EP2949591B1 - Behälter und ventilanordnung zur speicherung und abgabe von substanzen und dazugehöriges verfahren - Google Patents
Behälter und ventilanordnung zur speicherung und abgabe von substanzen und dazugehöriges verfahren Download PDFInfo
- Publication number
- EP2949591B1 EP2949591B1 EP15000463.8A EP15000463A EP2949591B1 EP 2949591 B1 EP2949591 B1 EP 2949591B1 EP 15000463 A EP15000463 A EP 15000463A EP 2949591 B1 EP2949591 B1 EP 2949591B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- valve
- substance
- valve opening
- container
- storage chamber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
- A45D40/00—Casings or accessories specially adapted for storing or handling solid or pasty toiletry or cosmetic substances, e.g. shaving soaps or lipsticks
- A45D40/26—Appliances specially adapted for applying pasty paint, e.g. using roller, using a ball
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D35/00—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor
- B65D35/02—Body construction
- B65D35/04—Body construction made in one piece
- B65D35/06—Body construction made in one piece from metallic material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D35/00—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor
- B65D35/02—Body construction
- B65D35/04—Body construction made in one piece
- B65D35/08—Body construction made in one piece from plastics material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D35/00—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor
- B65D35/24—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor with auxiliary devices
- B65D35/36—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor with auxiliary devices for applying contents to surfaces
- B65D35/38—Nozzles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D47/00—Closures with filling and discharging, or with discharging, devices
- B65D47/04—Closures with discharging devices other than pumps
- B65D47/20—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge
- B65D47/2018—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure
- B65D47/205—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure the valve being formed by a tubular flexible sleeve surrounding a rod-like element provided with at least one radial passageway which is normally closed by the sleeve
Definitions
- the subject invention relates to a method and a container for aseptically storing and dispensing a substance.
- Flexible tubes are used to store a variety of powder, liquid, gel, creamy and pasty products having a broad range of viscosities.
- the flexible tubes have a cover which is removed to expose a simple release aperture.
- low pressure is required to express the contents therein.
- Undesirable oozing and collection of product that can clog the release aperture is common.
- the traditional tube is opened, the contents are not only subject to the environment but a quantity of air is normally sucked into the tube.
- liquid lipstick is particularly poorly suited for dispensing by prior art containers.
- the liquid lipstick becomes contaminated, evaporates due to air passage losing moisture, and ultimately is unusable if not unsafe before complete utilization of the product.
- the tips become contaminated, dirty and sticky or crusty as well as allowing the lipstick to continue to flow when not being used.
- valves are frequently designed to work with mechanical pumps or like actuators that are capable of creating relatively high valve opening pressures.
- Exemplary dispensers of this type are illustrated in U.S. Patent Nos. RE 37,047 , 6,032,101 , 5,944,702 , and 5,746,728 and U.S. Publication Nos. US2002/0074362 A1 , US2002/0017294 A1 .
- Squeeze tube-type dispensers are not capable of creating the necessary valve opening pressures, and therefore such prior art valves do not work effectively with squeeze tubes.
- the valve substantially prevents the ingress of air, other gases or vapors, or bacteria therethrough or otherwise into the tube during dispensing.
- the containers may maintain the substances contained therein in a sterile and/or airless condition throughout substantial periods of storage, shelf life and/or use. Accordingly, the containers of the present invention are particularly well suited for dispensing multiple doses of sterile and/or non-preserved (or "preservative-free") products or other substances requiring storage in an airless condition.
- valve seat diameter a degree of interference between the valve cover and valve seat, the predetermined radial thickness of the valve portion, and a predetermined modulus of elasticity of the valve cover material, is selected to (i) define a predetermined valve opening pressure generated upon manually squeezing the tube that allows passage of the substance from the storage chamber through the valve opening, and (2) hermetically seal the valve and prevent the ingress of bacteria through the valve and into the tube in the normally closed position.
- the tube and valve assembly of the present invention enables a sufficiently low valve opening pressure to allow the substance to be dispensed through the valve by manually squeezing the tube, yet the valve also hermetically seals the tube and prevents the ingress of bacteria or other impurities into the tube.
- Another advantage of the currently preferred embodiments of the present invention is that the seal formed by the valve substantially prevents any creep of the material during the storage or shelf-life.
- Another advantage of the one-way valve assembly is that after dispensing the product does not remain in the one-way valve which could cause improper sealing and potential contamination.
- the one-way valve employed in the preferred embodiments of the present invention further maintains the interior of the tube in a hermetically-sealed condition throughout the storage, shelf-life and/or use of the container.
- Yet another advantage of the present invention is that because the product may be maintained in an airless condition in the tube, the containers may be used in virtually any orientation, and furthermore, may be used in low gravity environments. Still another advantage is the ability to optimize the valve opening pressure for flow, ease of use and a desired valve opening pressure for products of varying viscosities.
- the invention herein is scalable which is useful when storing larger quantities of product having an extended shelf life.
- Another advantage of the currently preferred embodiments of the present invention is the flow path is substantially linear which allows for a more consistent flow rate and velocity of the product.
- the linear flow path also helps to prevent pockets in which a viscous material could become trapped or even create a flow path for a source of contamination.
- the container referred to generally by reference numeral 100.
- the container includes a nozzle 102 and body 104 depending from the nozzle 102.
- the body 104 defines an interior which retains a creamy, pasty, liquid or other product (not shown) to be dispensed.
- the body 104 and nozzle 102 are sterilized, the body 104 is filled with the product, such as a perishable food, cosmetic, household, pharmaceutical, cosmeceutical, medicinal or other product or substance, and the nozzle 102 is attached to seal the contents of the body 104 from the atmosphere.
- the contents are sterilized by an appropriate method such as gamma radiation and the like as would be appreciated by those of ordinary skill in the pertinent art.
- the container 100 and the product contained therein can be sterilized, if desired, in any of numerous different ways that are currently or later become known for performing this function.
- the product can be sterilized prior to filling same into the container, or the product can be in-line sterilized during filling of the container.
- a cap 106 threadably engages the nozzle 102 to prevent inadvertent release of the product.
- the cap 106 is removed and pressure is applied to the body 104 by manually squeezing the body 104 and, in turn, to the nozzle 102 to allow release of the product.
- the nozzle 102 releases the product without exposing the remaining product to the external atmosphere; thus, the sterility and/or airless condition of the interior of the body 104 is maintained and the shelf life of the product is not decreased. Further, bacteria or other contaminants are prevented from passing through the valve and into the interior of the body 104, as described further below.
- the body 104 is a tube with a closed end 108 defining a normally closed seal and an open end 110 for sealingly connecting to the nozzle 102.
- the open end 110 has a neck 111 which defines an outlet 113 therethrough for releasing the product. Threads 115 about the circumference of the neck 111 couple the body 104 to the nozzle 102.
- the body 104 is pliable such that a high percentage of the product therein can be easily utilized.
- the body 104 may be all plastic, aluminum, a combination thereof, and/or a plurality of other suitable materials well known to those skilled in the art now and later discovered.
- the body 104 is made from a coextruded sheet containing various combinations of LDPE, LLDPE, HDPE, tie resins and foil.
- the body 104 can be customized for the application, for example, by color, shape, decoration, coatings and the like. Additionally, the container 100 can be sized to be portable or otherwise as may be desired.
- the body 104 preferably also provides a barrier to oxygen, moisture, flavor loss and the like.
- the product contained within the container may be any of numerous different types of cosmetics, such as eye and lip treatments, including, for example, lip gloss, eye colors, eye glaze, eye shadow, lip color, moisturizers and make-up, such as cover-up, concealer, shine control, mattifying make-up, and line minimizing make-up, personal care items such as lotions, creams and ointments, oral care items such as toothpaste, mouth washes and/or fresheners, pharmaceutical products such as prescription and over-the-counter drugs, dermatological products, such as products for treating acne, rosacea, and pigmentation disorders, cosmeceutical products, such as moisturizers, sunscreens, anti-wrinkle creams, and baldness treatments, nutraceuticals, other over-the-counter products, household items such as adhesives, glues, paints and cleaners, industrial items such as lubricants, dyes and compounds, and food items such as icing, cheese, yogurt, milk, tomato paste, and baby food, and condiments, such as mustard, ket
- the cap 106 is preferably made of plastic. Preferably, the cap 106 prevents inadvertent release of the product from the container 100. Additional tamper-evident features can be included to comply with FDA guidelines as would be appreciated by those of ordinary skill in the pertinent art.
- the container 100 also may be packaged in a box for additional ease of handling and safety.
- the nozzle 102 is for releasing the product upon application of manual pressure to the body 104 by squeezing the body in a conventional manner, such as squeezing the body on opposites sides relative to each other and, in turn, transmitting a substantially radially-directed force into the body.
- squeezing the body the pressure of the product or other substance contained within the body is increased until the pressure is greater than the valve opening pressure of the nozzle 102 to, in turn, dispense the product within the container through the nozzle.
- the nozzle 102 includes an outer body or valve cover 112 at a distal end or tip, and an inner body 114 having a distal end or tip defining a valve seat that is coupled to the outer body or valve cover 112.
- the inner body 114 further defines a proximal end coupled to the body 104.
- An intermediate portion of the inner body 114 defines circumferential threads 116 for engaging the cap threads 118.
- the proximal portion of the inner body 114 defines internal threads 120 for engaging the body threads 115.
- the outer body or valve cover 112 receives an inner nozzle portion or tip 124 defining the valve seat of the inner body 114.
- the interface of the outer body 112 and the inner nozzle portion 124 defines a seam 125 which is normally closed (i.e., the inner and outer nozzle portions are abutting one another as shown in the drawings), but can be opened by the flow of product of sufficient pressure (i.e., equal to or greater than the valve opening pressure) into the seam 125 to release the product through the nozzle 120.
- the outer body 112 is preferably molded from a relatively flexible plastic material in comparison to the inner body 114. Thus, the outer body 112 can be flexed relative to the inner nozzle portion 124 to open the seam 125 to release the product through the nozzle 120.
- the inner body 114 includes an annular flange 126 which fits within a corresponding recess in the outer body 112, for retaining the inner body 114 within the outer body 112 and securing the outer body or valve cover against axial movement.
- the inner body 114 is therefore pressed into the outer body 112 and coupled to the outer body by guiding the flange 126 into the corresponding recess.
- the annular flange 126 also substantially prevents undesirable flow of the product between the annular flange 126 and outer body 112.
- the inner body 114 can be molded as an integral part of the body 104.
- the inner body 114 includes a first substantially cylindrical wall 136 essentially defining a hollow shaft projecting in the axial direction of the container 100 and threadably engaging the distal end of the body 104.
- the proximal end and intermediate portion of the inner body 114 define a first channel 138 which is sized and configured to align with the outlet 113 of the neck 111.
- the distal portion of the inner body 114 defines a relatively narrower second channel 142 axially aligned with the first channel 138.
- a plurality of release apertures 140, in communication with the second channel 142, are defined in a sidewall of the distal portion of the inner body 114 for allowing exit of the product therethrough.
- the cross-sectional area of the release apertures 140 is at least about 60% of the total cross-sectional area of the sidewall; although various size release apertures 140, both larger and smaller, may be selected to achieve the desired performance as would be appreciated by those of ordinary skill in the art based upon review of the subject disclosure.
- the container 100 is actuated to release the product through the nozzle 120 by depressing the body 104 by hand.
- pressure develops within the body 104, the first channel 138, the second channel 142 and the release apertures 140.
- the pressure facilitates the flow of product from the body 104 through the seam 125.
- the pressurized product flows through the release aperture 140, into the seam 125, and out through the tip of the nozzle 120 for release.
- the valve opening pressure is sufficiently low so that manually squeezing the body will create sufficient pressure to cause the pressurized product within the container to open the seam 125 and dispense therethrough.
- the seam 125 returns to its normally closed position to substantially prevent any product that is exposed to air from flowing back into the container 100 and otherwise seal the container.
- the container 100 is then ready to be actuated again to release another amount of product.
- One advantage of this type of container 100 is that once a dose of product is released, the seam 125 of the nozzle 120 closes, and thus substantially prevents the product which has been exposed to air or foreign particles from passing back through the nozzle 120 and into the container 100, which can, in some instances, contaminate the remainder of the product in the container 100.
- This advantage is particularly important when storing multiple-dose quantities of sterile and/or preservative-free formulations of medicament, perishable food, cosmetics, and the like.
- an o-ring 119 is included to prevent the product from inadvertently being released between the body 104 and inner body 114.
- the o-ring 119 is seated between the container body 104 and the inner body 114 for forming a hermetic seal therebetween.
- the nozzle 102 differs from the nozzle described above in that the inner body 114 of the valve assembly includes a first substantially fiusto-conical or tapered portion 127 extending between the base of the body and the valve seat 124. Further, the plural flow apertures 140 (only one shown) extend through the tapered portion 127.
- each flow aperture 140 is formed contiguous to the axially-elongated valve seat 124.
- the valve cover 112 includes a cover base 129 mounted on the body base and fixedly secured against axial movement relative thereto by the annular flange 126 of the body base being received within the corresponding annular recess of the cover base.
- a valve portion 131 of the valve cover overlies the valve seat 124.
- the valve portion 131 defines a predetermined radial thickness and a diameter less than a diameter of the valve seat to thereby form an interference fit therebetween.
- the valve portion 131 and valve seat 124 define the normally closed, annular, axially extending valve opening 125 therebetween.
- the valve portion 131 is movable radially between the normally closed position with the valve portion engaging the valve seat, as shown in FIG. 4B , and an open position with a segment of the valve portion spaced radially away from the valve seat to allow the passage of substance at a predetermined valve opening pressure therebetween.
- the valve cover 112 further defines a second substantially frusto-conical shaped portion 133 extending between the cover base and valve portion 131 that overlies the first substantially frusto-conical shaped portion 127 of the body and forms an interference fit therebetween
- the dispensed product defines an unobstructed, axially extending flow path between the interior of the body 104 and the flow apertures 140.
- the outlet apertures in the substantially frusto-conical or tapered portion 127 of the inner body, and by forming the radially inner side of each aperture either contiguous to, or substantially contiguous to the annular, axially-extending valve seat 124 as shown, the head loss encountered in dispensing the product from the interior of the container through the flow apertures 140 is substantially minimized, thus facilitating a relatively low valve opening pressure.
- the container and valve assembly enables the product to be easily and comfortably dispensed through the nozzle by manually squeezing the tube, yet the valve assembly maintains a hermetic seal that substantially prevents the ingress of bacteria or other unwanted impurities through the valve and into the interior of the container.
- the valve portion 131 and the frusto-conical shaped portion 133 of the valve cover define a tapered cross-sectional profile such that the radial thickness of the cover in these sections progressively decreases in the direction from the interior to the exterior of the valve assembly.
- one advantage of this configuration is that once the product enters the interior end of the seam or valve opening 124, the energy required to successively open the remaining axial segments of the tapered and valve portions 133 and 131 progressively decreases, thus causing substantially all substance that enters the valve opening to be dispensed through the valve opening, and thereby prevent the residual seepage of such substance.
- a respective annular segment of the valve portion 131 engages the valve seat 124 to thereby prevent fluid communication between the exterior and the interior of the valve.
- valve assembly preferably continuously maintains the interior of the container hermetically sealed, even during dispensing, thus permitting the container to hold multiple doses of products that must be maintained in a sterile and/or airless condition, such as "preservative-free" formulations.
- the axial extent of the valve seat 124 i.e., the sealing surface of the valve seat
- the sealing surface of the valve seat is made sufficiently long to ensure that this objective can be achieved.
- FIGS. 5-8 another embodiment of the container of the present invention is indicated generally by the reference numeral 200.
- the container 200 is substantially the same as the container 100 described above, and therefore like reference numerals preceded by the numeral "2" instead of the numeral "1", are used to indicate like elements whenever possible.
- the primary difference of the container 200 in comparison to the container 100 is that the inner portion 202 is integral with the body 104 thereby eliminating the need for a neck and distinct inner portion.
- plastic pellets are melted while passing through an extruder.
- the extruder may thereby produce a single layer or a multiple layer continuous sleeve.
- the sleeve is cut to a desired length to form the body 204.
- the headless body 204 is loaded onto a mandrel where the inner body 214 is injected, compression molded or welded thereto, as is known to those of ordinary skill in the pertinent art. At this time, silk screening or additional printing may be applied to the external surface of the body.
- the body 204 is then filled with the selected product and the outer body 212 is coupled to the inner body 214 to seal the container 200.
- a filling machine may be provided in a sterile environment.
- a variety of filling machines are available and an exemplary one is the liquid filler available from Pack West of 4505 Little John St., Baldwin Park, CA 91706.
- the product may be injected into the body 204 before or after the nozzle 202 is in place.
- the cap 206 is then applied.
- the cap 206 prevents inadvertent release of the product during handling.
- Filling may include injecting a sterilizing agent such as liquid hydrogen peroxide at a pressure above atmospheric into containers made of polyethylene terephthalate or other suitable material for sterilization thereof.
- a sterilizing agent such as liquid hydrogen peroxide
- a stream of hot sterile air can hasten evaporation thereof.
- the sterile product can fill the container and displace the hot air until a portion of the sterile fluid can be suctioned away to insure the entire contents are sterile.
- the proper closure in the form of a sterilized nozzle can be applied.
- the container may be filled in accordance with the teachings of U.S. Patent No. 6,351,924 , U.S. Patent No. 6,372,276 and/or U.S. Patent No. 6,355,216 .
- a container has a flexible shoulder 290 sealing the interior of the tubular body 204 from the ambient atmosphere.
- the distal end of the body 204 is spaced radially outwardly relative to the base of the inner body 214 to define a normally-closed fill opening 291 therebetween.
- the flexible shoulder 290 defines an annular sealing member 293 that extends axially inwardly into the space formed between the base of the inner body 214 and tubular body 204.
- the flexible shoulder 290 is preferably formed of an elastomeric material that normally engages the adjacent base of the inner body 214 and forms a fluid-tight or hermetic seal therebetween.
- a filling member (not shown) is moved either adjacent to, or into the aperture 291, and the product is pumped therethrough, as indicated by the arrow "a".
- the filling member or the flow of product in the direction of the arrow "a” causes the sealing member 293 to flex radially away from the inner body base 214 and open the flow aperture 291 to allow the product to flow therethrough and into the interior of the container.
- the sealing member 293 returns to the normally closed position to hermetically seal the flow opening 291 and thereby seal the product within the container.
- a cap or other closure 295 may be secured to the shoulder 290 after filling to prevent any unwanted substances from being inadvertently or otherwise introduced through the flow opening 291 and into the interior of the container.
- the closure 295 may take any of numerous different configurations that are currently or later become known for performing this function, and the closure is preferably tamper proof such that if anyone does tamper with the sealed closure the tampering will be evident and the container may be discarded. As may be recognized by those of ordinary skill in the pertinent art based on the teachings herein, there are a variety of useful apparatus and methods for filling that are currently and may later become known to those of ordinary skill in the pertinent art, and such apparatus and methods equally may be used to fill the different containers of the present invention.
- FIGS. 9-12 another embodiment of the container of the present invention is indicated generally by the reference numeral 300.
- the container 300 is similar to the containers 100 and 200 described above, and therefore like reference numerals preceded by the numeral "3" instead of the numerals "1" and “2", are used to indicate like elements whenever possible.
- the primary difference of the container 300 in comparison to the containers 100, 200 is that the nozzle 302 is a different configuration.
- the nozzle 302 may be composed of any suitably durable, moldable, somewhat flexible material, such as a plastic material, and preferably is composed of a material which has been found to be compatible with the particular product contained therein, such as those materials sold under the trademarks VELEX® and LEXAN®, both owned by the General Electric Company of Fairfield, Connecticut, or under the trademark KRATON® owned by Kraton Polymers U.S. LLC.
- the inner body 314 of the nozzle 302 is preferably molded of one piece and comprises a truncated, conical-shaped or frusto-conical shaped body portion 313 ( Figure12 ) terminating in a post or valve seat 317 on one end and a shoulder or cylindrical wall 336 on the other end.
- the body portion 313 is oriented at an angle of about 45 degrees or less with respect to the axis of the container 300 to minimize the head loss of the product when dispensed. In a preferred embodiment, the angle of the body portion 313 is about 30 degrees.
- the shoulder 336 defines an axial flow path 348 which is greater in diameter than the post 317.
- the diameter of the post 317 is larger than that of the axial flow path 348 to increase the size of the flow opening and correspondingly reduce the required valve opening pressure.
- the diameter (or radial or lateral dimension) of the valve seat of the nozzle disclosed herein can be adjusted, along with one or more of the degree of interference between the valve cover and the valve seat, the radial thickness of the valve portion of the valve cover, and the modulus of elasticity of the valve cover material, to achieve a desired valve opening pressure.
- one or more of these variables also can be selected to ensure that the valve assembly hermetically seals the interior of the container and prevents the ingress or bacteria or other unwanted substances through the valve and into the tube.
- the axial extent of the valve seat or post 317 (i.e., the sealing surface between the valve seat and valve cover) is sufficiently long so that at any time during dispensing, a respective portion of the valve cover engages the valve seat to thereby prevent fluid communication between the product retained within the container and the ambient atmosphere.
- the post 317 has three regions labeled 1, 2 and 3.
- the first region 1 is the area in which the valve cover 312 blocks the flow aperture 340.
- the third region 3 is the area from which the substance exits the container 300.
- the second region 2 is the area intermediate the first region 1 and the third region 3.
- Each region 1, 2, 3 has an associated pressure P1, P2 and P3, respectively.
- each pressure P1, P2, P3 is equal to zero.
- pressure builds in the first region 1 until a portion of the valve cover 312 unseats from the post 317.
- the substance flows into the second region 2 creating rising pressure in the second region 2 and third region 3 where P1>P2>P3.
- the valve cover 312 reseats on the post 317 in the first region 1 to retain the hermetic seal and prevent any opportunity for contamination to enter the container 300.
- the relative pressure relationship is as follows P1 ⁇ P2>P3>0.
- the valve cover 312 preferably defines a cross-sectional (or radial) thickness that is progressively reduced moving axially in the direction from the interior to the exterior of the valve assembly.
- the valve cover defines a tapered cross-sectional profile that tapers inwardly when moving axially in the direction from the interior toward the exterior of the valve.
- the interface between the valve cover and valve seat may define a decreasing level of radial interference when moving axially in the direction from the interior toward the exterior of the valve assembly, i.e., the valve cover may define a greater degree of radial interference with the valve seat in region 1 than in region 2, and may define a greater degree of radial interference in region 2 than in region 3 at the tip of the nozzle. Accordingly, the energy required to open the respective segments of the valve cover progressively decreases when moving axially in the direction from the interior toward the exterior of the valve.
- valve cover As a result, once the base region I of the valve is opened and the substance enters the normally closed seam or valve opening, the resilient nature of the valve cover, and construction of the valve assembly as described above, causes the valve cover to progressively return itself to the normally closed position and, in turn, force the dosage of substance axially through the seam. Further, the valve cover forces the substance within the seam out through the tip of the nozzle, and thus prevents substance from collecting within the valve and creating residual seepage at a later point in time.
- a flange 326 is disposed coaxially with the conical-shaped portion 313 and extends radially therefrom.
- the conical-shaped portion 313 is frusto-conical-shaped.
- the flange 326 helps retain the outer body 312 and creates a constrained surface overlying the flow aperture 340 to, in turn, reduce and otherwise prevent the residual seepage of material.
- An annular recess 319 is formed between the conical-shaped portion 313 and the flange 326. It will be recognized that the conical-shaped portion 313 and flange 326 may be molded together or separately. Similarly, the inner body 314 and tube 304 may be integral or distinct components.
- the conical-shaped portion 313 comprises a central bore 342 in communication with the interior of the tube 304 by axial flow path 348.
- the central bore 342 terminates in a plurality of release apertures 340 through which the product may flow axially.
- Container 300 includes three release apertures 340 approximately equally spaced relative to each other about the axis of the nozzle 302 such that, in cross-section, the area defined by the release apertures 340 is greater than the remaining solid portions.
- the nozzle 302 may include any desired number of such release apertures in any desired configuration depending upon the application of the dispenser or otherwise as required.
- the configuration of release apertures are at least about 50% of the annular area, and most preferably between about 70% and about 90%.
- the outer body cover 312 may be composed of any durable, resilient and flexible material having the desired modulus of elasticity, such as an elastomeric material.
- the outer body cover 312 is composed of a thermo-elastic material, such as a styrene-butadiene elastomer sold under the trademark KRATON®.
- suitable materials include without limitation polyvinylchloride, APEX FLEXALLOYTM material available from Teknor Apex Company, SANTOPRENE® rubber available from Advanced Elastomer Systems and butyl rubber.
- the inner body 314 is fabricated from KRATON® material which has a modulus of elasticity of approximately 4.1 Mpa and the outer cover 312 is fabricated from SANTOPRENE® material which has a modulus of elasticity of approximately 2.6 Mpa to approximately 4.1 Mpa.
- the outer body cover 312 comprises a mounting portion 321 and a tapered portion 323 which cooperate with the inner body 314 to provide a hermetic one-valve.
- the mounting portion 321 defines an annular recess that engages the conical-shaped portion 313 and the flange 326 to couple the outer body cover 312 thereto.
- the inner body 314 may be slightly oversized in order to provide a resilient interference fit.
- the outer body cover 312 is molded to the same dimension as the inner body 314 and post-molding shrinkage of the outer body cover 312 results in the desired interference fit.
- the outer body or valve cover 312 when mounted, is dimensioned and configured to resiliently engage the inner body 314 whereby the tapered portion 323 and post or valve seat 317 form a normally-closed, one-way valve therebetween.
- the cross-sectional thickness of the tapered portion 323 gradually decreases in the axial direction toward the distal end or tip of the nozzle.
- the pressure required to open the valve seat gradually decreases to facilitate the release of the product through the one-way valve, while simultaneously preventing air or other gases from passing through the one-way valve in the opposite direction.
- a substantially annular segment of the outer body cover 312 engages the post 317 throughout any period of dispensing to maintain a hermetic seal between the interior and ambient atmosphere as shown in Figures 12A-C .
- the degree of interference between the tapered portion 323 of the valve cover and the valve seat 217 may progressively decrease in a direction from the interior to the exterior of the nozzle 302 by varying the inner diameter of the outer body cover 312 and/or the size of the inner body 314.
- a cap (not shown) couples to the threads 316 of the inner body 314 to seal the nozzle 302 and prevent inadvertent discharge of the product.
- the nozzle 402 is similar to the nozzles described above, and therefore like reference numerals preceded by the numeral "4" instead of the numerals "1", “2” and “3", are used to indicate like elements whenever possible.
- One advantage of the configuration illustrated in embodiments 300 and 400 is that the product follows a substantially straight flow path extending in a direction parallel to the axis of the container 300,400. This relatively straight and smooth flow path allows the product to flow through the nozzles 302, 402 with relatively little head loss, thus allowing lesser force to dispense the product and preventing spaces where the product may undesirably collect.
- valve seat 317 it maybe desirable to make the outer diameter of the valve seat 317 as large as possible to thereby decrease the requisite valve opening pressure that must be generated upon the squeeze tube 404 in order to open the valve and dispense product through the valve.
- the present inventor has recognized that a variety of factors can affect the valve opening pressure, including the diameter of the valve seat 417, the modulus of elasticity of the valve cover 412, the degree of interference between the valve cover 412 and valve seat 417, and the thickness and shape of the valve seat 417. All other factors being equal, the volumetric flow rate of material through the valve will be greater for increasing diameters of the valve seat 417 and the requisite valve opening pressure will decrease.
- the present inventor has recognized that it may be desirable to (1) increase the diameter of the valve seat 417 in comparison to prior art valves in order to decrease the requisite valve opening pressure that must be created upon squeezing the tube; (2) decrease the head loss of the product flowing through the valve in comparison to prior art valves; and (3) decrease the stored elastic energy in the valve upon dispensing the product through the valve in order to, in turn, decrease the residual seepage of product through the valve.
- a significant advantage of the valves illustrated in FIGS. 9-15 and in the additional embodiments described herein is that the flow openings 440 define flow paths substantially parallel to the axes of the containers to, in turn, minimize the head loss of products flowing through the valves.
- valve seat diameter a degree of interference between the valve cover 312 and valve seat 317, the predetermined radial thickness of the valve portion 323 of the valve cover 317, and a predetermined modulus of elasticity of the valve cover 312 material, can be selected to (1) define a predetermined valve opening pressure generated upon manually squeezing the tube 304 that allows passage of the substance from the storage chamber through the valve opening 340, and (2) hermetically seal the valve 302 and prevent the ingress of bacteria or other unwanted substances or impurities through the valve 302 and into the tube 304 in the normally closed position.
- valve seat 417 extends through the nozzle 402 into the interior of the tube.
- the valve body 414 defines a plurality of flow apertures 440 that extend angularly about the valve seat 424, and are angularly spaced relative to each other with corresponding solid portions formed therebetween.
- the valve body defines three angularly extending flow apertures 440.
- the flow apertures 440 preferably extend through at least about 60% of the annulus on which they lie, and most preferably extend through between about 70% and about 90% of the annulus on which they lie. As also shown typically in FIG.
- valve seat 424 defines a tapered distal portion, and the valve portion 423 of the valve cover defines a tapered cross-sectional profile as described above.
- valve seat may take any of numerous different configurations, include a straight profile or consistent diameter from one end to the other, or a tapered or other varying configuration, in order to achieve certain performance criteria or other desired objectives.
- the configuration of the nozzle 402 can be varied to achieve a desired valve opening pressure and to ensure the consistent formation of a hermetic seal in the normally closed position.
- the outer cover 412 can have varying levels of interference and modulus of elasticity which contribute to the valve opening pressure, i.e. the stress required in the circumferential direction to open the valve.
- Table 1 provides exemplary data for the embodiment of Figure 15A at five locations A-E illustrated in FIG. 15A .
- the tube 404 defines a maximum diameter D1
- the valve seat 424 defines a constant diameter D2
- the axial length of the valve seat (or the scaling surface of the valve seat) is defined as "L" and extends between point "A" at the tip of the nozzle, and point “B” adjacent to the radially inner edges of the flow apertures 440.
- the valve portion 423 defines an inner annular surface 427 that extends axially in engagement with the valve seat 424 and cooperates with the valve seat to define the length "L" of the sealing surface.
- the relaxed or unstretched diameter of the annular surface 427 of the valve portion is defined as D3.
- the inner diameter D3 of the annular surface 427 is less than the outer diameter D2 of the valve seat 424 in order to form an interference fit and thus a hermetic seal therebetween.
- the line drawing shows the valve cover lines in both the stretched and unstretched states to illustrate visually the interference between the valve cover and inner body.
- the degree of interference between the valve seat and valve cover is substantially constant along the length "L" of the sealing surface. However, as indicated above, the degree of interference may be varied, if desired. Exemplary values for the parameters for currently preferred embodiments of the present invention are illustrated in Table II below.
- valve seat outer diameter D2 and the valve cover inner diameter D3 are labeled "I” and is determined based on the differences in the two diameters divided by two.
- the thickness of the valve cover at point A is labeled "T1(A)” and the thickness of the valve cover at point B is labeled "T2(B)”.
- valve opening pressure corresponds to a force that is substantially radially directed onto a mid-portion of the tubular body within the range of about 2.4 kg and about 2.9 kg. In another embodiment of the present invention, wherein the valve seat diameter D2 is 10 mm, the valve opening pressure corresponds to a force of about 5.4 kg that is substantially radially directed onto a mid-portion of the tubular body.
- the valve opening pressure corresponds to a substantially radially directed force applied to a mid-portion of the tubular body within the range of about 1 kg through about 6 kg, and more preferably within the range of about 2 kg through about 4 kg, and most preferably within the range of about 2.4 kg through about 2.9 kg.
- the length "L" of the valve seat (or sealing surface thereof) is preferably at least about 30% of the diameter D2 of the valve seat, and is preferably within the range of about 40% to about 85% of the diameter D2 of the valve seat.
- the valve seat necessarily may define a smaller diameter D2, and therefore the ratio of the length "L" of the valve seat to the diameter D2 typically will be greater the smaller the tube.
- the length "L" of the valve seat is preferably within the range of about 25% to about 75% of the valve seat diameter D2, and most preferably is within the range of about 35% to about 65% of the valve seat diameter D2.
- the length "L" of the valve seat is preferably at least about 60% of the diameter D2, is more preferably at least about 75% of the diameter D2, and is most preferably greater than 75% of the diameter D2.
- the containers disclosed herein may receive liquids, suspensions, gels, creams, pasty products, fluids, and the like which typically are at risk for growing germs or in the past have required preservatives.
- the container may store vacuum packed, UHT milk alleviating the need for refrigeration, baby formula, toothpaste, premeasured dosages of baby food in accordance with the principles disclosed in U.S. Patent App. No. 10/272,577 filed October 16, 2003 as well as petrogels, beverages carbonated and otherwise, yogurt, honey, ketchup, mustard, mayonnaise and tartar sauce in single or multiple servings.
- FIGS. 16 and 17 another container embodying the present invention is indicated generally by the reference numeral 500.
- the container 500 is substantially the same as the containers described above in connection with FIGS. 1-14 , and therefore like reference numerals preceded by the numeral "5" instead of the numerals "1" through “4", are used to indicate like elements whenever possible.
- the container 500 includes a dispensing tip 511 shaped to conformably contact a user's lips by defining, for example, a substantially concave surface contour. It will be appreciated by those of ordinary skill in the pertinent art that a different contour for conformably and/or comfortably contacting a user's skin or lips may be utilized.
- the inner body 514 of the nozzle 502 is preferably molded of one piece and terminates in a post or valve seat 517 on one end and a shoulder 536 on the other end.
- the shoulder 536 has a projection 538 for sealingly engaging a projection 505 of the flexible tube 504 to, in turn, secure the nozzle 502 to the tube 504.
- the inner body is fabricated from KRATON® material exhibiting a hardness of about 65 shore A
- the valve cover 512 is fabricated from KRATON® material exhibiting a hardness of about 20 shore A.
- these hardnesses are only exemplary, and may be changed as desired to meet certain performance criteria or otherwise as desired.
- FIG. 18 another container embodying the present invention is indicated generally by the reference numeral 600.
- the container 600 is substantially the same as container 500, and therefore like reference numerals preceded by the numeral "6" instead of the numerals "1" through “5", are used to indicate like elements.
- the container 600 includes a tip region 611 having a substantially frusto-conical surface contour for conformably contacting or substantially conformably contacting a user's facial or other skin area, or otherwise for effectively and comfortably applying a released product to a desired area.
- the shape of the nozzle tip may take any of numerous different shapes and/or configurations that are currently or later become known for performing the functions of the nozzle tip, including conformably or otherwise contact a particular surface area of interest.
- FIG. 19 another container embodying the present invention is indicated generally by the reference numeral 700.
- the nozzle 702 of container 700 is substantially the same as the nozzles above, and therefore like reference numerals preceded by the numeral "7" instead of the numerals "1" through “6", are used to indicate like elements whenever possible.
- the body 704 of the container 700 has a resilient outer wall 760 and base 762 sealingly connected to the lowermost end of the outer wall 760.
- the outer wall 12 has a cross-section to accommodate a user's hand and is fabricated from a resilient plastic such as low density polyethylene so that the outer wall 112 can be heat sealed to the other components of the container 700.
- a resilient plastic such as low density polyethylene
- the base 762 is sealed to the lowermost end of the outer wall 760.
- the base 762 is sized and configured such that the container 700 can be rested in an upstanding manner thereon.
- An air check valve 770 regulates the flow of air to and from the space 772 between the interior of the outer wall 760 and exterior of the inner bag 764.
- a vent hole 774 in the base 762 admits ambient air into the space 772 via the check valve 770 after a dispensing cycle to allow the outer wall 760 to return to an oval cross-sectional shape.
- a ring 776 surrounds the check valve 770 to prevent an inner bag 764 from interfering with the operation of the check valve 770.
- the flexible inner bag 764 contains the product and is secured to the outer wall 760 at a top edge 766.
- the inner bag 764 is secured to the interior of the outer wall 760 at a point 768 approximately intermediate the ends of the outer wall 760 to insure substantially complete emptying of the inner bag 764 without extraordinary force being applied to the outer wall 760.
- the inner bag 764 is fabricated from a low flexural modulus material to prevent significantly adding to the force required to dispense the product contained within the interior 765 thereof.
- the nozzle 702 selectively and hermetically seals the interior of the inner bag 762 from the ambient air. By preventing air from entering into the interior 765 of the inner bag 764, the nozzle 702 not only retains the sterility of the interior 765 but aids in initiating the next dispensing cycle without appreciable belching or excessive squeezing of the outer wall 760. During the dispensing cycle, the outer wall 760 is squeezed and deforms to increase the pressure within the space 772 and thereby increase the pressure within the interior 765 of the inner bag 764. Although an amount of air escapes through vent hole 774, the pressure overcomes the engagement of the valve cover 712 and the product flows out of flow apertures 740 as described above.
- the outer wall 769 begins to return to the undeformed shape which creates a vacuum within space 772.
- the vacuum forces the check valve 770 to open allowing ambient air to enter via vent hole 774 to, in turn, cause the inner bag to move toward the nozzle 702 and allow the outer wall 760 to return to shape.
- the nozzle 702 quickly opens again to allow the product to be released again in a hermetic manner.
- the inner bag 764 flexes about the midpoint 768 until substantially all of the product is dispensed from the interior 765.
- the outer wall 760 is fabricated from a relatively rigid material to, in turn, increase the pressure required to deform the outer wall 760 and/or facilitate generating pressure.
- the nozzle 702 can be configured for an increased opening pressure. It will be appreciated by those of ordinary skill in the art upon review of the subject disclosure that the concepts of container 700 can be readily adapted to any of a number of configurations for containers such as, without limitation, a flexible tube as shown above and the check valve may be located at any of several suitable locations.
- FIGS. 20A-22B three additional containers embodying the present invention are indicated generally by the reference numerals 800,900 and 1000, respectively.
- the nozzles of these containers are substantially the same as the nozzles above, and therefore like reference numerals preceded by a different numeral instead of the numerals "1" through “7", are used to indicate like elements whenever possible.
- the following description is directed to the differences in the containers.
- the outer cover 860 is formed into a decorative shape and receives a cartridge 864.
- the cartridge 864 selectively engages the outer cover 860 by a snap fit mechanism 867 and has the inner body 814 formed integrally therewith.
- a new valve cover 812 may be used each time a cartridge 864 is replaced or the same valve cover 812 may be reused.
- the outer cover 860 is a semi-rigid or rigid material such as colored plastic or glass to further add to the aesthetics of the container 800.
- the entire outer cover 812 is rigid and a pump is included to dispense the product as shown in U.S. Patent Application No. 10/001,745 filed October 23, 2001 .
- a handle 803 allows easy carrying and use of the container 800.
- valve opening pressure can be optimized to release even highly viscous products such as honey, syrups, lubricating greases, petrogels, caulking compounds and other materials ranging from one centipoise to thousands of centipoise of viscosity while at the same time maintaining the integrity and sterility of the remaining product.
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- Engineering & Computer Science (AREA)
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- Check Valves (AREA)
Claims (16)
- Ein Verfahren zum aseptischen Lagern und Ausgeben einer Substanz, das die folgenden Schritte umfasst:(a) steriles Abfüllen und aseptisches Speichern von Substanz in einer Einheit (100, 200, 300, 400, 500, 600, 700, 800, 900, 1000), wobei die Einheit (100, 200, 300, 400, 500, 600, 700, 800, 900, 1000) eine Speicherkammer mit variablem Volumen und ein Einwegventil umfasst, das in Fluidverbindung mit der Speicherkammer mit variablem Volumen verbunden ist und das ein elastisches Ventilelement (112, 212, 312, 412, 512, 612, 712, 812, 912, 1012) aufweist, das eine normalerweise geschlossene Ventilöffnung bildet, wobei das Ventilelement (112, 212, 312, 412, 512, 612, 712, 812, 912, 1012) in Reaktion auf eine Substanz am Einlass der Ventilöffnung, wenn diese einen Ventilöffnungsdruck übersteigt, zwischen einer normalerweise geschlossenen Stellung und einer geöffneten Stellung bewegbar ist, bei der wenigstens ein Abschnitt des Ventilelements (112, 212, 312, 412, 512, 612, 712, 812, 912, 1012) von der geschlossenen Stellung beabstandet ist, um den Durchtritt von Substanz aus der Speicherkammer mit variablem Volumen durch die Ventilöffnung zu ermöglichen, und das Einwegventil eine solche Struktur aufweist, dass das Ventilelement (112, 212, 312, 412, 512, 612, 712, 812, 912, 1012) über mindestens einem Teil eines Ventilsitzes (124, 317, 417,517, 617, 717, 817, 917, 1017) liegt, wobei das Ventilelement (112, 212, 312, 412, 512, 612, 712, 812, 912, 1012) und der Ventilsitz (124, 317, 417, 517, 617, 717, 817, 917, 1017) zwischen sich eine Naht (125, 225, 425) definieren, die die Ventilöffnung bildet, und das Ventilelement (112, 212, 312, 412, 512, 612, 712, 812, 912, 1012) am Ventilsitz (124, 317, 417, 517, 617, 717, 817, 917, 1017) in der geschlossenen Stellung zur Anlage kommt, wenn die Substanz den Ventilöffnungsdruck nicht überschreitet, wobei die Einheit mehrere Portionen der Substanz enthält, die in einem aseptischen Zustand ist und innerhalb der Speicherkammer gegenüber der Umgebungsatmosphäre hermetisch abgedichtet ist;(b) Beaufschlagen der Substanz am Einlass zur Ventilöffnung mit einem Druck, der zumindest gleich einem Ventilöffnungsdruck ist, und Bewegen des elastischen Ventilelements (112, 212, 312, 412, 512, 612, 712, 812, 912, 1012) zwischen (i) der normalerweise geschlossenen Stellung und (ii) der geöffneten Stellung, bei der wenigstens ein Abschnitt des Ventilelements (112, 212, 312, 412, 512, 612, 712, 812, 912, 1012) von der geschlossenen Stellung beabstandet ist, und, im Gegenzug, Abgeben zumindest eines Teils der Substanz aus der Speicherkammer mit variablem Volumen durch die Ventilöffnung, wobei das Einwegventil zuerst an einem stromaufwärtigen Ende der Ventilöffnung öffnet, und der Ventilsitz entlang der Naht eine ausreichende Länge aufweist, so dass, im Wesentlichen über einen beliebigen Zeitraum der Abgabe von Substanz durch die Ventilöffnung, zumindest ein Abschnitt des Ventilelements (112, 212, 312, 412, 512, 612, 712, 812, 912, 1012) in Anlage an dem Ventilsitz (124, 317, 417, 517, 617, 717, 817, 917, 1017) ist, um eine hermetische Abdichtung zwischen der Ventilöffnung und der Umgebungsatmosphäre aufrecht zu erhalten, wobei das Einwegventil eine Struktur nach einem oder mehreren von (b1) bis (b3) hat; um zu gewährleisten, dass die Energie, die benötigt wird, um aufeinanderfolgende Segmente des Ventilelements (112, 212, 312, 412, 512, 612, 712, 812, 912, 1012) in Richtung von dem stromaufwärtigen Ende zu einem stromabwärtigen Ende der Ventilöffnung hin progressiv abnimmt:(b1) das Ventilelement (112, 212, 312, 412, 512, 612, 712, 812, 912, 1012) definiert eine abnehmende Wandstärke in einer Richtung von einem stromaufwärtigen Ende zu einem stromabwärtigen Ende der Ventilöffnung;(b2) der Ventilsitz (124, 317, 417, 517, 617, 717, 817, 917, 1017) ist verjüngt; und/oder;(b3) das Ventilelement (112, 212, 312, 412, 512, 612, 712, 812, 912, 1012) bildet einen Presssitz mit dem Ventilsitz (124, 317, 417, 517, 617, 717, 817, 917, 1017) und definiert einen abnehmenden Grad an Presssitz dazwischen in einer Richtung von einem stromaufwärtigen Ende zu einem stromabwärtigen Ende der Ventilöffnung.
- Ein Verfahren wie in Anspruch 1 definiert, wobei die Abgabe bei Raumtemperatur erfolgt.
- Ein Verfahren wie in Anspruch 1 definiert, das ferner das Bereitstellen eines rohrförmigen Abschnitts (104, 204, 304, 404, 504, 704) umfasst, der in Fluidverbindung zwischen der Speicherkammer mit variablem Volumen und dem Einwegventil gekoppelt ist.
- Ein Verfahren wie in Anspruch 1 definiert, das ferner das Bereitstellen eines relativ starren Aussenbehälters (760, 860, 960, 1060) aufweist, in dem die Speicherkammer mit variablem Volumen aufgenommen ist.
- Ein Verfahren wie in einem der vorhergehenden Ansprüche definiert, ferner umfassend das Bereitstellen einer Pumpe, die konfiguriert ist, um die Substanz am Einlass zur Ventilöffnung unter Druck zu setzen, um die Substanz durch sie dort hindurch abzugeben.
- Ein Verfahren wie in Anspruch 5 definiert, wobei die Pumpe zwischen der Speicherkammer mit variablem Volumen und dem Einwegventil gekoppelt ist und ausgebildet ist, Substanz aus der Speicherkammer mit variablem Volumen in die Ventilöffnung zu pumpen und dadurch die Substanz abzugeben.
- Ein Verfahren wie in Anspruch 5 oder 6 definiert, wobei der rohrförmige Abschnitt (104, 204, 304, 404, 504, 704) zusammenquetschbar ist und die Pumpe ausgebildet ist, den rohrförmigen Abschnitt (104, 204, 304, 404, 504, 704) zu quetschen, um die Substanz unter Druck zu setzen.
- Ein Verfahren wie in Anspruch 1 definiert, ferner umfassend den Schritt des Sterilisierens der Substanz vor dem Schritt des sterilen Füllens der Speicherkammer mit variablem Volumen mit der Substanz.
- Ein Verfahren wie Anspruch 1 definiert, ferner umfassend den Schritt des Pumpens von Substanz aus der Speicherkammer mit variablem Volumen und in die Ventilöffnung, um die Substanz dort hindurch abzugeben.
- Ein Behälter zur Aufbewahrung und Abgabe einer Substanz daraus, umfassend:einen Körper, der eine hermetisch dichte Speicherkammer mit variablem Volumen definiert, die in sich eine Substanz enthält, welche innerhalb der Speicherkammer hermetisch gegenüber der Umgebungsatmosphäre abgedichtet ist; undein Einwegventil mit einem Ventilelement (112, 212, 312, 412, 512, 612, 712, 812, 912, 1012), das aus einem elastischen Material gebildet ist und eine normalerweise geschlossene Ventilöffnung und einen Einlass zu der Ventilöffnung bildet, der mit der Speicherkammer mit variablem Volumen in Fluidverbindung bringbar ist, wobei das Ventilelement (112, 212, 312, 412, 512, 612, 712, 812, 912, 1012) in Reaktion auf eine Substanz am Einlass zu der Ventilöffnung, die einen Ventilöffnungsdruck übersteigt, zwischen einer normalerweise geschlossenen Stellung und einer geöffneten Stellung bewegbar ist, bei der wenigstens ein Abschnitt des Ventilelements (112, 212, 312, 412, 512, 612, 712, 812, 912, 1012) von der geschlossenen Stellung beabstandet ist, um den Durchtritt von Substanz aus der Speicherkammer mit variablem Volumen durch die Ventilöffnung zu ermöglichen;wobei das Ventilelement (112, 212, 312, 412, 512, 612, 712, 812, 912, 1012) über zumindest einem Teil des Ventilsitzes (124, 317, 417, 517, 617, 717, 817, 917, 1017) liegt, das Ventilelement (112, 212, 312, 412, 512, 612, 712, 812, 912, 1012) und der Ventilsitz (124, 317, 417, 517, 617, 717, 817, 917, 1017) zwischen sich eine die Ventilöffnung bildende Naht (125, 225, 425) definieren, und in der geschlossenen Stellung das Ventilelement (112, 212, 312, 412, 512, 612, 712, 812, 912, 1012) in Anlage am Ventilsitz (124, 317, 417, 517, 617, 717, 817, 917, 1017) ist, wenn die Substanz nicht den Ventilöffnungsdruck übersteigt;dadurch gekennzeichnet, dass dann, wenn das Fluid den Ventilöffnungsdruck übersteigt, das Einwegventil zuerst an einem stromaufwärtigen Ende der Ventilöffnung öffnet, und der Ventilsitz entlang der Naht eine ausreichende Länge aufweist, so dass, im Wesentlichen über einen beliebigen Zeitraum der Abgabe von Substanz durch die Ventilöffnung, zumindest ein Abschnitt des Ventilelements (112, 212, 312, 412, 512, 612, 712, 812, 912, 1012) in Anlage an dem Ventilsitz (124, 317, 417, 517, 617, 717, 817, 917, 1017) ist, um eine hermetische Abdichtung zwischen der Ventilöffnung und der Umgebungsatmosphäre aufrecht zu erhalten, wobei das Einwegventil eine Struktur gemäss einem oder mehreren von (a) bis (c) hat, um sicherzustellen, dass die Energie, die benötigt wird, um aufeinanderfolgende Segmente des Ventilelements (112, 212, 312, 412, 512, 612, 712, 812, 912, 1012) zu öffnen, in Richtung von dem stromaufwärtigen Ende zu einem stromabwärtigen Ende der Ventilöffnung hin progressiv abnimmt:(a) das Ventilelement (112, 212, 312, 412, 512, 612, 712, 812, 912, 1012) definiert eine abnehmende Wandstärke in einer Richtung von einem stromaufwärtigen Ende zu einem stromabwärtigen Ende der Ventilöffnung;(b) der Ventilsitz (124, 317, 417, 517, 617, 717, 817, 917, 1017) ist verjüngt; und/oder;(c) das Ventilelement (112, 212, 312, 412, 512, 612, 712, 812, 912, 1012) bildet mit dem Ventilsitz (124, 317, 417, 517, 617, 717, 817, 917, 1017) einen Presssitz und definiert dazwischen einen Grad an Presssitz, der in einer Richtung von einem stromaufwärtigen Ende zu einem stromabwärtigen Ende der Ventilöffnung abnimmt;derart, dass bei der Abgabe und/oder Haltbarkeitsdauer der Substanz das Einwegventil und/oder die Speicherkammer:(i) jegliche in der Speicherkammer verbleibende Substanz in einem aseptischen Zustand, gegenüber der Umgebungsatmosphäre abgeschlossen, im wesentlichen luftlos, und bei Umgebungstemperatur gehalten ist;(ii) im Wesentlichen ein Eindringen von Luft in das Einwegventil und/oder die Speicherkammer mit variablem Volumen verhindert ist; und(iii) im Wesentlichen das Eindringen von Bakterien oder anderen unerwünschten Verunreinigungen in das Einwegventil und/oder die Speicherkammer mit variablem Volumen verhindert ist.
- Ein Behälter wie in Anspruch 10 definiert, der zudem mit einem rohrförmigen Abschnitt (104, 204, 304, 404, 504, 704) aufweist, der in Fluidverbindung zwischen der Speicherkammer mit variablem Volumen und dem Einwegventil gekoppelt ist.
- Ein Behälter wie in Anspruch 10 oder 11 definiert, ferner umfassend einen relativ starren Aussenbehälter (760, 860, 960, 1060), der in sich die Speicherkammer mit variablem Volumen aufnimmt.
- Ein Behälter wie in einem beliebigen der Ansprüche 10 -12 definiert, wobei der Behälter (100, 200, 300, 400, 500, 600, 700, 800, 900, 1000) ferner eine Pumpe umfasst, die so konfiguriert ist, dass sie Substanz am Einlass zur Ventilöffnung unter Druck setzt, um die Substanz durch sie hindurch abzugeben.
- Ein Behälter wie in Anspruch 13 definiert, wobei die Pumpe zwischen der Speicherkammer mit variablem Volumen und dem Einwegventil eingekoppelt ist und dazu ausgebildet ist, Substanz aus der Speicherkammer in die Ventilöffnung zu pumpen, um die Substanz durch sie hindurch abzugeben.
- Ein Behälter wie in Anspruch 13 oder 14 definiert, wobei der rohrförmige Abschnitt (104, 204, 304, 404, 504, 704) zusammenquetschbar ist und die Pumpe ausgebildet ist, den rohrförmigen Abschnitt (104, 204, 304, 404, 504, 704) zu quetschen, um die Substanz unter Druck zu setzen.
- Ein Behälter wie in Anspruch 10 definiert, wobei das Einwegventil ferner den Ventilkörper, der den Ventilsitz definiert (124, 317, 417, 517, 617, 717, 817, 917, 1017) und eine Ausströmöffnung aufweist, die sich durch den Ventilkörper und/oder den Ventilsitz hindurch erstreckt.
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US40339602P | 2002-08-13 | 2002-08-13 | |
US44292403P | 2003-01-27 | 2003-01-27 | |
EP03755736A EP1546021B1 (de) | 2002-08-13 | 2003-08-13 | Behälter und ventilanordnung zum lagern und abgeben von substanzen und verwandtes verfahren |
EP10188052.4A EP2289813B1 (de) | 2002-08-13 | 2003-08-13 | Behälter and Ventilanordnung zum Lagern und Abgeben von Substanzen und verwandtes Verfahren. |
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EP03755736A Division EP1546021B1 (de) | 2002-08-13 | 2003-08-13 | Behälter und ventilanordnung zum lagern und abgeben von substanzen und verwandtes verfahren |
EP10188052.4A Division EP2289813B1 (de) | 2002-08-13 | 2003-08-13 | Behälter and Ventilanordnung zum Lagern und Abgeben von Substanzen und verwandtes Verfahren. |
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EP2949591A1 EP2949591A1 (de) | 2015-12-02 |
EP2949591B1 true EP2949591B1 (de) | 2018-02-21 |
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EP15000463.8A Expired - Lifetime EP2949591B1 (de) | 2002-08-13 | 2003-08-13 | Behälter und ventilanordnung zur speicherung und abgabe von substanzen und dazugehöriges verfahren |
EP10188052.4A Expired - Lifetime EP2289813B1 (de) | 2002-08-13 | 2003-08-13 | Behälter and Ventilanordnung zum Lagern und Abgeben von Substanzen und verwandtes Verfahren. |
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EP10188052.4A Expired - Lifetime EP2289813B1 (de) | 2002-08-13 | 2003-08-13 | Behälter and Ventilanordnung zum Lagern und Abgeben von Substanzen und verwandtes Verfahren. |
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EP (2) | EP2949591B1 (de) |
CN (3) | CN101274685B (de) |
ES (1) | ES2355487T3 (de) |
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RU2527119C2 (ru) * | 2006-01-05 | 2014-08-27 | Медикал Инстилл Текнолоджис, Инк. | Односторонний клапан, устройство и способ применения клапана |
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CN105475802A (zh) * | 2007-10-04 | 2016-04-13 | 因斯蒂尔医学技术有限公司 | 用于配制和无菌充注液体产品的设备和方法 |
CN101721304A (zh) * | 2008-10-22 | 2010-06-09 | 黑龙江福和华星制药集团股份有限公司 | 一种含有刺五加浸膏的包装物及包装方法 |
JP6097848B2 (ja) | 2013-11-26 | 2017-03-15 | ネステク ソシエテ アノニム | 消費可能製品パッケージ用のアダプタ及びこれを使用する方法 |
CN104743224A (zh) * | 2014-07-28 | 2015-07-01 | 李国� | 馅料储存容器 |
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CN106466045B (zh) * | 2016-08-30 | 2023-08-11 | 嘉兴市腾翔塑业有限公司 | 带涂抹头的化妆品容器 |
TW201811292A (zh) * | 2016-09-13 | 2018-04-01 | 加拿大商凡爾克斯醫藥系統公司 | 用於監控及控制使用旋轉台將藥物液體無菌裝填及密封於藥物容器的方法及裝置 |
CN107811395B (zh) * | 2017-09-14 | 2019-11-19 | 浙江伟飒塑业有限公司 | 一种膏体化妆品包装容器 |
CN109436544A (zh) * | 2018-12-25 | 2019-03-08 | 南京工程学院 | 一种新型可发光牙膏盖 |
CN110215042A (zh) * | 2019-06-14 | 2019-09-10 | 上海保柏日化有限公司 | 一种旋转挤压式液体分配装置 |
JP2022543122A (ja) * | 2019-08-02 | 2022-10-07 | ノードソン コーポレーション | ディスペンスチップ及びディスペンスチップを製造するための方法 |
CN112590269B (zh) * | 2020-12-03 | 2022-07-08 | 嘉兴市腾翔塑业有限公司 | 一种封尾pe软管及其生产工艺 |
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- 2003-08-13 CN CNB038217546A patent/CN100386247C/zh not_active Expired - Fee Related
- 2003-08-13 CN CN2008100837612A patent/CN101274683B/zh not_active Expired - Fee Related
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Also Published As
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ES2355487T3 (es) | 2011-03-28 |
CN101274685B (zh) | 2011-09-07 |
EP2289813A1 (de) | 2011-03-02 |
CN1705589A (zh) | 2005-12-07 |
CN101274685A (zh) | 2008-10-01 |
CN100386247C (zh) | 2008-05-07 |
EP2949591A1 (de) | 2015-12-02 |
CN101274683B (zh) | 2011-11-23 |
CN101274683A (zh) | 2008-10-01 |
EP2289813B1 (de) | 2015-02-18 |
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