ES2057043T5 - Procedimiento para la micronizacion de glibenclamida. - Google Patents
Procedimiento para la micronizacion de glibenclamida.Info
- Publication number
- ES2057043T5 ES2057043T5 ES89117998T ES89117998T ES2057043T5 ES 2057043 T5 ES2057043 T5 ES 2057043T5 ES 89117998 T ES89117998 T ES 89117998T ES 89117998 T ES89117998 T ES 89117998T ES 2057043 T5 ES2057043 T5 ES 2057043T5
- Authority
- ES
- Spain
- Prior art keywords
- glibenclamide
- micronization
- procedure
- microfine
- entails
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/59—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cephalosporin Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
SE DESCRIBE UN PROCEDIMIENTO PARA LA ELABORACION DE UNA FORMA MICRONIZADA DE GLIBENCLAMIDA DON FORMULA (I) CON UNA SUPERFICIE DE PARTICULAS ACTIVAS DE POR LE MENOS M (AL CUADRADO) /G DSEGUN BET. PARA ELLO, SE ACIDULA CON UN ACIDO LA SUSPENSION EN AGUA DE UNA SAL POCO SOLUBLE DE LA GLIBENCLAMIDA, CON LO QUE SE ORIGINA EL PRECIPITADO DE GLIBENCLAMIDA MICROFINA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3833439A DE3833439A1 (de) | 1988-10-01 | 1988-10-01 | Verfahren zur mikronisierung von glibenclamid |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2057043T3 ES2057043T3 (es) | 1994-10-16 |
ES2057043T5 true ES2057043T5 (es) | 1996-11-01 |
Family
ID=6364187
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89117998T Expired - Lifetime ES2057043T5 (es) | 1988-10-01 | 1989-09-28 | Procedimiento para la micronizacion de glibenclamida. |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0362704B2 (es) |
JP (1) | JPH02149516A (es) |
AT (1) | ATE89268T1 (es) |
AU (1) | AU620448B2 (es) |
DE (2) | DE3833439A1 (es) |
ES (1) | ES2057043T5 (es) |
FI (1) | FI894598A (es) |
GR (1) | GR3020754T3 (es) |
NZ (1) | NZ230828A (es) |
PT (1) | PT91835A (es) |
ZA (1) | ZA897421B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE250418T1 (de) | 1998-07-15 | 2003-10-15 | Merck Sante Sas | Tabletten enthaltend eine kombination von glibenclamid und metformin |
US6586438B2 (en) | 1999-11-03 | 2003-07-01 | Bristol-Myers Squibb Co. | Antidiabetic formulation and method |
HU229352B1 (en) * | 1999-11-03 | 2013-11-28 | Bristol Myers Squibb Co | Medicament comprising the combination of metformin and glyburide |
US20010036479A1 (en) | 2000-01-14 | 2001-11-01 | Gillian Cave | Glyburide composition |
WO2009073711A1 (en) | 2007-12-04 | 2009-06-11 | Remedy Pharmaceuticals, Inc. | Improved formulations and methods for lyophilization and lyophilates provided thereby |
DE102008000351B4 (de) | 2008-02-20 | 2017-08-10 | Aristo Pharma Gmbh | Verfahren zur Herstellung eines Ebastin enthaltenden Granulats sowie einer festen pharmazeutischen Zusammensetzung, Ebastin enthaltendes Granulat und dessen Verwendung |
FR2987268B1 (fr) | 2012-02-28 | 2014-07-11 | Ammtek | Formulations liquides de sulfamides hypoglycemiants |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DD91647A (es) * | ||||
DE1301812B (de) * | 1965-07-27 | 1969-08-28 | Hoechst Ag | Verfahren zur Herstellung von Benzolsulfonylharnstoffen |
CA889876A (en) * | 1970-09-10 | 1972-01-04 | Frank W. Horner Limited | Purification of glyburide |
NL7314765A (es) * | 1972-10-31 | 1974-05-02 | ||
DE2348334C2 (de) * | 1973-09-26 | 1982-11-11 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue Zubereitungsform des N-4-[2-(5-Chlor-2-methoxybenzamido)äthyl]- phenyl-sulfonyl-N'-cyclohexylharnstoffs |
DD204915B1 (de) * | 1981-12-16 | 1986-05-07 | Goldner Richard | Verfahren zur herstellung von reinem n-(4-(beta- geschweifte klammer auf 2-methoxy-5-chlor-benzamido geschweifte klammer zu -aethyl)-phenylsulfonyl)-n'-cyclohexylharnstoff |
DD248115A1 (de) * | 1984-04-11 | 1987-07-29 | Dresden Arzneimittel | Verfahren zur herstellung von n-(4-(ss- 5-chlor-2-methoxy-benzamido -ethyl)-phenylsulfonyl)-n'-cyclohexylharnstoff in feiner verteilung |
RO89209A2 (ro) * | 1984-06-12 | 1986-05-30 | Intreprinderea De Medicamente Si Coloranti"Sintofarm",Ro | Procedeu pentru obtinerea de glibenclamid sub forma de microparticule |
-
1988
- 1988-10-01 DE DE3833439A patent/DE3833439A1/de not_active Withdrawn
-
1989
- 1989-09-28 FI FI894598A patent/FI894598A/fi not_active Application Discontinuation
- 1989-09-28 EP EP89117998A patent/EP0362704B2/de not_active Expired - Lifetime
- 1989-09-28 AU AU42302/89A patent/AU620448B2/en not_active Ceased
- 1989-09-28 AT AT89117998T patent/ATE89268T1/de not_active IP Right Cessation
- 1989-09-28 DE DE8989117998T patent/DE58904332D1/de not_active Expired - Lifetime
- 1989-09-28 ES ES89117998T patent/ES2057043T5/es not_active Expired - Lifetime
- 1989-09-28 PT PT91835A patent/PT91835A/pt unknown
- 1989-09-29 ZA ZA897421A patent/ZA897421B/xx unknown
- 1989-09-29 JP JP1252475A patent/JPH02149516A/ja active Pending
- 1989-09-29 NZ NZ230828A patent/NZ230828A/en unknown
-
1996
- 1996-08-08 GR GR960401977T patent/GR3020754T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ZA897421B (en) | 1990-06-27 |
ATE89268T1 (de) | 1993-05-15 |
EP0362704B1 (de) | 1993-05-12 |
PT91835A (pt) | 1990-04-30 |
EP0362704B2 (de) | 1996-08-07 |
AU620448B2 (en) | 1992-02-20 |
ES2057043T3 (es) | 1994-10-16 |
EP0362704A1 (de) | 1990-04-11 |
AU4230289A (en) | 1990-04-05 |
JPH02149516A (ja) | 1990-06-08 |
DE3833439A1 (de) | 1991-09-12 |
DE58904332D1 (de) | 1993-06-17 |
GR3020754T3 (en) | 1996-11-30 |
NZ230828A (en) | 1991-07-26 |
FI894598A (fi) | 1990-04-02 |
FI894598A0 (fi) | 1989-09-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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