ES2008421A6 - Procedimiento para la obtencion de derivados de la pilocarpina. - Google Patents

Procedimiento para la obtencion de derivados de la pilocarpina.

Info

Publication number
ES2008421A6
ES2008421A6 ES8800263A ES8800263A ES2008421A6 ES 2008421 A6 ES2008421 A6 ES 2008421A6 ES 8800263 A ES8800263 A ES 8800263A ES 8800263 A ES8800263 A ES 8800263A ES 2008421 A6 ES2008421 A6 ES 2008421A6
Authority
ES
Spain
Prior art keywords
pilocarpine derivatives
pilocarpine
derivatives
confusional
mania
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8800263A
Other languages
English (en)
Inventor
Rene Amstutz
Georg Bolliger
Gideon Shapiro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES2008421A6 publication Critical patent/ES2008421A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE LA PILOCARPINA DE FORMULA I EN DONDE R1 A R5 SE DEFINEN COMO SE INDICA EN LA DESCRIPCION. COMPRENDE REACCIONAR UN COMPUESTO DE FORMULA II CON UN SULFURO DE FOSFORO (P4S10) O CON EL REACTIVO DE LAWESSON DE FORMULA III. LOS COMPUESTOS I SON MEDICAMENTOS APROPIADOS PARA EL TRATAMIENTO DE LA DEMENCIA SENIL, LA ENFERMEDAD DE ALZHEIMER, LAS CONDICIONES DE CONFUSION EN LA EDAD AVANZADA, LA MYASTHENIA GRAVIS, LA ESQUIZOFRENIA, LA MANIA O EL GLAUCOMA.
ES8800263A 1987-01-31 1988-01-29 Procedimiento para la obtencion de derivados de la pilocarpina. Expired ES2008421A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3702940 1987-01-31

Publications (1)

Publication Number Publication Date
ES2008421A6 true ES2008421A6 (es) 1989-07-16

Family

ID=6319976

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8800263A Expired ES2008421A6 (es) 1987-01-31 1988-01-29 Procedimiento para la obtencion de derivados de la pilocarpina.

Country Status (27)

Country Link
US (1) US4835174A (es)
JP (1) JPS63201185A (es)
KR (1) KR880009013A (es)
AT (1) AT395852B (es)
AU (1) AU607966B2 (es)
BE (1) BE1001005A3 (es)
CA (1) CA1327805C (es)
CH (1) CH675721A5 (es)
CS (1) CS411291A3 (es)
DK (1) DK46288A (es)
ES (1) ES2008421A6 (es)
FI (1) FI90080C (es)
FR (1) FR2610322B1 (es)
GB (1) GB2200910B (es)
GR (1) GR880100042A (es)
HU (1) HU204047B (es)
IE (1) IE61989B1 (es)
IL (1) IL85252A (es)
IT (1) IT1219827B (es)
LU (1) LU87122A1 (es)
MY (1) MY102415A (es)
NL (1) NL8800099A (es)
NZ (1) NZ223359A (es)
PH (1) PH24837A (es)
PT (1) PT86666B (es)
SE (1) SE466150B (es)
ZA (1) ZA88665B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4882343A (en) * 1987-08-28 1989-11-21 G. D. Searle & Co. Biarylalkylimidazole derivatives as anti-depressants
US5861431A (en) * 1995-06-07 1999-01-19 Iotek, Inc. Incontinence treatment
MX2020004666A (es) 2017-11-17 2022-01-26 Cellix Bio Private Ltd Compuestos de pilocarpina con ácido lipoico para el tratamiento de trastornos oculares.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2457047A (en) * 1946-02-13 1948-12-21 Monsanto Chemicals 2-(2'-thenyl)-4, 5-dihydroimidazoles and process for making the same
GB1601310A (en) * 1978-05-23 1981-10-28 Lilly Industries Ltd Aryl hydantoins
JPS56131579A (en) * 1980-03-17 1981-10-15 Kissei Pharmaceut Co Ltd Novel 1-substituted imidazole derivative
JPS58150566A (ja) * 1982-03-03 1983-09-07 Yoshitomi Pharmaceut Ind Ltd 新規イミダゾ−ル誘導体
DE3228266A1 (de) * 1982-07-29 1984-02-02 A. Nattermann & Cie GmbH, 5000 Köln Imidazolylalkylthiophene, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3329028A1 (de) * 1983-08-11 1985-02-28 Cassella Ag, 6000 Frankfurt Substituierte (2-amino-2-imidazolin-1-yl)-essigsaeurederivate, verfahren zu ihrer herstellung, ihre verwendung und sie enthaltende pharmazeutische zubereitungen

Also Published As

Publication number Publication date
GB2200910B (en) 1991-01-16
CA1327805C (en) 1994-03-15
KR880009013A (ko) 1988-09-13
NZ223359A (en) 1991-03-26
FI90080B (fi) 1993-09-15
NL8800099A (nl) 1988-08-16
SE466150B (sv) 1992-01-07
AU607966B2 (en) 1991-03-21
IL85252A (en) 1992-03-29
MY102415A (en) 1992-06-17
CS411291A3 (en) 1992-06-17
FR2610322A1 (fr) 1988-08-05
IL85252A0 (en) 1988-07-31
DK46288D0 (da) 1988-01-29
PT86666B (pt) 1992-04-30
FR2610322B1 (fr) 1990-02-16
GB2200910A (en) 1988-08-17
SE8800293L (sv) 1988-08-01
PH24837A (en) 1990-10-30
HUT50168A (en) 1989-12-28
IE880244L (en) 1988-07-31
US4835174A (en) 1989-05-30
ZA88665B (en) 1989-09-27
GB8801804D0 (en) 1988-02-24
AU1096088A (en) 1988-08-04
PT86666A (pt) 1988-02-01
IE61989B1 (en) 1994-12-14
HU204047B (en) 1991-11-28
JPS63201185A (ja) 1988-08-19
BE1001005A3 (fr) 1989-06-06
AT395852B (de) 1993-03-25
IT8847578A0 (it) 1988-01-29
FI90080C (fi) 1993-12-27
CH675721A5 (es) 1990-10-31
GR880100042A (el) 1988-12-16
ATA18288A (de) 1992-08-15
DK46288A (da) 1988-08-01
FI880430A (fi) 1988-08-01
SE8800293D0 (sv) 1988-01-29
FI880430A0 (fi) 1988-01-29
IT1219827B (it) 1990-05-24
LU87122A1 (fr) 1988-08-23

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19991102