp | リポソ−ム製剤 |
JPS61353A (ja) * | 1984-06-13 | 1986-01-06 | テルモ株式会社 | 薬剤投与装置 |
JPS6176414A (ja) * | 1984-09-21 | 1986-04-18 | Shionogi & Co Ltd | リポソーム製剤の製法 |
NL8503097A (nl) * | 1985-11-11 | 1987-06-01 | Leuven Res & Dev Vzw | Geneesmiddel met thrombolytische werking. |
KR870005646A (ko) * | 1985-12-16 | 1987-07-06 | 로버트 엘. 미니어 | 수술후 유착형성 억제방법 |
EP0451880A3 (en) * | 1986-05-15 | 1991-12-27 | Emory University | An ex vivo tissue perfusion composition and the use thereof |
US4861597A (en) * | 1986-05-20 | 1989-08-29 | Wako Pure Chemical Industries, Ltd. | Novel functionallized liposomes and a process for production thereof |
JPH01115164A (ja) * | 1987-10-28 | 1989-05-08 | Oki Electric Ind Co Ltd | 半導体装置 |
US5000887A (en) * | 1988-05-17 | 1991-03-19 | Liposome Technology, Inc. | Preparation of uniform-size liposomes |
-
1990
- 1990-05-15 WO PCT/US1990/002739 patent/WO1990014078A1/en active IP Right Grant
- 1990-05-15 ES ES90909024T patent/ES2085352T3/es not_active Expired - Lifetime
- 1990-05-15 AT AT90909024T patent/ATE135200T1/de not_active IP Right Cessation
- 1990-05-15 AU AU58105/90A patent/AU635541B2/en not_active Ceased
- 1990-05-15 EP EP90909024A patent/EP0472657B1/en not_active Expired - Lifetime
- 1990-05-15 JP JP2508509A patent/JPH05501855A/ja active Pending
- 1990-05-15 DK DK90909024.3T patent/DK0472657T3/da active
- 1990-05-15 DE DE69025934T patent/DE69025934T2/de not_active Expired - Fee Related
- 1990-05-16 CA CA002016949A patent/CA2016949C/en not_active Expired - Fee Related
-
1994
- 1994-12-09 US US08/352,975 patent/US5503850A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DK0472657T3 (da) | 1996-06-17 |
DE69025934T2 (de) | 1996-09-19 |
AU5810590A (en) | 1990-12-18 |
ATE135200T1 (de) | 1996-03-15 |
US5503850A (en) | 1996-04-02 |
WO1990014078A1 (en) | 1990-11-29 |
EP0472657A4 (en) | 1992-07-08 |
JPH05501855A (ja) | 1993-04-08 |
DE69025934D1 (de) | 1996-04-18 |
CA2016949C (en) | 1996-12-10 |
AU635541B2 (en) | 1993-03-25 |
EP0472657B1 (en) | 1996-03-13 |
EP0472657A1 (en) | 1992-03-04 |
CA2016949A1 (en) | 1990-11-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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