ES2038668T3 - Vasodilatadores de benzotiazepina dotados de sustitucion aralquilica. - Google Patents
Vasodilatadores de benzotiazepina dotados de sustitucion aralquilica.Info
- Publication number
- ES2038668T3 ES2038668T3 ES198787307316T ES87307316T ES2038668T3 ES 2038668 T3 ES2038668 T3 ES 2038668T3 ES 198787307316 T ES198787307316 T ES 198787307316T ES 87307316 T ES87307316 T ES 87307316T ES 2038668 T3 ES2038668 T3 ES 2038668T3
- Authority
- ES
- Spain
- Prior art keywords
- vasodilators
- benzotiazepine
- aralquilica
- substitution
- benzothiazepines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A N-AMINOALQUIL 1,5-BENZOTIAZEPINAS DE FORMULA GENERAL (I) PARA EL TRATAMIENTO DE LA ANGINA O LA HIPERTENSION O PARA LA PREVENCION DE ATAQUES CARDIACOS EN MAMIFEROS, EN PARTICULAR PARA EMPLEO COMO VASODILATADORES CORONARIOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89829886A | 1986-08-20 | 1986-08-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2038668T3 true ES2038668T3 (es) | 1993-08-01 |
Family
ID=25409243
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES198787307316T Expired - Lifetime ES2038668T3 (es) | 1986-08-20 | 1987-08-19 | Vasodilatadores de benzotiazepina dotados de sustitucion aralquilica. |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0256888B1 (es) |
JP (1) | JP2622385B2 (es) |
AT (1) | ATE64925T1 (es) |
DE (1) | DE3771143D1 (es) |
ES (1) | ES2038668T3 (es) |
GR (1) | GR3002249T3 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2624117B1 (fr) * | 1987-12-08 | 1991-02-22 | Synthelabo | Derives de hydroxy-3 (methoxy-4 phenyl)-2 (methylamino-2 ethyl)-5 dihydro-2,3 5h-benzothiazepine-1,5 one-4, leur preparation et leur application en therapeutique |
FR2630109B1 (fr) * | 1988-04-19 | 1991-11-29 | Synthelabo | Derives de ((n-(amino-2 oxo-2 ethyl)methylamino)-2 ethyl)-5 hydroxy-3 (methoxy-4 phenyl)-2 dihydro-2,3 5h-benzothiazepine-1,5 one-4, leur preparation et leur application en therapeutique |
US4902684A (en) * | 1988-06-20 | 1990-02-20 | E. R. Squibb & Sons, Inc. | Benzazepine and benzothiazepine derivatives |
FR2638745B1 (fr) * | 1988-11-08 | 1994-01-14 | Synthelabo | Derives de ((n-alkylthioalkyl-methylamino)-2 ethyl)-5 benzothiazepine-1,5 one-4, leur preparation et leur application en therapeutique |
FR2641536B1 (fr) * | 1989-01-11 | 1991-03-15 | Synthelabo | Derives d'alcanoyloxy-3 ((n-(aryl-2 oxo-2 ethyl) methylamino)-2 ethyl)-5 (methoxy-4 phenyl)-2 dihydro-2,3 5h-benzothiazepine-1,5 one-4, leur preparation et leur application en therapeutique |
US4952692A (en) * | 1989-04-04 | 1990-08-28 | E. R. Squibb & Sons, Inc. | Benzazepine derivatives |
US4946840A (en) * | 1989-04-06 | 1990-08-07 | E. R. Squibb & Sons, Inc. | Benzazepine and benzothiazepine derivatives |
US5134139A (en) * | 1989-08-31 | 1992-07-28 | Tanabe Seiyaku Co., Ltd. | 1,5-benzothiazepine derivatives and preparation thereof |
IT1240686B (it) * | 1990-04-27 | 1993-12-17 | Luso Farmaco Inst | Derivati 1,5-benzotiazepinonici, loro preparazione e uso farmaceutico |
FR2670785B1 (fr) * | 1990-12-20 | 1993-07-09 | Synthelabo | Derives de (methoxy-4 phenyl)-2 (methylamino-2 ethyl)-5 dihydro-2,3 5h-benzothiazepine-1,5 one-4, leur preparation et leur application en therapeutique. |
FR2672601B1 (fr) * | 1991-02-08 | 1994-10-14 | Synthelabo | Derives de benzo-1,5-thiazepine, leur preparation et leur application en therapeutique. |
WO2005035505A2 (en) * | 2003-09-30 | 2005-04-21 | Artesian Therapeutics, Inc. | Compounds with phosphodiesterase inhibiting and calcium channel blocking activities |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4567175A (en) * | 1983-06-03 | 1986-01-28 | Tanabe Seiyaku Co., Ltd. | 8-Chloro-1,5-benzothiazepine derivatives |
US4590188A (en) * | 1984-02-18 | 1986-05-20 | Tanabe Seiyaku Co., Ltd. | 1,5-benzothiazepine derivatives and their pharmaceutical use |
GB2167063A (en) * | 1984-11-17 | 1986-05-21 | Tanabe Seiyaku Co | 6 or 9-chloro-1, 5-benzothiazepine derivatives |
-
1987
- 1987-08-19 AT AT87307316T patent/ATE64925T1/de not_active IP Right Cessation
- 1987-08-19 DE DE8787307316T patent/DE3771143D1/de not_active Expired - Lifetime
- 1987-08-19 ES ES198787307316T patent/ES2038668T3/es not_active Expired - Lifetime
- 1987-08-19 EP EP87307316A patent/EP0256888B1/en not_active Expired - Lifetime
- 1987-08-20 JP JP62205290A patent/JP2622385B2/ja not_active Expired - Lifetime
-
1991
- 1991-07-04 GR GR91400829T patent/GR3002249T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE3771143D1 (de) | 1991-08-08 |
GR3002249T3 (en) | 1992-12-30 |
ATE64925T1 (de) | 1991-07-15 |
EP0256888A1 (en) | 1988-02-24 |
EP0256888B1 (en) | 1991-07-03 |
JPS63119478A (ja) | 1988-05-24 |
JP2622385B2 (ja) | 1997-06-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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