EP2691305B1 - Système de remplissage et procédé de remplissage - Google Patents

Système de remplissage et procédé de remplissage Download PDF

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Publication number
EP2691305B1
EP2691305B1 EP12709802.8A EP12709802A EP2691305B1 EP 2691305 B1 EP2691305 B1 EP 2691305B1 EP 12709802 A EP12709802 A EP 12709802A EP 2691305 B1 EP2691305 B1 EP 2691305B1
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EP
European Patent Office
Prior art keywords
line
valve
filling
container
branch
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP12709802.8A
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German (de)
English (en)
Other versions
EP2691305A1 (fr
Inventor
Paul Janssens
Michael Müller
Jean-Pierre Decheneux
Swen Weitemeier
Michael Fiedler
Steffen Strietzel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sartorius Lab Instruments GmbH and Co KG
Original Assignee
Sartorius Lab Instruments GmbH and Co KG
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Filing date
Publication date
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Publication of EP2691305A1 publication Critical patent/EP2691305A1/fr
Application granted granted Critical
Publication of EP2691305B1 publication Critical patent/EP2691305B1/fr
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/04—Methods of, or means for, filling the material into the containers or receptacles
    • B65B3/10—Methods of, or means for, filling the material into the containers or receptacles by application of pressure to material
    • B65B3/14—Methods of, or means for, filling the material into the containers or receptacles by application of pressure to material pneumatically
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/26—Methods or devices for controlling the quantity of the material fed or filled
    • B65B3/28—Methods or devices for controlling the quantity of the material fed or filled by weighing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B2210/00—Specific aspects of the packaging machine
    • B65B2210/06—Sterilising or cleaning machinery or conduits

Definitions

  • the invention further relates to a filling method using such a filling system, wherein in a first filling step by coordinated control of the valves of the valve carrier one or more target containers are filled with liquid from the reservoir and at least one hereinafter referred to as residual amount container target container remains unfilled.
  • Manifolds are for example from the EP 152 513 8B1 known.
  • a manifold is a hose system that connects a plurality of containers. As a container in particular flexible bag but also rigid or semi-rigid container, such as bottles in question.
  • the containers are connected via connecting lines with a common, referred to here as the parent line hose.
  • the trunk line is on the one hand connected to a supply hose and on the other hand can be connected to a discharge hose.
  • a sharp demarcation between the parent line and the feeder can be difficult in practice and, in the context of the present description, is primarily functional.
  • the supply line essentially provides the connection with a storage container, for example a storage tank.
  • the drain if present, may be used to discharge gas contained in the piping or in the target tanks during the bottling process.
  • the totality of supply line, trunk line and possibly derivative is referred to here as the main line.
  • the manifold with the connected containers is placed in a special filling device.
  • the containers are arranged individually, in particular lying or hanging in a support frame.
  • the filling device has a valve carrier which can be completely or partially integrated in the aforementioned carrier frame.
  • the valve carrier has a separately controllable valve, in particular a hose clamp valve, for each connecting line.
  • the valve carrier also includes a main valve with which the volume flow from the supply line can be controlled in the trunk line and which can be considered in practice as a functional boundary between the supply line and the main line.
  • the entire filling device including Manifold be positioned on an electronic scale, wherein the changes in the weight values can provide information about the filling process and the corresponding electronic signals can be used as control signals for the valve control.
  • the corresponding target container valve is closed and the process repeats with the next target container. After filling the desired number of destination container they are closed, eg welded and separated from the connecting lines.
  • a disadvantage of the known method is that a considerable amount of liquid in the trunk line and the connecting lines trunk line side of the target container valves remains. This disadvantage weighs the more difficult the more expensive the liquid, especially in the biotechnological and medical field, where Manifolds are widely used, extremely expensive liquids are handled.
  • the horizontal manifold is emptied again by the exhaust pipe connected to a compressed air source and the input of the manifold is decoupled from the supply pipe and connected to a collecting container.
  • the liquid in the drain pipes remains there, which corresponds to a pre-portioning for the subsequent, actual filling process.
  • the input of the manifold is closed and again compressed air is added to the end of the manifold, at the same time the tip valves of the exhaust pipes are opened.
  • the pre-portioned in the outlet tubes liquid is blown into the now provided under the tip valves bottles.
  • the liquid accumulated in the collecting container which has meanwhile been decoupled from the distributor pipe, is likewise blown back into the storage container by means of compressed air support.
  • a similar system in which instead of a manifold, a distribution tank is provided with outlet hoses connected thereto, is from the DE 196 40 664 C1 known. Both reservoir and distribution tank are here separately pressurized.
  • a generic filling system is also from the US 2010 236 340 known.
  • branch point is arranged trunk line side of the pump and the branch line leads to a compressed gas source.
  • the object is further achieved in conjunction with the features of the preamble of claim 6, characterized in that in a second filling step in the main remaining residual liquid is filled into the remainder tank by the associated target container valve open, the trunk closed at its end remote from the branch, the Supply line closed by means of the associated hose clamp valve of the double valve assembly and the branch line is opened by means of the associated hose clamp valve of the double valve assembly, so that pressurized gas from the compressed gas source presses the residual liquid into the residual quantity container.
  • the invention manifests itself first in a modification of both the manifold and the filling device. Both modifications must be coordinated.
  • a branch point is arranged in the region of the supply line, so that the actual supply line is still connected to the storage container and the branching branch line is connected to a compressed gas source, eg a compressed air compressor.
  • the filling device preferably the valve carrier
  • the valve carrier is expanded by a double valve arrangement, which in a preferred embodiment is designed as a common valve unit.
  • This double valve arrangement comprises two hose clamp valves, in one of which the actual supply line and in the other the branch line is inserted. It is important that both individual valves of the double valve arrangement can preferably be controlled independently, but at least oppositely to each other.
  • the residual amount container is connected to the trunk line over that of the connecting lines which is furthest from the branch point. This ensures that the largest part of the trunk line is between the Compressed gas inlet and the residue tank is located so that the maximum amount of residual liquid can be pressed into the residue tank.
  • a gas-permeable sterile filter is integrated in the branch line. This ensures that the pressurized gas does not contaminate the interior of the hose system. Sterile filtration at this point also allows the use of an unsterile source of pressurized gas, such as a conventional air compressor, in sterile operations.
  • a sterile filter on the trunk line facing side of the branch point be integrated into the derivative.
  • This arrangement of the sterile filter is particularly preferred since manifolds with drainage are in any case often equipped with a sterile filter in the drainage, in order to prevent contamination of the hose system and the liquid via these.
  • valve carrier further comprises a main valve with which a volume flow from the supply line to the main line can be controlled.
  • a main valve with which a volume flow from the supply line to the main line can be controlled.
  • it is also possible to dispense with a separate main valve if the individual valve associated with the actual supply line Dual valve assembly is functionally equipped so that it can take over the task of the conventional main valve.
  • the functional main valve can control the volume flow in several stages.
  • valve carrier further comprise an outlet valve with which a volume flow between the main line and the discharge line (if present) can be controlled.
  • outlet valve with which a volume flow between the main line and the discharge line (if present) can be controlled.
  • the target containers including the remainder container are used as flexible bags are formed.
  • the invention is of course also applicable to embodiments in which one, several or even all target containers are designed as rigid or semi-rigid container, for example as bottles.
  • the filling system comprises a manifold 100 and a filling device 200. Furthermore, a device periphery 300 is shown in the figures.
  • the manifold 100 comprises a main line, which consists of a supply line 102, a master line 104 adjoining this and a line 106 which in turn adjoins this. From the trunk line (104) branch off a plurality of connecting lines 108 and a remainder bag connecting line 108 'from.
  • the connection lines 108 each connect the trunk line 104 to a bag 110; Residual bag connection line 108 'connects trunk line 104 to a residue bag 110'.
  • the distinction between the bags 110 and the remainder bag 110 ' is made here only to simplify the explanation.
  • the supply line 102 of the manifold 100 is connected via a pump 302 to a reservoir 304, for example a tank.
  • the drain 106 of the manifold 100 has an integrated sterile filter 112 in the illustrated embodiment.
  • the manifold 100 is inserted into a filling device.
  • This has a support frame 202 for single storage of the bags 110, 110 '.
  • the support rack 202 is coupled to a valve column 204 which carries a plurality of valves.
  • the transition region between the supply line 102 and the trunk line 104 is inserted into a designed as a hose clamp valve main valve 206.
  • the transition region between the trunk line 104 and the discharge line 106 is inserted into an exhaust valve 208, which is likewise designed as a hose clamp valve.
  • each connecting line 108 is inserted into a bag valve 210 which is likewise designed as a hose clamping valve.
  • the residual quantity bag connecting line 108 ' is inserted into a residual quantity bag valve 210, which is likewise designed as a hose clamping valve.
  • the entire apparatus is mounted on an electronic balance, which is set up for the gravimetric filling quantity monitoring and for the corresponding output of control signals for the individual valves.
  • a compressed gas source 306 namely a compressed air compressor is shown.
  • the special coupling of the compressed gas source 306 is an essential part of the present invention.
  • the supply line 102 has a branch point 114 at which a branch line 116 branches off the supply line 102.
  • the branch line 116 is connected to the compressed gas source 306. It passes through a designed as a hose clamp valve first single valve 214a of a double-valve arrangement 214.
  • the supply-side conduit 102 passes through a second individual valve of the double-valve arrangement 214, likewise designed as a hose-clamping valve 214b, at the reservoir-side of the branching point 14.
  • a sterile filter 118 is arranged, which filters out any germs contained in the compressed gas and protects the manifold 100 from contamination.
  • the first individual valve 214a of the valve arrangement 214 is closed.
  • the filling process proceeds in a known manner until the bags 110 are filled and their associated bag valves 210 are closed.
  • the exhaust valve 208 is also closed at this time.
  • the second individual valve 214b of the valve assembly 214 are closed and the residual quantity bag valve 210 'and the first individual valve 214a of the double valve assembly 214 is opened in a subsequent step .
  • compressed gas flows from the compressed gas source 216 via the branching point 114 into the supply line 102 and presses the residual liquid remaining in the supply line 102 and the main line 104 into the residual quantity bag 110 '.
  • the residual quantity bag valve 210 'and the first individual valve 214a of the double valve arrangement 214 are closed and the residual quantity bag 110', as well as the remaining bags 110 can be separated with empty trunk line 104 and fed to the desired further treatment.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Basic Packing Technique (AREA)
  • Filling Of Jars Or Cans And Processes For Cleaning And Sealing Jars (AREA)

Claims (7)

  1. Système de remplissage comprenant un dispositif de remplissage (200) et un agencement de récipients (100) implanté dans le dispositif de remplissage (200),
    l'agencement de récipients comprenant :
    - une conduite principale de type flexible qui comporte une conduite d'alimentation (102), reliée avec un récipient de réserve (304) et équipée d'une pompe (302), ainsi qu'une conduite de distribution (104), disposée après la conduite d'alimentation (102) reliée dans une configuration linéaire, ainsi
    - qu'une pluralité de récipients de destination (110, 110') qui sont reliés, chacun, avec la conduite de distribution (104) par une conduite de liaison (108, 108') de type flexible,
    et le dispositif de remplissage (200) comprenant :
    - un cadre support (202) pour le stockage individuel des récipients de destination (110, 110'),
    - un support de vannes (204) avec une pluralité de vannes, comprenant une pluralité de vannes de récipients de destination (210, 210') correspondant à la pluralité de récipients de destination (110, 110'), par l'intermédiaire desquelles, chaque fois, un flux volumique peut être respectivement dirigé par l'une des conduites de liaison (108, 108'),
    où, à un point de bifurcation (114) dans la partie de la conduite d'alimentation (102), une conduite de dérivation (116) dérive de la conduite d'alimentation (102), et la conduite d'alimentation (102), avec la conduite de dérivation (116), du côté du point de bifurcation (114) opposé à la conduite de distribution, traversent un agencement de vannes doubles (214) avec deux vannes à pincement de flexibles (214a, 214b) pouvant être commandées dans des sens opposés, la conduite d'alimentation (102) étant insérée dans l'une (214b) des vannes et la conduite de dérivation (116) dans l'autre (214a),
    caractérisé en ce
    que le point de bifurcation (114) est agencé du coté de la conduite de distribution de la pompe (302) et que la conduite de dérivation (116) mène vers une source de gaz sous pression (306).
  2. Système de remplissage selon la revendication 1,
    caractérisé en ce
    qu'un filtre stérile (118) perméable aux gaz est intégré dans la conduite de dérivation (116).
  3. Système de remplissage selon l'une des revendications précédentes,
    caractérisé en ce
    que la conduite principale comporte en outre une dérivation (106) qui est disposée après la conduite de distribution (104) reliée dans une configuration linéaire.
  4. Système de remplissage selon l'une des revendications précédentes,
    caractérisé en ce
    que le support de vannes (204) comprend en outre une vanne principale (206), grâce à laquelle un flux volumique peut être commandé de la conduite d'alimentation (102) vers la conduite de distribution (104).
  5. Système de remplissage selon la revendication 3 ou la revendication 4, dans la mesure où elles sont dépendantes de la revendication 3,
    caractérisé en ce
    que le support de vannes (204) comprend en outre une vanne de sortie (208), à l'aide de laquelle un flux volumique peut être commandé entre la conduite de distribution (104) et la conduite de d'évacuation (106).
  6. Procédé de remplissage, moyennant l'utilisation d'un système de remplissage (10) selon la revendication 3,
    où, dans une première étape de remplissage, un ou plusieurs récipients de destination (110) sont remplis de liquide provenant du récipient de réserve (304) par une commande coordonnée des vannes du support de vannes (204) et où au moins un récipient destiné aux restes (110') reste non rempli,
    caractérisé en ce
    que, dans une deuxième étape de remplissage, qui est réalisée un temps après la première étape de remplissage, le liquide résiduel restant dans la conduite principale est versé dans le récipient destiné aux restes (110') en ouvrant la vanne de récipient de destination (210') correspondante, en fermant la conduite de distribution (104) à son extrémité opposée au point de bifurcation (114), en fermant la conduite d'alimentation (102) au moyen de la vanne à pincement de flexible (214b) correspondante de l'agencement des vannes doubles (214) et en ouvrant la conduite de dérivation (116) au moyen de la vanne à pincement de flexible (214a) correspondante de l'agencement de vannes doubles (214), de sorte que le gaz sous pression provenant de la source de gaz sous pression (306) comprime le liquide résiduel dans le récipient destiné aux restes (110').
  7. Procédé selon la revendication 6,
    caractérisé en ce
    que le récipient destiné aux restes (110') est relié avec la conduite de distribution (104) par la conduite de liaison qui est la plus éloignée du point de bifurcation (114) parmi les conduites de liaisons (108').
EP12709802.8A 2011-03-28 2012-03-14 Système de remplissage et procédé de remplissage Active EP2691305B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102011001584.1A DE102011001584B4 (de) 2011-03-28 2011-03-28 Abfüllsystem und Abfüllverfahren
PCT/EP2012/001141 WO2012130390A1 (fr) 2011-03-28 2012-03-14 Système de remplissage et procédé de remplissage

Publications (2)

Publication Number Publication Date
EP2691305A1 EP2691305A1 (fr) 2014-02-05
EP2691305B1 true EP2691305B1 (fr) 2015-02-18

Family

ID=45872901

Family Applications (1)

Application Number Title Priority Date Filing Date
EP12709802.8A Active EP2691305B1 (fr) 2011-03-28 2012-03-14 Système de remplissage et procédé de remplissage

Country Status (4)

Country Link
US (1) US9278769B2 (fr)
EP (1) EP2691305B1 (fr)
DE (1) DE102011001584B4 (fr)
WO (1) WO2012130390A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010060469B3 (de) * 2010-11-10 2011-11-10 Sartorius Ag Behälteranordnung und Verfahren zum Füllen von flexiblen Einwegbeuteln
US9315281B2 (en) * 2012-11-19 2016-04-19 Regeneron Pharmaceuticals, Inc. System and methods for use in dispensing biopharmaceutical materials
US20150347421A1 (en) * 2014-05-29 2015-12-03 Avaya Inc. Graph database for a contact center
US20160368629A1 (en) * 2015-05-20 2016-12-22 Stratos Group Llc Systems and methods for aliquoting fluids
EP3329947B1 (fr) * 2016-12-01 2021-06-02 Fenwal, Inc. Systèmes et procédés de remplissage et de finition
TW202144236A (zh) * 2020-02-14 2021-12-01 瑞士商赫孚孟拉羅股份公司 用於液體藥物產物之時間-壓力-充填系統

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE132568C (fr) *
US2791353A (en) * 1953-12-08 1957-05-07 Herman W Dorn Manually operable paint dispensing apparatus
SE9201037L (sv) * 1992-04-02 1993-05-17 Ivan Haakansson Saett och apparat foer att fylla vaetskedoser i behaallare
DE4341934A1 (de) * 1993-12-09 1995-06-14 Bosch Gmbh Robert Verfahren und Vorrichtung zum Dosieren und Abfüllen einer Flüssigkeit in Verpackungsbehälter
DE19640664C1 (de) * 1996-10-02 1998-02-05 Bosch Gmbh Robert Vorrichtung zum Abfüllen einer unter Druck stehenden Flüssigkeit
US6712963B2 (en) * 2002-06-14 2004-03-30 Scilog, Llc Single-use manifold for automated, aseptic transfer of solutions in bioprocessing applications
FR2937618B1 (fr) * 2008-10-23 2010-12-24 Commissariat Energie Atomique Dispositif sterile a usage unique de preparation d'un medicament radiopharmaceutique, systeme et procede mettant en oeuvre ce dispositif
EP2409130B1 (fr) * 2009-03-20 2013-12-04 Pbs Biotech, Inc. Système aseptique automatisable de prélèvement d'échantillons
DE102010060469B3 (de) * 2010-11-10 2011-11-10 Sartorius Ag Behälteranordnung und Verfahren zum Füllen von flexiblen Einwegbeuteln

Also Published As

Publication number Publication date
WO2012130390A1 (fr) 2012-10-04
DE102011001584A1 (de) 2012-10-04
DE102011001584B4 (de) 2018-11-08
US9278769B2 (en) 2016-03-08
EP2691305A1 (fr) 2014-02-05
US20140027010A1 (en) 2014-01-30

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