Classifications

• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
  • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
  • B01J13/02—Making microcapsules or microballoons
  • B01J13/06—Making microcapsules or microballoons by phase separation
  • B01J13/10—Complex coacervation, i.e. interaction of oppositely charged particles
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
  • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
  • B01F35/71—Feed mechanisms
  • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
  • B01F35/71825—Feed mechanisms characterised by the means for feeding the components to the mixer using means for feeding one phase surrounded by another phase without mixing during the feeding
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
  • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
  • B01F27/27—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices
  • B01F27/272—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed axially between the surfaces of the rotor and the stator, e.g. the stator rotor system formed by conical or cylindrical surfaces
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K9/00—Medicinal preparations characterised by special physical form
  • A61K9/10—Dispersions; Emulsions
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
  • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
  • B01F23/40—Mixing liquids with liquids; Emulsifying
  • B01F23/41—Emulsifying
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
  • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
  • B01F23/40—Mixing liquids with liquids; Emulsifying
  • B01F23/41—Emulsifying
  • B01F23/4105—Methods of emulsifying
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
  • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
  • B01F23/40—Mixing liquids with liquids; Emulsifying
  • B01F23/41—Emulsifying
  • B01F23/413—Homogenising a raw emulsion or making monodisperse or fine emulsions
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
  • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
  • B01F23/40—Mixing liquids with liquids; Emulsifying
  • B01F23/41—Emulsifying
  • B01F23/414—Emulsifying characterised by the internal structure of the emulsion
  • B01F23/4143—Microemulsions
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
  • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
  • B01F23/40—Mixing liquids with liquids; Emulsifying
  • B01F23/41—Emulsifying
  • B01F23/414—Emulsifying characterised by the internal structure of the emulsion
  • B01F23/4144—Multiple emulsions, in particular double emulsions, e.g. water in oil in water; Three-phase emulsions
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
  • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
  • B01F23/40—Mixing liquids with liquids; Emulsifying
  • B01F23/41—Emulsifying
  • B01F23/414—Emulsifying characterised by the internal structure of the emulsion
  • B01F23/4145—Emulsions of oils, e.g. fuel, and water
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
  • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
  • B01F23/40—Mixing liquids with liquids; Emulsifying
  • B01F23/43—Mixing liquids with liquids; Emulsifying using driven stirrers
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
  • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
  • B01F27/27—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
  • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
  • B01F33/80—Mixing plants; Combinations of mixers
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
  • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
  • B01F35/90—Heating or cooling systems
  • B01F35/92—Heating or cooling systems for heating the outside of the receptacle, e.g. heated jackets or burners
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
  • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
  • B01J13/02—Making microcapsules or microballoons
  • B01J13/06—Making microcapsules or microballoons by phase separation
  • B01J13/08—Simple coacervation, i.e. addition of highly hydrophilic material
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
  • C11D17/0008—Detergent materials or soaps characterised by their shape or physical properties aqueous liquid non soap compositions
  • C11D17/0017—Multi-phase liquid compositions
• • A—HUMAN NECESSITIES
  • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
  • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
  • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
• • A—HUMAN NECESSITIES
  • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
  • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
  • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
  • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
  • B01F35/90—Heating or cooling systems
  • B01F2035/99—Heating
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
  • B01F2215/00—Auxiliary or complementary information in relation with mixing
  • B01F2215/04—Technical information in relation with mixing
  • B01F2215/0413—Numerical information
  • B01F2215/0418—Geometrical information
  • B01F2215/0431—Numerical size values, e.g. diameter of a hole or conduit, area, volume, length, width, or ratios thereof

Definitions

• the present invention relates to a device for producing a dispersion.
• the invention also relates to a production assembly comprising at least one such device and a method for producing a dispersion using such a device.
• the Applicant manufactures and markets macroscopic dispersions and comprising elements visible to the naked eye, for example of diameter between 100 pm and 1500 pm, kinetically stable and optionally monodisperse.
• the production of a dispersion comprising elements dispersed in a continuous phase generally consists in mixing at least two phases that are substantially immiscible with one another, either directly in the production vessel or in a reactor. online.
• An object of the invention is to provide a production device making it possible to easily obtain, with high production yields, dispersed elements, in particular macroscopic and, where appropriate, monodisperse, and / or in concentration. high, even in the presence of at least one phase of high viscosity, while easily controlling the effects of the change of scale of production.
• the invention relates to a production device of the aforementioned type, characterized in that the dispersion comprising elements comprising at least a first phase, dispersed in a continuous phase substantially immiscible with the first phase, the device comprising:
• At least one production nozzle comprising at least a first conduit intended to convey a first fluid suitable for constituting the first phase, a second conduit surrounding, preferably coaxially, at least a part of the first conduit, the second conduit being clean to convey a second fluid suitable for constituting the continuous phase, and an outlet, the nozzle being adapted to form at the outlet a fluid jet comprising at least the first fluid and the second fluid surrounding the first fluid, preferably coaxially, and
• At least one device for mechanical fragmentation of the fluid jet disposed in the vicinity of the exit of the nozzle, the fragmentation device comprising a part movable with respect to the nozzle, intended to mechanically break up the fluid jet into a plurality of elements comprising the first fluid dispersed in the continuous phase.
• the device according to the invention has one or more of the following characteristics, taken separately or in any technically possible combination:
• the mechanical fragmentation device is mobile with respect to the nozzle
• the production nozzle comprises a third duct of which at least a portion is surrounded, preferably in a coaxial manner, by at least a portion of the first duct, the third duct being adapted to convey a third fluid substantially immiscible with the first fluid, the fluid jet comprising the third fluid, the first fluid surrounding the third fluid, preferably coaxially, and the second fluid surrounding the first fluid, preferably coaxially, each element dispersed in the continuous phase comprising an outer core formed by the first fluid, and at least one, preferably a single, inner core formed by the third fluid disposed in the outer core;
• each element comprises a bark (or membrane), preferably formed of a coacervate layer, at the interface between the first phase and the continuous phase, and optionally also at the interface between the first phase and the third fluid; when this third fluid is present;
• the first phase of the elements forms a bark formed of a layer comprising at least one gelling agent, in particular chosen from a gelling agent thermosensitive solid at room temperature and atmospheric pressure, a polysaccharide, in particular a multivalent ion reactive polyelectrolyte, between the third fluid and the continuous phase;
• at least one gelling agent in particular chosen from a gelling agent thermosensitive solid at room temperature and atmospheric pressure, a polysaccharide, in particular a multivalent ion reactive polyelectrolyte, between the third fluid and the continuous phase;
• the device comprises at least one independent conduit intended to convey to the dispersion an additional fluid comprising at least one solution for increasing the viscosity of the continuous phase;
• the device comprises at least one heating device for heating at least the first fluid, and optionally the second fluid and / or the third fluid, at least in the production nozzle;
• the device comprises at least one cooling device capable of cooling the dispersion, in particular when the device comprises at least one heating device as described above;
• the mobile part of the fragmentation device comprises a rotary or oscillating scraper provided with successive openings;
• the successive openings are adapted to pass successively opposite the nozzle during the displacement of the movable portion relative to the nozzle;
• the elements have a substantially spherical shape
• At least 60%, even at least 70%, preferably at least 80%, and better still at least 90% of the elements have an average diameter greater than or equal to 10 ⁇ m, preferably greater than or equal to 50 ⁇ m, in particular greater than or equal to 100 ⁇ m, even greater than or equal to 200 ⁇ m, better still greater than or equal to 300 ⁇ m, in particular greater than or equal to 400 ⁇ m, and better still greater than or equal to 500 ⁇ m;
• the first fluid and / or the second fluid and / or, when present, the third fluid is not a gas
• the device further comprises at least one mixer capable of exerting on the elements a homogeneous controlled shear, preferably said mixer comprising at least one cell formed by at least:
• the elements are subjected to a step of refining in size during which they are subjected to a shear capable of fragmenting them into elements of homogeneous and controlled diameters.
• the refining step is carried out in a high-shear Couette type cell, according to a process described in document EP3144058.
• the invention also relates to a production assembly of a dispersion comprising a plurality of production devices as described above, and a fluid distribution system capable of supplying each device with at least first fluid and second fluid and optionally in the third fluid, preferably the outlets of the nozzles opening in the same chamber.
• the assembly according to the invention has one or more of the following characteristics, taken separately or in any combination technically possible:
• the devices are arranged in at least one centripetal circle, the nozzle outlets being oriented towards a center of the circle;
• the devices are arranged in at least one centrifugal circle, the nozzle outlets being oriented towards the outside of the circle;
• the devices are arranged in at least one circle, the nozzle outlets being parallel to each other;
• the fragmentation device is common to all the devices
• the moving part of the common fragmentation device comprises a rotary or oscillating scraper arranged to traverse an inner contour of the centripetal circle;
• the moving part of the common fragmentation device comprises a rotary or oscillating scraper arranged to traverse an outer contour of the centrifugal circle;
• the movable part of the common fragmentation device comprises a rotary wiper or oscillating arranged to come opposite the outputs of the nozzles parallel to each other.
• the invention further relates to a method of manufacturing a dispersion comprising elements comprising at least a first phase dispersed in a continuous phase, the process comprising at least the following steps:
• the fluid jet formed by coextrusion, comprising at least the first fluid and the second fluid surrounding the first fluid, preferably coaxially;
• the method according to the invention has one or more of the following characteristics, taken separately or in any technically possible combination:
• the method comprises a step of flowing a third fluid in a third conduit, at least a portion of the third conduit being surrounded, preferably coaxially, by at least a portion of the first conduit, the fluid jet also comprising the third fluid, the first fluid surrounding the third fluid, preferably coaxially;
• the method comprises a step of refining in size, during which a controlled and homogeneous shear is applied to the elements in a mixer, the mixer being in particular of the Couette type, comprising two coaxial cylinders, an outer cylinder of internal radius R 0 and an inner cylinder of outer radius R ,, the outer cylinder being fixed and the inner cylinder rotating with an angular velocity w.
• the phases of the dispersion form a macroscopically inhomogeneous mixture. This is particularly the case when the scattered elements have a macroscopic character.
• dispersions may be denoted by the term "emulsions”.
• the dispersions according to the invention do not comprise a surfactant.
• the invention finally relates to a composition, in particular a cosmetic composition, comprising at least one dispersion as described above and, optionally, a physiologically acceptable medium.
• FIG. 1 is a schematic longitudinal sectional view of a production device according to the invention.
• FIG. 2 is a schematic longitudinal sectional view of a second production device according to the invention.
• FIG. 3 is a perspective view of a production assembly according to the invention comprising a plurality of production devices
• FIG. 4 is a view similar to Figure 1 of a production device according to the invention
• FIG. 5 is a view of an example of dispersion according to the invention in which the elements of the dispersion are in the form of drops formed by a device according to the invention
• FIG. 6 is a view of an example of dispersion according to the invention wherein the elements of the dispersion are in the form of capsules formed by a device according to the invention.
• the viscosity of the dispersions according to the invention can vary significantly, which makes it possible to obtain varied textures.
• each of the phases forming a dispersion according to the invention and / or the dispersion according to the invention has a viscosity ranging from 1 mPa.s to 500,000 mPa.s, preferably from 10 mPa.s to 300. 000 mPa.s, more preferably from 400 mPa.s to 200,000 mPa.s, in particular from 1,000 mPa.s to 100,000 mPa.s, and more particularly from 2,000 mPa.s to 150,000 mPa.s, or even from 2,000 mPa.s to 10,000 mPa.s as measured at 25 ° C.
• the viscosity is measured at room temperature and at ambient pressure, by the method described in WO2016 / 096995.
• the dispersion 12 comprising elements 14 comprising a first phase 16, dispersed in a continuous phase 18.
• the dispersion 12 is direct (ie oil-in-water type) or inverse (ie water-in-oil type).
• the dispersion 12 obtained is kinetically stable.
• the term "kinetically stable” is understood to mean, for example, that the dispersion is stable for at least two weeks, or even one month, preferably three months, and better still six months.
• stable it is meant that the dispersion retains a satisfactory visual homogeneity, that is to say without any dephasing or cremation perceptible to the eye, the absence of opacification of the continuous phase, the absence of aggregation elements between them, and in particular the absence of Oswald coalescence or ripening elements between them, and the absence of leakage of materials from the dispersed phase to the continuous phase, or vice versa.
• the first phase 16 is aqueous or oily, preferably oily, and immiscible with the continuous phase 18 at room temperature and at atmospheric pressure.
• miscible or “substantially immiscible” in the sense of the present invention is meant the solubility of a first phase (or fluid) in a second phase (or fluid) which, at room temperature and at atmospheric pressure, is advantageously less than or equal to 5% by mass.
• the continuous phase 18 is oily or aqueous, preferably aqueous, and in particular of a different nature from the first phase 16.
• the elements 14 are advantageously substantially spherical and preferably macroscopic.
• At least 60%, even at least 70%, preferably at least 80%, and better still at least 90%, of the elements 14 have an average diameter D greater than or equal to 10 ⁇ m, preferably greater than or equal to 50 ⁇ m. pm, in particular greater than or equal to 100 ⁇ m, even greater than or equal to 200 ⁇ m, and better still greater than or equal to 300 ⁇ m, in particular greater than or equal to 400 ⁇ m, and better still greater than or equal to 500 ⁇ m.
• At least 60%, even at least 70%, preferably at least 80%, and more preferably at least 90%, of the elements 14 have an average diameter D of between 10 ⁇ m and 3000 ⁇ m, in particular between 50 ⁇ m and 2500 ⁇ m, preferably between 100 ⁇ m and 2000 ⁇ m, in particular between 200 ⁇ m and 1500 ⁇ m, and even between 500 ⁇ m and 1000 ⁇ m.
• the elements 14 having a diameter greater than or equal to 100 ⁇ m, and represent a volume greater than or equal to 60%, even greater than or equal to 70%, preferably greater than or equal to 80%, and better still greater than or equal to 90% of the total volume of the dispersed phase
• the elements 14 advantageously have an apparent monodispersity (that is, they are perceived in the eye as identical spheres in diameter).
• apparent monodispersity is meant, for a given population of elements 14, a coefficient of variation Cv of the average diameter D of the elements 14 of between 10% and 30%, and better still between 15% and 20%.
• the average diameter D of the elements 14 is for example measured by analysis of a photograph of a batch consisting of N elements 14, by an image processing software. Typically, according to this method, the diameter is measured in pixels, then reported in pm, depending on the size of the container containing the elements 14 of the dispersion 12.
• the value of N is chosen greater than or equal to 30, so that this analysis reflects in a statistically significant manner the diameter distribution of the elements of said emulsion.
• N is advantageously greater than or equal to 100, especially in the case where the dispersion is polydispersed.
• the diameter Di of each element 14 is measured, and the average diameter is obtained.
• the standard deviation s of a dispersion reflects the distribution of the diameters Di of the elements
• the coefficient of variation can be calculated:
• This parameter reflects the distribution of the diameters of the elements 14 as a function of the average diameter thereof.
• the coefficient of variation Cv of the diameters of the elements 14 is advantageously less than 30%, preferably less than 20%, and better still less than 10%, or even less than 5%.
• the monodispersity can be demonstrated by placing a sample of a dispersion according to the invention in a bottle with a constant circular section. A gentle stirring by rotating a quarter of a turn for half a second around the axis of symmetry through the bottle, followed by a rest of half a second is performed, before repeating the operation in the opposite direction, and this four times in a row.
• the elements of the dispersed phase are organized in a crystalline form when they are monodispersed. Thus, they have a stack in a repeating pattern in three dimensions. It is then possible to observe, a regular stack which indicates a good monodispersity, an irregular stack reflecting the polydispersity of the dispersion 12. Where appropriate, those skilled in the art will be able to adjust the viscosity of the phases, in particular of the continuous phase 18, for a satisfactory implementation of this method of characterization of monodispersity.
• the dispersion 12 may advantageously comprise a fraction greater than or equal to 2%, preferably greater than or equal to 5%, better still greater than or equal to 10%, in particular greater than or equal to 15%, better still greater than or equal to 20%, and in particular greater than or equal to 30% by weight of first phase 16, in particular of oil (s), relative to the total weight of dispersion 12.
• first phase 16 in particular of oil (s)
• the maximum fraction in dispersed phase, in particular in oil (s), achievable in direct dispersion is about 15%.
• the dispersion 12 may advantageously comprise a fraction of between 15% and 60%, preferably between 20% and 50%, in particular between 30% and 40% by weight of first phase 16, in particular of oil (s). ), relative to the total weight of the dispersion 12.
• each element 14 of the dispersion is formed of a first phase drop 16.
• each element 14 of the dispersion may comprise at least one bark 16A.
• Those skilled in the art will be able to make the adaptations and / or adjustments necessary to ensure the formation of this bark 16A, taking into account, in particular, the particularities of the device according to the invention.
• the bark 16A may be formed of a coacervate layer at the interface between the first phase 16 and the continuous phase 18.
• This coacervate layer is advantageously formed by interaction between at least one first polymer precursor of the coacervate initially contained in the first phase 16 and at least a second precursor polymer coacervate initially contained in the continuous phase 18.
• the first polymer is a hydrophilic polymer and the second precursor polymer is a lipophilic polymer, or vice versa.
• a "first coacervate precursor polymer / second coacervate precursor polymer” pair is especially a "carbomer / amodimethicone" pair. Examples of elements of this type are described in WO2012120043, the contents of which are incorporated by reference.
• a device according to the invention is furthermore advantageous in that it makes it possible to form a dispersion 12 while avoiding the use of an intermediate liquid generally used to delay the migration of one of the two polymers involved. in the coacervation reaction to the interface between the dispersed phase 16 and the continuous phase 18 and without clogging of the nozzle.
• each element 14 of the dispersion 12 comprises at least one first gelling agent in the first phase 16 and optionally at least one second gelling agent in the continuous phase 18.
• the elements 14 of the dispersion 12 according to this second variant has improved kinetic stability and mechanical strength despite the absence of bark.
• the first phase 16 and / or the continuous phase 18 are, for example, gelled. Examples of hydrophilic or lipophilic gelling agents are described in the application filed under No. FR1752208, the contents of which are incorporated by reference.
• the dispersion 12 comprises at least one first gelling agent in the first phase 16 and optionally at least one second gelling agent in the continuous phase 18, each element 14 further comprising a bark, in particular particular formed of a coacervate layer at the interface between the first phase 16 and the continuous phase 18 by interaction between at least a first polymer initially contained in the first phase 16 and at least a second polymer initially contained in the continuous phase 18
• This variant is advantageous in that it leads to an even better kinetic stability of the dispersion 12.
• the device 10 comprises a production nozzle 20 capable of forming a fluid jet 22, a mechanical fragmentation device 24 intended to mechanically fragment the fluid jet 22 and preferably a chamber 26 for containing and evacuating the dispersion 12.
• the nozzle 20 comprises at least a first duct 30, a second duct 32 and an outlet 34, defined in a frame 35 carrying the nozzle 20.
• fluid jet is meant the flow of several fluids in laminar flow in a common direction, and in particular a flow in which the fluids flow in forming successive cylindrical layers, preferably concentric, arranged one around the other.
• the first duct 30 and the second duct 32 each comprise a succession of at least one substantially cylindrical duct segment in the frame 35.
• the first conduit 30 is intended to convey a first fluid 36, suitable for forming the first phase 16, from a first fluid first supply channel 36.
• the first conduit 30 opens into the second conduit 32, for example at half the length of the second duct 32.
• the segment of the first duct 30 opening into the second duct extends along a flow axis X-X '.
• the second conduit 32 and the first conduit 30 open at the outlet 34 of the nozzle 20 on the same plane.
• the second duct 32 is intended to convey a second fluid 40, suitable for forming the continuous phase 18, from a second channel 42 for supplying second fluid 40.
• the second duct 32 opens at the outlet 34 of the nozzle 20, and surrounds , preferably coaxially, a portion of the first conduit 30 over a portion of the length of the second conduit 32.
• the segment of the second conduit 32 opening at the outlet 34 extends along the flow axis X-X '.
• the nozzle 20 is thus able to form the fluid jet 22 by coextrusion at the outlet 34, the second fluid 40 surrounding, preferably coaxially, the first fluid 36 in the fluid jet 22.
• the fluid jet 22 flows in the vicinity of the outlet 34 in a direction substantially parallel to the flow axis X-X '.
• the outlet 34 is an opening in the frame 35, preferably opening into the chamber 26.
• the opening 34 is part of an opening plane substantially orthogonal to the flow axis X-X '.
• the mechanical fragmentation device 24 is disposed in the vicinity of the outlet 34 of the nozzle 20, and comprises a movable part 50 with respect to the nozzle 34 and an actuator (not shown) intended to set the moving part 50 in motion.
• the movable portion 50 is adapted to fractionate the fluid jet 22 mechanically, that is to say that the displacement of the movable portion 50 intersects the fluid jet 22, preferably regularly, to divide it mechanically.
• the fractionation of the fluid jet 22 takes place at one time, and for a very short time, which makes it possible to control the mechanical action of fragmentation as well as the size of the elements 14.
• the movable portion 50 has through openings 52 along the flow axis X-X ', advantageously regularly spaced from each other.
• the through apertures 52 have sizes and / or different surfaces from each other.
• This particular embodiment makes it possible, for example, to form dispersions according to the invention comprising at least two populations of dispersed elements of different sizes, which can impact the visual and / or the sensoriality and / or the homogeneity of the effect. , especially cosmetic, sought after.
• the movable part 50 has the shape of a planar or cylindrical grid, comprising an alternation of bars or wires, in particular of metal, and of openings 52.
• Each opening 52 advantageously has a transverse extent substantially equal to a transverse extent of the opening 34, in a plane orthogonal to the flow axis X-X '.
• the opening 52 is adapted to allow the flow of the fluid jet 22 when it is opposite the outlet 34.
• the actuator is intended to move the movable portion 50 in a direction substantially transverse to the direction of flow of the fluid jet 22 through the outlet 34.
• the actuator comprises for example an electric motor and a crank-rod system.
• the movable portion 50 is thus movable at least between a closed position, in which the outlet 34 is not facing one of the openings 52 and the movable portion 50 is substantially in the axis X-X 'of the flow fluid jet 22, and an open position in which the outlet 34 is opposite one of the openings 52 and the movable portion 50 allows the flow of the fluid jet 22 without fractionation of the latter.
• the actuator is configured to move the movable portion 50 between the open position and the closed position at a predetermined frequency, so as to fragment the fluid jet 22 and thus form the dispersion 12 according to the invention.
• the speed (or frequency) of movement of the movable portion 50 between the open position and the closed position, the dimensions of the movable portion 50 and / or the opening 52, the spacing between the movable portion 50 and the opening 52 and / or the flow rates imposed on the first fluid 36 and the second fluid 40 determine the size of the elements 14.
• the elements 14 are monophasic and comprise only the first fluid 36, and optionally a bark 16A as mentioned above.
• the volume of the elements 14 depends on the displacement frequency of the mobile part 50, the dimensions of the mobile part 50 and / or the opening 52, the spacing between the mobile part 50 and the opening 52 and / or flow rates imposed on the first fluid 36 and the second fluid 40, and therefore on the fluid jet 22.
• the volume ratio of the elements 14 and the continuous phase 18 depends on the ratio of the flow rates of the first fluid 36 and the second fluid 40 to the outlet 34 of the nozzle 20.
• the chamber 26 is intended to receive the dispersion 12 resulting from the fragmentation of the fluid jet 22 and to evacuate the dispersion 12 for distribution.
• the chamber 26 is situated directly at the outlet 34 of the nozzle 20, so that the nozzle 20 opens directly into the receptacle 26 through the fragmentation device 24.
• the device 10 further comprises at least one mixer in which the dispersion 12 is injected, capable of exerting a controlled and homogeneous shear on the elements 14.
• the mixer comprises at least one shear cell.
• the mixer is adapted to improve the monodispersity of the elements 14, the elements 14 being subjected to shear capable of fragmenting them into elements 14 of homogeneous and controlled diameters, as described in more detail in EP3144058.
• the dispersion 12 obtained comprises elements 14 having an improved size homogeneity.
• the shear cell is advantageously a Couette type cell, comprising at least two coaxial rotary cylinders.
• the cylinders comprise, for example, an outer cylinder having an internal radius Ro and an internal cylinder having an outer radius Ri, with Ro> Ri.
• the outer cylinder is for example fixed, and the inner cylinder is for example animated with a rotational movement at constant angular velocity w.
• the dispersion 12 is disposed between the outer cylinder and the inner cylinder, and sheared by the differential movement of the two cylinders.
• the shear cell comprises two parallel rotating disks, or two parallel oscillating plates.
• the device 10 further comprises at least one independent conduit 62 adapted to convey at the level of the dispersion 12 at least one additional fluid 64 from an independent channel 66 for supplying additional fluid 64 comprising at least one solution for increasing the viscosity of the continuous phase 18.
• the second fluid 40 is thus miscible with the additional fluid 64.
• a solution for increasing the viscosity is, for example, a solution containing a base, especially a alkali hydroxide, such as sodium hydroxide, and is especially described in WO2015055748 whose contents are incorporated by reference.
• the movable portion of the fragmentation device 24 comprises a rotary wiper 80 rotatable about a central axis Z-Z 'at a constant angular velocity.
• the scraper 80 is for example a hollow-axis rotor, substantially circular and has openings 82 oriented radially, opening on an outer contour 84 of the scraper 80.
• the openings 82 open into the central recessed portion of the scraper 80.
• the openings 82 are regularly spaced along the outer contour 84.
• the outer contour 84 extends in the vicinity of the outlet 34, and is orthogonal to the flow axis X-X ', so that the outer contour is substantially tangent to the plane of the opening 34.
• the fragmentation device 24 is thus movable by rotation around the central axis ZZ 'between the open position in which one of the openings 82 is opposite the outlet 34 and the closed position, as described above.
• the actuator is for example a clean electric motor to drive the rotary wiper in rotation about the central axis Z-Z '.
• the frequency of passage of the position closed at the open position then depends on the rotational angular speed of the scraper 80 and the angular difference between two successive openings 82.
• the wiper 80 is driven by an oscillating rather than a rotary movement, preferably at a constant angular velocity.
• the device 10 comprises a nozzle 20 comprising the first conduit 30 and the second conduit 32 and a third conduit 100. At least a portion of the third conduit 100 is surrounded, preferably coaxially, by at least a portion of the first conduit 30.
• the third conduit 100 is adapted to convey a third fluid 102, and provided by a third channel 104 for supplying third fluid 102.
• the fluid jet 22 then comprises the first fluid 36, the second fluid 40 surrounding the first fluid 36, preferably coaxially, and the third fluid 102 surrounded by the first fluid 36, preferably coaxially, the fluid jet 22 being formed by coextrusion.
• Each of the elements 14 formed after fragmentation of the fluid jet 22 then comprises, at least temporarily, an outer core 1 10 formed by the first fluid 36, and at least one, preferably a single, inner core 1 12 formed by the third fluid 102 disposed in the outer heart 1 10.
• the third fluid 102 and the first fluid 36 are substantially miscible.
• This variant is advantageous in that it allows the encapsulation within the same phase of raw materials not compatible with each other, or even of a nature to impact the proper functioning of the device 10.
• miscible or “substantially miscible” in the sense of the present invention is meant the solubility of a first phase (or fluid) in a second phase (or fluid) which, at room temperature and at atmospheric pressure, is advantageously greater than 5% by mass.
• the third fluid 102 comprises high levels of vegetable oils and the first fluid 36 comprises at least one lipophilic cationic polymer precursor of the coarcervate , in particular an amodimethicone, as described above, in an oil known to be a good solvent for the cationic polymer.
• the third fluid 102 and the first fluid 36 each comprise active agents capable of reacting with each other; thus, these assets govern together after the formation of the elements 14.
• the third fluid 102 and the first fluid 36 are substantially immiscible.
• the dispersion 12 is thus multiple, in particular double, and in particular of the water-in-oil-in-water, oil-in-water-in-oil or oil-in-oil-in-water type. This makes it possible to form two-phase elements.
• the two-phase elements 14 form drops provided with a multicomponent core, that is to say comprising an inner core 1 12 formed by the third fluid 102 and an outer core 1 10 formed of the first fluid. 36 completely surrounding the inner core 1 12.
• these drops comprise a bark, in particular coacervate, as described above at the interface between the first fluid 36 and the continuous phase 18, or even further between the first fluid 36 and the third fluid 102. Such a drop is illustrated in FIG.
• the dispersion 12 is such that the first phase 16 comprises at least a first gelling agent and optionally the continuous phase 18 comprises at least one second gelling agent.
• the two-phase elements 14 according to this second variant have improved kinetic stability and mechanical strength despite the absence of bark and the gelling of the outer core 1 10 makes it possible to prevent creaming or sedimentation of the inner core 1 12. Examples of gelling agents are described in the application filed under No. FR1752208 whose contents are incorporated by reference.
• the elements 14 form drops based on a combination of the first and second examples above.
• the elements 14 form capsules comprising a core 1 13 formed by the third fluid 102 and a bark 16C formed by the first fluid 36 disposed around the core 1 13. Such a capsule is illustrated in FIG.
• the bark may be made from at least one gelling agent.
• Such a gelling agent may for example be chosen from a heat-sensitive gelling agent that is solid at room temperature and at atmospheric pressure, such as by the agar, and / or be chosen from a polysaccharide, in particular a polyelecrolyte reactive with multivalent ions, such as for example an alginate.
• the gelling of the polyelectrolyte imposes the presence in the second fluid 40 of at least one reagent capable of reacting with the polyelectrolyte to change it from a liquid state to a gelled state.
• a reagent is typically a solution comprising multivalent ions such as alkaline earth metal ions selected for example from calcium ions, barium ions, magnesium ions, and mixtures thereof.
• gelling agents in particular heat-sensitive agents, polysaccharides, in particular polyelectrolytes reactive with multivalent ions, and reagents capable of reacting with the polyelectrolyte to change it from a liquid state to a gelled state are described in WO2010063937.
• the second fluid 40 comprises at least one reagent capable of reacting with the polyelectrolyte present in the first fluid 36 to change it from a liquid state to a gelled state
• the first fluid 36 and / or the second fluid 40 comprises in addition at least at least one gelling retarder, such as, for example, a tetrasodium pyrophosphate.
• the device 10 further comprises at least one clean heating device for heating at least the first fluid 36 and / or the second fluid 40, for example at the level of the feed channel 38 first. fluid 36 and / or the channel 42 for supplying second fluid 40 and / or in the nozzle 20.
• the heating device is for example disposed in the vicinity of the first conduit 30 and / or the second conduit 32, and in particular surrounds the first conduit 30 and / or the second conduit 32, preferably coaxially.
• the heating device comprises, for example, a heating resistor and an electric generator, and is suitable for heating the first fluid 36 and / or the second fluid 40 by Joule effect.
• the heating device comprises, for example, a heat exchanger.
• the heater is adapted to heat the third fluid 102, and is disposed adjacent the third channel 104 for supplying third fluid 102 and / or third conduit 100, or is capable of heating both the first fluid 36, the second fluid 40 and the third fluid 102 and located in the vicinity of the first conduit 30, the second conduit 32 and the third conduit 100.
• Production set 75 Referring to Figure 3, there is described a production assembly 75 comprising a plurality of production devices 10 according to the first embodiment previously described.
• the production devices 10 are arranged around at least one centripetal circle, with their respective flow axes X-X 'converging towards the center of the circle.
• the production devices 10 are arranged in a centripetal circle whose center is situated on the central axis Z-Z '.
• the production devices 10 are arranged in at least two superimposed centripetal circles, the centers of which are aligned along the central axis Z-Z '.
• Such an embodiment is advantageous in that it makes it possible to easily increase the production yields in dispersion 12 according to the invention, if necessary without multiplying the conduits 38, 42 and optionally 104 supply, respectively, with fluids. 36, 40 and 102.
• the outputs 34 of the devices 10 open into the same shared chamber 26, intended to receive the dispersion 12 produced by each of the devices 10.
• the production assembly 75 comprises a fluid distribution system capable of supplying each production device 10 with first fluid 36, second fluid 40, and optionally third fluid 102, via first channels 38, second channels respectively. 42 and optionally third channels 104.
• the devices 10 share the same first channel 38 and the same second channel 42 and optionally the same third channel 104, the first channel 38 and the second channel 42 and optionally the third channel 104 being substantially circular and concentric with the centripetal circle.
• each first channel 38 opens into (s) first (s) conduit (s) 30 and each second channel 42 opens into (s) second (s) conduit (s) 32, or each third channel 104 opens into the (s) third (s) 100 through at least a pressure drop, for example formed by a reduced section channel portion.
• the pressure drop causes a slowing down of the flow of the first fluid 36, respectively the second fluid 40, or even the third fluid 102 upstream of the nozzle 20.
• the channel portions have a section in a plane transverse to the direction of flow of the first fluid 36, respectively the second fluid 40, or even the third fluid 102, of smaller area than the cross sections of the first channel 38 and the first conduit 30, respectively of the second channel 42 and the second conduit 32, or even the third channel 104 and the third conduit 100. Due to the pressure drop produced, it is possible to regulate the flow of the first fluid 36, respectively of the second fluid 40, or even the third fluid 102 downstream of the pressure drop and thus to homogenize the fluid (s) injected (s) in the production devices 10.
• the fluid distribution system comprises for example a first pump fluidly connected to the first channel 38 and a first fluid reservoir 36.
• the first pump is adapted to circulate the first fluid 36 in the first channel 38 and to supply the devices 10 first fluid 36 with predetermined flow.
• the fluid distribution system also comprises a second pump fluidly connected to the second channel 42 and to a second fluid reservoir 40.
• the second pump is capable of circulating the second fluid 40 in the second channel 42 and supplying the devices 10 with second fluid 40 with a predetermined flow rate, equal or not to the flow rate of the first fluid 36.
• the fluid distribution system also comprises a third pump fluidly connected to the third channel 104 and a third fluid reservoir 102.
• the third pump is adapted to circulate the third fluid 102 in the third channel 104 and to supply the devices 10 in the third fluid 102 with a predetermined flow rate, equal or not to the flow rate of the first fluid 36 and / or the second fluid 40.
• the devices 10 advantageously share the same fragmentation device, which comprises a rotary wiper 80 as described above.
• the rotary scraper 80 is arranged to traverse an inner contour 83 of the centripetal circle and thus be substantially tangent to the plane of opening of each of the outlets 34 of the devices 10.
• the inner contour 83 of the centripetal circle and the outer contour 84 of the scraper 80 are advantageously separated by a distance less than or equal to 1 mm, preferably less than or equal to 0.5 mm, and better still less than or equal to 0.2 mm.
• the openings 82 of the rotary scraper 80 are advantageously regularly spaced angularly, the rotary scraper is therefore adapted to fragment the fluid jets 22 formed by each of the nozzles 20 at the same predetermined frequency and thus form the elements 14 identically to the output 34 of FIG. each of the nozzles 20.
• the openings 82 of the rotary scraper 80 may also have different sizes and / or surfaces from each other, the rotary scraper then being adapted to form at least two populations of elements 14 of different sizes.
• the devices advantageously share the same fragmentation device, which comprises an oscillating wiper 80.
• the production devices 10 of the assembly 75 are arranged around at least one centrifugal circle, with their respective flow axes X-X 'diverging from the center of the circle.
• outlets 34 of the devices 10 are oriented towards the outside of the centrifugal circle and open into the same shared substantially annular chamber 26 arranged around the production devices 10.
• the fluid distribution system is as described above, the first channel 38, the second channel 42 and optionally the third channel 104 for dispensing fluids being disposed internally with respect to the production devices 10, for example in the vicinity of the central axis Z-Z '.
• the rotating or oscillating wiper 80 is shared between the devices 10 and arranged to traverse an outer contour of the centrifugal circle.
• An inner contour of the wiper 80 is thus substantially tangent to the outlets 34 of the devices 10, as described above.
• outlets 34 of the nozzles 20 are arranged substantially parallel to each other, and substantially parallel to the central axis Z-Z '.
• the rotating or oscillating scraper 80 is arranged to face the outlets of the nozzles 20 parallel to each other.
• the scraper 80 has, for example, the shape of a disk rotating around the central axis Z-Z ', having apertures 52 passing therethrough in the vicinity of its periphery, arranged to face the outlets 34 and opening into the chamber 26.
• the scraper 80 has a thickness greater than or equal to 5 mm, in particular greater than or equal to 10 mm, or even greater than or equal to 20 mm, and preferably less than or equal to 200 mm, advantageously less than or equal to 100 mm.
• the opening (s) 52 may thus have the shape of a tunnel, for example circular or oblong, which constitutes an environment conducive to the realization of stabilization phenomena dispersed elements under mild conditions, especially when the bark is formed of a coacervate layer as described above, then allowing the dispersion to better withstand disturbances and / or shear phenomena that may occur in the chamber 26.
• the fragmentation device 24 according to this second embodiment may further advantageously comprise at least one cooling system.
• Such an "integrated" and continuous cooling system has improved cooling performance and space optimization compared to a conventional cooling system best disposed at the chamber 26.
• the production process comprises a preliminary step of supplying the production device 10, as well as a first fluid 36 and a second fluid 40 that is substantially immiscible with the first fluid 36.
• the first fluid 36 is supplied via a first fluid supply duct 38 connected fluidly to a first duct 30 and the second fluid 40 is supplied via a second duct 42.
• second fluid supply 40 fluidly connected to a second conduit 32 of a nozzle 20 of the device 10.
• the method comprises at least one flow step, in the direction of an outlet 34 of the nozzle 20 in a direction of flow X-X ', the first fluid 36 in a first conduit 30 and the second fluid 40 in a second conduit 32, said second conduit 32 surrounding, preferably coaxially, at least a portion of the first conduit 30.
• the method then comprises a step of forming a fluid jet 22 at the outlet 34 of the nozzle 20, the fluid jet 22 being formed by coextrusion and comprising the first fluid 36 and the second fluid 40 surrounding the first fluid 36, preferably coaxially.
• the fluid jet 22 flows in the direction of flow X-X ', and transversely to an opening plane of the outlet 34.
• the method comprises a step of moving a moving part 50 of a fragmentation device 24 of the production device 10, to fragment the fluid jet 22 and obtain a dispersion 12 according to the invention.
• the mobile part 50 is displaced in a direction substantially orthogonal to the flow direction X-X ', and substantially tangentially to the opening plane of the outlet 34.
• the movable portion 50 is moved by an actuator so as to form the elements 14 at a fixed predetermined frequency.
• the elements 14 are then substantially identical to each other, so that the dispersion 12 obtained is monodisperse.
• the movable portion 50 is a rotary scraper 80, the displacement of the movable portion 50 is then a rotation about a central axis Z-Z 'at a constant angular velocity.
• the movable portion 50 is a scraper with oscillating rather than rotary motion at constant angular velocity.
• An outer contour 84 of the rotary wiper then extends in the vicinity of the outlet 34, substantially tangentially to the opening plane of the outlet 34.
• the method finally comprises a step of recovering the dispersion 12 comprising the elements 14 dispersed in the continuous phase 18.
• the method comprises the step of flowing the first fluid 36 and second fluid 40 as described above, as well as a third fluid 102 in a third duct 100 surrounded at least in part by preferably coaxially, by at least a portion of the first conduit 30.
• the third fluid 102 is substantially miscible with the first fluid 36.
• the third fluid 102 is substantially immiscible with the first fluid 36.
• the fluid jet 22 thus formed by coextrusion comprises the first fluid 36, the second fluid 40 and the third fluid 102, in which the second fluid 40 surrounds the first fluid 36, preferably in a coaxial manner, and the first fluid 36 surrounds the third fluid 102, preferably coaxially.
• the elements 14 are monophasic or two-phase.
• the method further comprises a step of refining in size, during which a controlled and homogeneous shear is applied to the elements 14 in a mixer, the mixer being in particular as described above.
• the method further comprises a step of filtering the dispersion 12 to harvest only the elements 14.
• a dispersion 12 according to the invention in particular the dispersed phase 16 (first fluid 36) and / or the continuous phase 18 (second fluid 40) and / or the third fluid 102, may further comprise at least one additional compound different from the precursor polymers of the coacervate, gelling agents and polysaccharides mentioned above.
• a dispersion 12 according to the invention may furthermore comprise powders, flakes, coloring agents, especially chosen from water-soluble or non-fat-soluble, liposoluble or non-organic or inorganic dyes, pigments, optical effect materials, liquid crystals, and mixtures thereof, particulate agents insoluble in the fatty phase, emulsifying and / or non-emulsifying silicone elastomers, preservatives, humectants, stabilizers, chelators, emollients, modifying agents selected from pH, strength agents osmotic and / or refractive index modifiers etc ... or any usual cosmetic additive, and mixtures thereof.
• coloring agents especially chosen from water-soluble or non-fat-soluble, liposoluble or non-organic or inorganic dyes, pigments, optical effect materials, liquid crystals, and mixtures thereof, particulate agents insoluble in the fatty phase, emulsifying and / or non-emulsifying silicone elastomers, preservatives, hum
• a dispersion 12 according to the invention may further comprise at least one active agent, in particular biological or cosmetic, preferably chosen from hydrating agents, healing agents, depigmenting agents, UV filters, desquamating agents, antioxidants, active agents stimulating the synthesis of dermal and / or epidermal macromoleculars, agents dermodecontracting agents, antiperspirants, soothing agents, anti-aging agents, perfuming agents and mixtures thereof.
• active agent in particular biological or cosmetic, preferably chosen from hydrating agents, healing agents, depigmenting agents, UV filters, desquamating agents, antioxidants, active agents stimulating the synthesis of dermal and / or epidermal macromoleculars, agents dermodecontracting agents, antiperspirants, soothing agents, anti-aging agents, perfuming agents and mixtures thereof.
• active agent in particular biological or cosmetic, preferably chosen from hydrating agents, healing agents, depigmenting agents, UV filters, desquamating agents, antioxidants, active agents stimulating the synthesis of dermal and / or epidermal
• any additional compound (s) mentioned above and / or their respective amounts so that the device and / or the advantageous properties of a dispersion according to the invention are not not or substantially unaffected by the proposed addition.
• the nature and / or the amount of the additional compound (s) depends (s) on the aqueous or oily (or oily) nature of the phase of the dispersion according to the invention.
• a dispersion according to the invention may be a topical and therefore non-oral composition, or a food composition.
• a dispersion according to the invention is directly usable, at the end of the aforementioned preparation processes, as a composition, in particular a cosmetic composition.
• the dispersions according to the invention may comprise, in addition to the aforementioned ingredients, at least one physiologically acceptable medium.
• physiologically acceptable medium means a medium suitable for cosmetic applications, and particularly suitable for the application of a composition of the invention to a keratinous material, in particular the skin and / or the hair, and more particularly the skin.
• the physiologically acceptable medium is generally adapted to the nature of the medium to which the composition is to be applied, as well as to the appearance under which the composition is to be packaged.
• the physiologically acceptable medium is directly represented by the continuous phase as described above.
• the cosmetic compositions of the invention may be, for example, a cream, an emulsion, a lotion, a serum, a gel and an oil for the skin (hands, face, feet, etc.), a foundation (liquid, paste ) a preparation for baths and showers (salts, foams, oils, gels, etc.), a hair care product (hair dye and bleach), a cleaning product (lotions, powders, shampoos), a care product for the hair (lotions, creams, oils), a styling product (lotions, lacquers, glossines), a product for shaving (soaps, foams, lotions, etc.), a product intended to be applied to the lips, a product solar, a tanning product without sun, a product for whitening the skin, an anti-wrinkle product.
• the cosmetic compositions of the invention may be an anti-aging serum, a youth serum, a moisturizing serum or a scented water.
• the present invention also relates to a non-therapeutic method for the cosmetic treatment of a keratin material, in particular the skin and / or the hair, and more particularly the skin, comprising a step of applying to said keratin material at least one composition or at least one layer of a cosmetic composition mentioned above.

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• 2018
  • 2018-01-24 FR FR1850550A patent/FR3077011B1/fr active Active
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