ES2083595T3 - Derivados de indol que inhiben la biosintesis de leucotrienos. - Google Patents
Derivados de indol que inhiben la biosintesis de leucotrienos.Info
- Publication number
- ES2083595T3 ES2083595T3 ES91917405T ES91917405T ES2083595T3 ES 2083595 T3 ES2083595 T3 ES 2083595T3 ES 91917405 T ES91917405 T ES 91917405T ES 91917405 T ES91917405 T ES 91917405T ES 2083595 T3 ES2083595 T3 ES 2083595T3
- Authority
- ES
- Spain
- Prior art keywords
- pct
- leucotrene
- indol
- biosynthesis
- inhibiting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Abstract
SE PRESENTAN COMPUESTOS DE INDOLIL SUSTITUIDOS DE LA FORMULA (I) QUE SON POTENTES INHIBIDORES DE LAS ENZIMAS DE LA LIPOXIGENASA Y SON UTILES COMO AGENTES PARA AL TRATAMIENTO DE ALERGIAS Y ENFERMEDADES INFLAMATORIAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/570,248 US5095031A (en) | 1990-08-20 | 1990-08-20 | Indole derivatives which inhibit leukotriene biosynthesis |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2083595T3 true ES2083595T3 (es) | 1996-04-16 |
Family
ID=24278860
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91917405T Expired - Lifetime ES2083595T3 (es) | 1990-08-20 | 1991-08-07 | Derivados de indol que inhiben la biosintesis de leucotrienos. |
Country Status (12)
Country | Link |
---|---|
US (2) | US5095031A (es) |
EP (1) | EP0544819B1 (es) |
JP (1) | JPH06500557A (es) |
AT (1) | ATE131051T1 (es) |
CA (1) | CA2090006A1 (es) |
DE (1) | DE69115280T2 (es) |
DK (1) | DK0544819T3 (es) |
ES (1) | ES2083595T3 (es) |
GR (1) | GR3019198T3 (es) |
IE (1) | IE912855A1 (es) |
PT (1) | PT98710B (es) |
WO (1) | WO1992003132A1 (es) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5252585A (en) * | 1992-02-03 | 1993-10-12 | Merck Frosst Canada, Inc. | Fluorinated quinoline indoles as inhibitors of the biosynthesis of leukotrienes |
US5229516A (en) * | 1989-10-27 | 1993-07-20 | American Home Products Corporation | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase |
HUT64023A (en) * | 1991-03-22 | 1993-11-29 | Sandoz Ag | Process for producing aminoguanidine derivatives and pharmaceutical compositions comprising such compounds |
US5214204A (en) * | 1991-07-19 | 1993-05-25 | Abbott Laboratories | Arylamidoalkyl-n-hydroxyurea compounds having lipoxygenase inhibitory activity |
FR2680366B1 (fr) * | 1991-08-13 | 1995-01-20 | Adir | Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
US5290798A (en) * | 1991-09-30 | 1994-03-01 | Merck Frosst Canada, Inc. | (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
CA2079374C (en) * | 1991-09-30 | 2003-08-05 | Merck Frosst Canada Incorporated | (bicyclic-azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
US5190968A (en) * | 1991-09-30 | 1993-03-02 | Merck Frosst Canada, Inc. | (Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene biosynthesis |
US5308850A (en) * | 1991-09-30 | 1994-05-03 | Merck Frosst Canada, Inc. | (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
US5389650A (en) * | 1991-09-30 | 1995-02-14 | Merck Frosst Canada, Inc. | (Azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
WO1993011731A2 (en) * | 1991-12-12 | 1993-06-24 | The Trustees Of The University Of Pennsylvania | Alicyclic peptidomimetics |
CA2129429A1 (en) * | 1992-02-13 | 1993-08-14 | Richard Frenette | (azaaromaticalkoxy) indoles as inhibitors of leukotriene biosynthesis |
US5274096A (en) * | 1992-03-17 | 1993-12-28 | Merck & Co., Inc. | Hydrazine synthesis |
US5334719A (en) * | 1992-06-17 | 1994-08-02 | Merck Frosst Canada, Inc. | Bicyclic(azaaromatic)indoles as inhibitors of leukotriene bisynthesis |
CA2136241C (en) * | 1992-06-22 | 2004-01-27 | Richard Frenette | Fluorinated quinoline indoles as inhibitors of the biosynthesis of leukotrienes |
FR2692574B1 (fr) * | 1992-06-23 | 1995-06-23 | Sanofi Elf | Derives hydroxy-4 benzenethio, leur preparation ainsi que leur utilisation pour la preparation de derives aminoalkoxybenzenesulfonyles. |
DE4233100A1 (de) * | 1992-10-01 | 1994-04-07 | Hoechst Ag | Verfahren zur stereoselektiven Synthese von 3-substituierten 2-Sulfonylmethylpropionsäuren sowie Zwischenprodukte |
US5288743A (en) * | 1992-11-20 | 1994-02-22 | Abbott Laboratories | Indole carboxylate derivatives which inhibit leukotriene biosynthesis |
US5374635A (en) * | 1993-03-29 | 1994-12-20 | Merck Frosst Canada, Inc. | Furo[3,2-b]pyridines and thieno[3,2-b]pyridines as inhibitors of leukotriene biosynthesis |
US5424329A (en) * | 1993-08-18 | 1995-06-13 | Warner-Lambert Company | Indole-2-carboxamides as inhibitors of cell adhesion |
FR2734816B1 (fr) * | 1995-05-31 | 1997-07-04 | Adir | Nouveaux aryl (alkyl) propylamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US5756531A (en) * | 1996-04-30 | 1998-05-26 | Abbott Laboratories | Iminoxy derivatives of indole and indene compounds as inhibitors of prostaglandin biosynthesis |
US5750558A (en) * | 1996-06-06 | 1998-05-12 | Abbott Laboratories | Oxime derivatives of indole and indene compounds as inhibitors of prostaglandin biosynthesis |
WO1998029408A1 (fr) * | 1996-12-26 | 1998-07-09 | Nikken Chemicals Co., Ltd. | Derives de n-hydroxyuree et compositions medicinales a base de ces derives |
NZ506329A (en) * | 1998-02-25 | 2004-01-30 | Inst Genetics Llc | Inhibitors of phospholipase enzymes |
US6500853B1 (en) | 1998-02-28 | 2002-12-31 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
FR2799756B1 (fr) * | 1999-10-15 | 2001-12-14 | Adir | Nouveaux derives benzothiopheniques, benzofuraniques et indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
RU2337909C2 (ru) * | 2002-02-01 | 2008-11-10 | Ф.Хоффманн-Ля Рош Аг | Замещенные индолы и фармацевтическая композиция, обладающая агонистической активностью в отношении альфа-1a/l адренорецептора |
SE0201635D0 (sv) * | 2002-05-30 | 2002-05-30 | Astrazeneca Ab | Novel compounds |
TW200307542A (en) | 2002-05-30 | 2003-12-16 | Astrazeneca Ab | Novel compounds |
SE0202241D0 (sv) * | 2002-07-17 | 2002-07-17 | Astrazeneca Ab | Novel Compounds |
SE0301569D0 (sv) * | 2003-05-27 | 2003-05-27 | Astrazeneca Ab | Novel compounds |
SE0302232D0 (sv) * | 2003-08-18 | 2003-08-18 | Astrazeneca Ab | Novel Compounds |
SE0303180D0 (sv) * | 2003-11-26 | 2003-11-26 | Astrazeneca Ab | Novel compounds |
US20050244458A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular neuropathies |
GB0500604D0 (en) * | 2005-01-13 | 2005-02-16 | Astrazeneca Ab | Novel process |
US8399666B2 (en) * | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
US20070219206A1 (en) * | 2005-11-04 | 2007-09-20 | Amira Pharmaceuticals, Inc. | 5-lipoxygenase-activating protein (flap) inhibitors |
US20070225285A1 (en) * | 2005-11-04 | 2007-09-27 | Amira Pharmaceuticals, Inc. | 5-lipoxygenase-activating protein (flap) inhibitors |
GB2431927B (en) * | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
US20070244128A1 (en) * | 2005-11-04 | 2007-10-18 | Amira Pharmaceuticals, Inc. | 5-lipoxygenase-activating protein (flap) inhibitors |
JP2009538289A (ja) * | 2006-05-26 | 2009-11-05 | アストラゼネカ・アクチエボラーグ | ビアリールまたはヘテロアリール置換インドール |
JP2010511632A (ja) | 2006-11-30 | 2010-04-15 | アミラ ファーマシューティカルス,インコーポレーテッド | 5−リポキシゲナーゼ活性化タンパク質インヒビターおよび一酸化窒素モジュレーターを含んでいる組成物および治療法 |
US20100204282A1 (en) * | 2007-02-05 | 2010-08-12 | Hutchinson John H | Reverse indoles as 5-lipoxygenase-activating protein (FLAP) inhibitors |
TW200920369A (en) * | 2007-10-26 | 2009-05-16 | Amira Pharmaceuticals Inc | 5-lipoxygenase activating protein (flap) inhibitor |
JP5791500B2 (ja) * | 2008-05-23 | 2015-10-07 | パンミラ ファーマシューティカルズ,エルエルシー. | 5−リポキシゲナーゼ活性化タンパク質阻害剤 |
US8546431B2 (en) | 2008-10-01 | 2013-10-01 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
AU2011248175A1 (en) * | 2010-05-06 | 2012-10-25 | Merck Sharp & Dohme Corp. | Aza-Indole derivatives useful as modulators of FAAH |
WO2015120038A1 (en) | 2014-02-04 | 2015-08-13 | Bioscience Pharma Partners, Llc | Use of flap inhibitors to reduce neuroinflammation mediated injury in the central nervous system |
US10500178B2 (en) | 2015-03-13 | 2019-12-10 | The Board Of Trustees Of The Leland Stanford Junior University | LTB4 inhibition to prevent and treat human lymphedema |
WO2020003119A1 (en) | 2018-06-25 | 2020-01-02 | Suzhou Mednes Pharma Tech Co., Ltd. | Compounds and methods for treatment of hedgehog pathway associated conditions |
AU2022292554A1 (en) | 2021-06-14 | 2024-01-04 | Scorpion Therapeutics, Inc. | Urea derivatives which can be used to treat cancer |
TW202340187A (zh) * | 2021-12-20 | 2023-10-16 | 加拿大商費爾哈芬製藥公司 | Oxer1拮抗劑及其用途 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3859305A (en) * | 1970-03-10 | 1975-01-07 | Degussa | Indole aminoketones |
US3931229A (en) * | 1973-08-23 | 1976-01-06 | Warner-Lambert Company | 3-Thiomethyl-2[2-(dialkylamino)ethyl]indoles |
US4021448A (en) * | 1975-10-21 | 1977-05-03 | Sterling Drug Inc. | 2-Substituted-indole-1-lower-alkanecarboxamides |
US4119638A (en) * | 1976-11-29 | 1978-10-10 | G. D. Searle & Co. | Thio-ester of 1 (p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid |
US4464379A (en) * | 1981-06-01 | 1984-08-07 | A. Nattermann & Cie Gmbh | Indol acetic acid derivatives and anti-inflamatory and related uses thereof |
US4556672A (en) * | 1984-03-19 | 1985-12-03 | Pfizer Inc. | 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents |
US4654360A (en) * | 1984-06-01 | 1987-03-31 | Syntex (U.S.A.) Inc. | 1,2,3-trisubstituted indoles for treatment of inflammation |
US4675332A (en) * | 1984-12-10 | 1987-06-23 | Warner-Lambert Company | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents |
GB8623429D0 (en) * | 1985-10-17 | 1986-11-05 | Ici America Inc | Carboximide derivatives |
GB8707051D0 (en) * | 1986-04-15 | 1987-04-29 | Ici America Inc | Heterocyclic carboxamides |
GB8623819D0 (en) * | 1986-10-03 | 1986-11-05 | Glaxo Group Ltd | Heterocyclic compounds |
NZ222878A (en) * | 1986-12-17 | 1991-02-26 | Merck Frosst Canada Inc | 3-hetero-substituted-n-benzyl-indole derivatives, and pharmaceutical compositions |
US4873259A (en) * | 1987-06-10 | 1989-10-10 | Abbott Laboratories | Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds |
US4992464A (en) * | 1987-02-10 | 1991-02-12 | Abbott Laboratories | Heteroaryl N-hydroxy amides and ureas with polar substituents as 5-lipoxygenase inhibitors |
US5179703A (en) * | 1987-11-17 | 1993-01-12 | International Business Machines Corporation | Dynamically adaptive environment for computer programs |
NZ234883A (en) * | 1989-08-22 | 1995-01-27 | Merck Frosst Canada Inc | Quinolin-2-ylmethoxy indole derivatives, preparation and pharmaceutical compositions thereof |
IE903206A1 (en) * | 1989-09-07 | 1991-03-13 | Abbott Lab | Indole-, benzofuran-, and benzothiophene-containing¹lipoxygenase-inhibiting compounds |
-
1990
- 1990-08-20 US US07/570,248 patent/US5095031A/en not_active Expired - Fee Related
-
1991
- 1991-08-07 AT AT91917405T patent/ATE131051T1/de not_active IP Right Cessation
- 1991-08-07 US US07/969,294 patent/US5459150A/en not_active Expired - Fee Related
- 1991-08-07 WO PCT/US1991/005621 patent/WO1992003132A1/en active IP Right Grant
- 1991-08-07 DE DE69115280T patent/DE69115280T2/de not_active Expired - Fee Related
- 1991-08-07 CA CA002090006A patent/CA2090006A1/en not_active Abandoned
- 1991-08-07 DK DK91917405.2T patent/DK0544819T3/da active
- 1991-08-07 EP EP91917405A patent/EP0544819B1/en not_active Expired - Lifetime
- 1991-08-07 JP JP3516031A patent/JPH06500557A/ja active Pending
- 1991-08-07 ES ES91917405T patent/ES2083595T3/es not_active Expired - Lifetime
- 1991-08-12 IE IE285591A patent/IE912855A1/en unknown
- 1991-08-19 PT PT98710A patent/PT98710B/pt not_active IP Right Cessation
-
1996
- 1996-03-05 GR GR960400602T patent/GR3019198T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE131051T1 (de) | 1995-12-15 |
PT98710A (pt) | 1992-07-31 |
IE912855A1 (en) | 1992-02-26 |
GR3019198T3 (en) | 1996-06-30 |
WO1992003132A1 (en) | 1992-03-05 |
CA2090006A1 (en) | 1992-02-21 |
EP0544819A1 (en) | 1993-06-09 |
US5095031A (en) | 1992-03-10 |
DK0544819T3 (da) | 1996-04-09 |
EP0544819B1 (en) | 1995-12-06 |
DE69115280T2 (de) | 1996-06-13 |
DE69115280D1 (de) | 1996-01-18 |
EP0544819A4 (en) | 1993-10-20 |
PT98710B (pt) | 1999-01-29 |
US5459150A (en) | 1995-10-17 |
JPH06500557A (ja) | 1994-01-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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