ZA897421B - Process for the micronization of glibenolamide - Google Patents

Process for the micronization of glibenolamide

Info

Publication number
ZA897421B
ZA897421B ZA897421A ZA897421A ZA897421B ZA 897421 B ZA897421 B ZA 897421B ZA 897421 A ZA897421 A ZA 897421A ZA 897421 A ZA897421 A ZA 897421A ZA 897421 B ZA897421 B ZA 897421B
Authority
ZA
South Africa
Prior art keywords
glibenclamide
glibenolamide
micronization
microfine
entails
Prior art date
Application number
ZA897421A
Inventor
Ottmar Jaenicke
Jaenicke Ottmar
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6364187&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA897421(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ZA897421B publication Critical patent/ZA897421B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
    • C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/59—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to carbon atoms of rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

A process for preparing a micronised form of glibenclamide of the formula <IMAGE> with a BET surface area of the active compound particles of at least 3 m<2>/g is described. It entails a suspension of a sparingly soluble salt of glibenclamide in water being acidified with an acid. The result is a microfine precipitate of glibenclamide.
ZA897421A 1988-10-01 1989-09-29 Process for the micronization of glibenolamide ZA897421B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3833439A DE3833439A1 (en) 1988-10-01 1988-10-01 METHOD FOR MICRONIZING GLIBENCLAMIDE

Publications (1)

Publication Number Publication Date
ZA897421B true ZA897421B (en) 1990-06-27

Family

ID=6364187

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA897421A ZA897421B (en) 1988-10-01 1989-09-29 Process for the micronization of glibenolamide

Country Status (11)

Country Link
EP (1) EP0362704B2 (en)
JP (1) JPH02149516A (en)
AT (1) ATE89268T1 (en)
AU (1) AU620448B2 (en)
DE (2) DE3833439A1 (en)
ES (1) ES2057043T5 (en)
FI (1) FI894598A (en)
GR (1) GR3020754T3 (en)
NZ (1) NZ230828A (en)
PT (1) PT91835A (en)
ZA (1) ZA897421B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE250418T1 (en) 1998-07-15 2003-10-15 Merck Sante Sas TABLETS CONTAINING A COMBINATION OF GLIBENCLAMIDE AND METFORMIN
US6586438B2 (en) 1999-11-03 2003-07-01 Bristol-Myers Squibb Co. Antidiabetic formulation and method
HU229352B1 (en) * 1999-11-03 2013-11-28 Bristol Myers Squibb Co Medicament comprising the combination of metformin and glyburide
US20010036479A1 (en) 2000-01-14 2001-11-01 Gillian Cave Glyburide composition
WO2009073711A1 (en) 2007-12-04 2009-06-11 Remedy Pharmaceuticals, Inc. Improved formulations and methods for lyophilization and lyophilates provided thereby
DE102008000351B4 (en) 2008-02-20 2017-08-10 Aristo Pharma Gmbh Process for the preparation of an ebastine-containing granule and a solid pharmaceutical composition, ebastine-containing granules and its use
FR2987268B1 (en) 2012-02-28 2014-07-11 Ammtek LIQUID FORMULATIONS OF HYPOGLYCEMIC SULFAMIDES

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD91647A (en) *
DE1301812B (en) * 1965-07-27 1969-08-28 Hoechst Ag Process for the preparation of benzenesulfonylureas
CA889876A (en) * 1970-09-10 1972-01-04 Frank W. Horner Limited Purification of glyburide
NL7314765A (en) * 1972-10-31 1974-05-02
DE2348334C2 (en) * 1973-09-26 1982-11-11 Boehringer Mannheim Gmbh, 6800 Mannheim New form of preparation of N-4- [2- (5-chloro-2-methoxybenzamido) ethyl] -phenyl-sulfonyl-N'-cyclohexylurea
DD204915B1 (en) * 1981-12-16 1986-05-07 Goldner Richard METHOD OF PREPARING PURE N- (4- (BETA-WELDED BRACKET ON 2-METHOXY-5-CHLORO-BENZAMIDO WELDED BRACKET TO -ETHYL) -PHENYLSULFONYL) -N'-CYCLOHEXYL HARDILLARY
DD248115A1 (en) * 1984-04-11 1987-07-29 Dresden Arzneimittel METHOD OF PREPARING N- (4- (SS-5-CHLORO-2-METHOXY-BENZAMIDO-ETHHYL) -PHENYLSULFONYL) -N'-CYCLOHEXYL HARNON IN FINE DISTRIBUTION
RO89209A2 (en) * 1984-06-12 1986-05-30 Intreprinderea De Medicamente Si Coloranti"Sintofarm",Ro PROCESS FOR OBTAINING GLYBENCLAMIDE

Also Published As

Publication number Publication date
ATE89268T1 (en) 1993-05-15
EP0362704B1 (en) 1993-05-12
PT91835A (en) 1990-04-30
EP0362704B2 (en) 1996-08-07
AU620448B2 (en) 1992-02-20
ES2057043T3 (en) 1994-10-16
EP0362704A1 (en) 1990-04-11
AU4230289A (en) 1990-04-05
JPH02149516A (en) 1990-06-08
DE3833439A1 (en) 1991-09-12
DE58904332D1 (en) 1993-06-17
ES2057043T5 (en) 1996-11-01
GR3020754T3 (en) 1996-11-30
NZ230828A (en) 1991-07-26
FI894598A (en) 1990-04-02
FI894598A0 (en) 1989-09-28

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