ES2058219T3 - Lineas celulares transfectadas que expresan el receptor principal del rinovirus humano. - Google Patents
Lineas celulares transfectadas que expresan el receptor principal del rinovirus humano.Info
- Publication number
- ES2058219T3 ES2058219T3 ES88119774T ES88119774T ES2058219T3 ES 2058219 T3 ES2058219 T3 ES 2058219T3 ES 88119774 T ES88119774 T ES 88119774T ES 88119774 T ES88119774 T ES 88119774T ES 2058219 T3 ES2058219 T3 ES 2058219T3
- Authority
- ES
- Spain
- Prior art keywords
- cell lines
- human
- receptor protein
- express
- human rhinovirus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32711—Rhinovirus
- C12N2770/32722—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Inert Electrodes (AREA)
- Electrophonic Musical Instruments (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
LAS LINEAS DE CALCULOS DE MACUSFEROS NO FUMANOS QUE REPRESENTAN LA MAYOR PROTEINA RECEPTORA DE SINOVIRUS HUMANO. LAS LINEAS DE CALCULOS ESTAN PREPARADAS POR LA TRANSFECCION DE GUIAS DE DNA HUMANO, TAL COMO DNA DE ALULE HELA, EN CELULAS DE MAMIFEROS NO HUMANOS, TAL COMO CELULAS DE RATON. LOS TRANSFECTANTES PRIMARIOS PUEDEN SER TRANSFECTADO EN CELULAS ADICIONALES DE MAMIFEROS NO HUMANOS PARA PRODUCIR TRANSFECTANTES SECUNDARIOS. LA CLORIZACION DE LOS TRANSFECTANTES SECUNDARIOS PLRODUCEN LINEAS DE CELULAS QUE PRESENTAN UNA REPRESENTACION AUMENTADA DE LA PROTEINA RECEPTORA DE SINOVIRUS HUMANO E INMUNOGENES PARA PRODUCIR ANTICUERPOS, SU PARTICULAR ANTICUERPOS NONOCLONALES, CONTRA LA PROTEINA RECEPTORA. UN METODO GENERAL PARA CRIBAR CANDIDATOS DE DROGAS POR SU FACULTAD PARA BLOQUEAR EL ENLAZADOR DESLIGANTE A LA PROTEINA RECEPTORA SUPERFICIAL DE CELULAS HUMANAS ES TAMBIEN PROPORCIONADO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13037887A | 1987-12-08 | 1987-12-08 | |
US26257088A | 1988-10-25 | 1988-10-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2058219T3 true ES2058219T3 (es) | 1994-11-01 |
Family
ID=26828436
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88119774T Expired - Lifetime ES2058219T3 (es) | 1987-12-08 | 1988-11-28 | Lineas celulares transfectadas que expresan el receptor principal del rinovirus humano. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0319815B1 (es) |
JP (1) | JPH0242977A (es) |
AT (1) | ATE110771T1 (es) |
AU (1) | AU623105B2 (es) |
CA (1) | CA1341055C (es) |
DE (1) | DE3851309T2 (es) |
ES (1) | ES2058219T3 (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5831036A (en) * | 1987-05-04 | 1998-11-03 | Dana Farber Cancer Institute | Soluble fragments of human intercellular adhesion molecule-1 |
US5284931A (en) * | 1987-05-04 | 1994-02-08 | Dana Farber Cancer Institute | Intercellular adhesion molecules, and their binding ligands |
US7354588B1 (en) | 1987-05-04 | 2008-04-08 | Dana Farber Cancer Institute | Functional derivatives of ICAM-1 with altered ability to bind LFA-1 or HRV |
US5336603A (en) * | 1987-10-02 | 1994-08-09 | Genentech, Inc. | CD4 adheson variants |
US6710169B2 (en) | 1987-10-02 | 2004-03-23 | Genentech, Inc. | Adheson variants |
US6514936B1 (en) | 1988-09-01 | 2003-02-04 | Bayer Corporation | Antiviral methods using human rhinovirus receptor (ICAM-1) |
ZA896668B (en) * | 1988-09-01 | 1990-06-27 | Molecular Therapeutics Inc | A human rhinovirus receptor protein that inhibits virus infectivity |
US6143298A (en) * | 1988-09-01 | 2000-11-07 | Bayer Corporation | Soluble truncated forms of ICAM-1 |
ES2141076T3 (es) | 1988-09-01 | 2000-03-16 | Bayer Ag | Proteina del receptor de rinovirus humano que inhibe la infectividad del virus. |
US6051231A (en) * | 1988-09-01 | 2000-04-18 | Bayer Corporation | Antiviral methods and prepations |
ES2077572T3 (es) * | 1988-09-28 | 1995-12-01 | Dana Farber Cancer Inst Inc | Moleculas de adhesion intercelular, y sus ligandos de fijacion. |
NO900155L (no) * | 1989-01-24 | 1990-07-25 | Molecular Therapeutics Inc | Et opploeselig molekyl som er relatert til, men forskjellig fra icam-1. |
CA2008368C (en) * | 1989-01-24 | 2003-04-08 | Jeffrey Greve | Soluble molecule related to but distinct from icam-1 |
US5235049A (en) * | 1989-01-24 | 1993-08-10 | Molecular Therapeutics, Inc. | Nucleic acid sequences encoding a soluble molecule (SICAM-1) related to but distinct from ICAM-1 |
EP0387701B1 (en) * | 1989-03-09 | 1992-08-12 | Boehringer Ingelheim Pharmaceuticals Inc. | Use of intercellular adhesion molecules, and their binding ligands in the treatment of asthma |
US6797270B1 (en) | 1989-03-16 | 2004-09-28 | Center For Blood Research, Inc. | Functional derivatives of the intercellular adhesion molecule ICAM-1 in anti-viral therapy |
US6777191B1 (en) | 1989-03-16 | 2004-08-17 | Center For Blood Research, Inc. | Use of functional derivatives of the intercellular adhesion molecule ICAM-1 in diagnosis of viral infection |
DE69029528T2 (de) * | 1989-03-16 | 1997-06-26 | Blood Res Center | Verwendung von funkionellen Derivaten des Interzellulär-Adhäsions-Moleküls ICAM-1 in einer Antivirus-Therapie |
US5674982A (en) * | 1990-07-20 | 1997-10-07 | Bayer Corporation | Multimeric form of human rhinovirus receptor protein |
US5871733A (en) * | 1990-07-20 | 1999-02-16 | Bayer Corporation | Multimeric forms of human rhinovirus receptor protein |
DE69131564T2 (de) * | 1990-07-20 | 2000-01-13 | Bayer Ag | Multimere Formen des menschlichen Rhinovirus-Rezeptorproteins |
US6107461A (en) * | 1990-07-20 | 2000-08-22 | Bayer Corporation | Multimeric forms of human rhinovirus receptor and fragments thereof, and method of use |
US6130202A (en) * | 1990-07-20 | 2000-10-10 | Bayer Corporation | Antiviral methods |
EP0510483A1 (en) * | 1991-04-22 | 1992-10-28 | Boehringer Ingelheim Pharmaceuticals Inc. | Method for the detection of viruses |
US7241569B2 (en) | 1993-01-18 | 2007-07-10 | Olympus Corporation | Method and a device for the evaluation of biopolymer fitness |
WO1994016313A2 (de) * | 1993-01-18 | 1994-07-21 | Evotec Biosystems Gmbh | Verfahren und vorrichtung zur bewertung der fitness von biopolymeren |
CN113402601A (zh) * | 2021-06-09 | 2021-09-17 | 河南中泽生物工程有限公司 | 一种抗非洲猪瘟病毒p54蛋白单克隆抗体的制备方法及应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2432170A1 (fr) * | 1978-06-12 | 1980-02-22 | Corning Glass Works | Procede de mesure de recepteurs d'antigene sur des membranes de cellules |
EP0169146A3 (en) * | 1984-07-20 | 1988-07-20 | Merck & Co. Inc. | Monoclonal antibodies directed against the cellular receptor of human rhinovirus |
EP0169729A3 (en) * | 1984-07-23 | 1988-08-03 | Becton Dickinson and Company | Recovery of cell receptors |
DE3712678A1 (de) * | 1987-04-14 | 1988-10-27 | Boehringer Ingelheim Int | Rezeptor der kleinen rhinovirus rezeptor gruppe |
US4893075A (en) * | 1988-08-29 | 1990-01-09 | Eaton Corporation | Dual speed sensor pickup assembly with anti-cross talk coils |
-
1988
- 1988-11-25 CA CA000584200A patent/CA1341055C/en not_active Expired - Fee Related
- 1988-11-28 EP EP88119774A patent/EP0319815B1/en not_active Expired - Lifetime
- 1988-11-28 AT AT88119774T patent/ATE110771T1/de not_active IP Right Cessation
- 1988-11-28 ES ES88119774T patent/ES2058219T3/es not_active Expired - Lifetime
- 1988-11-28 DE DE3851309T patent/DE3851309T2/de not_active Expired - Fee Related
- 1988-12-06 AU AU26594/88A patent/AU623105B2/en not_active Ceased
- 1988-12-08 JP JP63311007A patent/JPH0242977A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU623105B2 (en) | 1992-05-07 |
AU2659488A (en) | 1989-06-08 |
CA1341055C (en) | 2000-07-18 |
EP0319815B1 (en) | 1994-08-31 |
JPH0242977A (ja) | 1990-02-13 |
EP0319815A2 (en) | 1989-06-14 |
DE3851309T2 (de) | 1994-12-22 |
EP0319815A3 (en) | 1989-09-27 |
DE3851309D1 (de) | 1994-10-06 |
ATE110771T1 (de) | 1994-09-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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