ES2045027T3 - Igm purificadas. - Google Patents

Igm purificadas.

Info

Publication number
ES2045027T3
ES2045027T3 ES88111931T ES88111931T ES2045027T3 ES 2045027 T3 ES2045027 T3 ES 2045027T3 ES 88111931 T ES88111931 T ES 88111931T ES 88111931 T ES88111931 T ES 88111931T ES 2045027 T3 ES2045027 T3 ES 2045027T3
Authority
ES
Spain
Prior art keywords
igm
antibodies
less
nucleic acid
acid content
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88111931T
Other languages
English (en)
Inventor
George Dove
Gautam Mitra
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Inc filed Critical Miles Inc
Application granted granted Critical
Publication of ES2045027T3 publication Critical patent/ES2045027T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1214—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pseudomonadaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Detergent Compositions (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

SE PRESENTA UNA PREPARACION DE ANTICUERPO ESENCIALMENTE PURO Y ESTABILIZADO QUE COMPRENDE ANTICUERPOS IGM QUE TIENEN UNA PUREZA SUPERIOR AL 98% DE SU PESO Y UN CONTENIDO DE ACIDO NUCLEICO INFERIOR A 200 PG POR MG DE IGM. EN UNA DE SUS CONFIGURACIONES LOS ANTICUERPOS DE IGM DE UNA FUENTE MONOCLONAL ESTAN SUJETOS AL INTERCAMBIO DE IONES Y A LA EXCLUSION CROMATOGRAFICA EN UN PH ALCALINO PARA DAR UN IGM PURIFICADO QUE TIENE UN CONTENIDO DE ACIDO NUCLEICO MENOR DE 10 PG / MG DE IGM, PREFERIBLEMENTE MENOR QUE 4 PG / MG IGM. SE HA DESCUBIERTO UNA PREPARACION ESTABILIZADA Y ALTAMENTE PURIFICADA DE ANTICUERPOS ANTI "PSEUDOMONAS AERUGINOSA".
ES88111931T 1987-08-10 1988-07-25 Igm purificadas. Expired - Lifetime ES2045027T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8313687A 1987-08-10 1987-08-10

Publications (1)

Publication Number Publication Date
ES2045027T3 true ES2045027T3 (es) 1994-01-16

Family

ID=22176414

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88111931T Expired - Lifetime ES2045027T3 (es) 1987-08-10 1988-07-25 Igm purificadas.

Country Status (8)

Country Link
EP (1) EP0303088B1 (es)
JP (1) JP2730913B2 (es)
AT (1) ATE82136T1 (es)
AU (1) AU618745B2 (es)
CA (1) CA1341474C (es)
DE (1) DE3875852T2 (es)
ES (1) ES2045027T3 (es)
GR (1) GR3006536T3 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01197500A (ja) * 1988-01-29 1989-08-09 Sumitomo Chem Co Ltd ヒトモノクローナル抗体
DE3825429C2 (de) * 1988-07-27 1994-02-10 Biotest Pharma Gmbh Verfahren zur Herstellung eines intravenös verabreichbaren polyklonalen Immunglobulin-Präparates mit hohem IgM-Gehalt
EP0382031A3 (en) * 1989-02-10 1991-06-26 Miles Inc. Monoclonal antibodies in immune serum globulin
CA2049342A1 (en) * 1989-03-27 1990-09-28 Sally Bolmer Formulations for stabilizing of igm antibodies
JPH05507924A (ja) * 1990-07-03 1993-11-11 アクゾ・エヌ・ヴエー 免疫反応性化合物
JPH0565233A (ja) * 1991-03-08 1993-03-19 Mitsui Toatsu Chem Inc モノクローナル抗体含有凍結乾燥製剤
EP0852951A1 (de) 1996-11-19 1998-07-15 Roche Diagnostics GmbH Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern
EP1428537B1 (en) 2001-08-29 2008-11-19 Chugai Seiyaku Kabushiki Kaisha Stabilized preparations containing antibody
JP5452835B2 (ja) 2003-07-15 2014-03-26 中外製薬株式会社 形質転換細胞によるＩｇＭの産生とその定量方法
JP4671864B2 (ja) 2003-10-09 2011-04-20 中外製薬株式会社 タンパク質溶液の安定化方法
ATE518888T1 (de) 2003-10-09 2011-08-15 Chugai Pharmaceutical Co Ltd Stabilisierte lösung mit hoher igm-konzentration
CN102811737A (zh) * 2010-01-29 2012-12-05 阿克西斯股份有限公司 骨关节炎治疗及预防药物组合物和上述组合物的制造方法
US10570194B2 (en) 2015-08-06 2020-02-25 Grifols Worldwide Operations Limited Method for treating infectious diseases using a composition comprising plasma-derived immunoglobulin M (IgM)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS591691B2 (ja) * 1981-05-29 1984-01-13 株式会社ミドリ十字 静注用γ−グロブリン製剤
JPS59184133A (ja) * 1983-04-01 1984-10-19 Teijin Ltd ＩｇＭの調製法
US4604235A (en) * 1984-05-23 1986-08-05 J. T. Baker Chemical Company Purification of monoclonal antibodies
US4834975A (en) * 1984-05-25 1989-05-30 Genetics Corporation Human monoclonal antibodies to serotypic lipopolysaccharide determinants on gram-negative bacteria and their production
JPH0669961B2 (ja) * 1984-09-25 1994-09-07 株式会社ミドリ十字 免疫グロブリンの加熱処理方法

Also Published As

Publication number Publication date
ATE82136T1 (de) 1992-11-15
DE3875852D1 (de) 1992-12-17
AU2031588A (en) 1989-06-08
GR3006536T3 (es) 1993-06-30
JP2730913B2 (ja) 1998-03-25
EP0303088A3 (en) 1989-05-17
JPH02493A (ja) 1990-01-05
CA1341474C (en) 2005-03-08
DE3875852T2 (de) 1993-03-18
AU618745B2 (en) 1992-01-09
EP0303088B1 (en) 1992-11-11
EP0303088A2 (en) 1989-02-15

Similar Documents

Publication Publication Date Title
ES2045027T3 (es) Igm purificadas.
AU590896B2 (en) Improved formulations for recombinant beta-interferon
EP0391526A3 (en) Antibody purification process
ES2071628T3 (es) Separacion de proteina a de preparaciones de anticuerpos.
EP0283801A3 (en) Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies
FR2432038A1 (fr) Conjugues marques d'hydrazide d'acide naphtalene-1,2-dicarboxylique chimioluminescent et leur procede de preparation
AU1232188A (en) Novel pair of monoclonal antibodies to insulin-like growth factor i permits immunometric assay for igf-i
AU592952B2 (en) Monoclonal antibody stabilization
FR2560212B1 (fr) Anticorps monoclonaux contre l'interferon a2 et hybridomes produisant de tels anticorps
FR2590172B1 (fr) Nouvel antigene commun (psc-a) de pseudomonas aeruginosa protegeant contre l'infection provoquee par cet organisme
AU7495887A (en) Monoclonal antibodies to pseudomonas aeruginosa flagella
AU2518688A (en) A hybridoma producing a monoclonal antibody
EP0502553A3 (en) Peptide fragment from human villin and antibody thereto
AU7955687A (en) Method for purification of antibodies
FR2558481B1 (fr) Procede de preparation de l'acide 4-amino-3-hydroxybutyrique optiquement actif
JPS6467187A (en) Method of separating and refining t-pa
AU6639186A (en) Monoclonal antibodies to p. aeruginosa
AU1979283A (en) Nitroglycerine solution
AU2816389A (en) Chromosome banding by monoclonal antibodies to nuclear proteins
FR2422666A1 (fr) Nouveaux composes de type b-lactame utiles comme agents antimicrobiens et leur procede de preparation
MY102245A (en) Purification of antibodies
FR2619123B1 (fr) Acide desoxyribonucleique portant l'information genetique de la creatinase
FR2572397B1 (fr) Procede de preparation de l'acide 3-hydroxy-3-methyl-glutarique
ITMI932667A1 (it) Metodo per la produzione di anticorpi monoclonali specifici per le chemochine
GB8706514D0 (en) Conjugating horse-radish peroxidase to monoclonal antibody

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 303088

Country of ref document: ES