EP3071292B1 - Dispositif d'irradiation a rayonnement ionisant notamment pour la radiothérapie et/ou la radiobiologie - Google Patents

Dispositif d'irradiation a rayonnement ionisant notamment pour la radiothérapie et/ou la radiobiologie Download PDF

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EP3071292B1
EP3071292B1 EP14821721.9A EP14821721A EP3071292B1 EP 3071292 B1 EP3071292 B1 EP 3071292B1 EP 14821721 A EP14821721 A EP 14821721A EP 3071292 B1 EP3071292 B1 EP 3071292B1
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Prior art keywords
ionizing radiation
dose
control
detector
mev
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German (de)
English (en)
French (fr)
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EP3071292A1 (fr
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Philippe LIGER
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P M B
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P M B
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1064—Monitoring, verifying, controlling systems and methods for adjusting radiation treatment in response to monitoring
    • A61N5/1065—Beam adjustment
    • A61N5/1067—Beam adjustment in real time, i.e. during treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1071—Monitoring, verifying, controlling systems and methods for verifying the dose delivered by the treatment plan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N2005/1074—Details of the control system, e.g. user interfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
    • A61N2005/1089—Electrons

Definitions

  • the present invention relates to an ionizing radiation irradiation device, in particular for radiotherapy and / or radiology capable of delivering in a controlled and precise manner, in a programmed manner, high doses of ionizing radiation of at least 0.25 Gy, preferably 10 Gy, with an accuracy of at least 1 ⁇ Gy, preferably 1 nGy, in an energy range of between 1 MeV and 50 MeV, at very short times, that is to say, for example at least 0.1 ⁇ s, preferably 100 ⁇ s, or even 1 ms, or 100 ms.
  • an ionizing radiation irradiation device provided with a power pulse control system capable of producing an adjustable energy particle beam in a range of between 1 MeV and 50 MeV pulsed at a frequency ( f) desired with an adjustable pulse duration (d) of at least 1 ns, preferably 0.1 ⁇ s, and capable of delivering an absorbed dose rate up to 250 Gy / s or even up to 500 Gy / s or even up to 1000 Gy / s.
  • It relates more particularly to an ionizing radiation irradiation device, in particular for radiotherapy and / or radiobiology, in which the various means and systems constituting it are intelligently interconnected with one another in order to cooperate and form a control and regulation loop, in particular the power, so as to deliver in a controlled and accurate manner large doses of ionizing radiation of at least 0.25 Gy with an accuracy of at least 1 ⁇ Gy, preferably 1 nGy, at energies in a range between 1 MeV and 50 MeV, for very short instants, that is to say for example at least 0.1 microseconds, preferably 100 microseconds, or even 1 ms, or 100 ms.
  • an ionizing radiation irradiation device in particular for radiotherapy and / or radiobiology, comprising a rapid detector, also called “ultra-fast", capable of detecting a dose in very short times, for example at least 0.01 ns, coupled to a control electronics capable of controlling a dose delivered for a fraction of a second, for example for at least 0.1 ⁇ s, preferably 1 ⁇ s or 1 ms, and preferably for less than one second, or even less than 200 ms.
  • Radiotherapy is a method of locoregional treatment of cancers. It is with surgery, the most common treatment of cancer and can lead to a net remission alone. It can be used alone or combined with surgery and chemotherapy. Its indications are related to the type of tumor, its location, its stage and the general state of the target. In some cases, it has the advantage of being performed on an outpatient basis because the sessions can be short-term and the side effects less than those of chemotherapy. To do this, radiation therapy uses radiation to destroy cancer cells by affecting their ability to reproduce. The purpose of irradiation is to destroy all tumor cells while sparing healthy peripheral tissue.
  • WO 2012/085507 describes for example a method, and an associated device, for spatially controlling the incidence of an irradiating beam. Indeed, for some types of cancer X-ray treatment has the difficulty that the tumor can be located very close to part of the heart that it may be preferable to avoid irradiation.
  • an ionizing radiation irradiation device for radiotherapy and / or radiobiology comprises a linear electron or ion beam accelerator and a control and control electronics which makes it possible to stop the transmission globally. ionizing radiation when the dose prescribed by the operator is reached.
  • Conventional radiotherapy machines can now deliver ionizing radiation in the form of electrons or X-rays at energies of 3 to 25 MeV, at doses of the order of 1 Gy, with a dose rate of the order of 4 Gy per minute and with poor accuracy.
  • the major problems of these devices are characterized by the fact that they are not able to deliver in a controlled and precise manner, in a programmed and intelligent manner, high doses of ionizing radiation up to 250 Gy / s, even up to 500 Gy / s or even up to 1000 Gy / s, at energies in a range between 1 MeV and 50 MeV, at very short times, that is to say for example from less than 0.1 ⁇ s, preferably 100 ⁇ s, or even 1 ms or 100 ms.
  • Another major technical problem of these devices is that the various components of said devices are not fast enough and / or interconnected intelligently to cooperate together and form a sufficiently fast loop of regulation and control of the dose and / or sufficiently high dose rates to deliver a dose of ionizing radiation accurately at very short times.
  • the detector used saturates from a certain dose rate, usually as much as 10 Gy / s at best, which makes it impossible to detect very high dose rates, for example of the order of 250 Gy / s, even 500 Gy / s or even 1000 Gy / s.
  • Another technical problem that arises is that the dose control means and the control and control means are not effective to perform in a desired manner and very precise material, the delivery of a prescribed dose in a very short time .
  • the times which separate the beginning of the detection by the electronic control and control of the start of the emission by the accelerator on the one hand and the moment of detection by the electronic control and control of the exceeding of the prescribed dose of the stopping of the emission by the accelerator on the other hand be less than one millisecond, preferably less than a few microseconds.
  • the state of the art is known ionizing radiation irradiation devices capable of delivering dose rates as high as 10 kGy / s but in electrons only and at energies less than or equal to 10 MeV.
  • accelerators comprising control systems to inhibit irradiation in less than 100 ⁇ s, but their ion chamber detection system is not fast enough to detect the dose rate. , integrate it, compare it and stop the irradiation in less than 100 ms.
  • an ionizing radiation irradiation device particularly for radiotherapy and / or radiobiology, which can deliver in a controlled and precise manner large doses of ionizing radiation of at least 0, 25 Gy with an accuracy of at least 1 ⁇ Gy, preferably 1 nGy, at very short times, that is to say at least 0.1 ⁇ s, in particular 100 ⁇ s, or even 1 ms, or even 100 ms , in energy ranges between 1 MeV and 50 MeV.
  • a radiotherapy device comprising a pulsed source of electrons, capable of providing total exposure for at least one minute at the 1 Hz repetition rate and providing single doses of 10 Gy in about 30 ns.
  • a radiotherapy device comprising an ionizing radiation emitting means, a target, a dose detector, a dose control means.
  • none of the documents cited discloses a specific regulation and control loop intelligently connecting the various components of the ionizing radiation emitting device to efficiently deliver a dose of at least 1 Gy, in particular at least 10 Gy in energy ranges between 1 MeV and 25 MeV and preferably up to 50 MeV, at very short times, that is to say at least 0.1 microseconds, preferably 100 microseconds, or 1 ms, or 100 ms.
  • none of the documents cited discloses a detector capable of detecting a dose in very short times, preferably at least 0.01 ns, that is to say a high-speed detector.
  • none of the documents cited meets all the specifications for delivering an ionizing radiation dose rate of up to 250 Gy / s or even up to 500 Gy / s or even up to 1000 Gy / s in a single range of energy between 1 MeV and 25 MeV, even 50 MeV, in a controlled manner for periods of time less than 1 s, in particular 1 ms.
  • the object of the present invention is to provide an ionizing radiation irradiation device, in particular for radiotherapy and / or radiobiology, which remedies the problems mentioned above and improves the ionizing radiation irradiation devices known from the state of the art.
  • Said means (MER, MDD, MCD) and said system (SCC) constituting at least part of said device and being further interconnected intelligently to cooperate and form an intelligent control and regulation loop, including power , are configured to deliver and control doses of ionizing radiation of at least 0.01 Gy or even 0.25 Gy with an accuracy of at least 1 ⁇ Gy, preferably 1 nGy, at energies between 1 MeV and 50 MeV, for very brief instants, that is to say at least 0.1 ⁇ s, or even 100 ⁇ s, preferably 1 ms, or even 100 ms, or for example between 0.1 ⁇ s and 100 ms, preferably 100 ⁇ s or 1 ms.
  • the ionizing radiation emission means is a particle accelerator which comprises a power source and a control electronics, that is to say a pulse control system, said control electronics (or pulse control system) is directly connected to the dose control means (CDM) so as to automatically stop the power source when the dose absorbed, detected and measured has A predetermined and predetermined value is reached by the operator via the human machine interface (HMI), said human machine interface (HMI) further comprises a control station (PC) and a display interface management program.
  • HMI human machine interface
  • PC control station
  • the acceleration means is either microwave, induction or electrostatic.
  • the radiation emitting means further comprises several accelerating means connected in series and / or interspersed with means for deflecting or recirculating the particle beam through said one or more acceleration means, each being powered by at least one power source.
  • the detector is a semiconductor, in particular diamond, for example in monocrystalline or polycrystalline form, pure or doped, or silicon carbide, between two polarization electrodes to which a voltage of a few volts is applied.
  • adjustable according to the thickness of the detector via the human-machine interface and configured to obtain a very short response time, for example at least 0.01 ns, at high dose rates, that is to say say at least 0.01 Gy / s.
  • the semiconductor sensors were used for much lower energy ranges than in the context of the present invention, typically under 1 MeV and are known to have the drawbacks of having a variable sensitivity, making them particularly poorly adapted. in the medical field.
  • the detector is traversed by the beam and is configured to allow monitoring of the dose delivered to the patient during the treatment. It therefore detects the entire flow of ionizing radiation in real time. It could therefore be expected that the known detectors would provide information that is difficult to interpret. on the other hand, and especially saturate in the range of doses considered, but it has surprisingly appeared that, contrary to the prejudice of the skilled person, detectors of this type allowed, while being traversed by the entire flow of radiation ionizer for application to a patient, to give a significant value of this flow, both accurately and quickly.
  • a promising diamond detector in the context of the present invention is for example developed by the laboratory LCD (Laboratory Diamond Sensor) CEA Saclay.
  • control electronics (EC) of the dose control means (DCM) comprise means for measuring the electric current, in particular an electrical signal, produced by the interaction of the radiation with the detector, conversion means said electric current in absorbed dose rate unit and means for integrating said electric current configured to accurately measure the cumulative absorbed dose during the emission of ionizing radiation.
  • an electrical signal is produced by the detector, said electrical signal is measured and integrated by an electrometer during radiation emission, the integrated value of said electrical signal is directly compared to the value of the prescribed dose and predetermined by the the operator via the man-machine interface so that, as soon as the integrated value is greater than or equal to the prescribed and predetermined value, the signal of the particle emission triggering system is interrupted to stop, prohibit, instantaneously the emission of the radiation and, optionally, preferably the high voltage source in a sufficiently short time, for example at least 1 ns.
  • the detector comprises one or more quadrants or sectors or voxels each producing a signal detection or absorbed dose signal (SDA) and arranged intelligently, that is to say configured to allow to deduce from their detection signals (SDA) information characterizing the position, shape and / or energy of the beam ionizing radiation which passes through them on the one hand, and in order to control and regulate the ionizing radiation beam, in particular its position, its shape and / or its energy on the other hand.
  • SDA detection or absorbed dose signal
  • the figure 1 shows a general description of the principle of intelligent interconnection of the various components of the ionizing radiation irradiation device for radiotherapy and / or radiobiology object of the present invention.
  • This principle shows that the various members and / or sub-members constituting the device according to the invention cooperate together and form a control and regulation loop, in particular of control and regulation of power so as to deliver in a controlled and precise manner high doses of ionizing radiation of at least 0.25 Gy with an accuracy of at least 1 ⁇ Gy, preferably 1 nanogray (nGy), in an energy range of between 1 MeV and 50 MeV, in very short periods of time , that is to say for example between 0.1 ⁇ s and 100 ms, preferably 100 ⁇ s or 1 ms.
  • the device comprises four elements interconnected with one another: at least one ionizing radiation emitting means (MER), a dose detecting means (MDD), a control and control system (SCC) and a control means dose (CDM).
  • MER ionizing radiation emitting means
  • MDD dose detecting means
  • SCC control and control system
  • CDM control means dose
  • the control and command system is programmed by an operator via interface software to send, in real time, emission instruction (CE) signals by means of ionizing radiation emission (MER). ), detection setpoint (CD) signals by means of ionizing radiation dose detection (MDD) and absorbed dose guideline (ADC) signals by means of ionizing radiation dose control (CDM).
  • CE emission instruction
  • MER ionizing radiation emission
  • CD detection setpoint
  • ADC absorbed dose guideline
  • the ionizing radiation emitting means emits ionizing radiation (RI) corresponding to the ionizing radiation signal that interacts with the dose detecting means (MDD).
  • the interaction of the ionizing radiation (RI) with the dose detecting means (MDD) generates the sending of an absorbed dose signal (ADD) by the dose detecting means (MDD) to the control means of the drug. dose (CDM).
  • the dose control means (DCD) amplifies or attenuates, integrates and compares the absorbed dose signal (ADD) with the absorbed dose target signal (ADC).
  • the absorbed dose control means sends a signal which controls the interruption of the ionizing radiation emission means (MER), otherwise the emission of ionizing radiation (RI) continues according to the predefined prescriptions by the operator.
  • the arrangement of the different set-point and control components and their interconnections constituting the control and regulation loop makes it possible to deliver in a controlled and precise manner, in an intelligent manner, large doses of ionizing radiation of at least 0.25 Gy with an accuracy of at least 1 ⁇ Gy, preferably 1 nGy, in an energy range of between 1 MeV and 50 MeV, for very short instants, that is to say for example included between about 0.1 ⁇ s and 100 ms, preferably 100 ⁇ s or 1 ms.
  • the dose detecting means particularly comprises the ultra-fast detector capable of very accurately detecting a dose in very short times, for example at least 0.01 ns, coupled to a means of detection.
  • dose control which includes a control electronics (EC).
  • Said control electronics (EC) is capable of controlling a delivered dose of at least 0.01 Gy, or even at least 0.25 Gy for at least 0.1 ⁇ s, even 100 ⁇ s, or even 1 ms, or even 100 ms.
  • the ultra-fast detector of the dose detection means is in particular made of diamond and is comprised between two polarization electrodes at the terminals of which is connected the control electronics (EC) of the dose control means (CDM).
  • EC control electronics
  • CDM dose control means
  • SDA electrical detection signal
  • the conversion electronics of the electrical signal produced by the interaction of diamond and ionizing radiation is for example calibrated using an absolute measuring instrument of accumulated absorbed dose during an ionizing radiation emission.
  • the ultra-fast detector comprises one or more so-called "primary" detectors which each comprise several small detectors qualified as secondary, that is to say one or more quadrants or sectors or voxels each producing a detection signal (SDA) and arranged to derive from their detection signals (SDA) information characterizing the position, the shape and / or the energy of the ionizing radiation beam passing through them on the one hand, and so as to control and regulate the ionizing radiation beam, in particular its position, its shape and / or its energy on the other hand.
  • SDA detection signal
  • it has four quadrants or sectors or voxels arranged in a square.
  • each detector qualified primary detector comprises several detection zones or several small detectors qualified secondary.
  • the ultrafast detector may be a stack of primary detectors in the form of disks of semiconductor material, separated into a plurality of secondary detectors.
  • the detector is a semiconductor, in particular diamond, between two polarization electrodes to which a voltage of a few volts is applied via the human-machine interface, which makes it possible to obtain a very fast response time. short, e.g. at least 0.01 ns, at high dose rates, i.e. at least 0.01 Gy / s.
  • said detector may be made of silicon carbide.
  • the semiconductor, in particular diamond is comprised between two polarization electrodes across which a bias voltage of a few volts (TP) is applied, for example one volt per micrometer of diamond thickness between the electrodes.
  • the bias voltage (TP) is adjustable by the control and command system (SCC) via the HMI.
  • SCC control and command system
  • a polarization interconnection means which allows both to provide the bias voltage (TP) controlled by the control and command system (SCC) and to transmit the absorbed dose signal.
  • SDA dose control
  • the dose control means comprises means for measuring the electrical signal (SDA), in particular measuring current, produced by the radiation emitted through the detector, in particular by interaction between the detector and the ionizing radiation which crosses it, means for converting said electrical detection signal (SDA), in particular current, into an absorbed dose rate monitoring unit and means for integrating said electrical detection signal (SDA), in particular current, so as to measure accurately the cumulative absorbed dose during the emission of ionizing radiation.
  • SDA electrical signal
  • SDA electrical detection signal
  • SDA electrical detection signal
  • SDA electrical detection signal
  • SDA electrical detection signal
  • the chosen detector offers the advantage of having a very short response time of the order of a nanosecond or even of a lower order than the nanosecond. It also offers a high resistance to ionizing radiation, properties of interactions with ionizing radiation similar to that of water, that is to say that the energy deposited by the ionizing radiation through it is comparable to that that the same radiation would deposit in water, the conversion of such energy into an electrical detection signal (SDA) making the latter representative of the dose deposited by the ionizing radiation in the living matter, typically a patient. It also offers a linear current response of the electrical signal with respect to the dose rate over wide ranges of high dose rates, and / or the pulse duration (d) of the ionizing radiation. It also offers a constant current response to the energy of ionizing radiation.
  • diamond a suitable material for measuring a high dose rate of ionizing radiation, in particular a dose rate of at least 25 Gy / s or even at least 50 Gy / s, in particular.
  • Very short ionizing radiation pulses of the order of 100 ns, for a long life, that is to say at least 500 hours.
  • the control and command system is provided with a functional control system of the various members of said device according to the invention.
  • This control and command system mainly comprises the human machine interface (HMI) comprising several buttons and organs for managing and programming the device, in particular as regards dose or absorbed dose rate or dose rate delivered. of ionizing radiation.
  • the Control and Command System further comprises visualization tools and several secondary means control, including tactile and non-tactile means, switches, etc., necessary for the implementation of the device. These means allow an operator to program in a controlled and desired manner and in a very precise manner, in an intelligent manner, all at once, the nature of the radiation, the absorbed dose and / or the absorbed dose rate and possibly the dose rate. delivered, of ionizing radiation, in a desired duration, and the pulse regime.
  • the gate impulse parameters, amplitude, frequency (f) and pulse duration (d), number of pulses per pulse train or pulse train duration, duration between pulse trains and the number of impulse train or total emission time (D) are defined by the operator via the man-machine interface and suitable software. These parameters are transmitted to a programmed electronics to generate synchronization signals of the high frequency pulses (HF) of the accelerator and electron gun grid pulses or particle beam source triggering. The signals are amplified by low voltage electronics to generate gate pulses and by power electronics for high frequency pulse (HF) output.
  • HF high frequency pulses
  • the detector is placed in the ionizing radiation beam to measure the absorbed dose rate that this ionizing radiation can produce in the material with which it interacts, typically a patient.
  • the signal (SDA) produced by the detector in the form of an electric current is measured and integrated by the control electronics (EC) of the dose control means (DCD), in particular an electrometer, during the transmission of the ionizing radiation and the integrated value is compared to the value of the prescribed absorbed dose (CDA) by the operator via the human-machine interface (HMI).
  • the gate pulse signal drops to its negative bias voltage with respect to the cathode so as to prohibit transmission.
  • the duration of emission of ionizing radiation can therefore be controlled and stopped in real time and the dose delivered is accurate to the value close to the dose produced by the last ionizing radiation pulse.
  • the measurement function of the detection signal can for example be provided by an amplifier or attenuator according to the amplitude of the signal, followed by a sample-and-hold circuit.
  • the dose control means (CDM) is a means configured to control the triggering and stopping of the ionizing radiation emitting means (MER), it includes the control and control electronics (EC).
  • the control and control electronics (EC) comprises the amplifier or attenuator amplifying or attenuating, according to the amplitude, a signal emitted by the detector, the integrator integrating for the duration of the transmitting said amplified or attenuated signal and the comparator continuously comparing said integrated signal to the predetermined dose guidelines (ADC) predetermined by the operator.
  • ADC predetermined dose guidelines
  • the transmitter consists of a power source that is triggered and stopped by the electronics of the control and command system (SCC).
  • SCC control and command system
  • the operator controls the triggering of a programmed transmission via the human-machine interface (HMI).
  • HMI human-machine interface
  • CCS Control and Control System
  • CDM dose control means
  • the comparator output signal automatically drops to a predetermined and predefined value and triggers the stopping of the source of the electron beam, in particular of the ionizing radiation emitting means (MER), and the stopping of the high voltage source (HT) of the accelerator in a sufficiently short time, that is to say preferably less than 100 microseconds so that the detected dose does not exceed the prescribed dose.
  • All the aforementioned means constituting the control and regulation loop, in particular power, constituting the device object of the present invention, are interconnected intelligently as previously described, to cooperate and form an intelligent control and regulation loop , in particular power, so as to deliver in a controlled and precise manner large doses of ionizing radiation, that is to say preferably at least 0.01 Gy and preferably at least 0.25 Gy with an accuracy of at least 1 ⁇ Gy, preferably 1 nGy, in a range of energy between 1 MeV and 50 MeV, at very short times, that is to say for example between about 0.1 ⁇ s and 100 ms, preferably 100 ⁇ s or 1 ms.
  • the ionizing radiation emission means consists mainly of the particle accelerator comprising a power source and the pulse control system which is for example directly connected to the dose control means (CDM). so as to automatically stop the power source when the absorbed, detected and measured dose has reached the prescribed and predetermined value by the operator via the human-machine interface (HMI).
  • CDM dose control means
  • Said human machine interface further comprises a control station (PC) and a visualization interface management program.
  • the HMI also includes pushbuttons and indicator lights for racks, enclosures and / or electronic boards that contain Control System Electronics (SCC) and Dose Control Device (CDM) electronics. .
  • SCC Control System Electronics
  • CDM Dose Control Device
  • a signal is produced by the detector in the form of electric current, said signal is measured and integrated by an electrometer during radiation emission, the integrated value of said signal is directly compared to the value of the prescribed and predetermined dose by the operator via the human-machine interface (HMI) so that, as soon as the integrated value is greater than or equal to the prescribed and predetermined value, the gate pulse signal automatically falls back to a predetermined value corresponding to the voltage of polarization with respect to the cathode to prohibit and instantly stop the emission of ionizing radiation and possibly the high voltage source in a sufficiently short time, for example at least 1 ns.
  • HMI human-machine interface
  • the figure 4 is an embodiment representing an ionizing radiation (MER) emitting means.
  • This means for emitting ionizing radiation (MER) comprises at least one source of particles, in particular electrons.
  • Said source comprises for example at least one cathode (1), anode (3) and a grid (2).
  • the gate further includes a low-voltage bias (6) which controls the extraction and flow rate of particles removed from the cathode.
  • the ionizing radiation emission means (MER) further comprises a filament (7), supplied with voltage, in particular at low voltage, for heating the cathode and thus making it emissive, that is to say, in order to be able to extract particles.
  • the gate is configured so that the particles extracted from the cathode pass through said gate.
  • the cathode and the anode are connected to a high voltage power supply HT (5).
  • the particles having passed through the gate are accelerated towards the anode forming a particle beam.
  • the particle beam source may for example be a source triggerable by a laser beam, or a source triggered by a polarized gate or a polarized electrode.
  • the source is composed of a photocathode or a plasma, an anode and a laser beam that illuminates the photocathode or the plasma to trigger the emission of electrons by the photocathode or by the plasma.
  • the anode is provided with an orifice allowing extraction of the particle beam and its injection into a means of acceleration (8) of the particle beam (4).
  • the ionizing radiation emission means further comprises a vacuum chamber, that is to say a very low pressure, for example at most 10 -6 mbar.
  • the ionizing radiation emission means (MER) further comprises a transmission window or a conversion target (9) which converts the particle beam (4) into ionizing radiation (4 bis) by transmission from the vacuum chamber to the outside atmosphere. This is how ionizing radiation is emitted.
  • the ionizing radiation emitting means is provided with a power pulse control system which comprises a power generator supplying the particle beam acceleration means and a switching electronics.
  • the power pulse control system is capable of producing an adjustable and desired energy particle beam in a range of between 1 MeV and 50 MeV, pulsed at a desired frequency (f), typically between 5 Hz and 1 kHz. , with an adjustable pulse duration (d) of at least 1 ns, preferably 0.1 ⁇ s and capable of delivering an absorbed dose rate of up to 250 Gy / s, or even up to 500 Gy / s or even up to 1000 Gy / s.
  • the particle flow in other words the particle beam current, is controlled by the bias voltage (6) applied to the gate. It is the combination of energy and particle beam current that determines the absorbed dose rate that can be delivered by the ionizing radiation emitting means (MER).
  • MER ionizing radiation emitting means
  • the ionizing radiation emitting means is further provided with a particle beam source triggered by the gate (2).
  • the particle beam current generated by the gate source is directly a function of the bias voltage (6) of said gate (2), in particular in the form of a signal having a pulse duration (d) of at least 1 ns, preferably 0.1 ⁇ s, a pulse frequency (f) and a bias voltage amplitude.
  • the switching electronics supplying said gate can operate in several modes, in particular in recurring mode for long-term irradiation, in single-pulse mode for irradiations with very short durations of less than 1 ms or even 100 ⁇ s, and in semi-recurrent mode for the irradiations composed of several trains of pulses, frequencies chosen and separated according to selected delays.
  • the shape of the gate bias signal can be programmed at will with pulses of variable duration, variable frequency, variable amplitude and with at least a predefined delay between pulses and / or between pulse trains.
  • the switching electronics of the radiation emitting means (MER) power pulse control system comprise analog inputs and outputs for acquiring all the useful information, both the controlled values and the measured values, relative to each other. the current and the heating voltage of the particle beam source, and the bias voltage amplitude of the grid bias.
  • the emitter of the ionizing radiation is a particle accelerator, in particular a linear accelerator, for example a linear electron accelerator.
  • the electron beam from the accelerator can be used directly as ionizing radiation after passing through a window (9) which separates the vacuum from the accelerator chamber and the external atmosphere, or the accelerator can be equipped with a target for converting the power of the X-ray electron beam which then constitutes the useful ionizing radiation.
  • the accelerator produces a beam of desired energy and current particles, especially energy in a range of between 1 MeV and 50 MeV, preferably the range of 3 MeV to 25 MeV.
  • the current and the energy are defined by the operator via the man-machine interface to obtain the desired ionizing radiation in the previously chosen range.
  • the acceleration means (8) is either microwave wave or induction or electrostatic.
  • the acceleration means (8) is particularly an accelerating cavity.
  • the radiation emission means further comprises a plurality of acceleration means, in particular one or more accelerating cavities, mounted in series and / or interposed with means for deflecting or recirculating the particle beam through said one or more accelerator means, each accelerator means being powered by at least a power source which can be powered by at least one modulator, said modulator being itself powered by a high voltage source HT.
  • an electron beam of adjustable energy in a range between 1 MeV and 50 MeV and average current 100 ⁇ A can be used as ionizing radiation.
  • Any other type of accelerator of higher or lower frequency, or even DC, that is to say electrostatic (that is to say a accelerator with continuous voltage) can be used as long as the energy range and the average current correspond to the previously indicated values.
  • the beam is pulsed at an adjustable frequency (f) of between 5 Hz and 200 Hz with a pulse duration (d) adjustable between 0.05 ⁇ s and 4.5 ⁇ s and a minimum amplitude of 100 mA.
  • This accelerator is more powerful, able to accelerate a primary electron beam of average intensity greater than 1 mA.
  • This accelerator may be a linear copper cavity accelerator, or a superconducting linear accelerator, or any other type of accelerator corresponding to the requirements of the expected result object of the present invention.
  • a linear accelerator comprising a copper cavity
  • it is pulsed at frequencies (f) greater than 200 Hz, with a pulse duration (d) of at least 5 ⁇ s and a peak intensity of at least minus 1 A.
  • It may consist of several accelerating cavities in series, each powered by its own source of high frequency power (HF).
  • the power sources may be amplification means comprising a vacuum chamber and making it possible to carry out amplifications of medium and high power microwave narrowband, for example the klystrons, and these amplification means are themselves powered by conventional modulators or solid state modulators.
  • the source accelerator beam system includes a DC or electrostatic electron gun (ie a DC voltage electron gun) of the triode type or of the laser-triggered photocathode type or the electrode or laser-triggered plasma type . It may be for example a DC high voltage gun with a thermionic cathode gate. The cathode is brought to a negative potential of ten to several tens of kilovolts. The anode remains at the ground potential, in particular 0 V (zero volts).
  • a DC or electrostatic electron gun ie a DC voltage electron gun
  • the cathode is brought to a negative potential of ten to several tens of kilovolts.
  • the anode remains at the ground potential, in particular 0 V (zero volts).
  • the gate plays the role of trigger by being brought to a negative potential and lower by ten or a hundred volts with respect to the cathode to not emit and at a negative potential but higher than that of the cathode for issue.
  • the amplitude of the peak current emitted by the cathode depends on its potential difference with respect to that of the gate.
  • Adjustable frequency (f), adjustable duration (d) and adjustable voltage pulse pulses are sent to the gate in phase with the high voltage (HV) pulses of the cathode supply to generate a desired pulsed beam and injected for acceleration of particles in the high frequency (HF) cavities of the accelerator.
  • the device according to the invention has the advantage of offering the operator the possibility of programming the type of ionizing radiation, the energy of the radiation, the dose rate of ionizing radiation absorbed and / or to be delivered, and the duration irradiation or the dose of ionizing radiation to be absorbed and / or delivered.

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Radiation-Therapy Devices (AREA)
EP14821721.9A 2013-11-20 2014-11-20 Dispositif d'irradiation a rayonnement ionisant notamment pour la radiothérapie et/ou la radiobiologie Active EP3071292B1 (fr)

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PL14821721T PL3071292T3 (pl) 2013-11-20 2014-11-20 Urządzenie napromieniowujące promieniowaniem jonizującym w szczególności do radioterapii i/lub radiobiologii

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FR1302672A FR3013225B1 (fr) 2013-11-20 2013-11-20 Dispositif d'irradiation a rayonnement ionisant, notamment pour la radiotherapie et/ou la radiobiologie
PCT/FR2014/052979 WO2015075388A1 (fr) 2013-11-20 2014-11-20 Dispositif d'irradiation a rayonnement ionisant notamment pour la radiothérapie et/ou la radiobiologie

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HK1223057A1 (zh) 2017-07-21
WO2015075388A1 (fr) 2015-05-28
FR3013225B1 (fr) 2018-09-14
EP3071292A1 (fr) 2016-09-28
US20160287905A1 (en) 2016-10-06
CN105848714B (zh) 2019-10-01
SG10201804103YA (en) 2018-07-30
ES2730946T3 (es) 2019-11-13
CN105848714A (zh) 2016-08-10
US10071264B2 (en) 2018-09-11
PL3071292T3 (pl) 2019-12-31
AU2014351643B2 (en) 2018-12-20
JP6510519B2 (ja) 2019-05-08
FR3013225A1 (fr) 2015-05-22
WO2015075388A9 (fr) 2016-05-19
JP2016537128A (ja) 2016-12-01
CA2929804C (fr) 2023-02-28
CA2929804A1 (fr) 2015-05-28
AU2014351643A1 (en) 2016-06-30
BR112016011303B1 (pt) 2019-12-31

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