ES2085297T3 - Procedimiento para preparar derivados de poli(etilenglicol) y proteina modificada. - Google Patents
Procedimiento para preparar derivados de poli(etilenglicol) y proteina modificada.Info
- Publication number
- ES2085297T3 ES2085297T3 ES90109806T ES90109806T ES2085297T3 ES 2085297 T3 ES2085297 T3 ES 2085297T3 ES 90109806 T ES90109806 T ES 90109806T ES 90109806 T ES90109806 T ES 90109806T ES 2085297 T3 ES2085297 T3 ES 2085297T3
- Authority
- ES
- Spain
- Prior art keywords
- modified protein
- poly
- procedure
- ethylene glycol
- preparing derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Polymers & Plastics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
DERIVADOS DE ETILENO GLICOL DE ALTA PUREZA DE FORMULA (I) SE USAN COMO MODIFICADORES DE PROTEINA DE INTERFERONES, T-PA, EGF, VARIAS HORMONAS,ETC. LAS PROTEINAS MODIFICADAS DE ESTE MODO TIENEN ANTIGENICIDAD MINIMIZADA, PROLONGADA SEMI-VIDA PARA EL PLASMA, O TRANSFERENCIA MEJORADA PARA TEJIDOS. TAMBIEN SE DESCUBRE UN NUEVO PROCESO PARA PREPARAR DERIVADOS DE POLIETILENO GLICOL DE ALTA PUREZA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13419189 | 1989-05-27 | ||
JP13419289 | 1989-05-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2085297T3 true ES2085297T3 (es) | 1996-06-01 |
Family
ID=26468359
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90109806T Expired - Lifetime ES2085297T3 (es) | 1989-05-27 | 1990-05-23 | Procedimiento para preparar derivados de poli(etilenglicol) y proteina modificada. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0400472B1 (es) |
AT (1) | ATE136315T1 (es) |
CA (1) | CA2017543A1 (es) |
DE (1) | DE69026306T2 (es) |
DK (1) | DK0400472T3 (es) |
ES (1) | ES2085297T3 (es) |
GR (1) | GR3019991T3 (es) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2675807B1 (fr) * | 1991-04-23 | 1994-07-01 | Medgenix Group Sa | Conjugue de calcitonine et de polyethylene glycol. |
AU2147192A (en) * | 1991-06-28 | 1993-01-25 | Genentech Inc. | Method of stimulating immune response using growth hormone |
US5382657A (en) * | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
US5951974A (en) * | 1993-11-10 | 1999-09-14 | Enzon, Inc. | Interferon polymer conjugates |
US5932462A (en) * | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
TW517067B (en) | 1996-05-31 | 2003-01-11 | Hoffmann La Roche | Interferon conjugates |
RO121474B1 (ro) | 1997-06-06 | 2007-06-29 | Kyowa Hakko Kogyo Co., Ltd. | Polipeptide modificate chimic |
EP0922446A1 (en) * | 1997-12-03 | 1999-06-16 | Applied Research Systems Ars Holding N.V. | Solution-phase site-specific preparation of GRF-PEG conjugates |
WO2001051510A2 (en) | 2000-01-10 | 2001-07-19 | Maxygen Holdings Ltd | G-csf conjugates |
JP2003521930A (ja) | 2000-02-11 | 2003-07-22 | マキシゲン・エイピーエス | 第VII因子または第VIIa因子様分子 |
US6881789B2 (en) * | 2000-05-30 | 2005-04-19 | Viridis Biotech Inc. | Polyubiquitin based hydrogel and uses thereof |
CZ20032526A3 (cs) | 2001-02-27 | 2003-12-17 | Maxygen Aps | Nové molekuly podobné interferonu beta |
AU2002303869B2 (en) | 2001-05-21 | 2007-08-16 | Novartis Ag | Pulmonary administration of chemically modified insulin |
EP1517710B1 (en) | 2002-06-21 | 2011-03-30 | Novo Nordisk Health Care AG | Pegylated factor vii glycoforms |
US7553930B2 (en) | 2003-01-06 | 2009-06-30 | Xencor, Inc. | BAFF variants and methods thereof |
ATE448323T1 (de) | 2003-03-05 | 2009-11-15 | Halozyme Inc | Lösliches hyaluronidase-glycoprotein (shasegp), verfahren zu seiner herstellung, verwendungen und dieses enthaltende pharmazeutische zusammensetzungen |
US7871607B2 (en) | 2003-03-05 | 2011-01-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases |
WO2004084949A2 (en) * | 2003-03-20 | 2004-10-07 | Xencor | Generating protein pro-drugs using reversible ppg linkages |
MXPA05012313A (es) | 2003-05-12 | 2006-04-18 | Affymax Inc | Peptidos que se unen al receptor de eritropoyetina. |
DK1629007T3 (da) | 2003-05-12 | 2009-06-29 | Affymax Inc | Hidtil ukendte peptider som binder til erythropoietin-receptoren |
NZ543934A (en) | 2003-05-12 | 2008-06-30 | Affymax Inc | Novel spacer moiety for poly (ethylene glycol)-modified peptide-based compounds |
EP1626983B8 (en) * | 2003-05-12 | 2010-12-22 | Affymax, Inc. | Novel poly (ethylene glycol) modified erythropoietin agonists and uses thereof |
CN102516386A (zh) | 2003-10-10 | 2012-06-27 | 诺沃挪第克公司 | Il-21衍生物 |
EP2633866A3 (en) | 2003-10-17 | 2013-12-18 | Novo Nordisk A/S | Combination therapy |
CN103755800B (zh) | 2004-02-02 | 2016-02-24 | Ambrx公司 | 经修饰的人类生长激素多肽与其用途 |
JP2008502788A (ja) | 2004-06-08 | 2008-01-31 | アルザ コーポレイション | 4成分縮合反応による高分子コンジュゲートの調製 |
BRPI0512235A (pt) | 2004-06-18 | 2008-02-19 | Ambrx Inc | polipeptìdeos ligadores de antìgenos e seus usos |
MX2007000568A (es) * | 2004-07-16 | 2007-03-30 | Nektar Therapeutics Al Corp | Conjugados de una fraccion gm-csf y un polimero. |
EP1674113A1 (en) | 2004-12-22 | 2006-06-28 | F. Hoffmann-La Roche Ag | Conjugates of insulin-like growth factor-1 (IGF-1) and poly(ethylene glycol) |
CN103690936A (zh) | 2004-12-22 | 2014-04-02 | Ambrx公司 | 经修饰的人类生长激素 |
US7919461B2 (en) | 2005-06-03 | 2011-04-05 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
US8324159B2 (en) | 2005-06-03 | 2012-12-04 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
US7550433B2 (en) | 2005-06-03 | 2009-06-23 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
EP1893632B1 (en) | 2005-06-17 | 2015-08-12 | Novo Nordisk Health Care AG | Selective reduction and derivatization of engineered factor vii proteins comprising at least one non-native cysteine |
JP2009520949A (ja) | 2005-11-16 | 2009-05-28 | アンブルックス,インコーポレイテッド | 非天然アミノ酸を含んでいる組成物および方法 |
JP2009537609A (ja) | 2006-05-24 | 2009-10-29 | ノボ ノルディスク ヘルス ケア アーゲー | 延長されたfixアナログ及び誘導体 |
CL2007002502A1 (es) | 2006-08-31 | 2008-05-30 | Hoffmann La Roche | Variantes del factor de crecimiento similar a insulina-1 humano (igf-1) pegilados en lisina; metodo de produccion; proteina de fusion que la comprende; y su uso para tratar la enfermedad de alzheimer. |
US8552158B2 (en) | 2006-08-31 | 2013-10-08 | Hoffmann-La Roche Inc. | Method for the production of insulin-like growth factor-1 |
CN106008699A (zh) | 2006-09-08 | 2016-10-12 | Ambrx公司 | 经修饰的人类血浆多肽或Fc骨架和其用途 |
CA2682147C (en) | 2007-03-30 | 2017-08-08 | Ambrx, Inc. | Modified fgf-21 polypeptides and their uses |
NZ603812A (en) | 2007-11-20 | 2014-06-27 | Ambrx Inc | Modified insulin polypeptides and their uses |
MX2010008632A (es) | 2008-02-08 | 2010-08-30 | Ambrx Inc | Leptina-polipeptidos modificados y sus usos. |
EP2318029B1 (en) | 2008-07-23 | 2017-11-01 | Ambrx, Inc. | Modified bovine g-csf polypeptides and their uses |
CA2737040C (en) * | 2008-09-19 | 2017-05-02 | Nektar Therapeutics | Polymer conjugates of therapeutic peptides |
US20110171161A1 (en) | 2008-09-19 | 2011-07-14 | Nektar Therapeutics | Polymer conjugates of protegrin peptides |
EP2334334A1 (en) | 2008-09-19 | 2011-06-22 | Nektar Therapeutics | Polymer conjugates of nesiritide peptides |
CA2738033C (en) | 2008-09-26 | 2019-11-26 | Ambrx, Inc. | Non-natural amino acid replication-dependent microorganisms and vaccines |
KR101647164B1 (ko) | 2008-09-26 | 2016-08-09 | 암브룩스, 인코포레이티드 | 변형된 동물 에리트로포이에틴 폴리펩티드 및 이의 용도 |
RS58728B1 (sr) | 2008-12-09 | 2019-06-28 | Halozyme Inc | Produženi rastvorljivi ph20 polipeptidi i njihove upotrebe |
CN102666578A (zh) | 2009-12-21 | 2012-09-12 | Ambrx公司 | 经过修饰的猪促生长素多肽和其用途 |
PE20121707A1 (es) | 2009-12-21 | 2012-12-17 | Ambrx Inc | Polipeptidos de somatotropina bovina modificados y sus usos |
WO2011107591A1 (en) | 2010-03-05 | 2011-09-09 | Rigshospitalet | Chimeric inhibitor molecules of complement activation |
EP2569331A1 (en) | 2010-05-10 | 2013-03-20 | Perseid Therapeutics LLC | Polypeptide inhibitors of vla4 |
DK2595624T3 (en) | 2010-07-20 | 2018-03-26 | Halozyme Inc | Methods of treating or preventing adverse side effects associated with administration of an anti-hyaluronan agent |
US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
RS59193B1 (sr) | 2010-08-17 | 2019-10-31 | Ambrx Inc | Modifikovani polipeptidi relaksina i njihova primena |
TWI480288B (zh) | 2010-09-23 | 2015-04-11 | Lilly Co Eli | 牛顆粒細胞群落刺激因子及其變體之調配物 |
WO2013004607A1 (en) | 2011-07-01 | 2013-01-10 | Bayer Intellectual Property Gmbh | Relaxin fusion polypeptides and uses thereof |
US20130071394A1 (en) | 2011-09-16 | 2013-03-21 | John K. Troyer | Compositions and combinations of organophosphorus bioscavengers and hyaluronan-degrading enzymes, and methods of use |
MX342735B (es) | 2011-10-24 | 2016-10-07 | Halozyme Inc | Diagnostico acompañante para terapia con agente anti-hialuronano y metodos de uso del mismo. |
BR112014016195A2 (pt) | 2011-12-30 | 2020-10-27 | Halozyme, Inc. | variantes de polipeptídio ph20, formulações e usos das mesmas |
JP6042527B2 (ja) | 2012-04-04 | 2016-12-14 | ハロザイム インコーポレイテッド | 抗ヒアルロナン剤と腫瘍標的タキサンの組み合わせ治療 |
CN104583235B (zh) | 2012-06-08 | 2019-03-01 | 苏特罗生物制药公司 | 含位点特异非天然氨基酸残基的抗体、其制备和使用方法 |
US9732161B2 (en) | 2012-06-26 | 2017-08-15 | Sutro Biopharma, Inc. | Modified Fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use |
ES2907763T3 (es) | 2012-08-31 | 2022-04-26 | Sutro Biopharma Inc | Aminoácidos modificados que comprenden un grupo azido |
US9278124B2 (en) | 2012-10-16 | 2016-03-08 | Halozyme, Inc. | Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods |
TW201534726A (zh) | 2013-07-03 | 2015-09-16 | Halozyme Inc | 熱穩定ph20玻尿酸酶變異體及其用途 |
ES2865473T3 (es) | 2013-07-10 | 2021-10-15 | Sutro Biopharma Inc | Anticuerpos que comprenden múltiples residuos de aminoácidos no naturales sitio-específicos, métodos para su preparación y métodos de uso |
WO2015054658A1 (en) | 2013-10-11 | 2015-04-16 | Sutro Biopharma, Inc. | Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use |
TR201907471T4 (tr) | 2014-08-28 | 2019-06-21 | Halozyme Inc | Bir hiyalüronan ayrıştırıcı enzim ve bir bağışıklık kontrol noktası inhibitörüyle kombinasyon terapisi. |
TW202124419A (zh) | 2014-10-24 | 2021-07-01 | 美商必治妥美雅史谷比公司 | 經修飾之fgf-21多肽及其用途 |
WO2018148419A1 (en) | 2017-02-08 | 2018-08-16 | Bristol-Myers Squibb Company | Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof |
US20190351031A1 (en) | 2018-05-16 | 2019-11-21 | Halozyme, Inc. | Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20 |
AU2019337610A1 (en) | 2018-09-11 | 2021-05-06 | Ambrx, Inc. | Interleukin-2 polypeptide conjugates and their uses |
AU2019361206A1 (en) | 2018-10-19 | 2021-06-03 | Ambrx, Inc. | Interleukin-10 polypeptide conjugates, dimers thereof, and their uses |
MX2021009644A (es) | 2019-02-12 | 2021-09-08 | Ambrx Inc | Composiciones que contienen, metodos y usos de conjugados de anticuerpo-agonista de tlr. |
JP2023517595A (ja) | 2020-03-11 | 2023-04-26 | アンブルックス,インコーポレイテッド | インターロイキン-2ポリペプチド結合物およびその使用方法 |
AU2021327396A1 (en) | 2020-08-20 | 2023-03-23 | Ambrx, Inc. | Antibody-TLR agonist conjugates, methods and uses thereof |
IL307282A (en) | 2021-04-03 | 2023-11-01 | Ambrx Inc | Antidote conjugates against HER2 and their applications |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60156395A (ja) * | 1984-01-17 | 1985-08-16 | Mihama Hisaharu | 修飾リパーゼ |
ES8800982A1 (es) * | 1985-07-05 | 1987-12-01 | Takeda Chemical Industries Ltd | Un metodo para producir la enzima superoxido-dismutasa modificada con derivados de polietilenglicol y triazina. |
-
1990
- 1990-05-23 EP EP90109806A patent/EP0400472B1/en not_active Expired - Lifetime
- 1990-05-23 DK DK90109806.1T patent/DK0400472T3/da active
- 1990-05-23 ES ES90109806T patent/ES2085297T3/es not_active Expired - Lifetime
- 1990-05-23 DE DE69026306T patent/DE69026306T2/de not_active Expired - Fee Related
- 1990-05-23 AT AT90109806T patent/ATE136315T1/de not_active IP Right Cessation
- 1990-05-25 CA CA002017543A patent/CA2017543A1/en not_active Abandoned
-
1996
- 1996-05-20 GR GR960401366T patent/GR3019991T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE136315T1 (de) | 1996-04-15 |
CA2017543A1 (en) | 1990-11-27 |
DE69026306T2 (de) | 1996-10-17 |
EP0400472A3 (en) | 1991-06-26 |
EP0400472A2 (en) | 1990-12-05 |
DE69026306D1 (de) | 1996-05-09 |
DK0400472T3 (da) | 1996-05-13 |
EP0400472B1 (en) | 1996-04-03 |
GR3019991T3 (en) | 1996-08-31 |
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