EP3135327A1 - Pompe destinee au transport de liquides et procede de determination d'un debit - Google Patents

Pompe destinee au transport de liquides et procede de determination d'un debit Download PDF

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Publication number
EP3135327A1
EP3135327A1 EP15183195.5A EP15183195A EP3135327A1 EP 3135327 A1 EP3135327 A1 EP 3135327A1 EP 15183195 A EP15183195 A EP 15183195A EP 3135327 A1 EP3135327 A1 EP 3135327A1
Authority
EP
European Patent Office
Prior art keywords
temperature
pump
determining
liquid
flow rate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP15183195.5A
Other languages
German (de)
English (en)
Inventor
Constantin Wiesener
Marcus GRANEGGER
Michael Frischke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Berlin Heart GmbH
Original Assignee
Berlin Heart GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Berlin Heart GmbH filed Critical Berlin Heart GmbH
Priority to EP15183195.5A priority Critical patent/EP3135327A1/fr
Priority to US15/756,092 priority patent/US20180243491A1/en
Priority to DE112016003906.9T priority patent/DE112016003906A5/de
Priority to PCT/EP2016/070325 priority patent/WO2017037025A1/fr
Priority to CN201680056924.0A priority patent/CN108136086A/zh
Publication of EP3135327A1 publication Critical patent/EP3135327A1/fr
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
    • A61M60/126—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
    • A61M60/148—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/20—Type thereof
    • A61M60/205—Non-positive displacement blood pumps
    • A61M60/216—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
    • A61M60/226—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller the blood flow through the rotating member having mainly radial components
    • A61M60/232—Centrifugal pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/40—Details relating to driving
    • A61M60/403—Details relating to driving for non-positive displacement blood pumps
    • A61M60/422—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being electromagnetic, e.g. using canned motor pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/50—Details relating to control
    • A61M60/508—Electronic control means, e.g. for feedback regulation
    • A61M60/515—Regulation using real-time patient data
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/50—Details relating to control
    • A61M60/508—Electronic control means, e.g. for feedback regulation
    • A61M60/515—Regulation using real-time patient data
    • A61M60/523—Regulation using real-time patient data using blood flow data, e.g. from blood flow transducers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/50—Details relating to control
    • A61M60/508—Electronic control means, e.g. for feedback regulation
    • A61M60/538—Regulation using real-time blood pump operational parameter data, e.g. motor current
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
    • A61M60/818—Bearings
    • A61M60/82—Magnetic bearings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A61M2205/3334—Measuring or controlling the flow rate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3368—Temperature

Definitions

  • the invention is in the field of electrical engineering and mechanical engineering and can be used with particular advantage in the field of medical technology.
  • the invention relates to pumps for conveying liquids.
  • the present innovation is based on the object of providing a pump for conveying liquids, which allows the most reliable determination of the flow rate.
  • the object is achieved, in particular in the case of a blood pump, with a device for determining the flow rate, wherein a device integrated into the pump for supplying or discharging heat energy to or from the fluid being pumped and a device for determining a temperature, which is integrated into the pump, a temperature change or a temperature gradient is provided.
  • the temperature element (means for supplying or discharging heat energy)
  • the temperature changes depending on the time that the liquid to be conveyed is in contact with the means for supplying or discharging heat energy , and thus depending on the flow rate.
  • the temperature or temperature change achieved thereby or the temperature gradient achieved thereby is measured and used to determine a flow rate by means of known reference values or a characteristic field.
  • the means for supplying or dissipating heat energy integrated into the pump may be a temperature element that "generates” or “absorbs” heat (that is, of course, causes a conversion between heat energy and another form of energy) and that with the delivered liquid directly into Contact is, for example, is surrounded by this. It may be, for example, a heating wire or a Peltier element.
  • a generated temperature or a temperature gradient By one or more temperature measurements on the liquid to be conveyed or close to the temperature element, a generated temperature or a temperature gradient, a temperature change or a temperature gradient can be determined.
  • a first temperature sensor can be provided at the pump inlet, downstream of this a temperature element with respect to the conveying direction of the liquid and further downstream, for example at the pump outlet, a further temperature sensor.
  • the temperature element can be controlled accordingly, so that a reproducible heat input is produced in the liquid.
  • a flow rate through the pump can then be determined from the temperature and its course or the temperature difference and course between the temperatures measured at the pump inlet and at the pump outlet.
  • a particular embodiment of the invention provides that a device for supplying heat energy to the pumped liquid is formed by a drive motor integrated in the pump.
  • the heat energy converted in the drive motor of the pump can be calculated from the motor current and the voltage so that a determination of the heat input into the liquid is possible.
  • a device for supplying heat energy to the pumped liquid is formed by one or more active, in particular magnetic bearings integrated into the pump.
  • the Bearings of a pump rotor can be considered as heat sources whose performance can be determined, for example in controlled magnetic bearings by monitoring the current through the bearing electromagnets.
  • the heat energy introduced by the bearings can also be used in connection with the determined temperature or a determined temperature difference to determine the flow rate. It is also possible to take into account the sum of the power converted in the bearings and the motor drive power as heat input.
  • a further embodiment of the invention may provide for a fleece or cooling element, in particular in the form of a heating wire or a cooling element, in particular a Peltier element, to be arranged in or directly on the housing of the pump.
  • a heating or cooling element which may be formed as a heating wire or as a Peltier element or in another known form, a defined positive or negative heat input may be introduced into the flowing liquid, and it may be the temperature change or a temperature gradient corresponding sensors are detected near the temperature element itself or for example upstream and downstream of the heating or cooling element.
  • the function of the device in this case is similar to a hot wire anemometer.
  • a device for determining the temperature, a temperature change or a temperature gradient comprises a first and / or a second temperature sensor, wherein one of the temperature sensors in the flow of the fluid to be delivered upstream and the other temperature sensor is disposed downstream of the means for supplying or dissipating heat energy.
  • a device for determining the temperature, a temperature change or a temperature gradient comprises a first and / or a second temperature sensor, wherein one of the temperature sensors in the flow of fluid to be conveyed upstream of a pump rotor and the other temperature sensor downstream of the Pump rotor is arranged.
  • the pump rotor may also include the drive motor of the pump, so that the heat input through the engine is to be taken into account, either as a single heat input or in addition to the heat input through a heating element. It can also be a cooling element combined with the heat input by the engine and the total heat balance can be detected by temperature measurements.
  • a device for determining the temperature or a temperature change is arranged directly on the heating or cooling element or integrated in this.
  • the temperature measurement or the detection of the temperature change or a gradient is carried out directly at the point at which the heat input or the removal of heat occurs, so that other influences can be largely eliminated.
  • a physical property of the element that changes with temperature may be used directly for detecting the temperature magnitude, such as when a temperature-dependent resistor or a thermocouple is integrated in the heating or cooling element.
  • a device for determining a temperature change is disposed directly on the heating or cooling element and that a control device for adjusting a temperature, a temperature change or a temperature gradient is provided to a given target value, wherein the achievement the heating or cooling power to be supplied to the target value is regulated.
  • This can be targeted by a regulation on the achievement of a certain temperature or a specific temperature gradient, wherein the flow rate is determined by the necessary influence for the control variable, such as the supplied energy (eg., Electricity).
  • the supplied energy eg., Electricity
  • a heat-emitting area and / or a cooling area of a temperature element is arranged in the flow of the liquid to be conveyed and that one or more temperature sensors for continuous temperature detection of the element and / or the liquid flowing past are provided.
  • the temperature development of the fluid to be delivered is used, but the temperature development of the temperature element, ie the heating or cooling element.
  • This is basically heated or cooled by an electrical control, wherein a heat transfer takes place to the surrounding medium, which is dependent on the flow rate.
  • Such a device allows particularly well the integration of the temperature element with the temperature sensors.
  • thermocouple is provided for detecting the temperature of the temperature element.
  • the invention relates, in addition to a pump of the type described above, to a method for determining the flow rate of a liquid to be conveyed by a pump of the type described above, wherein the flow rate taking into account a detected heating or cooling capacity, temperature, a temperature difference, a electric motor power and in particular a rotational speed of the pump and an electrical bearing performance is determined.
  • a particular embodiment of the innovation may be, for example, that an exchange region of a temperature element, in particular a Peltier element, which is in communication with the liquid to be conveyed is alternately cooled and heated, and that the temperature of the exchange region is continuously measured and determined from the temperature changes and / or Heating or cooling power flow rate is determined.
  • a temperature element in particular a Peltier element
  • FIG. 1 shows schematically in a longitudinal section a pump according to the invention 1, which may be, for example, a blood pump for use on living patients.
  • a pump may be implantable or partially implantable.
  • Such pumps can also be used for other medical or non-medical purposes. Particular advantages result from a space-saving integration and / or structural connection of one or more flow sensors with the pump.
  • Such a pump typically has a pump housing 2 with a pump inlet 3 and a pump outlet 4. Between the inlet 3 and the outlet 4, a fluid channel 5 is provided, which in the example shown extends in a first region 6 in the axial direction and in a second region 7 at least partially in the radial direction. Within the axial region 6 of the fluid channel 5, a rotor 8 is provided, which is drivable about the axis of rotation 9 and has in its radial outer region conveying elements 10 in the form of conveying blades, which are not shown in detail.
  • the fluid for example, blood
  • the fluid promoted by the pump inlet 3 in the axial direction 9, wherein the Fluid also gets a twist and is at least partially discharged in the radial direction outwards and in the circumferential direction in the second region 7 of the fluid channel 5, wherein it is conveyed by centrifugal forces to the radially outer pump outlet.
  • flow sensors In order to determine the flow rate of the pump, flow sensors should be arranged in a region of the fluid channel 5 in which the flow is as homogeneous as possible. For this purpose, flow sensors, for example, directly to the pump inlet and / or pump outlet 4 to arrange meaningful. However, it is not excluded that such flow sensors can be arranged at other locations of the pump, where locally a flow can be detected representative of the total flow through the pump.
  • FIG. 1 In the flow direction upstream of the rotor 8 is in FIG. 1 a Strömungsleitrad 11 shown, the flow guide elements, which give the incoming flow, for example, a twist, which improves the delivery capacity of the pump.
  • the innovation is based inter alia on the idea that the flow rate of such a pump can be measured by local entry of energy or local dissipation of energy and simultaneous detection of the temperature development, since the evolution of temperature with appropriate heat supply or removal of the heat transfer by the passing Blood / the passing liquid is determined.
  • a temperature element 14 can be provided within the pump between a first temperature sensor 12 and a second temperature sensor 13, via which a heat energy input into the liquid is possible, for example, a heating resistor which is electrically controlled.
  • the supplied heat energy can be determined exactly, and it can for example by means of the first and second sensors 12, 13 of the temperature difference be determined, which is achieved by the heating means of the temperature element 14.
  • the heat can be taken into account in the underlying calculation model, which is entered by an electric pump drive in the liquid.
  • the energy input per unit time ie. H. the heat output
  • the proportionality factor is determined by a product of the density of the blood, the specific heat capacity and the flow rate of the blood.
  • the registered energy can be calculated from the electrical power of the motor drive of the pump and, if present, the temperature element 14.
  • ⁇ ⁇ ⁇ c ⁇ Qb T inlet - T outlet .
  • ⁇ corresponds to the input of the thermal energy per time
  • ⁇ density of the blood
  • c the specific heat capacity
  • Qb the flow rate of the blood
  • FIG. 2 shows for a better understanding of the pump structure from a view in the axial direction 9 of the pump FIG. 1 , Wherein Arrows 15, 16, the flow direction of the blood in the region 7 of the fluid channel 5 is indicated, the blood in the circumferential direction 17 and strives radially outward and then flows to the pump outlet 4. There, a cannula 18 is connected, through which the blood is further promoted.
  • FIG. 3 is schematically on the pump housing in addition to FIG. 1 a stator 19 of a pump drive is shown, wherein the stator 19 concentrically surrounds the rotor 8 in the pump housing.
  • the rotor 8 contains corresponding Magnetic elements that serve to realize a brushless electric motor. At least a portion of the heat generated by the flow of current in the stator 19 is introduced into the fluid channel 5.
  • a bearing device 20 which comprises a first part 20a of the bearing rotating with the rotor 8 and a stationary part 20b of the bearing.
  • the fixed part 20b of the bearing is part of a magnetic circuit which can be closed, for example, via parts of the pump housing 2 and the stator 19, wherein in this magnetic circuit, a controllable electromagnet is integrated, which can control the magnetic forces in the axial direction or to a Axial bearing of the rotor 8 to effect.
  • the electrical power required for this purpose can also be included in the calculation of the heat input, ie in the calculation of the total thermal energy input into the blood flowing through the pump.
  • a control unit 21 is shown schematically, which is connected by means of lines 22, 23 with the active, heat-emitting elements of the pump, so the stator 19 and the bearing device 20, and can determine the registered electrical and therefore thermal power.
  • the control unit 21 is connected to the first and second sensors 12, 13, so that it can also detect the temperature difference between the pump inlet 3 and pump outlet 4.
  • the controller 21 may include a microcontroller, by means of which the blood flow can be determined directly from the detected temperature difference and the registered power.
  • the temperature sensors 12, 13 may be held, for example, in the region of the pump inlet 3 by means of a star in the fluid channel 5, or a temperature sensor may be arranged in front of the rotor in the region of the Vorleitrades 11 and attached to the leader wheel 11.
  • a temperature sensor may, for example, also be fastened to the inner wall of the housing 2 in the area of the pump inlet.
  • a temperature sensor can likewise be held in the outlet channel by means of a carrier star.
  • the temperature sensor 13 may also be attached to a wall of the pump outlet channel 4.
  • the temperature element can be connected to a sensor, so that, for example, a heating resistor is coupled to a temperature sensor, for example a thermocouple, or a Peltier element to a thermocouple, or both the electrical energy in a heating resistor and the temperature can be converted of the heating resistor are measured by the temperature dependence of the electrical resistance.
  • a heating resistor is coupled to a temperature sensor, for example a thermocouple, or a Peltier element to a thermocouple, or both the electrical energy in a heating resistor and the temperature can be converted of the heating resistor are measured by the temperature dependence of the electrical resistance.
  • FIG. 5 This is in FIG. 5 an element shown below.
  • a metallic conductor element 24 is shown, on which electrodes 25, 26 are applied.
  • the conductor element 24 is arranged in a fluid flow, which is indicated by the arrow 27, which shows the flow direction. If, as indicated by the arrow 28, a current flows through the conductor 24, it will at least partially also flow through the electrodes 25, 26, depending on the resistance values Transition regions thermocouples are formed, where a thermoelectric voltage caused by the action of the current in the region of the material transition. By means of this thermoelectric voltage, which can be measured, the temperature at the conductor 24 can be determined very accurately.
  • the Peltier effect can be exploited, which brings about heat production, for example in the region of the current entry from the conductor 24 into a better conducting electrode 25 (represented by the arrow 29) representing a heat input), while in the region in which the current from the electrode 25, 26 reenters the conductor 24, a heat absorption occurs, represented by the arrow 30.
  • a temperature change takes place on the conductor 24, which can be detected by means of the above-described thermal effect by a voltage change.
  • the conductor as in the example shown, is surrounded by a fluid, it is actively cooled by the fluid.
  • the temperature changes at a given flow rate depend on the flow rate of the circulating medium.
  • the flow rate of the liquid or of the blood can then be determined for a given current through the conductor 24 from the detected thermal voltage.
  • Peltier element in which both the heating and the cooling areas are in contact with blood from a blood pump may have the advantage that the temperature of the blood remains largely unchanged due to simultaneous, locally distributed heating and cooling.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Mechanical Engineering (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Medical Informatics (AREA)
  • External Artificial Organs (AREA)
EP15183195.5A 2015-08-31 2015-08-31 Pompe destinee au transport de liquides et procede de determination d'un debit Withdrawn EP3135327A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP15183195.5A EP3135327A1 (fr) 2015-08-31 2015-08-31 Pompe destinee au transport de liquides et procede de determination d'un debit
US15/756,092 US20180243491A1 (en) 2015-08-31 2016-08-29 Pump for conveying fluids, and method for determining a flow rate
DE112016003906.9T DE112016003906A5 (de) 2015-08-31 2016-08-29 Pumpe zur Förderung von Flüssigkeiten sowie Verfahren zur Ermittlung einer Flussrate
PCT/EP2016/070325 WO2017037025A1 (fr) 2015-08-31 2016-08-29 Pompe pour le pompage de liquides et procédé de détermination du débit
CN201680056924.0A CN108136086A (zh) 2015-08-31 2016-08-29 用于输送流体的泵以及用于确定流量的方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15183195.5A EP3135327A1 (fr) 2015-08-31 2015-08-31 Pompe destinee au transport de liquides et procede de determination d'un debit

Publications (1)

Publication Number Publication Date
EP3135327A1 true EP3135327A1 (fr) 2017-03-01

Family

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Family Applications (1)

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EP15183195.5A Withdrawn EP3135327A1 (fr) 2015-08-31 2015-08-31 Pompe destinee au transport de liquides et procede de determination d'un debit

Country Status (5)

Country Link
US (1) US20180243491A1 (fr)
EP (1) EP3135327A1 (fr)
CN (1) CN108136086A (fr)
DE (1) DE112016003906A5 (fr)
WO (1) WO2017037025A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117244171B (zh) * 2023-11-20 2024-03-12 安徽通灵仿生科技有限公司 一种心室辅助***的冲洗设备的自适应控制方法及装置

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4465063A (en) 1982-05-25 1984-08-14 University Of Utah Cardiac flow measurement system and method
WO1991019170A1 (fr) * 1990-06-04 1991-12-12 Mcpherson's Limited Detecteur de debit et systeme de commande
US20090306585A1 (en) * 2008-05-08 2009-12-10 Changlin Pang Implantable pumps and cannulas therefor
US20140073837A1 (en) * 2012-09-13 2014-03-13 Circulite, Inc. Blood flow system with variable speed control
US20140100414A1 (en) * 2012-09-05 2014-04-10 Heartware, Inc. Vad integrated flow sensor
WO2014141284A2 (fr) * 2013-03-13 2014-09-18 Magenta Medical Ltd. Pompe rénale

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7971480B2 (en) * 2008-10-13 2011-07-05 Hitachi Metals, Ltd. Mass flow controller having a first pair of thermal sensing elements opposing a second pair of thermal sensing elements
JP4996578B2 (ja) * 2008-10-28 2012-08-08 株式会社サンメディカル技術研究所 多孔性構造体を具備する医療用装置又は器具
WO2012112378A2 (fr) * 2011-02-18 2012-08-23 Vascor Inc. Systèmes d'assistance circulatoire

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4465063A (en) 1982-05-25 1984-08-14 University Of Utah Cardiac flow measurement system and method
WO1991019170A1 (fr) * 1990-06-04 1991-12-12 Mcpherson's Limited Detecteur de debit et systeme de commande
US20090306585A1 (en) * 2008-05-08 2009-12-10 Changlin Pang Implantable pumps and cannulas therefor
US20140100414A1 (en) * 2012-09-05 2014-04-10 Heartware, Inc. Vad integrated flow sensor
US20140073837A1 (en) * 2012-09-13 2014-03-13 Circulite, Inc. Blood flow system with variable speed control
WO2014141284A2 (fr) * 2013-03-13 2014-09-18 Magenta Medical Ltd. Pompe rénale

Also Published As

Publication number Publication date
DE112016003906A5 (de) 2018-05-24
US20180243491A1 (en) 2018-08-30
CN108136086A (zh) 2018-06-08
WO2017037025A1 (fr) 2017-03-09

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