ES2066794T3 - Polietilenglicolcarbaminatos. - Google Patents

Polietilenglicolcarbaminatos.

Info

Publication number
ES2066794T3
ES2066794T3 ES88810484T ES88810484T ES2066794T3 ES 2066794 T3 ES2066794 T3 ES 2066794T3 ES 88810484 T ES88810484 T ES 88810484T ES 88810484 T ES88810484 T ES 88810484T ES 2066794 T3 ES2066794 T3 ES 2066794T3
Authority
ES
Spain
Prior art keywords
formula
compounds
carbaminates
polyethylene glycol
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88810484T
Other languages
English (en)
Inventor
Heinrich Dr Peter
Theophile Moerker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Application granted granted Critical
Publication of ES2066794T3 publication Critical patent/ES2066794T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/08Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32Polymers modified by chemical after-treatment
    • C08G65/329Polymers modified by chemical after-treatment with organic compounds
    • C08G65/337Polymers modified by chemical after-treatment with organic compounds containing other elements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32Polymers modified by chemical after-treatment
    • C08G65/329Polymers modified by chemical after-treatment with organic compounds
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/24Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Phenolic Resins Or Amino Resins (AREA)

Abstract

COMPUESTO DE FORMULA (I). SIENDO A1, A2, A3 INDEPENDIENTES UNOS DE OTROS REPRESENTA HIDROGENO O UN RESTO ACILO; R ALQUILO CON HASTA CUATRO ATOMOS DE CARBONO; X UN RESTO DE LA FORMULA (II); M UN NUMERO DE 0 A 1; N UN NUMERO DE 0 A 9. EL GRUPO CARBONILO PUEDE LIGARSE CON EL OXIGENO O CON EL HIDROGENO. ADEMAS SE OBTIENE LAS SALES DEL COMPUESTO DE FORMULA (I) Y ASI COMO COMPLEJOS METALICOS DE DICHOS COMPUESTOS DE FORMULA (I). SE EMPLEAN COMO QUELATOS METALICOS O COMO MEDIOS DE AYUDA EN DIAGNOSTICOS.
ES88810484T 1987-07-23 1988-07-15 Polietilenglicolcarbaminatos. Expired - Lifetime ES2066794T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH279487 1987-07-23

Publications (1)

Publication Number Publication Date
ES2066794T3 true ES2066794T3 (es) 1995-03-16

Family

ID=4241735

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88810484T Expired - Lifetime ES2066794T3 (es) 1987-07-23 1988-07-15 Polietilenglicolcarbaminatos.

Country Status (21)

Country Link
US (3) US5185368A (es)
EP (1) EP0300969B1 (es)
JP (1) JPH0813795B2 (es)
KR (1) KR890002250A (es)
AT (1) ATE117328T1 (es)
AU (1) AU617677B2 (es)
DD (1) DD281810A5 (es)
DE (1) DE3852793D1 (es)
DK (1) DK410988A (es)
ES (1) ES2066794T3 (es)
FI (1) FI93351C (es)
HU (1) HU201517B (es)
IE (1) IE65550B1 (es)
IL (1) IL87184A (es)
MX (1) MX12394A (es)
NO (1) NO171684C (es)
NZ (1) NZ225506A (es)
PH (1) PH26779A (es)
PT (1) PT88060B (es)
YU (1) YU142188A (es)
ZA (1) ZA885336B (es)

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MX12394A (es) * 1987-07-23 1993-12-01 Ciba Geigy Ag Procedimiento par la obtencion de carbamatos de polietilenglicol.
EP0300966B1 (de) * 1987-07-23 1992-10-14 Ciba-Geigy Ag Verfahren zur selektiven N-Acylierung von Amino-hydroxamsäurederivaten und darin verwendete Ausgangsstoffe
ES2042061T3 (es) * 1988-06-08 1993-12-01 Ciba-Geigy Ag Procedimiento para la obtencion de derivados carbamoilados del acido hidroxamico.
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US5310539A (en) * 1991-04-15 1994-05-10 Board Of Regents, The University Of Texas System Melanin-based agents for image enhancement
US5254724A (en) * 1991-10-30 1993-10-19 University Of Florida Research Foundation, Inc. Method for synthesis of desferrioxamine B, analogs and homologs thereof
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US5811127A (en) 1992-06-15 1998-09-22 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US5792451A (en) 1994-03-02 1998-08-11 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5489491A (en) * 1992-07-22 1996-02-06 Golovin; Milton N. Curable polymer precursors for solid electrolytes
US5401516A (en) * 1992-12-21 1995-03-28 Emisphere Technologies, Inc. Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof
US5643957A (en) 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6610329B2 (en) * 1993-04-22 2003-08-26 Emisphere Technologies Inc. Compositions for the delivery of antigens
DE69434418T2 (de) 1993-04-22 2005-12-22 Emisphere Technologies, Inc. Orale Dareichungsform
US5709861A (en) 1993-04-22 1998-01-20 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US5958457A (en) 1993-04-22 1999-09-28 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US5605672A (en) * 1993-06-09 1997-02-25 The General Hospital Corporation Blood pool imaging composition and method of its use
IL106064A (en) * 1993-06-18 1997-11-20 Yissum Res Dev Co Gallium complexes for the treatment of free radical-induced diseases
US5618838A (en) * 1993-06-18 1997-04-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem Gallium complexes for the treatment of free radical-induced diseases
US5965121A (en) 1995-03-31 1999-10-12 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5866536A (en) 1995-03-31 1999-02-02 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6001347A (en) 1995-03-31 1999-12-14 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
CN1151836C (zh) 1995-03-31 2004-06-02 艾米斯菲尔技术有限公司 用作传送活性剂的化合物和组合物
US5989539A (en) 1995-03-31 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5650386A (en) 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
US6090958A (en) 1995-03-31 2000-07-18 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5820881A (en) 1995-04-28 1998-10-13 Emisphere Technologies, Inc. Microspheres of diamide-dicarboxylic acids
US6051258A (en) 1995-06-07 2000-04-18 Emisphere Technologies, Inc. Proteinoid emulsions and methods for preparation and use thereof
US5667806A (en) 1995-06-07 1997-09-16 Emisphere Technologies, Inc. Spray drying method and apparatus
US5824345A (en) 1995-06-07 1998-10-20 Emisphere Technologies, Inc. Fragrances and flavorants
US5750147A (en) 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
DE19681560T1 (de) 1995-09-11 1998-08-20 Emisphere Tech Inc Verfahren zur Herstellung von omega-Aminoalkansäure-Derivaten aus Cycloalkanonen
US7026116B1 (en) * 1996-04-04 2006-04-11 Bio-Rad Laboratories, Inc. Polymorphisms in the region of the human hemochromatosis gene
US6140305A (en) 1996-04-04 2000-10-31 Bio-Rad Laboratories, Inc. Hereditary hemochromatosis gene products
US6849399B1 (en) 1996-05-23 2005-02-01 Bio-Rad Laboratories, Inc. Methods and compositions for diagnosis and treatment of iron misregulation diseases
JP2000512671A (ja) 1996-06-14 2000-09-26 エミスフェアー テクノロジーズ インク マイクロカプセル化香料及び調製方法
US6060513A (en) 1997-02-07 2000-05-09 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5804688A (en) 1997-02-07 1998-09-08 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5990166A (en) 1997-02-07 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5879681A (en) 1997-02-07 1999-03-09 Emisphere Technolgies Inc. Compounds and compositions for delivering active agents
US5876710A (en) 1997-02-07 1999-03-02 Emisphere Technologies Inc. Compounds and compositions for delivering active agents
US6358504B1 (en) 1997-02-07 2002-03-19 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5939381A (en) 1997-02-07 1999-08-17 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6313088B1 (en) 1997-02-07 2001-11-06 Emisphere Technologies, Inc. 8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents
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US5962710A (en) 1997-05-09 1999-10-05 Emisphere Technologies, Inc. Method of preparing salicyloylamino acids
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DK107752C (da) * 1960-10-11 1967-07-03 Ciba Geigy Fremgangsmåde til fremstilling af trihydroxamsyrer eller salt eller metalkomplekser deraf.
US3471476A (en) * 1964-05-18 1969-10-07 Tino Gaeumann Trihydroxamic acids
US3634407A (en) * 1969-06-19 1972-01-11 Ciba Geigy Corp Heavy metal complexes of trihydroxamic acids
US4612122A (en) * 1981-06-29 1986-09-16 Clara Ambrus Removing heavy metal ions from blood
US4419365A (en) * 1981-12-21 1983-12-06 Ciba-Geigy Corporation Method of treating Alzheimer's disease
US4671901A (en) * 1984-01-26 1987-06-09 Oral-D Orally effective ion chelators
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US5089644A (en) * 1985-01-04 1992-02-18 Salutar Inc. Preparation of oxamine complexes
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MX12394A (es) * 1987-07-23 1993-12-01 Ciba Geigy Ag Procedimiento par la obtencion de carbamatos de polietilenglicol.
ES2047149T3 (es) * 1988-01-20 1994-02-16 Ciba Geigy Ag Procedimiento para la obtencion de compuestos complejos.
GB8808305D0 (en) * 1988-04-08 1988-05-11 Nycomed As Compositions
US4999445A (en) * 1988-06-10 1991-03-12 The Regents Of The University Of California Contrast agents for magnetic resonance imaging of the small intestine and hepatobiliary system
IL91047A (en) * 1989-07-19 1993-06-10 Yissum Res Dev Co Zinc complexes for the treatment of free radical- induced diseases

Also Published As

Publication number Publication date
US5424057A (en) 1995-06-13
DK410988D0 (da) 1988-07-22
ZA885336B (en) 1989-03-29
NO171684B (no) 1993-01-11
EP0300969B1 (de) 1995-01-18
ATE117328T1 (de) 1995-02-15
NZ225506A (en) 1990-12-21
NO883246D0 (no) 1988-07-21
AU1929088A (en) 1989-01-27
DK410988A (da) 1989-01-24
NO883246L (no) 1989-01-24
AU617677B2 (en) 1991-12-05
JPH0813795B2 (ja) 1996-02-14
DE3852793D1 (de) 1995-03-02
PT88060B (pt) 1995-03-01
EP0300969A2 (de) 1989-01-25
FI93351B (fi) 1994-12-15
US5328992A (en) 1994-07-12
PT88060A (pt) 1989-06-30
IE882249L (en) 1989-01-23
KR890002250A (ko) 1989-04-10
FI883470A0 (fi) 1988-07-22
DD281810A5 (de) 1990-08-22
IL87184A (en) 1993-04-04
NO171684C (no) 1993-04-21
IL87184A0 (en) 1988-12-30
JPS6447749A (en) 1989-02-22
MX12394A (es) 1993-12-01
IE65550B1 (en) 1995-11-01
FI93351C (fi) 1995-03-27
PH26779A (en) 1992-10-13
EP0300969A3 (en) 1990-12-19
FI883470A (fi) 1989-01-24
HU201517B (en) 1990-11-28
HUT47529A (en) 1989-03-28
US5185368A (en) 1993-02-09
YU142188A (en) 1990-04-30

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