EP3792274A4 - RECOMBINANT IMMUNE REGULATORY PROTEIN MUTANTS FROM GANODERMA LUCIDUM AND THEIR USE - Google Patents
RECOMBINANT IMMUNE REGULATORY PROTEIN MUTANTS FROM GANODERMA LUCIDUM AND THEIR USE Download PDFInfo
- Publication number
- EP3792274A4 EP3792274A4 EP18780732.6A EP18780732A EP3792274A4 EP 3792274 A4 EP3792274 A4 EP 3792274A4 EP 18780732 A EP18780732 A EP 18780732A EP 3792274 A4 EP3792274 A4 EP 3792274A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- application
- ganoderma lucidum
- protein mutant
- immunoregulatory protein
- recombinant ganoderma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/375—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Basidiomycetes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1754—Insulin-like growth factor binding proteins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710226093.3A CN107118263B (zh) | 2017-04-08 | 2017-04-08 | 重组灵芝免疫调节蛋白突变体及其应用 |
PCT/CN2018/078934 WO2018184448A1 (zh) | 2017-04-08 | 2018-03-14 | 重组灵芝免疫调节蛋白突变体及其应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3792274A1 EP3792274A1 (en) | 2021-03-17 |
EP3792274A4 true EP3792274A4 (en) | 2022-02-16 |
Family
ID=59726255
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP18780732.6A Pending EP3792274A4 (en) | 2017-04-08 | 2018-03-14 | RECOMBINANT IMMUNE REGULATORY PROTEIN MUTANTS FROM GANODERMA LUCIDUM AND THEIR USE |
Country Status (4)
Country | Link |
---|---|
US (1) | US20190352345A1 (zh) |
EP (1) | EP3792274A4 (zh) |
CN (1) | CN107118263B (zh) |
WO (1) | WO2018184448A1 (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107118263B (zh) * | 2017-04-08 | 2020-07-03 | 张喜田 | 重组灵芝免疫调节蛋白突变体及其应用 |
CN112646009B (zh) * | 2019-08-27 | 2022-02-08 | 上海交通大学 | 灵芝免疫调节蛋白突变体及应用 |
CN111748543A (zh) * | 2020-07-01 | 2020-10-09 | 吉林大学 | 免疫调节蛋白突变体及其核苷酸序列、重组质粒载体、工程菌、构建方法与应用 |
EP4386008A1 (en) * | 2021-08-09 | 2024-06-19 | Changchun Intellicrown Pharmaceutical Co., Ltd. | New mutant of recombinant ganoderma lucidum immunoregulatory protein and application thereof |
CN113717865B (zh) * | 2021-09-17 | 2023-06-09 | 北京东方红航天生物技术股份有限公司 | 一种灵芝突变菌株及其应用 |
Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0568561A (ja) * | 1991-08-13 | 1993-03-23 | Meiji Milk Prod Co Ltd | ゲノムdna配列 |
WO2004092210A2 (en) * | 2003-04-17 | 2004-10-28 | National University Of Singapore | Molecules having immunomodulatory activity |
US20110318429A1 (en) * | 2010-06-29 | 2011-12-29 | Mycomagic Biotechnology Co., Ltd. | Uses of an Immunomodulatory Protein (GMI) from Ganoderma Microsporum |
WO2015058536A1 (zh) * | 2013-10-25 | 2015-04-30 | 张喜田 | 重组灵芝免疫调节蛋白在制备治疗帕金森病药物中的应用 |
CN104817637A (zh) * | 2015-04-30 | 2015-08-05 | 上海市农业科学院 | 一种草菇免疫调节蛋白FIP-vvo78及其制备方法 |
CN104817634A (zh) * | 2015-04-30 | 2015-08-05 | 上海市农业科学院 | 一种草菇免疫调节蛋白FIP-vvo98及其制备方法 |
CN104892735A (zh) * | 2015-04-30 | 2015-09-09 | 上海市农业科学院 | 一种草菇免疫调节蛋白FIP-vvo82及其制备方法 |
WO2015135483A1 (en) * | 2014-03-13 | 2015-09-17 | Yeastern Biotech Co., Ltd | Combination therapy for ameliorating adverse side effects caused by chemotherapy |
WO2016034081A1 (en) * | 2014-09-02 | 2016-03-10 | Yeastern Biotech Co., Ltd | Methods and compositions for treating c-met associated cancers |
EP3034515A1 (en) * | 2013-10-15 | 2016-06-22 | Zhang, Xitian | Fusion protein of ganoderma lucidum immunoregulatory protein and human serum albumin, and production method therefor and uses thereof |
CN106188255A (zh) * | 2016-07-18 | 2016-12-07 | 中国农业科学院农产品加工研究所 | 一种真菌免疫调节蛋白FIP‑dsq2及其应用 |
CN106432442A (zh) * | 2016-10-12 | 2017-02-22 | 上海市农业科学院 | 一种虎皮香菇免疫调节蛋白Fip‑lti1及其制备方法和应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101205553A (zh) * | 2007-12-13 | 2008-06-25 | 吉林大学 | 一种重组灵芝免疫调节蛋白制备方法 |
CN101475632B (zh) * | 2008-01-03 | 2012-01-04 | 张喜田 | 具有抗肿瘤作用的重组灵芝免疫调节蛋白及其药物制剂 |
CN103417953B (zh) * | 2013-08-16 | 2015-06-17 | 张喜田 | 重组灵芝免疫调节蛋白(rLZ-8)在制备治疗黑色素瘤药物中的应用 |
CN104043105A (zh) * | 2014-06-18 | 2014-09-17 | 张喜田 | 重组灵芝免疫调节蛋白rLZ-8在治疗肺癌,喉癌和脑胶质瘤中的应用 |
US9827288B2 (en) * | 2015-09-21 | 2017-11-28 | Mycomagic Biotechnology Co., Ltd. | Method for treating a refractory or relapsed lung cancer |
CN107118263B (zh) * | 2017-04-08 | 2020-07-03 | 张喜田 | 重组灵芝免疫调节蛋白突变体及其应用 |
-
2017
- 2017-04-08 CN CN201710226093.3A patent/CN107118263B/zh active Active
-
2018
- 2018-03-14 EP EP18780732.6A patent/EP3792274A4/en active Pending
- 2018-03-14 WO PCT/CN2018/078934 patent/WO2018184448A1/zh active Application Filing
- 2018-03-14 US US16/462,941 patent/US20190352345A1/en active Pending
Patent Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0568561A (ja) * | 1991-08-13 | 1993-03-23 | Meiji Milk Prod Co Ltd | ゲノムdna配列 |
WO2004092210A2 (en) * | 2003-04-17 | 2004-10-28 | National University Of Singapore | Molecules having immunomodulatory activity |
US20110318429A1 (en) * | 2010-06-29 | 2011-12-29 | Mycomagic Biotechnology Co., Ltd. | Uses of an Immunomodulatory Protein (GMI) from Ganoderma Microsporum |
EP3034515A1 (en) * | 2013-10-15 | 2016-06-22 | Zhang, Xitian | Fusion protein of ganoderma lucidum immunoregulatory protein and human serum albumin, and production method therefor and uses thereof |
WO2015058536A1 (zh) * | 2013-10-25 | 2015-04-30 | 张喜田 | 重组灵芝免疫调节蛋白在制备治疗帕金森病药物中的应用 |
WO2015135483A1 (en) * | 2014-03-13 | 2015-09-17 | Yeastern Biotech Co., Ltd | Combination therapy for ameliorating adverse side effects caused by chemotherapy |
WO2016034081A1 (en) * | 2014-09-02 | 2016-03-10 | Yeastern Biotech Co., Ltd | Methods and compositions for treating c-met associated cancers |
CN104817637A (zh) * | 2015-04-30 | 2015-08-05 | 上海市农业科学院 | 一种草菇免疫调节蛋白FIP-vvo78及其制备方法 |
CN104817634A (zh) * | 2015-04-30 | 2015-08-05 | 上海市农业科学院 | 一种草菇免疫调节蛋白FIP-vvo98及其制备方法 |
CN104892735A (zh) * | 2015-04-30 | 2015-09-09 | 上海市农业科学院 | 一种草菇免疫调节蛋白FIP-vvo82及其制备方法 |
CN106188255A (zh) * | 2016-07-18 | 2016-12-07 | 中国农业科学院农产品加工研究所 | 一种真菌免疫调节蛋白FIP‑dsq2及其应用 |
CN106432442A (zh) * | 2016-10-12 | 2017-02-22 | 上海市农业科学院 | 一种虎皮香菇免疫调节蛋白Fip‑lti1及其制备方法和应用 |
Non-Patent Citations (1)
Title |
---|
See also references of WO2018184448A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO2018184448A1 (zh) | 2018-10-11 |
CN107118263B (zh) | 2020-07-03 |
EP3792274A1 (en) | 2021-03-17 |
US20190352345A1 (en) | 2019-11-21 |
CN107118263A (zh) | 2017-09-01 |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 20220119 |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61P 35/00 20060101ALI20220113BHEP Ipc: A61P 35/04 20060101ALI20220113BHEP Ipc: A61K 38/16 20060101ALI20220113BHEP Ipc: C07K 14/375 20060101AFI20220113BHEP |