ES2045027T3 - Igm purificadas. - Google Patents
Igm purificadas.Info
- Publication number
- ES2045027T3 ES2045027T3 ES88111931T ES88111931T ES2045027T3 ES 2045027 T3 ES2045027 T3 ES 2045027T3 ES 88111931 T ES88111931 T ES 88111931T ES 88111931 T ES88111931 T ES 88111931T ES 2045027 T3 ES2045027 T3 ES 2045027T3
- Authority
- ES
- Spain
- Prior art keywords
- igm
- antibodies
- less
- nucleic acid
- acid content
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1214—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pseudomonadaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Detergent Compositions (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
SE PRESENTA UNA PREPARACION DE ANTICUERPO ESENCIALMENTE PURO Y ESTABILIZADO QUE COMPRENDE ANTICUERPOS IGM QUE TIENEN UNA PUREZA SUPERIOR AL 98% DE SU PESO Y UN CONTENIDO DE ACIDO NUCLEICO INFERIOR A 200 PG POR MG DE IGM. EN UNA DE SUS CONFIGURACIONES LOS ANTICUERPOS DE IGM DE UNA FUENTE MONOCLONAL ESTAN SUJETOS AL INTERCAMBIO DE IONES Y A LA EXCLUSION CROMATOGRAFICA EN UN PH ALCALINO PARA DAR UN IGM PURIFICADO QUE TIENE UN CONTENIDO DE ACIDO NUCLEICO MENOR DE 10 PG / MG DE IGM, PREFERIBLEMENTE MENOR QUE 4 PG / MG IGM. SE HA DESCUBIERTO UNA PREPARACION ESTABILIZADA Y ALTAMENTE PURIFICADA DE ANTICUERPOS ANTI "PSEUDOMONAS AERUGINOSA".
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8313687A | 1987-08-10 | 1987-08-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2045027T3 true ES2045027T3 (es) | 1994-01-16 |
Family
ID=22176414
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88111931T Expired - Lifetime ES2045027T3 (es) | 1987-08-10 | 1988-07-25 | Igm purificadas. |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0303088B1 (es) |
JP (1) | JP2730913B2 (es) |
AT (1) | ATE82136T1 (es) |
AU (1) | AU618745B2 (es) |
CA (1) | CA1341474C (es) |
DE (1) | DE3875852T2 (es) |
ES (1) | ES2045027T3 (es) |
GR (1) | GR3006536T3 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01197500A (ja) * | 1988-01-29 | 1989-08-09 | Sumitomo Chem Co Ltd | ヒトモノクローナル抗体 |
DE3825429C2 (de) * | 1988-07-27 | 1994-02-10 | Biotest Pharma Gmbh | Verfahren zur Herstellung eines intravenös verabreichbaren polyklonalen Immunglobulin-Präparates mit hohem IgM-Gehalt |
EP0382031A3 (en) * | 1989-02-10 | 1991-06-26 | Miles Inc. | Monoclonal antibodies in immune serum globulin |
CA2049342A1 (en) * | 1989-03-27 | 1990-09-28 | Sally Bolmer | Formulations for stabilizing of igm antibodies |
JPH05507924A (ja) * | 1990-07-03 | 1993-11-11 | アクゾ・エヌ・ヴエー | 免疫反応性化合物 |
JPH0565233A (ja) * | 1991-03-08 | 1993-03-19 | Mitsui Toatsu Chem Inc | モノクローナル抗体含有凍結乾燥製剤 |
EP0852951A1 (de) | 1996-11-19 | 1998-07-15 | Roche Diagnostics GmbH | Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern |
EP1428537B1 (en) | 2001-08-29 | 2008-11-19 | Chugai Seiyaku Kabushiki Kaisha | Stabilized preparations containing antibody |
JP5452835B2 (ja) | 2003-07-15 | 2014-03-26 | 中外製薬株式会社 | 形質転換細胞によるIgMの産生とその定量方法 |
JP4671864B2 (ja) | 2003-10-09 | 2011-04-20 | 中外製薬株式会社 | タンパク質溶液の安定化方法 |
ATE518888T1 (de) | 2003-10-09 | 2011-08-15 | Chugai Pharmaceutical Co Ltd | Stabilisierte lösung mit hoher igm-konzentration |
CN102811737A (zh) * | 2010-01-29 | 2012-12-05 | 阿克西斯股份有限公司 | 骨关节炎治疗及预防药物组合物和上述组合物的制造方法 |
US10570194B2 (en) | 2015-08-06 | 2020-02-25 | Grifols Worldwide Operations Limited | Method for treating infectious diseases using a composition comprising plasma-derived immunoglobulin M (IgM) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS591691B2 (ja) * | 1981-05-29 | 1984-01-13 | 株式会社ミドリ十字 | 静注用γ−グロブリン製剤 |
JPS59184133A (ja) * | 1983-04-01 | 1984-10-19 | Teijin Ltd | IgMの調製法 |
US4604235A (en) * | 1984-05-23 | 1986-08-05 | J. T. Baker Chemical Company | Purification of monoclonal antibodies |
US4834975A (en) * | 1984-05-25 | 1989-05-30 | Genetics Corporation | Human monoclonal antibodies to serotypic lipopolysaccharide determinants on gram-negative bacteria and their production |
JPH0669961B2 (ja) * | 1984-09-25 | 1994-09-07 | 株式会社ミドリ十字 | 免疫グロブリンの加熱処理方法 |
-
1988
- 1988-07-25 DE DE8888111931T patent/DE3875852T2/de not_active Expired - Lifetime
- 1988-07-25 AT AT88111931T patent/ATE82136T1/de not_active IP Right Cessation
- 1988-07-25 ES ES88111931T patent/ES2045027T3/es not_active Expired - Lifetime
- 1988-07-25 EP EP88111931A patent/EP0303088B1/en not_active Expired - Lifetime
- 1988-08-02 AU AU20315/88A patent/AU618745B2/en not_active Expired
- 1988-08-09 JP JP63197281A patent/JP2730913B2/ja not_active Expired - Lifetime
- 1988-08-09 CA CA000574199A patent/CA1341474C/en not_active Expired - Fee Related
-
1992
- 1992-12-14 GR GR920402910T patent/GR3006536T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE82136T1 (de) | 1992-11-15 |
DE3875852D1 (de) | 1992-12-17 |
AU2031588A (en) | 1989-06-08 |
GR3006536T3 (es) | 1993-06-30 |
JP2730913B2 (ja) | 1998-03-25 |
EP0303088A3 (en) | 1989-05-17 |
JPH02493A (ja) | 1990-01-05 |
CA1341474C (en) | 2005-03-08 |
DE3875852T2 (de) | 1993-03-18 |
AU618745B2 (en) | 1992-01-09 |
EP0303088B1 (en) | 1992-11-11 |
EP0303088A2 (en) | 1989-02-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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