EP3499160B1 - Lyophilisateur, installation de lyophilisateur, procédé de fonctionnement d'un lyophilisateur et nouvelle utilisation d'un chariot - Google Patents

Lyophilisateur, installation de lyophilisateur, procédé de fonctionnement d'un lyophilisateur et nouvelle utilisation d'un chariot Download PDF

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Publication number
EP3499160B1
EP3499160B1 EP17207708.3A EP17207708A EP3499160B1 EP 3499160 B1 EP3499160 B1 EP 3499160B1 EP 17207708 A EP17207708 A EP 17207708A EP 3499160 B1 EP3499160 B1 EP 3499160B1
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EP
European Patent Office
Prior art keywords
loading
units
unloading
freeze dryer
pushing device
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EP17207708.3A
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German (de)
English (en)
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EP3499160A1 (fr
Inventor
Martin Christ
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MARTIN CHRIST GEFRIERTROCKNUNGSANLAGEN GmbH
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MARTIN CHRIST GEFRIERTROCKNUNGSANLAGEN GmbH
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Priority to ES17207708T priority Critical patent/ES2787019T3/es
Priority to EP17207708.3A priority patent/EP3499160B1/fr
Publication of EP3499160A1 publication Critical patent/EP3499160A1/fr
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    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B25/00—Details of general application not covered by group F26B21/00 or F26B23/00
    • F26B25/001—Handling, e.g. loading or unloading arrangements
    • F26B25/003—Handling, e.g. loading or unloading arrangements for articles
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B9/00—Machines or apparatus for drying solid materials or objects at rest or with only local agitation; Domestic airing cupboards
    • F26B9/06—Machines or apparatus for drying solid materials or objects at rest or with only local agitation; Domestic airing cupboards in stationary drums or chambers
    • F26B9/066—Machines or apparatus for drying solid materials or objects at rest or with only local agitation; Domestic airing cupboards in stationary drums or chambers the products to be dried being disposed on one or more containers, which may have at least partly gas-previous walls, e.g. trays or shelves in a stack

Definitions

  • the invention relates to a freeze dryer and a freeze drying system with a freeze dryer and a method for operating a freeze dryer.
  • the invention relates to a new use of a slide of a freeze dryer.
  • Freeze dryers are used for the gentle drying of high-quality items to be dried, in particular pharmaceutical or biopharmaceutical items.
  • the material to be dried contains a solvent (e.g. water or any other liquid) which should be removed by freeze-drying.
  • the material to be dried is freeze-dried in drying vessels, which can also be referred to as vials.
  • Such vials have a container and a lid or stopper.
  • the stopper is partially open during the freeze-drying process so that it does not close the container in a fluid-tight manner and sublimed solvent can escape from the interior of the vial during the freeze-drying process. Once the solvent has been largely removed from the material to be dried and the vials at the end of the freeze-drying process, the stopper is completely closed to create a fluid-tight seal.
  • the material to be dried is introduced into the drying vessel in a drying chamber of the freeze dryer and frozen there.
  • several drying vessels in a loading and unloading level can be automatically fed to a shelf of the freeze dryer via a carriage.
  • a multiplicity of drying vessels are automatically fed over the slide successively to a plurality of standing surfaces of the freeze dryer arranged one above the other, which are arranged via a standing surface drive for loading from below from below a loading and unloading level Recording space can be lifted into the loading and unloading level and can be lowered from above into the loading and unloading level for unloading.
  • a so-called primary drying takes place, in that in the product chamber at low pressure or technical vacuum and low temperature the solvent contained in the material to be dried directly from the frozen state to the gaseous state without the intermittent occurrence of a liquid phase sublimated.
  • the previously sublimed solvent is deposited as ice in an ice condenser chamber, which is in particular connected to or integrally formed with the drying chamber (for example on a cooled cooling coil of the ice condenser chamber).
  • Secondary drying can follow the explained primary drying, in which more strongly bound solvent is removed by heating the material to be dried and lowering the pressure.
  • the end product of freeze drying which is referred to as lyophilisate, remains in the drying vessels in the drying chamber.
  • the sealed drying vessels with the material to be dried are then moved out of the drying chamber again, which can be done automatically via a slide and can be achieved when using several stacked shelves while successively lowering the shelves into the loading and unloading level.
  • the publication WO 2012/048789 A1 discloses the use of a slide guided in relation to lateral guides for pushing in and out drying containers in and out of a drying chamber of a freeze dryer.
  • the drying vessels are pushed in and, on the other hand, pushed out by means of different end faces of the slide.
  • the carriage is driven by a linear motor, the primary part of which is integrated in the guides, while the secondary part is integrated in the carriage.
  • the floor space with the drying vessels arranged thereon is raised, with which the carriage can be moved past under the floor space with the drying vessels arranged thereon, with the subsequent subsequent lowering of the floor space with the drying vessels.
  • the slide has a U-shaped configuration in plan view, the base leg of the U forming a pushing device with the two end faces coming into contact with the drying vessels, while the side legs of the U have the secondary parts.
  • the side legs of the U can be arranged in pipe sockets carried by the housing of the drying chamber, which are otherwise designed as sight glasses of the freeze dryer.
  • the publication WO 2013/136161 discloses a sled with which drying vessels can be inserted into a drying chamber for loading as well as pushed out of the drying chamber for unloading after the drying has been carried out.
  • the publication suggests WO 2013/136161 for a first (with regard to the embodiment according to WO 2012/048789 A1 Corresponding) alternative to raise the footprint with the drying vessels arranged on it so that the slide in its configuration used for inserting and along the degree of freedom of movement that is also used during the insertion of the drying vessels underneath the footprint with the drying vessels arranged on it move the drying chamber to a rear parking position.
  • the floor space with the drying vessels arranged thereon can then be lowered back into the original plane and the drying vessels can then be pushed out.
  • the publication suggests a second alternative WO 2013/136161 the use of a push rod, which is arranged for pushing in and pushing out the drying vessels in the plane of the drying vessels, so that the drying vessels rest against the push rod and, by moving the push rod in the loading and unloading direction, pushing the drying vessels in and out can be.
  • the slide formed with the push rod is brought into the rear parking position without the lifting surface with the drying vessels arranged thereon being raised.
  • a collision of the push rod with the drying vessels arranged on the non-raised shelf is avoided by increasing the height of the push rod in such a way that the push rod is arranged on the drying vessels in a space between the top of the drying vessels and an underside of any overlying surface can.
  • the push rod In the raised state of the push rod, the push rod can thus be moved past the drying vessels until the rear parking position is reached. In the rear park position, the push rod is then lowered again, which then (after the drying process has been carried out) enables the drying vessels to be pushed out.
  • the push rod for a first embodiment can be moved translationally in the vertical direction.
  • the push rod is angled in a U-shaped manner in both end regions, the side legs of the U forming swivel arms for pivoting the push rod and the swivel arms being rotatably mounted in the end regions relative to drive and guide units of the slide. If the push rod is pivoted such that the U is oriented horizontally, the push rod can interact with the drying vessels in order to push them in or push them out.
  • the push rod for loading should be arranged in a front position in the direction of insertion, while it should be moved to a rear position for unloading.
  • WO 2013/136161 discloses embodiments in which the drive and guide units of the slide arranged on both sides of the standing surface are coupled to one another exclusively via the push rod, as well as embodiments in which the drive and guide units are also coupled via a coupling rod.
  • Drive means and energy supply means can be integrated into the drive and guide units, it also being proposed that the drive means and energy supply means can be integrated into the push rod or another housing part connecting the drive and guide units.
  • the carriage can be driven by an electromagnetic linear motor.
  • the drive of the carriage via a belt drive, a worm drive or a rotating flexible shaft is proposed.
  • two different drive units can be used on the one hand to drive the slide and on the other hand to move the push rod.
  • the present invention proposes a combination of these two basic ideas, for which the person skilled in the art has so far had no reason.
  • the reason for this is that, in the opinion of the person skilled in the art, lifting the pushing device of the slide had previously to be regarded as superfluous if the slide in the freeze dryer had already undermined the shelves.
  • a pushing device is used in the slide, the relative position of which in relation to the drive and / or guide units of the slide can be changed in a plan view.
  • This can mean that the pusher is only moved in a horizontal plane of movement or parallel to the direction of insertion and extension relative to the drive and / or guide units.
  • Carriage designed in this way is used for a freeze dryer in which one position moves between the loading of the storage surface and the unloading of the storage surface in an idle stroke, in which the carriage is moved past the drying vessels without interacting with the drying vessels the footprint is moved to a position behind the footprint by driving under the footprint.
  • This underrunning of the footprint takes place in particular in a state in which the bottom footprint is raised in the case of a plurality of previously loaded footprints, so that the carriage passes under all loaded footprints.
  • this does not (only) depend on a degree of freedom of the thrust device in relation to the drive and / or guide units in the vertical direction, but rather (at least also) on a relative degree of freedom in a plan view, i.e. in a horizontal plane or in the loading direction and unloading.
  • a first solution to the problem on which the invention is based consists in a novel use of a slide with a (at least also) horizontal degree of freedom of the pusher device in relation to the drive and / or guide units for a freeze dryer, in which the parking space (in particular the lowest floor space) is driven under or all floor spaces).
  • a further solution to the problem on which the invention is based is a freeze dryer which has a control logic which controls the drive and / or guide units in such a way that they first move the carriage in the loading direction, with which drying vessels are pushed onto a shelf.
  • the control unit then controls the shelf drive in such a way that the shelves with the drying vessels arranged thereon are raised. All of the shelves or the bottom shelf with drying vessels arranged thereon are preferably raised.
  • the drive and / or guide units of the slide are controlled so that they move the slide under the footprint (under the lowest footprint and in particular under all footprints) into a position arranged behind the footprint and the drying vessels arranged thereon.
  • this position can be a parking position between the shelves and the rear wall of the drying chamber.
  • control unit controls the drive and / or guide units in such a way that they move the carriage in the unloading direction, with the result that drying vessels are pushed off the shelf, which can be done successively for all shelves by successively moving them into the loading area. and the discharge level are lowered, as is known in principle from the prior art mentioned at the beginning.
  • the control logic is designed in such a way that it controls the drive of the thrust device between the aforementioned method steps (namely between loading by pushing the drying vessels onto the shelf and moving the carriage in the unloading direction by pushing the drying vessels off the shelf). that this is the Relative position of the pusher relative to the drive and / or guide units changed in the plan view. This is preferably done after loading and before driving under the shelves in the idle stroke.
  • a relative position of the pusher device relative to the drive and / or guide units is changed in plan view between pushing on the drying vessels and pushing down the drying vessels.
  • the height of the interspaces can be minimized or, for example, reduced to 10 mm or less, while all that is required is a single lifting of all the storage spaces to be unloaded with a stroke of 50 mm in order to enable the bottom storage space to be passed underneath.
  • a reduction in the overall height of the freeze dryer by up to 450 mm is possible according to the invention.
  • the undesired running over of the drying vessels can be avoided, which can lead to contamination of the drying vessels, for example in the form of whirled up abrasion particles or impurities or as a result of a disturbance in the desired flow around the drying vessels.
  • the drive and / or guide units are formed with a belt drive
  • this drive concept already results in a relatively large extension of the drive and / or guide units in the loading and unloading direction.
  • the pushing device should have the smallest possible extent in the loading and unloading direction. The reason for this is that in a parking position the pusher between the rear wall of the drying chamber and the shelves must be arranged.
  • an enlarged extension of the pusher in the loading and unloading direction means that the horizontal extension of the drying chamber is ultimately larger, which is undesirable.
  • a further geometrical boundary condition for the design of the carriage is the requirement that successive rows of drying vessels are delivered by a conveyor belt, which in each case conveys the rows horizontally but transversely to the loading and unloading direction.
  • the carriage In order to be able to successively push the rows of drying vessels from the conveyor belt in the direction of the drying chamber, the carriage must be arranged on the side of the conveyor belt facing away from the drying chamber. If the carriage is then moved (for example by a cross conveyor on which the carriage is arranged) transversely to the conveying direction of the conveyor belt in the direction of the drying chamber, the end face of the pusher comes into contact with the row of drying vessels. Before this, however, the carriage must be moved so far away from the drying chamber that the row of drying vessels can be fed in without colliding with the carriage.
  • the slide must be moved further away from the drying chamber and the successive strokes for moving the rows of drying vessels in the direction of the drying chamber down from the conveyor belt enlarge, which is also undesirable. Due to the degree of freedom according to the invention for the pusher device in relation to the drive and / or guide units, the pusher device can be moved into the optimal relative position in relation to the drive and / or guide units in the different phases of the operation of the freeze dryer.
  • the carriage is moved in the idle stroke along the loading and unloading plane in which it is also moved during the loading stroke and the unloading stroke.
  • there is one footprint during the empty stroke there are several footprints during the empty stroke or all of the footprints are raised via a footprint drive during the empty stroke so that the carriage can move along under a footprint or the lowest loaded footprint.
  • the lowest footprint it is possible for the lowest footprint to be raised to enable the empty stroke only with a vertical stroke which is smaller than the sum of the height of the drying vessels and the plate thickness of the lowest footprint.
  • the change in the relative position of the pushing device with respect to the drive and / or guide units is preferably carried out in plan view, with the possible change in the relative position, the lifting of all the storage surfaces and the Empty stroke of the carriage takes place immediately after loading and / or before the drying process is carried out, while for another embodiment this takes place after the drying process has been carried out.
  • the pushing device is displaced translationally relative to the drive and / or guide units, in particular in a horizontal plane or parallel to the loading and unloading direction and / or loading and unloading plane.
  • the change in the relative position of the thrust device with respect to the drive and / or guide units takes place in a top view by pivoting the thrust device with respect to the drive and / or guide units about a transverse axis.
  • the slide can have, for example in accordance with the prior art mentioned at the outset, a pivotable U-shaped bracket, the base leg of which forms a push strut, while the side struts serve as pivot arms for pivoting the push strut.
  • the pusher device is rigidly attached to the drive and / or guide units.
  • a change in the relative position of the pusher device with respect to the drive and / or guide units in a plan view can be achieved by pivoting or rotating the pusher device, in particular by a suitable turning device, together with the drive and / or guide units about a transverse axis so that it is "turned upside down".
  • a suitable turning device together with the drive and / or guide units about a transverse axis so that it is "turned upside down”.
  • the pushing device is not centered on the loading and unloading direction on the drive and / or guide units, such a “turning over” of the carriage leads to the desired change in the relative position.
  • both the pushing-in and pushing-out of the drying vessels can be carried out by the pushing device.
  • the drying vessels are pushed in with a first, preferably vertically oriented end face of the pusher device, while the drying vessels are pushed out with a second, preferably vertical, front side of the pusher device.
  • the two drive and / or guide units can be connected exclusively via the pusher device, or a further coupling device connecting the drive and / or guide units to one another is arranged in such a way that it does not interact with the drying vessels.
  • the drying vessels are pushed in with one end face of the pushing device, while the drying vessels are pushed out with one end face of a coupling device.
  • the insertion it is also possible for the insertion to take place with the end face of the coupling device, while the pushing out is carried out with an end face of the pushing device.
  • a change in the relative position of the thrust device with respect to the drive and / or guide units can be at any position along the path of the slide and at any time during the loading, the freeze-drying process and the unloading and at any place inside or outside the Drying chamber.
  • the pusher device is not pivotable, but rather can be displaced horizontally and translationally with respect to the drive and / or guide units, the relative position of the pusher device can be changed within the drying chamber or even during the idle stroke when moving under the shelves.
  • the change in the relative position of the pusher device relative to the drive and / or guide units takes place in a plan view outside the drying chamber.
  • a turning device is used to turn the slide over, this means that such a turning device does not have to be arranged within the drying chamber, which would in turn undesirably increase the size of the drying chamber.
  • a free space (preferably in the vertical direction) can be used outside of the drying chamber to enable the swiveling. If this were to take place within the drying chamber, there would also have to be free installation space in the vertical direction to be provided.
  • the pusher device can return to its original height at which it is arranged as low as possible above the loading and unloading level.
  • the thrust device can be brought into a relative position with respect to the drive and / or guide units, in which it can be arranged in a particularly space-saving manner in the parking position, that is to say between storage spaces and the rear wall of the drying chamber.
  • such a space-saving arrangement in the parking position is characterized in that the slide in the position arranged behind the standing surface and the drying vessels arranged thereon is at least partially (for example with a part of a drive and / or guide unit) in a recess ( a pipe socket or a sight glass) of the rear wall of the freeze dryer is arranged.
  • the drive, a control unit and / or battery There are various possibilities for the arrangement of the drive, a control unit and / or battery. For example, outside of the drying chamber, in the drying chamber, in a guide of the slide, and the like. ⁇ . be arranged.
  • the pushing device or coupling device can be used in a multifunctional manner, which may result in a further reduction in the installation space requirements.
  • a carriage 1 which has two drive and / or guide units 2, 3.
  • the drive and / or guide units 2, 3 can here serve to generate the drive movement of the slide 1 or at least participate in this and / or serve to guide the slide 1 during the passage of the loading stroke, the unloading stroke and the empty stroke.
  • these can interact with guides (cf. the guides 39, 40, 48, 49 below).
  • the guides preferably extend both inside a drying chamber of the freeze dryer and outside the same.
  • the guides are oriented parallel to one another and oriented parallel to the direction of movement of the slide 1 via the loading stroke, the unloading stroke and the empty stroke.
  • the guides can have temporary or permanent gaps, particularly in the entry area into the freeze dryer. In the event that the gaps cannot be closed by a longitudinal displacement during the loading stroke, the unloading stroke and / or the empty stroke, the drive and / or guide units and the guides must be suitably designed so that such gaps can be passed over.
  • the drive and / or guide units 2, 3 have a belt drive.
  • the guides (preferably on the top) have a toothing which interacts with the belt drive. It is possible that the guides also guide the rows of drying vessels laterally during loading and unloading. As far as possible, however, additional guides are provided for this.
  • the guides can be arranged on the shelves or can be arranged to the side thereof, in the latter case a pair of guides can be used for loading and unloading all the shelves.
  • the drive and / or guide units 2, 3 have a drive arranged outside the drying chamber and coupling means, in particular a joint system, connecting the drive to the drive and / or guide units 2, 3 (cf. DE 103 07 571 A1 . WO 2005/121671 A1 ).
  • the drives can also be integrated in the drive and / or guide units (and possibly also at least partially in the pushing device), with the drives then wheels of the drive and / or guide units can drive which can frictionally interact with the guides, can interact with toothing in the racks of the guides or can drive a circumferential belt which interacts frictionally or via an external toothing with the guides (see, for example, the "LyoShuttle Drive” system of applicant).
  • the two drive and / or guide units 2, 3 each have a drive and serve to guide the slide 1, or that only one drive and / or guide unit 2 has a drive and serves to guide the slide 1 while the other drive and / or guide unit 3 is used exclusively to guide the carriage 1.
  • control signals and / or the power supply to the sled can be transmitted in a wired or wireless manner.
  • control signals and / or the energy supply via the guides on the slide, for example via induction or a sliding contact or customer.
  • a battery can also be integrated in the slide 1, for example, which serves to supply energy to the slide 1, charging the battery in a wired or wireless manner in selected operating positions, such as a parking position of the slide 1 within the drying chamber , for example in the space between the shelves and the rear wall of the freeze dryer, or outside the freeze dryer (cf. EP 3 144 618 B1 ).
  • Fig. 1 shows a first embodiment of a carriage 1 in a plan view.
  • the drive and / or guide units 2, 3 are connected to one another here via a pushing device 4 and a coupling device 5.
  • the coupling device 5 connects the drive and / or guide units 2, 3 firmly and rigidly to one another.
  • the coupling device 5 is designed as a coupling strut 6, which is fastened in its two end regions to a housing of the drive and / or guide units 2, 3.
  • the pusher 4 is designed here as a bracket 7.
  • the bracket 7 is pivotable about a pivot axis 8 for this embodiment.
  • the bracket 7 is formed in a first approximation U-shaped with a base leg formed by a push strut 9, which is oriented parallel to the pivot axis 8, and two side struts 10, 11, which are oriented vertically to the pivot axis 8 and whose end regions facing away from the push strut 9 are pivotably guided by journals 12, 13 relative to the housings of the drive and / or guide units 2, 3.
  • a push strut 9 which is oriented parallel to the pivot axis 8
  • two side struts 10, 11 which are oriented vertically to the pivot axis 8 and whose end regions facing away from the push strut 9 are pivotably guided by journals 12, 13 relative to the housings of the drive and / or guide units 2, 3.
  • the coupling strut 6 and the push strut 9 are arranged directly adjacent to one another at a small distance 16 from one another, arranged at the same height and arranged in a common horizontal plane which is a distance from the contact surface of the drive and / or guide units 2, 3 from have a footprint of the freeze dryer that is smaller than the height of the drying vessels arranged on the shelf.
  • the bracket 7 According to the unloading position Fig. 1 can the bracket 7 upwards by 180 ° in the loading position Fig. 2 are pivoted, in which the coupling strut 6 and the push strut 9 are also arranged at the same height and in a common horizontal plane. In this case, however, there is an increased distance 17 in the direction of the loading stroke 14 and unloading stroke 15.
  • the pivoting of the bracket 7 thus leads to a displacement of the push strut 9 in a plan view, which corresponds to the difference between the distance 17 and the distance 16 and is approximately twice as large is like the longitudinal extension of the side struts 10, 11.
  • a second embodiment of the carriage 1 is shown, which is basically according to the embodiment Fig. 1 and 2 corresponds, but here the coupling device 5 with the coupling strut 6 has been omitted.
  • the pushing device 4 comes into operative connection with the drying vessels 25 in the loading position and in the unloading position with end faces arranged on opposite sides.
  • Fig. 5 and 6 show a third embodiment of the carriage 1, wherein Fig. 5 the unloading position and Fig. 6 shows the loading position.
  • the pushing device 4 also has a push strut 9 here.
  • the push strut 9 is not part of a pivotable bracket 7. Rather, the push strut 9 is movable along a translational degree of freedom 18 along guides 19, 20 of the drive and / or guide units 2, 3.
  • the translational degree of freedom 18 is oriented parallel to the loading stroke 14 and the unloading stroke 15.
  • the push strut 9 comes into operative connection with the drying vessels 25 in the loading position and in the unloading position with end faces arranged on opposite sides.
  • a freeze drying system 21 in different process steps of a process 73, which is shown schematically in Fig. 16 is shown.
  • the freeze drying system 21 has a conveyor device 22, in particular in a conveyor belt 23.
  • the conveyor device 22 is used to cycle rows 24a, 24b, 24c, ... of drying vessels 25 in a conveying direction 26 into a loading position (which is shown in FIG Fig. 7 taken from row 24a).
  • the carriage 1 is located on a cross conveyor 29.
  • the cross conveyor 29 is arranged on the side of the conveyor 26 facing away from a freeze dryer 35.
  • the pusher 4 of the carriage 1 is in the loading position on the cross conveyor 29.
  • the cross conveyor 29 has a rear position in which it is arranged with the carriage 1 on the side of the conveyor 22 facing away from the freeze dryer 35.
  • the cross conveyor 29 In a front position, which in Fig. 7 is taken, the cross conveyor 29 is partially arranged above the conveyor 22.
  • the cross conveyor 29 can be moved back and forth between the front and rear positions by means of a suitable actuator, in particular an actuating cylinder.
  • a suitable actuator in particular an actuating cylinder.
  • the end face 36 of the pusher 4 forms with a guide ruler 76 which is oriented vertically and parallel to the conveying direction 26 and vertically from the plane predetermined by the conveying device 22 and the loading bridge 30
  • a guide channel for a row 24a of the drying vessels 25 can be moved out at the top, the width of the guide channel corresponding approximately to the diameter of the drying vessels 25.
  • a method step 28 the row 24a delivered is pushed down by the conveyor 22 onto the loading bridge 30, for which purpose the guide ruler is lowered until the next row 24b is delivered.
  • a method step 31 it is checked whether all the rows 24 which are to be fed to a footprint 32 have already been pushed onto the loading bridge 30. If this is not the case, the method steps 27, 28 are repeated, which has the consequence that further rows 24b, 24c, ... are pushed onto the loading bridge 30.
  • the cross conveyor device 29 has cross conveyor guides 33a, 33b, on which the carriage 1 according to FIG Fig. 2 stands in the loading position braked or locked.
  • the respective row 24 is pushed down from the conveyor device 22 by a transverse conveyor stroke 34 of the transverse conveyor guides 33a, 33b, with which the carriage 1 also executes a transverse conveyor stroke 34.
  • the result of this is that the end face 36 of the push strut 9 facing the row 24 and the freeze dryer 35 comes to rest against the row 24 of the drying vessels 25 standing on the conveyor 22 and this goes down from the conveyor 22 in the direction of the transverse conveyor stroke 34 and onto the Loading bridge 30 pushes.
  • a drive of the drive and / or guide units 2, 3 of the carriage 1 is actuated in a method step 42 such that the carriage 1 moves down from the cross conveyor guides 33a, 33b in the direction of the loading stroke 14 and onto the guides 39, 40 is driven.
  • the slide 1 is moved further via the loading stroke 14 thus formed to directly in front of the footprint 32, whereby all rows 24 are pushed onto the footprint 32 (cf. transition from Fig. 9 to Fig. 10 ).
  • a method step 43 the carriage 1 is then moved back via the guides 39, 40 back onto the cross conveyor guides 33a, 33b of the cross conveyor 29.
  • the previously loaded footprint 32 is then moved in a method step 74 from the previously used loading and unloading level 70 in a vertical direction upwards via a footprint drive 72 (which can also be used to raise any other previously loaded footprints arranged above the footprint 32). and a further floor space 44, which was previously located below the loading and unloading level 70, can be raised into the loading and unloading level 70 via the floor space drive 72.
  • a connection of the loading bridge 30 to the footprint 32 must be released, which serves, for example, to ensure a coaxial alignment of the guides 39, 40 of the loading bridge 30 to guides 48, 49 of the freeze dryer 35.
  • the loading bridge 30 has two loading bridge parts 77, 78 lying one behind the other in the direction of the loading stroke 14 and adjoining one another flush.
  • the loading bridge part 77 is fixedly provided on the freeze drying system 21 and is arranged directly adjacent to the conveyor 22.
  • the loading bridge part 78 is pivotable about a pivot axis oriented transversely to the loading stroke 14 between a loading position and a release position.
  • Fig. 12 to recognize that the loading bridge part 78 in a pivoting direction 61 from the in Fig. 12 effective loading position can be pivoted clockwise into the release position indicated by dash-dotted lines, so that the loading bridge part 78 can be pivoted out of the loading and unloading plane 70.
  • the in Fig. 12 to recognize that the loading bridge part 78 in a pivoting direction 61 from the in Fig. 12 effective loading position can be pivoted clockwise into the release position indicated by dash-dotted lines, so that the loading bridge part 78 can be pivoted out of the loading and unloading plane 70.
  • the loading bridge part 78 is arranged in the loading and unloading plane 70 and is arranged flush with the loading bridge part 77 and the standing surface 32 arranged in the loading and unloading plane 70.
  • the loading bridge part 78 is connected to the footprint 32 to ensure the previously described coaxial alignment of the guides 39, 40, 48, 49.
  • the loading bridge part 78 is pivoted out of the loading and unloading plane 70 in the release position, so that the front edge of the loading bridge part 78 in the direction of the loading stroke 14 is spaced apart from the freeze dryer 35 and the standing surface 32 and the rear edge in the direction of the loading stroke 14 of the dock leveler 78 is spaced from the dock leveler 77.
  • the design of the loading bridge 30 with the loading bridge parts 77, 78 has the advantage that, on the one hand, the swiveling of the loading bridge part 78 into the release position makes it possible to move the footprint 32, while, on the other hand, new rows of drying vessels 25 are already being delivered via the conveyor 22 can and they can already be pushed onto the dock leveler 77.
  • the two-part design of the loading bridge 30 with the loading bridge parts 77, 78 thus enables the connection between the loading bridge 30 and the associated footprint to be released at the same time and thus the lifting of this footprint and the conveying of rows 24 of drying vessels 25 onto the loading bridge part 78.
  • next storage space 44 can then be loaded, and accordingly at least one further storage space 45 can also be loaded subsequently.
  • the items to be dried can be frozen in the drying vessels 25 and freeze drying. It is possible that after the freeze-drying process has ended, the shelves are each lowered in such a way that the undersides of the shelves push the stoppers of the drying vessels 25 on the shelf below them, whereby the stoppers assume a sealed closed position. Subsequently, the entrance-side door of the freeze dryer 35 is opened again (possibly after transferring the loading bridge part 78 into the release position).
  • all of the shelves 32, 44, 45,... are raised via the shelf drive 72 to a height above the loading and unloading level 70 that is at least greater than the vertical extent of the carriage 1 in the area the pusher 4 when it is in the unloading position.
  • This height is preferably smaller than the distance between adjacent shelves 32, 44, 45, whereby this height can even be smaller than the height of the drying vessels 25.
  • a method step 71 the carriage 1 is now transferred to the unloading position, which is the case for the carriage Fig. 1 and 2 by pivoting the bracket 7 by 180 °. This change in the operating position of the carriage 1 from the loading position to the unloading position takes place outside the drying chamber 41.
  • the carriage 1 passes under all of the shelves 32, 44, 45 and thus also the bottom shelf 45, preferably all of the shelves being loaded.
  • the carriage 1 travels from the guides 39, 40 arranged outside the drying chamber 41 to the guides 48, 49 arranged coaxially within the drying chamber 41 as a result of the above-mentioned connections Fig. 11 and 12 shown. This passing underneath all of the shelves 32, 44, 45 is referred to elsewhere as the "idle stroke".
  • the carriage 1 At the end of the empty stroke, the carriage 1 has completely or at least in the area of the pusher 4, in plan view, passed the shelves 32, 44, 45 and has reached a parking position 50 (cf. Fig. 13 ). If the carriage 1 is in the parking position 50, the shelves 32, 44, 45 can be lowered again, so that the lowest shelf 45 is again in the loading and unloading plane 70.
  • the drive and / or guide units 2, 3 In the park position, have at least partially entered U-shaped recesses 51, 52 of a rear wall 53 of the drying chamber 41 of the freeze dryer 35. These depressions 51, 52 can be formed, for example, by pipe sockets or sight glasses of the drying chamber 41.
  • the rear wall 53 forms a projection 54, which has entered between the side struts 10, 11 of the bracket 9 and into the space between the drive and / or guide units 2, 3, resulting in a compact arrangement.
  • the projection 54 would have to be shifted outward by an amount which corresponds approximately to twice the longitudinal extension of the side struts 10, 11 of the bracket 7, which results in a significant increase in the freeze dryer 35 would result.
  • a drive 59 of the drive and / or guide units 2, 3 of the carriage 1 is controlled in such a way that it moves in the direction of the unloading stroke 15.
  • the end face 57 of the coupling device 5 comes into contact with the drying vessels 25 and pushes the drying vessels 25 down from the lowest storage space 45 and onto the loading bridge 30 and from there periodically onto the conveyor 22, where the drying vessels 25 are also cyclically in rows in the conveying direction 26 be promoted.
  • a method step 58 the carriage 1 is then moved back into the parking position 50 behind the parking spaces 32, 44, 45 and the parking space 44 is lowered into the loading and unloading plane 70, for which purpose the loading bridge part 78 can be pivoted as described above ,
  • the method step 56 for unloading the standing surface 44 is now repeated. This is followed by a lowering of the standing surface 32 and the unloading thereof in a corresponding manner.
  • the pusher 4 of the carriage 1 can first be transferred from the unloading position into the loading position in a method step 75, which is preferably done outside of the freeze dryer 35. Then the carriage 1 are again moved onto the cross conveyor guides 33a, 33b, whereby the loading and unloading process of the freeze dryer 35 is completed.
  • a drive 59 is integrated in the coupling device 5, here a hollow coupling strut 6 or a coupling housing.
  • a drive shaft of the drive 59 drives a toothed belt 60 of the drive and / or guide units 2, 3 via a belt wheel.
  • the toothed belt 60 has a toothing on both sides and engages in a corresponding toothing of the guides 39, 40, 48, 49.
  • Fig. 17 and 18 is shown the freeze drying system 21 when using a slide 1 according to Fig. 3 and 4 ,
  • Fig. 17 the carriage 1 in the loading position Fig. 4 at the beginning of the loading stroke 14
  • Fig. 18 shows the carriage 1 in the parking position 50 and the carriage 1 in the unloading position according to FIG Fig. 3 located. Otherwise this applies to the 7 to 16 Said accordingly.
  • the pusher 4 is not movably mounted on the housings of the drive and / or guide units 2, 3, but rather is firmly connected to the housings of the drive and / or guide units 2, 3.
  • the carriage 1 of the in Fig. 19 shown loading position in the unloading position according to Fig. 20 to transfer the entire carriage 1 is rotated or turned around a transverse axis, so that the top of the carriage becomes the bottom of the carriage 1 and vice versa.
  • the freeze drying system 21 has a Turning device 62.
  • the turning device 62 has a gripper 63, by means of which the slide 1 can be gripped from the side and can be turned (or “turned upside down”). This takes place when all of the shelves 32, 44, 45 have been loaded with drying vessels and before carrying out the empty stroke (in particular in method step 47).
  • FIG. 21 and 22 show the use of a sled Fig. 5 and 6 in a freeze-drying system 21.
  • the slide 1 is transferred from the loading position into the unloading position after loading the shelves 32, 44, 45 and before carrying out the empty stroke 64 of the slide 1, which here is due to the translatory movement of the push strut 9 along the translational Degree of freedom 18 is done.
  • Fig. 23 shows the control of a carriage 1, which is shown here schematically with the dashed box, on the one hand for moving the drive and / or guide units 2, 3 along the guides 39, 40, 48, 49 for executing the loading stroke 14, unloading stroke 15 in a highly schematic manner and idle strokes 64 and on the other hand to change the relative position of the pushing device 4 with respect to the drive and / or guide units 2, 3.
  • the required electrical energy is provided via a battery or an accumulator or another power supply 65.
  • a control unit 66 is also operated with this.
  • the control unit 66 generates a control signal for a drive 59 which drives a drive and / or guide unit 2, 3 such that it executes the loading stroke 14, the unloading stroke 15 and the idle stroke 64.
  • the drive 59 can, for example, drive a wheel, a drive part of a linear motor or a belt wheel for a toothed belt 60.
  • the control unit 66 also generates a control signal for a drive 67, which the pushing device 4 of the loading position into the unloading position and vice versa.
  • the control unit 66 coordinates the activity of the drives 59, 67 to carry out the method 73.
  • the control of the drives 59, 67 by the control unit 66 is coordinated with the operation of the conveyor 22 and the process control of the freeze dryer 35 Power supply 65 and the control unit 66 are provided separately from the freeze dryer 35 in the freeze drying system 21.
  • control unit 66 communicates with the drives 59, 67, which are part of the slide 1, in a wired manner, via sliding contacts or wirelessly.
  • Fig. 24 shows a different embodiment in which there is only a single drive 67.
  • the drive 67 is coupled to the pushing device 4 via a clutch 68, so that when the clutch 68 is closed, the drive 67 can drive the pushing device 4 in such a way that it assumes the loading position or the unloading position.
  • the drive 67 is connected via a clutch 69 to the drive elements for bringing about the loading stroke 14, the unloading stroke 15 and the empty stroke 64. With the clutch 69 closed, the drive 67 can thus move the carriage 1 forwards and backwards.
  • the mutual opening and closing of the couplings 68, 69 is coordinated via the control unit 66.
  • control unit 66 and the power supply 65 can be formed separately from the slide 1 or can also be integrated therein. It must be ensured here that the control unit 66 and the drive 67 store the current position of the toothed belt 60 and the slide 1 when the clutch 69 is opened, so that when the clutch 69 is closed later, the control unit 66 knows where the slide is located 1 is located. It is also possible that the drive is permanently coupled to the toothed belt 60 without a clutch 69, while a clutch 68 is only temporarily closed for the purpose of temporarily connecting the drive 67 to the thrust device 4.
  • the carriage 1 has interfaces 79, 80. Via the interface 79, a battery or an accumulator 65 can be supplied with electrical energy for recharging. Via the interface 80, the control unit 66 of the carriage 1 is connected to another control unit of the freeze drying system 21 Interfaces 79, 80 can be wired (by means of a flexible line moving with the movement of the slide, a sliding contact, etc.) or wireless.
  • freeze dryer 21 and / or the freeze dryer 35 that for such an embodiment the freeze dryer 35 or the freeze dryer 21 has a control unit which is equipped with control logic for carrying out the method.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Drying Of Solid Materials (AREA)

Claims (14)

  1. Utilisation
    a) d'un chariot (1),
    aa) qui comprend, de chacun des deux côtés d'une surface de pose (32 ; 44 ; 45) une unité d'entraînement et/ou de guidage (2, 3) et un dispositif de poussée (4) s'étendant entre les unités d'entraînement et/ou de guidage (2, 3) et/ou un dispositif de couplage (5) s'étendant entre les unités d'entraînement et/ou de guidage (2, 3), moyennant quoi, au moyen du dispositif de poussée (4) et/ou du dispositif de couplage (5), des récipients de séchage (25)
    - peuvent être poussés vers le haut, dans une course de chargement (14), dans un plan de chargement et de déchargement (70) d'un lyophilisateur (35), dans une direction de chargement, sur la surface de pose (32 ; 44 ; 45) et
    - peuvent être poussés vers le bas, dans une course de déchargement (15), dans le plan de chargement et de déchargement (70) du lyophilisateur (35), dans une direction de déchargement, hors de la surface de pose (32 ; 44 ; 45) du lyophilisateur (35) et
    ab) dans lequel, par l'intermédiaire d'un dispositif d'entraînement (59), la position relative du dispositif de poussée (4) par rapport aux unités d'entraînement et/ou de guidage (2, 3) en vue de dessus peut être modifiée,
    b) pour un lyophilisateur (35) ou une installation de lyophilisation (21) avec un lyophilisateur (35), dans lequel, dans une course à vide (64) entre le chargement de la surface de pose (32 ; 44 ; 45) et le déchargement de la surface de pose (32 ; 44 ; 45), le chariot (1) est déplacé d'une position devant la surface de pose (32 ; 44 ; 45) vers une position derrière la surface de pose (32 ; 44 ; 45) par abaissement de la surface de pose (32 ; 44 ; 45),
    c) moyennant quoi
    ca) dans la course à vide (64), la hauteur du côté inférieur du dispositif de poussée (4) et/ou du dispositif de couplage (5) au-dessus du plan de chargement et de déchargement (70) est inférieure à la hauteur des récipients de séchage (25) et/ou
    cb) ou la position relative du dispositif de poussée (4) par rapport aux unités d'entraînement et/ou de guidage (2, 3) dans la course à vide (64) correspond à la position relative di dispositif de poussée (4) par rapport aux unités d'entraînement et/ou de guidage (2, 3) dans la course de chargement (14) ou dans la course de déchargement (15).
  2. Lyophilisateur (35) ou installation de lyophilisation (21) avec un lyophilisateur (35) avec
    a) une surface de pose (32 ; 44 ; 45) dont la hauteur au-dessus d'un entraînement de surface de pose (72) est variable et
    b) un chariot (1) qui comprend, sur chacun des deux côtés de la surface de pose (32 ; 44 ; 45), une unité d'entraînement et/ou de guidage (2, 3) et un dispositif de poussée (4) s'étendant entre les unités d'entraînement et/ou de guidage (2, 3) et/ou un dispositif de couplage (5) s'étendant entre les unités d'entraînement et/ou de guidage (2, 3), moyennant quoi, au moyen du dispositif de poussée (4) et/ou du dispositif de couplage (5), des récipients de séchage (25) peuvent, dans un plan de chargement et de déchargement (70) du lyophilisateur (35),
    - être poussés vers le haut, dans une course de chargement (14), dans une direction de chargement, vers la surface de pose (32 ; 44 ; 45) du lyophilisateur (35) et
    - être poussés vers le haut, dans une course de déchargement (15), dans une direction de déchargement, hors de la surface de pose (32 ; 44 ; 45) du lyophilisateur (35),
    c) moyennant quoi, par l'intermédiaire d'un dispositif d'entraînement (59), la position relative du dispositif de poussée (4) par rapport aux unités d'entraînement et/ou de guidage (2, 3) en vue de dessus peut être modifiée et
    d) une unité de commande existe, qui comprend une logique de commande qui
    da) contrôle les unités d'entraînement et/ou de guidage (2, 3) de façon à ce que celles-ci déplacent le chariot (1), dans la course de chargement (14) dans la direction de chargement, les récipients de séchage (25) étant ainsi poussés vers la surface de pose (32 ; 44 ; 45),
    db) contrôle l'entraînement de surface de pose (25) de façon à ce que la surface de pose (32 ; 44 ; 45) avec les récipients de séchage (25) disposés dessus soit soulevée,
    dc) contrôle les unités d'entraînement et/ou de guidage (2, 3) de façon à ce que celles-ci déplacent le chariot (1) sous la surface de pose (32 ; 44 ; 45), dans une course à vide (64), vers une position disposée derrière la surface de pose (32 ; 44 ; 45) et les récipients de séchage (25) disposés dessus et
    dd) contrôle les unités d'entraînement et/ou de guidage (2, 3) de façon à ce que celles-ci déplacent le chariot (1), dans la course de déchargement (15) dans la direction de déchargement, les récipients de séchage (25) étant ainsi poussés hors de la surface de pose (32 ; 44 ; 45),
    e) la logique de commande étant conçue de façon à ce que celle-ci contrôle, entre les étapes da) à dd), l'entraînement (59) pour une modification de la position relative du dispositif de poussée (4) par rapport aux unités d'entraînement et/ou de guidage (2, 3) de façon à ce que celui-ci modifie la position relative du dispositif de poussée (4) par rapport aux unités d'entraînement et/ou de guidage (2, 3) en vue de dessus, moyennant quoi,
    - dans la course à vide (64), la hauteur du côté inférieur du dispositif de poussée (4) et/ou du dispositif de couplage (5) au-dessus du plan de chargement et de déchargement (70) est inférieure à la hauteur des récipients de séchage (25) et/ou
    - la position relative du dispositif de poussée (4) par rapport aux unités d'entraînement et/ou de guidage (2, 3) dans la course à vide (64) correspond à la position relative du dispositif de poussée (4) par rapport aux unités d'entraînement et/ou de guidage (2, 3) dans la course de chargement (14) ou dans la course de déchargement (15).
  3. Procédé (73) pour l'exploitation d'un lyophilisateur (35) ou d'une installation de lyophilisation (21) avec un lyophilisateur (35) avec
    a) une surface de pose (32 ; 44 ; 45) dont la hauteur peut être modifiée par l'intermédiaire d'un entraînement de surface de pose (72) et
    b) un chariot (1) qui comprend, sur chacun des deux côtés de la surface de pose (32 ; 44 ; 45) une unité d'entraînement et/ou de guidage (2, 3) et un dispositif de poussée (4) s'étendant entre les unités d'entraînement et/ou de guidage (2, 3) et/ou un dispositif de couplage (5) s'étendant entre les unités d'entraînement et/ou de guidage (2, 3), moyennant quoi, au moyen du dispositif de poussée (4) et/ou du dispositif de couplage (5), des récipients de séchage (25) peuvent, dans un plan de chargement et de déchargement (70) du lyophilisateur (35)
    - être poussés vers le haut, dans une course de chargement (14), dans une direction de chargement, vers la surface de pose (32 ; 44 ; 45) du lyophilisateur (35) et
    - être poussés vers le haut, dans une course de déchargement (15), dans une direction de déchargement, hors de la surface de pose (32 ; 44 ; 45) du lyophilisateur (35),
    c) moyennant quoi, par l'intermédiaire d'un dispositif d'entraînement (59), la position relative du dispositif de poussée (4) par rapport aux unités d'entraînement et/ou de guidage (2, 3) en vue de dessus peut être modifiée et
    avec les étapes supplémentaires suivantes :
    a) les unités d'entraînement et/ou de guidage (2, 3) déplacent le chariot (1), dans la course de chargement (14) dans la direction de chargement, les récipients de séchage étant ainsi poussés vers la surface de pose (32 ; 44 ; 45),
    b) l'entraînement de surface de pose (72) soulève la surface de pose (32 ; 44 ; 45) avec les récipients de séchage (25) disposés dessus,
    c) les unités d'entraînement et/ou de guidage (2, 3) déplacent le chariot (1) dans une course à vide sous la surface de pose (45) soulevée vers une position disposée derrière la surface de pose (45) et les récipients de séchage (25) disposés dessus et
    d) les unités d'entraînement et/ou de guidage (2, 3) déplacent le chariot (1) dans la course de déchargement (15) dans la direction de déchargement, les récipients de séchage étant ainsi poussés hors de la surface de pose (32 ; 44 ; 45),
    e) moyennant quoi, entre les étapes a) à d), le dispositif d'entraînement (59) du dispositif de poussée (4) modifie la position relative du dispositif de poussée (4) par rapport aux unités d'entraînement et/ou de guidage (2, 3) et
    - dans la course à vide (64), la hauteur du côté inférieur du dispositif de poussée (4) et/ou du dispositif de couplage (5) au-dessus du plan de chargement et de déchargement (70) est inférieure à la hauteur des récipients de séchage (25) et/ou
    - la position relative du dispositif de poussée (4) par rapport aux unités d'entraînement et/ou de guidage (2, 3) dans la course à vide (64) correspond à la position relative du dispositif de poussée (4) par rapport aux unités d'entraînement et/ou de guidage (2, 3) dans la course de chargement (14) ou dans la course de déchargement (15).
  4. Utilisation, lyophilisateur (35), installation de lyophilisation (21) ou procédé (73) selon l'une des revendications précédentes, caractérisé en ce que la position relative du dispositif de poussée (4) par rapport aux unités d'entraînement et/ou de guidage (2, 3) en vue de dessus est modifiée grâce au fait que le dispositif de poussée (4) est déplacé par rapport aux unités d'entraînement et/ou de guidage (2, 3) avec un mouvement de translation le long d'un degré de liberté en translation (18).
  5. Utilisation, lyophilisateur (35), installation de lyophilisation (21) ou procédé (73) selon l'une des revendications précédentes, caractérisé en ce que la position relative du dispositif de poussée (4) par rapport aux unités d'entraînement et/ou de guidage (2, 3) en vue de dessus est modifiée grâce au fait que le dispositif de poussée (4) est pivoté par rapport aux unités d'entraînement et/ou de guidage (2, 3) autour d'un axe de pivotement (8).
  6. Utilisation, lyophilisateur (35), installation de lyophilisation (21) ou procédé (73) selon l'une des revendications précédentes, caractérisé en ce que la position relative du dispositif de poussée (4) par rapport aux unités d'entraînement et/ou de guidage (2, 3) en vue de dessus est modifiée grâce au fait que le dispositif de poussée (4) est pivoté conjointement avec les unités d'entraînement et/ou de guidage (2, 3) autour d'un axe transversal.
  7. Utilisation, lyophilisateur (35), installation de lyophilisation (21) ou procédé (73) selon l'une des revendications précédentes, caractérisé en ce que les unités d'entraînement et/ou de guidage (2, 3) sont reliées entre elles de manière mécanique aussi bien par l'intermédiaire du dispositif de poussée (4) mobile par rapport aux unités d'entraînement et/ou de guidage (2, 3) que par l'intermédiaire du dispositif de couplage (5) non mobile par rapport aux unités d'entraînement et/ou de guidage (2, 3).
  8. Utilisation, lyophilisateur (35), installation de lyophilisation (21) ou procédé (73) selon l'une des revendications précédentes, caractérisé en ce que l'introduction des récipients de séchage (25) avec une face frontale du dispositif de poussée (4) et l'expulsion des récipients de séchage (25) a lieu avec celle-ci ou avec une face frontale opposée du dispositif de poussée (4).
  9. Utilisation, lyophilisateur (35), installation de lyophilisation (21) ou procédé (73) selon la revendication 7, caractérisé en ce que
    a) l'introduction des récipients de séchage (25) a lieu avec une face frontale (36) du dispositif de poussée (4) et l'expulsion des récipients de séchage (25) a lieu avec une face frontale (57) du dispositif de couplage (5) et/ou
    b) l'expulsion des récipients de séchage (25) a lieu avec une face frontale (36) du dispositif de poussée (4) et l'introduction des récipients de séchage (25) a lieu avec une face frontale (57) du dispositif de couplage (5).
  10. Utilisation, lyophilisateur (35), installation de lyophilisation (21) ou procédé (73) selon l'une des revendications précédentes, caractérisé en ce que la modification de la position relative du dispositif de poussée (4) par rapport aux unités d'entraînement et/ou de guidage (2, 3) en vue de dessus a lieu à l'extérieur d'une chambre de séchage (41) du lyophilisateur (35).
  11. Utilisation, lyophilisateur (35), installation de lyophilisation (21) ou procédé (73) selon l'une des revendications précédentes, caractérisé en ce que la modification de la position relative du dispositif de poussée (4) par rapport aux unités d'entraînement et/ou de guidage (2, 3) en vue de dessus
    a) a lieu d'une position de chargement vers une position de déchargement après le chargement complet du lyophilisateur (35) et avant l'abaissement de l'ensemble des surfaces de pose (32 ; 44 ; 45) et/ou
    b) a lieu d'une position de déchargement vers une position de chargement après le déchargement complet du lyophilisateur (35) et
    - avant le déplacement du chariot (1) vers un dispositif de convoyage transversal (29),
    - avec le déplacement du chariot (1) vers un dispositif de convoyage transversal (29) ou
    - sur le dispositif de convoyage transversal (29).
  12. Utilisation, lyophilisateur (35), installation de lyophilisation (21) ou procédé (73) selon l'une des revendications précédentes, caractérisé en ce que le chariot (1) est disposé, dans la position se trouvant derrière la surface de pose (32 ; 44 ; 45) et les récipients de séchage (25) disposés dessus, au moins partiellement dans un creux (51, 52) d'une paroi arrière (53) du lyophilisateur (35).
  13. Utilisation, lyophilisateur (35), installation de lyophilisation (21) ou procédé (73) selon l'une des revendications précédentes, caractérisé en ce que, pour
    a) un déplacement du chariot (1) pour le chargement et le déchargement des récipients de séchage (25),
    b) un déplacement du chariot (1) pour l'abaissement de la surface de pose (32 ; 44 ; 45) dans une course à vide (64) et
    c) une modification de la position relative du dispositif de poussée (4) par rapport aux unités d'entraînement et/ou de guidage (2, 3) en vue de dessus le même dispositif d'entraînement (67) est utilisé.
  14. Utilisation, lyophilisateur (35), installation de lyophilisation (21) ou procédé (73) selon l'une des revendications précédentes, caractérisé en ce qu'au moins un dispositif d'entraînement (59, 67), une unité de commande (66) et/ou une alimentation de puissance (65) pour
    a) un déplacement du chariot (1) pour le chargement et le déchargement des récipients de séchage (25),
    b) un déplacement du chariot (1) pour l'abaissement de la surface de pose (32 ; 44 ; 45) dans une course à vide (64) et
    c) une modification de la position relative du dispositif de poussée (4) par rapport aux unités d'entraînement et/ou de guidage (2, 3) en vue de dessus est intégré dans le dispositif de poussée (4) ou dans le dispositif de couplage (5).
EP17207708.3A 2017-12-15 2017-12-15 Lyophilisateur, installation de lyophilisateur, procédé de fonctionnement d'un lyophilisateur et nouvelle utilisation d'un chariot Active EP3499160B1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ES17207708T ES2787019T3 (es) 2017-12-15 2017-12-15 Liofilizador, instalación de liofilización, procedimiento de funcionamiento un liofilizador y nuevo uso de un carro
EP17207708.3A EP3499160B1 (fr) 2017-12-15 2017-12-15 Lyophilisateur, installation de lyophilisateur, procédé de fonctionnement d'un lyophilisateur et nouvelle utilisation d'un chariot

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17207708.3A EP3499160B1 (fr) 2017-12-15 2017-12-15 Lyophilisateur, installation de lyophilisateur, procédé de fonctionnement d'un lyophilisateur et nouvelle utilisation d'un chariot

Publications (2)

Publication Number Publication Date
EP3499160A1 EP3499160A1 (fr) 2019-06-19
EP3499160B1 true EP3499160B1 (fr) 2020-02-26

Family

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EP17207708.3A Active EP3499160B1 (fr) 2017-12-15 2017-12-15 Lyophilisateur, installation de lyophilisateur, procédé de fonctionnement d'un lyophilisateur et nouvelle utilisation d'un chariot

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US11732964B2 (en) * 2020-04-15 2023-08-22 Navinta Iii Inc Lyophilization promoting element
DE102022103429B3 (de) 2022-02-14 2023-05-04 Martin Christ Gefriertrocknungsanlagen Gmbh Be- und Entladeeinrichtung für einen Gefriertrockner, Verfahren und Gefriertrocknungsanlage
CN118168305B (zh) * 2024-05-16 2024-07-02 济南东川机械制造有限公司 一种用于工件机加工后的快速干燥装置

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DE10307571A1 (de) 2003-02-22 2004-09-02 Steris Gmbh Einrichtung mit einer Stellfläche
GB0413117D0 (en) 2004-06-11 2004-07-14 Boc Group Plc Freeze dryer
DE102009049142B4 (de) 2009-10-12 2013-06-27 Martin Christ Gefriertrocknungsanlagen Gmbh Be- und Entladevorrichtung für eine Gefriertrocknungsanlage
DE102010047744A1 (de) 2010-10-11 2012-04-12 Martin Christ Gefriertrocknungsanlagen Gmbh Be- und Entladevorrichtung für eine Gefriertrocknungsanlage
DE102011117628B4 (de) 2011-11-04 2015-10-22 Martin Christ Gefriertrocknungsanlagen Gmbh Gefriertrockungsanlage mit einer Be- und Entladevorrichtung
ES2626445T3 (es) 2012-03-14 2017-07-25 I.M.A. Industria Macchine Automatiche S.P.A. Aparato para mover recipientes
ITMI20121275A1 (it) * 2012-07-23 2014-01-24 I M A Ind Macchine Automatic He S P A Apparato di movimentazione di piani di carico per macchine liofilizzatrici
ITMI20130841A1 (it) * 2013-05-23 2014-11-24 I M A Ind Macchine Automatic He S P A Dispositivo introduttore di flaconi

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EP3499160A1 (fr) 2019-06-19

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